The FGF family: biology, pathophysiology and therapy

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Thalidomide is an inhibitor of angiogenesis.

D'Amato, R. J., Loughnan, M. S., Flynn, E., & Folkman, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4082 · Cited by 2,454

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.7 · Cited by 2,089

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

White, K., Evans, W. E., O'Riordan, J., Speer, M., Econs, M., Lorenz-Depiereux, B., Grabowski, M., Meitinger, T., & Strom, T. (2000) · Nature Genetics · doi:10.1038/81664 · Cited by 1,467

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho

Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Baum, M. G., Schiavi, S. C., Hu, M. C., Moe, O. W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,381

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Presta, M., Dell’Era, P., Mitola, S. M. F., Moroni, E., Ronca, R., & Rusnati, M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.004 · Cited by 1,283

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., & Mohammadi, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00073-3 · Cited by 1,199

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

Meyers, E., Lewandoski, M., & Martin, G. (1998) · Nature Genetics · doi:10.1038/ng0298-136 · Cited by 1,126

Evolution of the Fgf and Fgfr gene families.

Itoh, N., & Ornitz, D. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.08.007 · Cited by 1,123

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

Francis, F., Hennig, S., Korn, B., Reinhardt, R., de Jong, P., Poustka, A. J., Lehrach, H. R., Rowe, P. S., Goulding, J. N., Summerfield, T. C., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-130 · Cited by 1,095

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

The parathyroid is a target organ for FGF23 in rats

Ben‐Dov, I. Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R. M., Kuro‐o, M., Mohammadi, M., Sirkis, R., Naveh‐Many, T., & Silver, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32409 · Cited by 951

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908

Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia

Jonsson, K. B., Zahradnik, R. J., Larsson, T. E., White, K. E., Sugimoto, T., Imanishi, Y., Yamamoto, T., Hampson, G., Koshiyama, H., Ljunggren, Ö., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020881 · Cited by 904

Sunitinib: From Rational Design to Clinical Efficacy

Chow, L. Q. M., & Eckhardt, S. G. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.3602 · Cited by 894

Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers

Spielberger, R. T., Stiff, P. J., Bensinger, W., Gentile, T., Weisdorf, D. J., Kewalramani, T., Shea, T. C., Yanovich, S., Hansen, K. S., Noga, S. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040125 · Cited by 891

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

Keller, M., Rüegg, A., Werner, S., & Beer, H. (2008) · Cell · doi:10.1016/j.cell.2007.12.040 · Cited by 851

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00067-1 · Cited by 847

Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

Dodé, C., Levilliers, J., Dupont, J., Paepe, A. D., Dû, N. L., Soussi‐Yanicostas, N., Coimbra, R. S., Delmaghani, S., Nouaille, S., Baverel, F., et al. (2003) · Nature Genetics · doi:10.1038/ng1122 · Cited by 839

Structural basis for fibroblast growth factor receptor activation

Mohammadi, M., Olsen, S. K., & Ibrahimi, O. A. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.008 · Cited by 761

sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways

Hacohen, N., Krämer, S., Sutherland, D., Hiromi, Y., & Krasnow, M. A. (1998) · Cell · doi:10.1016/s0092-8674(00)80919-8 · Cited by 750

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas

Cappellen, D., de Oliveira, C. C. B., Ricol, D., de Medina, S. D., Bourdin, J., Sastre-Garau, X., Chopin, D., Thiery, J., & Radvanyi, F. (1999) · Nature Genetics · doi:10.1038/12615 · Cited by 743

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

Cheng, H., Cao, Y., & Olson, L. (1996) · Science · doi:10.1126/science.273.5274.510 · Cited by 743

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

Requirement of FGF-4 for Postimplantation Mouse Development

Feldman, B., Poueymirou, W. T., Papaioannou, V. E., DeChiara, T. M., & Goldfarb, M. P. (1995) · Science · doi:10.1126/science.7809630 · Cited by 730

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesisPreprint

Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K., Donahee, M. H., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., et al. (2003) · Genes & Development · doi:10.1101/gad.1083503 · Cited by 714

Vascular endothelial growth factor enhances atherosclerotic plaque progression

Celletti, F. L., Waugh, J. M., Amabile, P. G., Brendolan, A., Hilfiker, P. R., & Dake, M. D. (2001) · Nature Medicine · doi:10.1038/86490 · Cited by 708

Heparan sulphate proteoglycans: the sweet side of development

Häcker, U., Nybakken, K. E., & Perrimon, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1681 · Cited by 701

Mechanisms underlying differential responses to FGF signaling.

Dailey, L., Ambrosetti, D., Mansukhani, A., & Basilico, C. (2005) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2005.01.007 · Cited by 701

VEGF Gene Delivery to Myocardium

Lee, R. J., Springer, M. L., Blanco-Bose, W. E., Shaw, R. M., Ursell, P. C., & Blau, H. M. (2000) · Circulation · doi:10.1161/01.cir.102.8.898 · Cited by 696

Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers

Larsson, T., Nisbeth, U. L. F., Ljunggren, Ö., Jüppner, H., & Jonsson, K. B. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00328.x · Cited by 689

Increased Circulatory Level of Biologically Active Full-Length FGF-23 in Patients with Hypophosphatemic Rickets/Osteomalacia

Yamazaki, Y., Okazaki, R., Shibata, M., Hasegawa, Y., Satoh, K., Tajima, T., Takeuchi, Y., Fujita, T., Nakahara, K., Yamashita, T., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021105 · Cited by 670

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

Riminucci, M., Collins, M. T., Fedarko, N. S., Cherman, N., Corsi, A., White, K. E., Waguespack, S. G., Gupta, A., Hannon, T. S., Econs, M. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18399 · Cited by 656

Pharmacological Treatment of Coronary Artery Disease With Recombinant Fibroblast Growth Factor-2

Simons, M., Annex, B. H., Laham, R. J., Kleiman, N. S., Henry, T. D., Dauerman, H. L., Udelson, J. E., Gervino, E. V., Pike, M. C., Whitehouse, M. J., et al. (2002) · Circulation · doi:10.1161/hc0802.104407 · Cited by 646

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

Chesi, M., Nardini, E., Brents, L. A., Schröck, E., Ried, T., Kuehl, W. M., & Bergsagel, P. L. (1997) · Nature Genetics · doi:10.1038/ng0797-260 · Cited by 637

Heparin Is Required for Cell-Free Binding of Basic Fibroblast Growth Factor to a Soluble Receptor and for Mitogenesis in Whole Cells

Ornitz, D. M., Yayon, A., Flanagan, J. G., Svahn, C. M., Levi, E., & Leder, P. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.240 · Cited by 632

The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel

Chang, Q., Hoefs, S. J. G., van der Kemp, A. W., Topala, C. N., Bindels, R. J. M., & Hoenderop, J. G. J. (2005) · Science · doi:10.1126/science.1114245 · Cited by 624

Roles of heparan-sulphate glycosaminoglycans in cancer

Sasisekharan, R., Shriver, Z. H., Venkataraman, G., & Narayanasami, U. (2002) · Nature reviews. Cancer · doi:10.1038/nrc842 · Cited by 621

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

Muenke, M., Schell, U., Hehr, A., Robin, N. H., Losken, H. W., Schinzel, A., Pulleyn, L. J., Rutland, P., Reardon, W., Malcolm, S., et al. (1994) · Nature Genetics · doi:10.1038/ng1194-269 · Cited by 614

Large induction of keratinocyte growth factor expression in the dermis during wound healing

Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J., & Williams, L. T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6896 · Cited by 612

Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

Colvin, J. S., Green, R. P., Schmahl, J., Capel, B., & Ornitz, D. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00284-7 · Cited by 596

Area Patterning of the Mammalian Cortex

O’Leary, D. D. M., Chou, S., & Sahara, S. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.010 · Cited by 593

Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis

Topaz, O., Shurman, D. L., Bergman, R., Indelman, M., Ratajczak, P., Mizrachi-Koren, M., Khamaysi, Z., Behar, D. M., Petronius, D., Friedman, V., et al. (2004) · Nature Genetics · doi:10.1038/ng1358 · Cited by 591

FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589

Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes

Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M. E., Williams, P. M., Soriano, R. H., Corpuz, R. T., Moffat, B., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1671 · Cited by 584

Functions of FGF signalling from the apical ectodermal ridge in limb development

Sun, X., Mariani, F. V., & Martin, G. (2002) · Nature · doi:10.1038/nature00902 · Cited by 581

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., et al. (2002) · Endocrinology · doi:10.1210/endo.143.5.8850 · Cited by 576

Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain

Yamashita, T., Yoshioka, M., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3696 · Cited by 553

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Goetz, R. M., Beenken, A., Ibrahimi, O. A., Kalinina, J., Olsen, S. K., Eliseenkova, A. V., Xu, C.-F., Neubert, T. A., Zhang, F., Linhardt, R. J., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 550

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

Orr‐Urtreger, A., Bedford, M. T., Burakova, T., Arman, E., Zimmer, Y., Yayon, A., Givol, D., & Lonai, P. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1205 · Cited by 547

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

Imura, A., Iwano, A., Tohyama, O., Tsuji, Y., Nozaki, K., Hashimoto, N., Fujimori, T., & Nabeshima, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.090 · Cited by 542

Keratinocyte growth factor is required for hair development but not for wound healing.Preprint

Guo, L., Degenstein, L., & Fuchs, E. V. (1996) · Genes & Development · doi:10.1101/gad.10.2.165 · Cited by 537

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.

Sitara, D., Razzaque, M., Hesse, M., Yoganathan, S., Taguchi, T., Erben, R., Jüppner, H., & Lanske, B. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.09.007 · Cited by 528

Induction of Neoangiogenesis in Ischemic Myocardium by Human Growth Factors

Schumacher, B., Pecher, P., Specht, B. U., & Stegmann, T. (1998) · Circulation · doi:10.1161/01.cir.97.7.645 · Cited by 527

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

Naski, M., Wang, Q., Xu, J.-S., & Ornitz, D. (1996) · Nature Genetics · doi:10.1038/ng0696-233 · Cited by 525

Angiogenic Gene Therapy (AGENT) Trial in Patients With Stable Angina Pectoris

Grines, C. L., Watkins, M. W., Helmer, G., Penny, W. F., Brinker, J., Marmur, J. D., West, A., Rade, J. J., Marrott, P. K., Hammond, H. K., et al. (2002) · Circulation · doi:10.1161/hc1102.105595 · Cited by 520

Salvage of Infarcted Myocardium by Angiogenic Action of Basic Fibroblast Growth Factor

Yanagisawa‐Miwa, A., UCHIDA, Y. M. D., Nakamura, F., Tomaru, T., Kido, H., Kamijo, T., Sugimoto, T., Kaji, K., Utsuyama, M., Kurashima, C., et al. (1992) · Science · doi:10.1126/science.1382313 · Cited by 518

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512

Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial

Lederman, R. J., Mendelsohn, F. O., Anderson, R. D., Saucedo, J. F., Tenaglia, A. N., Hermiller, J. B., Hillegass, W. B., Rocha‐Singh, K. J., Moon, T. E., Whitehouse, M. J., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08937-7 · Cited by 510

Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX

Liu, S., Guo, R., Simpson, L. G., Xiao, Z.-S., Burnham, C. E., & Quarles, L. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304544200 · Cited by 505

Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.Preprint

Liu, Z.-H., Xu, J.-S., Colvin, J. S., & Ornitz, D. (2002) · Genes & Development · doi:10.1101/gad.965602 · Cited by 501

Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model

Takagi, Y., Takahashi, J. A., Saiki, H., Morizane, A., Hayashi, T., Kishi, Y., Fukuda, H., Okamoto, Y., Koyanagi, M., Ideguchi, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21137 · Cited by 501

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 501

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497

Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis

Larsson, T. E., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, Ö., Tenenhouse, H. S., Jüppner, H., & Jonsson, K. B. (2004) · Endocrinology · doi:10.1210/en.2003-1768 · Cited by 497

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

Ichikawa, S., Imel, E. A., Kreiter, M. L., Yu, X., Mackenzie, D. S., Sorenson, A. H., Goetz, R. M., Mohammadi, M., White, K. E., & Econs, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31330 · Cited by 491

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.Preprint

Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N., & Takada, S. (2002) · Genes & Development · doi:10.1101/gad.965702 · Cited by 487

An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

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Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus

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Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans.

Logié, A., Dunois‐Lardé, C., Rosty, C., Levrel, O., Blanche, M., Ribeiro, A., Gasc, J., Jorcano, J., Werner, S., Sastre-Garau, X., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi127 · Cited by 191

Basic fibroblast growth factor in patients with intermittent claudication: results of a phase I trial

Lazarous, D. F., Unger, E. F., Epstein, S. E., Stine, A. M., Arevalo, J. L., Chew, E. Y., & Quyyumi, A. A. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00882-2 · Cited by 188

Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus

Chen, W.-W., Li, L., Yang, G.-Y., Li, K., Qi, X.-Y., Zhu, W., Tang, Y., Liu, H., & Boden, G. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-985148 · Cited by 186

Therapeutic angiogenesis in cardiology using protein formulations

Post, M. J. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00216-9 · Cited by 182

Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution

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Identification of a Domain within Peroxisome Proliferator-Activated Receptor γ Regulating Expression of a Group of Genes Containing Fibroblast Growth Factor 21 That Are Selectively Repressed by SIRT1 in Adipocytes

Wang, H., Qiang, L., & Farmer, S. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00992-07 · Cited by 181

Arteriogenesis, a new concept of vascular adaptation in occlusive disease

Scholz, D., Cai, W., & Schaper, W. K. A. (2001) · Angiogenesis · doi:10.1023/a:1016094004084 · Cited by 180

Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis

Ellman, M. B., An, H. S., Muddasani, P., & Im, H. (2008) · Gene · doi:10.1016/j.gene.2008.04.019 · Cited by 180

The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling

Böttcher, R. T., Pollet, N., Delius, H., & Niehrs, C. (2003) · Nature Cell Biology · doi:10.1038/ncb1082 · Cited by 170

Antisense, RNAi, and gene silencing strategies for therapy: Mission possible or impossible?

Rayburn, E. R., & Zhang, R. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.03.014 · Cited by 169

Role of the vitamin D receptor in FGF23 action on phosphate metabolism

Inoue, Y., Segawa, H., Kaneko, I., Yamanaka, S., Kusano, K., Kawakami, E., Furutani, J., Ito, M., Kuwahata, M., Saitô, H., et al. (2005) · Biochemical Journal · doi:10.1042/bj20041799 · Cited by 168

Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris

Unger, E. F., Gonçalves, L. M. M., Epstein, S. E., Chew, E. Y., Trapnell, C. B., Cannon, R. O., Quyyumi, A. A., Loscalzo, F., & Stiber, J. A. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00787-6 · Cited by 167

Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels

Goetz, R. M., Dover, K. Z., Laezza, F., Shtraizent, N., Huang, X., Tchetchik, D., Eliseenkova, A. V., Xu, C., Neubert, T. A., Ornitz, D. M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001842 · Cited by 161

A Novel Skeletal Dysplasia with Developmental Delay and Acanthosis Nigricans Is Caused by a Lys650Met Mutation in the Fibroblast Growth Factor Receptor 3 Gene

Tavormina, P. L., Bellus, G. A., Webster, M. K., Bamshad, M. J., Fraley, A. E., McIntosh, I., Szabo, J., Jiang, W. G., Jabs, E. W., Wilcox, W. R., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302275 · Cited by 161

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

Rand, V., Huang, J., Stockwell, T., Ferriera, S., Buzko, O. V., Lévy, S., Busam, D., Li, K., Edwards, J. B., Eberhart, C. G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507200102 · Cited by 160

Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074

Grand, E., Chase, A., Heath, C., Rahemtulla, A., & Cross, N. (2004) · Leukemia · doi:10.1038/sj.leu.2403347 · Cited by 158

Alternately Spliced NH2-terminal Immunoglobulin-like Loop I in the Ectodomain of the Fibroblast Growth Factor (FGF) Receptor 1 Lowers Affinity for both Heparin and FGF-1(*)

Wang, F., Kan, M., Yan, G.-C., Xu, J.-M., & Mckeehan, W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10231 · Cited by 157

Fibroblast Growth Factor 1

Hutley, L. J., Shurety, W., Newell, F., McGeary, R. P., Pelton, N., Grant, J., Herington, A. C., Cameron, D. P., Whitehead, J. P., & Prins, J. B. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3097 · Cited by 157

The Fibroblast Growth Factor Receptor-4 Arg388 Allele Is Associated with Prostate Cancer Initiation and Progression

Wang, J., Stockton, D. W., & Ittmann, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0408 · Cited by 156

Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein

Ruel, M., Laham, R. J., Parker, J. A., Post, M. J., Ware, J. A., Simons, M., & Sellke, F. W. (2002) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2002.121974 · Cited by 154

Genetic Ablation of Vitamin D Activation Pathway Reverses Biochemical and Skeletal Anomalies in Fgf-23-Null Animals

Sitara, D., Razzaque, M. S., St‐Arnaud, R., Huang, W. Y., Taguchi, T., Erben, R. G., & Lanske, B. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060329 · Cited by 153

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities

Ibrahimi, O. A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh235 · Cited by 153

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

Roumiantsev, S., Krause, D. S., Neumann, C. A., Dimitri, C. A., Asiedu, F., Cross, N. C. P., & Etten, R. A. V. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00053-4 · Cited by 152

LADD syndrome is caused by FGF10 mutations

Milunsky, J., Zhao, G., Maher, T. A., Colby, R., & Everman, D. (2006) · Clinical Genetics · doi:10.1111/j.1399-0004.2006.00597.x · Cited by 151

Constitutive Activation of Fibroblast Growth Factor Receptor-2 by a Point Mutation Associated with Crouzon Syndrome

Neilson, K. M., & Friesel, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26037 · Cited by 150

Inhibition of Activated Fibroblast Growth Factor Receptor 2 in Endometrial Cancer Cells Induces Cell Death Despite PTEN Abrogation

Byron, S. A., Gartside, M. G., Wellens, C. L., Mallon, M. A., Keenan, J. B., Powell, M. A., Goodfellow, P. J., & Pollock, P. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0770 · Cited by 149

Enhancement of Fibroblast Growth Factor (FGF) Activity by an FGF-binding Protein

Tassi, E., Alattar, A. A., Aigner, A. M., Swift, M. R., McDonnell, K., Karavanov, A. A., & Wellstein, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104933200 · Cited by 147

The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells

Trudel, S., Stewart, A. K., Rom, E., Wei, E. N., Li, Z. H., Kotzer, S., Chumakov, I., Singer, Y., Chang, H., Liang, S., et al. (2006) · Blood · doi:10.1182/blood-2005-10-4179 · Cited by 143

Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter

Segawa, H., Kawakami, E., Kaneko, I., Kuwahata, M., Ito, M., Kusano, K., Saitô, H., Fukushima, N., & Miyamoto, K. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1084-1 · Cited by 142

Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease.

van der Walt, J. M., Noureddine, M., Kittappa, R., Hauser, M. A., Scott, W., Mckay, R. D. G., Zhang, F.-Y., Stajich, J., Fujiwara, K., Scott, B., et al. (2004) · American Journal of Human Genetics · doi:10.1086/421052 · Cited by 141

Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling

Wu, X., Ge, H., Gupte, J., Weiszmann, J., Shimamoto, G., Stevens, J., Hawkins, N., Lemon, B., Shen, W., Xu, J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700130200 · Cited by 140

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

Wu, D. Q., Kan, M. K., SATO, G. H., Okamoto, T., & Sato, J. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55368-0 · Cited by 138

Delivery Strategies to Achieve Therapeutic Myocardial Angiogenesis

Kornowski, R., Fuchs, S., Leon, M. B., & Epstein, S. E. (2000) · Circulation · doi:10.1161/01.cir.101.4.454 · Cited by 137

The Fibroblast Growth Factor System and Mood Disorders

Turner, C. A., Akil, H., Watson, S. J., & Evans, S. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.026 · Cited by 131

Molecular mechanisms and clinical applications of angiogenesis

Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467

Basic and Therapeutic Aspects of Angiogenesis

Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771

Fibroblast growth factor signalling: from development to cancer

Turner, N. C., & Grose, R. P. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2780 · Cited by 2,768

Recent advances in bone tissue engineering scaffolds

Bose, S., Roy, M., & Bandyopadhyay, A. K. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.07.005 · Cited by 2,217

The Fibroblast Growth Factor signaling pathway

Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050

FGF Family: From Drug Development to Clinical Application

Hui, Q., Jin, Z., Li, X., Liu, C., & Wang, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071875 · Cited by 182

Therapeutic uses of FGFs

Zhang, J., & Li, Y. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.007 · Cited by 44

FGF-based drug discovery: advances and challenges

Chen, G., Chen, L., Li, X., & Mohammadi, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01125-w · Cited by 51

成纤维细胞生长因子家族：生物学特性，病理生理学作用及相关治疗方法

时小燕, & 郭靓 (2009)

Pathology and Therapeutic Significance of Fibroblast Growth Factors

Edirisinghe, O., Ternier, G., & Kumar, T. K. S. (2025) · Targets · doi:10.3390/targets3010005 · Cited by 8