The history of toll-like receptors - redefining innate immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444

Vascular Stress Signaling in Hypertension

Cicalese, S. M., da Silva, J. F., Priviero, F. B. M., Webb, R. C., Eguchi, S., & Tostes, R. C. (2021) · Circulation Research · doi:10.1161/circresaha.121.318053 · Cited by 54

Thrombosis in COVID-19 infection: Role of platelet activation-mediated immunity

Behzadifard, M., Fard, S. B., Ramazi, S., Atashi, A., & Eslamifar, Z. (2021) · Thrombosis Journal · doi:10.1186/s12959-021-00311-9 · Cited by 53

SARS-CoV-2 subunit vaccine adjuvants and their signaling pathways

Mekonnen, D. S., Mengist, H. M., & Jin, T. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1991794 · Cited by 55

Inflammation-driven NF-κB signaling represses ferroportin transcription in macrophages via HDAC1 and HDAC3

Marques, O., Horvat, N. K., Zechner, L., Colucci, S., Sparla, R., Zimmermann, S., Neufeldt, C. J., Altamura, S., Qiu, R., Müdder, K., et al. (2024) · Blood · doi:10.1182/blood.2023023417 · Cited by 55

Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia

Aslanidis, A., Karlstetter, M., Scholz, R., Fauser, S., Neumann, H., Fried, C., Pietsch, M., & Langmann, T. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0296-6 · Cited by 53

TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology

Chen, C.-Y., Liu, H., & Hsueh, Y. (2016) · EMBO Reports · doi:10.15252/embr.201642586 · Cited by 54

The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function

Kannegieter, N. M., Hesselink, D. A., Dieterich, M., Kraaijeveld, R., Rowshani, A. T., Leenen, P. J. M., & Baan, C. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170806 · Cited by 53

TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation

Park, S.-H., Shin, H., Shah, M., Cho, H.-Y., Anwar, M. A., Achek, A., Kwon, H., Byugsung, L., Yoo, T. H., & Choi, S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.023 · Cited by 54

Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity

Yang, L., Liu, S., Ding, J., Dai, R., He, C., Xu, K., Honaker, C. F., Zhang, Y., Siegel, P. B., & Meng, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01243 · Cited by 53

Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection

Kang, I., Chang, M. Y., Wight, T. N., & Frevert, C. W. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417751880 · Cited by 53

Immunoengineering with biomaterials for enhanced cancer immunotherapy

Xie, Y., Wei, L., & Tang, L. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1506 · Cited by 53

An IRAK1–PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy

Liu, P. H., Shah, R. B., Li, Y., Arshi, A., Ung, P. M. U., Raman, R., Gorbatenko, A., Kozono, S., Zhou, X. Z., Brechin, V., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0260-7 · Cited by 53

E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages

Lu, M., Zhu, X., Yang, Z., Zhang, W., Sun, Z., Ji, Q., Chen, X., Zhu, J., Wang, C., & Nie, S. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.01.015 · Cited by 53

Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection

Ionescu, V. A., Diaconu, C. C., Gheorghe, G., Mihai, M.-M., Diaconu, C. C., Bostan, M., & Bleoţu, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083733 · Cited by 55

Toll-like receptor pathway evolution in deuterostomes

Tassia, M. G., Whelan, N. V., & Halanych, K. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617722114 · Cited by 53

Immunostimulation and trained immunity in marine fish larvae

Rojo-Cebreros, A. H., Ibarra‐Castro, L., & Martínez-Brown, J. M. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.05.044 · Cited by 52

Immune response of pearl oysters to stress and diseases

Adzigbli, L., Hao, R., Jiao, Y., Deng, Y., Du, X., Wang, Q., & Huang, R. (2019) · Reviews in Aquaculture · doi:10.1111/raq.12329 · Cited by 52

“Repair Me if You Can”: Membrane Damage, Response, and Control from the Viral Perspective

Daussy, C. F., & Wodrich, H. (2020) · Cells · doi:10.3390/cells9092042 · Cited by 52

Type I interferonopathies—an expanding disease spectrum of immunodysregulation

Lee‐Kirsch, M. A., Wolf, C., Kretschmer, S., & Roers, A. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0500-x · Cited by 57

Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis

Wang, B., Zhou, W., Zhang, H., Wang, W., Zhang, B., & Li, S. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115930 · Cited by 53

An insight overview on COVID-19 mRNA vaccines: Advantageous, pharmacology, mechanism of action, and prospective considerations

Mirtaleb, M. S., Falak, R., Heshmatnia, J., Bakhshandeh, B., Taheri, R. A., Soleimanjahi, H., & Emameh, R. Z. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109934 · Cited by 55

TLR 3 engagement induces IRF ‐3‐dependent apoptosis in androgen‐sensitive prostate cancer cells and inhibits tumour growth in vivo

Gambara, G., Desideri, M., Stoppacciaro, A., Padula, F., Cesaris, P. D., Starace, D., Tubaro, A., Bufalo, D. D., Filippini, A., Elio Ziparo, A., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12379 · Cited by 51

Modulation of Toll-like receptor signaling in innate immunity by natural products

Chen, L., & Yu, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.02.005 · Cited by 51

Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains

Walker, D. G., Tang, T. M., & Lue, L. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.016 · Cited by 51

Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy

Buqué, A., Bloy, N., Aranda, F., Cremer, I., Eggermont, A. M. M., Fridman, W. H., Fucikova, J. P., Galon, J., Špíšek, R., Tartour, É., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1149674 · Cited by 50

Pathogenic bacterial toxins and virulence influences in cultivable fish

Sarkar, P., Issac, P. K., Raju, S. V., Elumalai, P., Arshad, A., & Arockiaraj, J. (2021) · Aquaculture Research · doi:10.1111/are.15089 · Cited by 50

BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis

Mu, W., Qian, S., Song, Y.-J., Yang, L., Song, S., Yang, Q., Liu, H., Liu, Y., Pan, D., Tang, Y., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101979 · Cited by 50

Injury-induced inflammatory signaling and hematopoiesis in Drosophila

Evans, C. J., Liu, T., Girard, J. R., & Banerjee, U. K. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119109119 · Cited by 51

Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-κB activation

Li, C., Chai, J., Li, H., Zuo, H., Wang, S., Qiu, W., Weng, S., He, J., & Xu, X. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.01.012 · Cited by 50

Hypoxia-inducible factor-1α regulation of myeloid cells

Stothers, C. L., Luan, L., Fensterheim, B. A., & Bohannon, J. K. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1710-1 · Cited by 52

Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes

Paracatu, L. C., & Schuettpelz, L. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01236 · Cited by 51

Silk sericin application increases bone morphogenic protein-2/4 expression via a toll-like receptor-mediated pathway

Jo, Y., Kweon, H., Kim, D. W., Baek, K., Chae, W., Kang, Y.-J., Oh, J.-H., Kim, S., & Garagiola, U. M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.09.021 · Cited by 50

Step up to the platelet: Role of platelets in inflammation and infection

Carestia, A., Godin, L. C., & Jenne, C. N. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.10.001 · Cited by 51

Exosomes from adipose-derived stem cells accelerate wound healing by increasing the release of IL-33 from macrophages

Wang, Y., Ding, H., Bai, R., Li, Q., Ren, B., Lin, P., Li, C., Chen, M., & Xu, X. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04203-x · Cited by 51

Homeostasis between gut-associated microorganisms and the immune system in Drosophila

You, H., Lee, W. J., & Lee, W. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.006 · Cited by 49

The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair

Ramnath, D., Powell, E. E., Scholz, G. M., & Sweet, M. J. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.014 · Cited by 49

Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway

Lei, W., Browning, J. D., Eichen, P. A., Lu, C., Mossine, V. V., Rottinghaus, G. E., Folk, W. R., Sun, G. Y., Lubahn, D. B., & Fritsche, K. L. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.06.013 · Cited by 49

Structure‐Based Design of Novel Human Toll‐like Receptor 8 Agonists

Kokatla, H. P., Sil, D., Tanji, H., Ohto, U., Malladi, S. S., Fox, L. M., Shimizu, T., & David, S. A. (2014) · ChemMedChem · doi:10.1002/cmdc.201300573 · Cited by 48

Innate immune activation of NFκB and its antagonism by poxviruses

Brady, G., & Bowie, A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.004 · Cited by 48

Ectodomain Architecture Affects Sequence and Functional Evolution of Vertebrate Toll-like Receptors

Wang, J., Zhang, Z., Liu, J., Zhao, J., & Yin, D. (2016) · Scientific Reports · doi:10.1038/srep26705 · Cited by 48

Immunomodulatory effect of APS and PSP is mediated by Ca2 + -cAMP and TLR4/NF-κB signaling pathway in macrophage

Wang, Z., Liu, Z., Zhou, L., Long, T., Zhou, X., & Bao, Y. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.018 · Cited by 48

Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice

Lu, P., Sodhi, C. P., Yamaguchi, Y., Jia, H., Prindle, T., Fulton, W. B., Vikram, A., Bibby, K. J., Morowitz, M. J., & Hackam, D. J. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.114 · Cited by 52

The Anti-Inflammatory Mediator, Vasoactive Intestinal Peptide, Modulates the Differentiation and Function of Th Subsets in Rheumatoid Arthritis

Villanueva‐Romero, R., Gutiérrez‐Cañas, I., Carrión, M., Pérez‐García, S., Seoane, I. V., Martínez, C., Gomariz, R. P., & Juarranz, Y. (2018) · Journal of Immunology Research · doi:10.1155/2018/6043710 · Cited by 48

A novel TLR4 binding protein, 40S ribosomal protein S3, has potential utility as an adjuvant in a dendritic cell-based vaccine

Park, H. J., Jang, G.-Y., Kim, Y. S., Park, J. H., Lee, S., Vo, M.-C., Lee, J., Han, H. D., Jung, I. D., Kang, T. H., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0539-7 · Cited by 48

Genetics on early onset inflammatory bowel disease: An update

Johnson, N., Rikhi, R., Rawat, S. S., Sharma, J., & Suri, D. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.003 · Cited by 48

The uterine immunological changes may be responsible for repeated implantation failure

Amjadi, F., Zandieh, Z., Mehdizadeh, M., Aghajanpour, S., Raoufi, E., Aghamajidi, A., & Aflatoonian, R. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103080 · Cited by 47

The physiology of MASLD: molecular pathways between liver and adipose tissues

Lee, W., Kipp, Z. A., Bates, E. A., Pauss, S. N., Martinez, G. J., & Hinds, T. D. (2025) · Clinical Science · doi:10.1042/cs20257571 · Cited by 52

Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE−/− mice and activate platelets via TLR2

Biswas, S., Liang, X., Panigrahi, S., Zimman, A., Wang, H., Yakubenko, V. P., Byzova, T. V., Salomon, R. G., & Podrez, E. A. (2016) · Blood · doi:10.1182/blood-2015-08-664300 · Cited by 47

Molecular-Level Interactions of Polyphosphazene Immunoadjuvants and Their Potential Role in Antigen Presentation and Cell Stimulation

Andrianov, A. K., Marin, A., & Fuerst, T. R. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b01251 · Cited by 47

Mathematics in modern immunology

Castro, M., Lythe, G., Molina-Parı́s, C., & Ribeiro, R. M. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0093 · Cited by 49

Reduced meal frequency alleviates high-fat diet-induced lipid accumulation and inflammation in adipose tissue of pigs under the circumstance of fixed feed allowance

Yan, H., Cao, S., Li, Y., Zhang, H., & Liu, J. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01928-3 · Cited by 47

Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway

Cheng, J., Sun, Y., Zhang, X., Zhang, F., Zhang, S., Yu, S., Qiu, X., Tan, L., Song, C., Gao, S., et al. (2014) · Archives of Virology · doi:10.1007/s00705-014-2148-6 · Cited by 46

Nanoparticle Based-immunotherapy Against Allergy

Gamazo, C., Gastaminza, G., Ferrer, M., Sanz, M. L., & Irache, J. M. (2014) · Immunotherapy · doi:10.2217/imt.14.63 · Cited by 46

High-Risk Human Papillomavirus Targets Crossroads in Immune Signaling

Tummers, B., & van der Burg, S. (2015) · Viruses · doi:10.3390/v7052485 · Cited by 51

Comparative genomic evidence for duplication of TLR1 subfamily and miiuy croaker TLR1 perceives LPS stimulation via MyD88 and TIRAP

Xu, T., Wang, Y., Li, J., Shu, C., Han, J., & Chu, Q. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.07.024 · Cited by 46

A role for viral infections in Parkinson’s etiology?

Olsen, L. K., Dowd, E., & McKernan, D. P. (2018) · Neuronal Signaling · doi:10.1042/ns20170166 · Cited by 48

SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

Li, Q., Wang, F., Wang, Q., Zhang, N., Zheng, J., Zheng, M., Liu, R., Cui, H., Wen, J., & Zhao, G. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008188 · Cited by 47

Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation

Jin, S., Kim, K. K., Park, B. S., Kim, D. H., Jeong, B., Kang, D., Lee, T. H., Park, J. W., Kim, J. G., & Lee, B. J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01846-w · Cited by 46

Cytotoxicity and Immune Dysfunction of Dendritic Cells Caused by Graphene Oxide

Yang, Z., Pan, Y., Chen, T., Li, L., Zou, W., Liu, D., Xue, D., Wang, X., & Lin, G. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01206 · Cited by 46

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity

Hopkins, E. L., Gu, W., Kobe, B., & Coleman, M. P. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.703532 · Cited by 48

A review of typical biological activities of glycyrrhetinic acid and its derivatives

Chen, L., Gong, J., Yong, X., Li, Y., & Wang, S. (2024) · RSC Advances · doi:10.1039/d3ra08025k · Cited by 45

Extracellular calcium elicits feedforward regulation of the Toll-like receptor-triggered innate immune response

Tang, S., Chen, T., Yang, M., Wang, L., Zhou, Y., Xie, B., Qian, C., Xu, S., Li, N., Cao, X., et al. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.59 · Cited by 46

Effects of TLR agonists and viral infection on cytokine and TLR expression in Atlantic salmon (Salmo salar)

Arnemo, M., Kavaliauskis, A., & Gjøen, T. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.03.023 · Cited by 45

A Small Molecule, Odanacatib, Inhibits Inflammation and Bone Loss Caused by Endodontic Disease

Hao, L., Chen, W., McConnell, M., Zhu, Z. G., Li, S., Reddy, M. S., Eleazer, P. D., Wang, M., & Li, Y. (2015) · Infection and Immunity · doi:10.1128/iai.01713-14 · Cited by 45

The role of Toll‐like receptor 10 in modulation of trained immunity

Mourits, V. P., Arts, R. J. W., Novakovic, B., Matzaraki, V., de Bree, L. C. J., Koeken, V. A. C. M., Moorlag, S. J. C. F. M., van Puffelen, J. H., Groh, L. A., van der Heijden, C. D. C. C., et al. (2019) · Immunology · doi:10.1111/imm.13145 · Cited by 45

Implications of endotoxins in wound healing: a narrative review

Rippon, M. G., Westgate, S. J., & Rogers, A. A. (2022) · Journal of Wound Care · doi:10.12968/jowc.2022.31.5.380 · Cited by 46

NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism

Ren, Z., Xu, Y., Li, T., Sun, W., Tang, Z., Wang, Y., Zhou, K., Li, J., Ding, Q., Liang, K., et al. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2022.06.009 · Cited by 44

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection

Johnston, D. G. W., Kearney, J., Zasłona, Z., Williams, M. A., O'Neill, L. A. J., & Corr, S. C. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00201 · Cited by 44

Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy

Lee, D., Rosenthal, C. J., Penn, N. E., Dunn, Z. S., Zhou, Y., & Yang, L. (2022) · Cancers · doi:10.3390/cancers14123005 · Cited by 44

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation

Pellegrini, E., Signor, L., Singh, S. P., Erba, E. B., & Cusack, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177161 · Cited by 45

Nucleosomes and neutrophil extracellular traps in septic and burn patients

Kaufman, T., Magosevich, D., Moreno, M. C., Guzman, M. A., D’Atri, L. P., Carestia, A., Fandiño, M. E., Fondevila, C. G., & Schattner, M. A. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.08.014 · Cited by 44

Improving Cancer Vaccine Efficiency by Nanomedicine

Cai, J., Wang, H., Wang, D., & Li, Y. (2019) · Advanced Biosystems · doi:10.1002/adbi.201800287 · Cited by 44

TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut

Wang, H., Kwon, Y. H., Dewan, V., Vahedi, F., Syed, S. A., Fontes, M. E., Ashkar, A. A., Surette, M. G., & Khan, W. I. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801034 · Cited by 44

TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation

Hasan, A., Akhter, N., Al-Roub, A., Thomas, R., Kochumon, S., Wilson, A., Koshy, M., Al‐Ozairi, E., Al‐Mulla, F., & Ahmad, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174112 · Cited by 44

The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation

Zhang, W. K., Zhuang, N., Liu, X., He, L., He, Y., Mahinthichaichan, P., Zhang, H., Kang, Y., Lu, Y., Wu, Q., et al. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0281-6 · Cited by 45

CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation

Cui, S., Wang, C., Bai, W., Li, J., Pan, Y., Huang, X., Yang, H., Feng, Z., Xiang, Q., Fei, L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz7290 · Cited by 44

Lactiplantibacillus plantarum postbiotic protects against Salmonella infection in broilers via modulating NLRP3 inflammasome and gut microbiota

Guan, L., Hu, A., Ma, S., Liu, J., Yao, X., Ye, T., Han, M., Yang, C., Zhang, R., Xiao, X., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103483 · Cited by 46

Pediatric Vaccine Adjuvants

Dowling, D. J., & Levy, O. (2015) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000893 · Cited by 43

Salmonella-induced inflammasome activation in humans

Bierschenk, D., Boucher, D., & Schroder, K. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.11.009 · Cited by 43

Particulate matter air pollution from the city of Quito, Ecuador, activates inflammatory signaling pathways in vitro

Bonilla, V. M. C., Díaz, V., & Sirois, C. M. (2017) · Innate Immunity · doi:10.1177/1753425917699864 · Cited by 43

Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico

Mobarak, E., Håversen, L., Manna, M., Rutberg, M., Levin, M. C., Perkins, R., Róg, T., Vattulainen, I., & Borén, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-31926-0 · Cited by 43

Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression

Xie, L., Yang, Y., Meng, J., Wen, T., Liu, J., & Xu, H. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.089 · Cited by 43

Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis

Jha, A., Thwaites, R. S., Tunstall, T., Kon, O. M., Shattock, R. J., Hansel, T. T., & Openshaw, P. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.07.012 · Cited by 43

Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

Mussari, C. P., Dodd, D. S., Sreekantha, R. K., Laxman, P., Wan, H., Posy, S., Critton, D., Ruepp, S. U., Subramanian, M., Watson, A., et al. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.0c00264 · Cited by 44

Key Player in Cardiac Hypertrophy, Emphasizing the Role of Toll-Like Receptor 4

Xiao, Z., Kong, B., Yang, H., Dai, C., Fang, J., Qin, T., & Huang, H. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.579036 · Cited by 43

Socs1 and Socs3 degrades Traf6 via polyubiquitination in LPS-induced acute necrotizing pancreatitis

Zhou, X., Liu, Z., Cheng, X., Zheng, Y., Zeng, F., & He, Y. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.342 · Cited by 43

Proteome and Secretome Analysis Reveals Differential Post-transcriptional Regulation of Toll-like Receptor Responses

Koppenol-Raab, M., Sjoelund, V. H., Manes, N. P., Gottschalk, R. A., Dutta, B., Benet, Z. L., Fraser, I. D. C., & Nita‐Lazar, A. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.064261 · Cited by 42

CNBP controls IL-12 gene transcription and Th1 immunity

Chen, Y., Sharma, S., de Assis, P. A., Jiang, Z., Elling, R., Olive, A. J., Hang, S., Bernier, J., Huh, J. R., Sassetti, C. M., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181031 · Cited by 42

Procyanidins exhibits neuroprotective activities against cerebral ischemia reperfusion injury by inhibiting TLR4-NLRP3 inflammasome signal pathway

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A review: Roles of carbohydrates in human diseases through regulation of imbalanced intestinal microbiota

Cheng, X., Zheng, J., Lin, A., Xia, H., Zhang, Z., Gao, Q., Lv, W., & Liu, H. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104197 · Cited by 44

Intake of Lactobacillus delbrueckii (pExu:hsp65) Prevents the Inflammation and the Disorganization of the Intestinal Mucosa in a Mouse Model of Mucositis

Barroso, F. A. L., de Jesus, L. C. L., de Castro, C. P., Batista, V. L., Ferreira, E. F., Fernandes, R. S., de Barros, A. L. B., Leclercq, S. Y., Azevedo, V., Mancha-Agresti, P. D. C., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9010107 · Cited by 43

Gut microbiota as a key player in triggering obesity, systemic inflammation and insulin resistance.

Escobedo, G., López‐Ortiz, E., & Torres-Castro, I. (2014) · PubMed · Cited by 42

The Role of TLR4 in M1 Macrophage-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells

Shi, J., Li, Q., Sheng, M., Zheng, M., Yu, M., & Zhang, L. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000453204 · Cited by 42

Discovery of 6-Amino-2-{[(1 S )-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8 H -purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

Biggadike, K., Ahmed, M., Ball, D. I., Coe, D. M., Dalmas, D. A., Edwards, C. D., Gibbon, B. H., Hardy, C. J., Hermitage, S. A., Hessey, J., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01647 · Cited by 42

Innate Immune Receptors

Muñoz‐Wolf, N., & Lavelle, E. C. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3566-6_1 · Cited by 43

Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway

Ding, Y., Peng, Z., Ding, L., & Peng, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00389 · Cited by 41

A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice

Kwon, H., Patra, M. C., Shin, H., Gui, X., Achek, A., Panneerselvam, S., Kim, D., Song, S.-J., Hong, R., Kim, K. S., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0244-0 · Cited by 41

The role of topical imiquimod in melanoma cutaneous metastases: A critical review of the literature

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Safety, Pharmacokinetics, and Pharmacodynamics of the Oral TLR8 Agonist Selgantolimod in Chronic Hepatitis B

Gane, E. J., Kim, H. J., Visvanathan, K., Kim, Y. J., Nguyen, A., Wallin, J. J., Chen, D. Y., McDonald, C., Arora, P., Tan, S. K., et al. (2021) · Hepatology · doi:10.1002/hep.31795 · Cited by 41

A human monocytic NF-κB fluorescent reporter cell line for detection of microbial contaminants in biological samples

Battin, C., Hennig, A., Mayrhofer, P., Kunert, R., Zlabinger, G. J., Steinberger, P., & Paster, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178220 · Cited by 41

Innate immunity's path to the N obel P rize 2011 and beyond

Wagner, H. (2012) · European Journal of Immunology · doi:10.1002/eji.201242404 · Cited by 18

Innate immunity and the 2011 Nobel Prize

Deobagkar‐Lele, M., Bhaskarla, C., Dhanaraju, R., Ponnusamy, M., & Nandi, D. (2012) · Resonance · doi:10.1007/s12045-012-0111-y · Cited by 1

Of Flies and Men—The Discovery of TLRs

Weiss, H. J., & O'Neill, L. A. J. (2022) · Cells · doi:10.3390/cells11193127 · Cited by 29

Nagroda Nobla 2011: dwa rodzaje odporności

Drela, N. (2012) · Cited by 1

2011 Nobel Prize in Physiology or Medicine

Tedgui, A., Owens, A. P., & Mackman, N. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.240432 · Cited by 8