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The FGF family: biology, pathophysiology and therapy
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The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.
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“As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as an endocrine hormone that signals to distinct targets throughout the body.”
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Thalidomide is an inhibitor of angiogenesis.
D'Amato, R. J., Loughnan, M. S., Flynn, E., & Folkman, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4082 · Cited by 2,454
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.7 · Cited by 2,089
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865
Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
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- Aono Y, et al. The neutralization of FGF-23 ameliorates hypophosphatemia and rickets in Hyp mice. J. Bone Miner. Res. 18, S16 (2003).
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Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Basic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771
Fibroblast growth factor signalling: from development to cancer
Turner, N. C., & Grose, R. P. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2780 · Cited by 2,768
Recent advances in bone tissue engineering scaffolds
Bose, S., Roy, M., & Bandyopadhyay, A. K. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.07.005 · Cited by 2,217
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
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Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
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Babina, I. S., & Turner, N. C. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.8 · Cited by 820
Tremaroli, V., Karlsson, F., Werling, M., Ståhlman, M., Kovatcheva-Datchary, P., Olbers, T., Fändriks, L., le Roux, C. W., Nielsen, J., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.009 · Cited by 757
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
Itoh, N., & Ornitz, D. M. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq121 · Cited by 726
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Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Science · doi:10.1126/science.1198363 · Cited by 637
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Katoh, M., & Nakagama, H. (2013) · Medicinal Research Reviews · doi:10.1002/med.21288 · Cited by 620
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591
Exploring mechanisms of FGF signalling through the lens of structural biology
Goetz, R. M., & Mohammadi, M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3528 · Cited by 597
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Min, H.-Y., & Lee, H.-Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00864-3 · Cited by 569
Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor
Zhao, Y., & Adjei, A. A. (2015) · The Oncologist · doi:10.1634/theoncologist.2014-0465 · Cited by 573
Fibroblast growth factors and their receptors in cancer
Wesche, J., Haglund, K., & Haugsten, E. M. (2011) · Biochemical Journal · doi:10.1042/bj20101603 · Cited by 543
Developmental pathways in the pathogenesis of lung fibrosis
Chanda, D., Otoupalova, E., Smith, S. R., Volckaert, T., Langhe, S. D., & Thannickal, V. J. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.08.004 · Cited by 525
Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
Gotink, K. J., & Verheul, H. M. W. (2009) · Angiogenesis · doi:10.1007/s10456-009-9160-6 · Cited by 526
Guagnano, V., Furet, P., Spanka, C., Bordas, V., Douget, M. L., Stamm, C., Brueggen, J., Jensen, M. R., Schnell, C., SCHMID, H. A., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2006222 · Cited by 485
Molecular Pathways: Fibroblast Growth Factor Signaling: A New Therapeutic Opportunity in Cancer
Brooks, A. N., Kilgour, E., & Smith, P. D. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0699 · Cited by 461
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424
Signaling pathways in obesity: mechanisms and therapeutic interventions
Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 490
Dieci, M. V., Arnedos, M., André, F., & Soria, J. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0362 · Cited by 417
FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)
Katoh, M. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2620 · Cited by 407
Lee, C., Kim, M., Kumar, A., Lee, H., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 484
Tabernero, J. M., Bahleda, R., Dienstmann, R., Infante, J. R., Mita, A. C., Italiano, A., Calvo, E., Moreno, V., Adamo, B., Gazzah, A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.60.7341 · Cited by 390
Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics
Ding, D., & Zhu, Q. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.12.036 · Cited by 394
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Farooq, M., Khan, A. W., Kim, M. S., & Choi, S. (2021) · Cells · doi:10.3390/cells10113242 · Cited by 387
FGF signalling: diverse roles during early vertebrate embryogenesis
Dorey, K., & Amaya, E. (2010) · Development · doi:10.1242/dev.037689 · Cited by 347
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.
Liu, J., Wang, Y., Akamatsu, Y., Lee, C. C., Stetler, R. A., Lawton, M. T., & Yang, G.-Y. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.004 · Cited by 335
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Gozgit, J. M., Wong, M. J., Moran, L. E., Wardwell, S., Mohemmad, Q. K., Narasimhan, N. I., Shakespeare, W. C., Wang, F., Clackson, T., & Rivera, V. M. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0450 · Cited by 322
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Haugsten, E. M., Więdłocha, A., Olsnes, S., & Wesche, J. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0168 · Cited by 320
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Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311
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Jonker, J., Suh, J. M., Atkins, A., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.-Q., Phillips, C. T., et al. (2012) · Nature · doi:10.1038/nature10998 · Cited by 286
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Belov, A. A., & Mohammadi, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015958 · Cited by 278
Self-citationEndocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
Suh, J. M., Jonker, J. W., Ahmadian, M., Goetz, R. M., Lackey, D. E., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T. H., et al. (2014) · Nature · doi:10.1038/nature13540 · Cited by 259
Self-citationFibroblast growth factors: key players in regeneration and tissue repair.
Maddaluno, L., Urwyler, C., & Werner, S. (2017) · Development · doi:10.1242/dev.152587 · Cited by 241
Xie, L., Su, X., Zhang, L., Yin, X., Tang, L., Zhang, X., Xu, Y., Gao, Z., Liu, K., Zhou, M., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3898 · Cited by 240
Itoh, N. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1024-2 · Cited by 241
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Basu-Roy, U., Seo, E., Ramanathapuram, L. V., Rapp, T. B., Perry, J. A., Orkin, S. H., Mansukhani, A., & Basilico, C. (2011) · Oncogene · doi:10.1038/onc.2011.405 · Cited by 239
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Teven, C. M., Farina, E. M., Rivas, J., & Reid, R. R. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.09.005 · Cited by 237
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Demidova‐Rice, T. N., Hamblin, M. R., & Herman, I. M. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000418541.31366.a3 · Cited by 240
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Hwang, S., Park, S., & Kwon, Y. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.006 · Cited by 239
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Patel-Hett, S. R., & D'Amore, P. A. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103213sp · Cited by 241
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Střı́ž, I., Brabcová, E., Kolesár, L., & Sekerková, A. (2014) · Clinical Science · doi:10.1042/cs20130497 · Cited by 231
FGF19 action in the brain induces insulin-independent glucose lowering
Morton, G. J., Matsen, M. E., Bracy, D. P., Meek, T. H., Hồng, N. T., Stefanovski, D., Bergman, R. N., Wasserman, D. H., & Schwartz, M. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70710 · Cited by 218
Borena, B. M., Martens, A., Broeckx, S. Y., Meyer, E., Chiers, K., Duchateau, L., & Spaas, J. H. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000374049 · Cited by 217
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Akl, M. R., Nagpal, P., Ayoub, N. M., Tai, B., Prabhu, S. A., Capac, C. M., Gliksman, M., Goy, A. H., & Suh, K. S. (2016) · Oncotarget · doi:10.18632/oncotarget.8203 · Cited by 212
Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.
Angelin, B., Larsson, T., & Rudling, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.001 · Cited by 210
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Gilbert, M. P., & Pratley, R. E. (2015) · Endocrine Reviews · doi:10.1210/er.2012-1042 · Cited by 211
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Ellman, M. B., Yan, D., Ahmadinia, K., Chen, D., An, H. S., & Im, H.-J. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24418 · Cited by 208
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Shi, H., Lin, C., Lin, B., Wang, Z., Zhang, H., Wu, F., Cheng, Y. H., Xiang, L., Di-Jiong, G., Luo, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059966 · Cited by 210
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Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach
Presta, M., Chiodelli, P., Giacomini, A., Rusnati, M., & Ronca, R. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.013 · Cited by 200
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Kobayashi, J., Kikuchi, A., Aoyagi, T., & Okano, T. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36627 · Cited by 199
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Knights, V., & Cook, S. J. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.001 · Cited by 201
Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy
Gacche, R. N., & Meshram, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.002 · Cited by 203
Chow, W. S., Xu, A., Woo, Y. C., Tso, A. W. K., Cheung, S., Fong, C. H.-Y., Tse, H., Chau, M. T., Cheung, B. M. Y., & Lam, K. S. L. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301599 · Cited by 193
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Matsumoto, K., Arao, T., Hamaguchi, T., Shimada, Y., Kato, K., Oda, I., Taniguchi, H., Koizumi, F., Yanagihara, K., Sasaki, H., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2011.603 · Cited by 192
Lee, J., Su, S.-Y., Changou, C. A., Yang, R., Tsai, K., Collins, M. T., ORWOLL, E. S., Lin, C., Chen, S., Shih, S., et al. (2016) · Modern Pathology · doi:10.1038/modpathol.2016.137 · Cited by 186
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Wu, A.-L., Coulter, S., Liddle, C., Wong, A., Eastham‐Anderson, J., French, D. M., Peterson, A. S., & Sonoda, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017868 · Cited by 185
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Zhou, M., Wang, X., Phung, V., Lindhout, D. A., Mondal, K., Hsu, J.-Y., Yang, H., Humphrey, M., Ding, X., Arora, T., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0208 · Cited by 183
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Murakami, M., Nguyen, L. T., Hatanaka, K., Schachterle, W., Chen, P., Zhuang, Z. W., Black, B. L., & Simons, M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44762 · Cited by 187
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STEVENSON, W. C., Cheng, S.-F., Dastjerdi, M. H., Ferrari, G., & Dana, R. (2012) · The Ocular Surface · doi:10.1016/j.jtos.2012.01.005 · Cited by 185
Lin, Z., Wu, Z., Yin, X., Liu, Y., Yan, X., Lin, S., Xiao, J., Wang, X., Feng, W., & Li, X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015534 · Cited by 179
Oxidative Stress, Diabetes, and Diabetic Complications
Wei, W., Liu, Q., Tan, Y., Liu, L., Li, X., & Cai, L. (2009) · Hemoglobin · doi:10.3109/03630260903212175 · Cited by 178
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Metadata
- Authors
- Beenken, A., & Mohammadi, M.
- Affiliations
- New York University (US)
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-03
- Volume
- 8
- Issue
- 3
- Pages
- 235-253
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC3684054
- OpenAlex
- W2027239974
- Cited by
- 1,945
- References
- 281
- Citations by year
- 2026: 71 · 2025: 112 · 2024: 114 · 2023: 132 · 2022: 127 · 2021: 125 · 2020: 141 · 2019: 123 · 2018: 114 · 2017: 121 · 2016: 119 · 2015: 126 · 2014: 129 · 2013: 97 · 2012: 111
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32-GM066704-05, T32GM066704)
- National Institute of Dental and Craniofacial Research (R01DE13686, R01DE013686)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- fibroblast growth factor, cancer therapy, cardiovascular disease, metabolic syndrome, FGF19, bile acid homeostasis, glucose homeostasis, phosphate homeostasis, angiogenesis, brain patterning, limb development, branching morphogenesis
- MeSH terms
- Animals, Cardiovascular Diseases, Fibroblast Growth Factors, Homeostasis, Humans, Neoplasms, Receptors, Fibroblast Growth Factor, Hypophosphatemia, Metabolic Syndrome
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