The history of toll-like receptors - redefining innate immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444

Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson’s disease

Olsen, L. K., Cairns, A. G., Ådén, J., Moriarty, N., Cabré, S., Alamilla, V., Almqvist, F., Dowd, E., & McKernan, D. P. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.036 · Cited by 21

Molecular characterization and expression of a novel Toll gene from the swimming crab Portunus trituberculatus

Li, M. C., Li, C., Wang, J., & Song, S. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.06.028 · Cited by 22

Pro-apoptotic signaling induced by Retinoic acid and dsRNA is under the control of Interferon Regulatory Factor-3 in breast cancer cells

Bernardo, A. R., Cosgaya, J. M., Aranda, A., & Jimenez-Lara, A. M. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1377-z · Cited by 21

Toll-like receptor 4-mediated expression of interleukin-32 via the c-Jun N-terminal kinase/protein kinase B/cyclic adenosine monophosphate response element binding protein pathway in chronic rhinosinusitis with nasal polyps

Cho, J.-S., Kim, J.-A., Park, J., Park, I., Han, I.-H., & Lee, H.-M. (2016) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21792 · Cited by 20

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS

Urbahn, M.-A., Kaup, S. C., Reusswig, F., Krüger, I., Spelleken, M., Jurk, K., Klier, M., Lang, P. A., & Elvers, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28331-y · Cited by 20

Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection

Bhalla, N., Gardner, C. L., Downs, S. N., Dunn, M., Sun, C., & Klimstra, W. B. (2019) · Journal of Virology · doi:10.1128/jvi.00872-19 · Cited by 20

Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway

Jin, X., Yuan, Y., Zhang, C., Yong, Z., Song, Y. Q., Wei, Z., & Zhang, G. (2020) · Journal of Veterinary Science · doi:10.4142/jvs.2020.21.e50 · Cited by 20

Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A Dragon-Like Weapon in a Non-fantasy Game of Thrones

Angrini, M., Varthaman, A., & Cremer, I. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-44518-8_9 · Cited by 20

Effects of Dietary Brown Rice on the Growth Performance, Systemic Oxidative Status, and Splenic Inflammatory Responses of Broiler Chickens under Chronic Heat Stress

Nanto-Hara, F., Ohtsu, H., Yamazaki, M., Hirakawa, T., Sato, K., & Murakami, H. (2020) · The Journal of Poultry Science · doi:10.2141/jpsa.0200063 · Cited by 20

Netrin-1 protects the SH-SY5Y cells against amyloid beta neurotoxicity through NF-κB/Nrf2 dependent mechanism

Zamani, E., Parviz, M., Roghani, M., Hosseini, M., Moghaddam, P. M., & Nikbakhtzadeh, M. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05996-1 · Cited by 20

IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

Akaki, K., Ogata, K., Yamauchi, Y., Iwai, N., Tse, K. M., Hia, F., Mochizuki, A., Ishihama, Y., Mino, T., & Takeuchi, O. (2021) · eLife · doi:10.7554/elife.71966 · Cited by 21

Toll-like Receptor Signaling Inhibitory Peptide Improves Inflammation in Animal Model and Human Systemic Lupus Erythematosus

Baek, W., Choi, Y. S., Lee, S.-W., Son, I.-O., Jeon, K.-W., Choi, S., & Suh, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312764 · Cited by 20

The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms

Ramnath, D., Gupta, K. D., Wang, Y., Abrol, R., Curson, J. E. B., Lim, J., Reid, R. C., Mansell, A., Blumenthal, A., Karunakaran, D., et al. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mr1021-260r · Cited by 20

Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression

Giurini, E. F., Madonna, M. B., Zloza, A., & Gupta, K. H. (2022) · Cancers · doi:10.3390/cancers14122923 · Cited by 20

Neofunctionalization of Toll Signaling in Insects: From Immunity to Dorsoventral Patterning

Roth, S. (2023) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120319-120223 · Cited by 20

A DNA-polymer hybrid nanocomplex based bi-adjuvant vaccine for tumor immunotherapy

Li, F., Ding, X., Lv, Z., Li, J., & Yang, D. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102061 · Cited by 20

Emerging single-cell technologies in immunology

Herderschee, J., Fenwick, C. W., Pantaleo, G., Roger, T., & Calandra, T. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.6ru0115-020r · Cited by 22

Rabies virus lipopeptide conjugated to a TLR7 agonist improves the magnitude and quality of the Th1-biased humoral immune response in mice

Liu, R., Wang, J., Yang, Y., Khan, I., & Zhu, N. (2016) · Virology · doi:10.1016/j.virol.2016.06.019 · Cited by 20

Human parechovirus and enterovirus initiate distinct CNS innate immune responses: Pathogenic and diagnostic implications

Fortuna, D., Cárdenas, A. M., Graf, E. H., Harshyne, L. A., Hooper, D. C., Prosniak, M., Shields, J., & Curtis, M. T. (2016) · Journal of Clinical Virology · doi:10.1016/j.jcv.2016.11.007 · Cited by 20

Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in peroxinectin gene expression in Fenneropenaeus penicillatus

Cai, S., Huang, Y., Wang, B., Jian, J., & Xu, Y. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.03.026 · Cited by 20

Toll-like receptor activation, vascular endothelial function, and hypertensive disorders of pregnancy

Balasubbramanian, D., Gelston, C. A. L., Mitchell, B. M., & Chatterjee, P. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.018 · Cited by 20

Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease

Bauer, A. K., Upham, B. L., Rondini, E. A., Tennis, M. A., Velmuragan, K., & Wiese, D. (2017) · Oncotarget · doi:10.18632/oncotarget.19463 · Cited by 20

Metabolism in Immune Cell Differentiation and Function

Chapman, N. M., Shrestha, S., & Chi, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1170-6_1 · Cited by 22

Neuroprotective effect of monophosphoryl lipid A, a detoxified lipid A derivative, in photothrombotic model of unilateral selective hippocampal ischemia in rat

Hosseini, S. M., Pourbadie, H. G., Sayyah, M., Zibaii, M. I., & Naderi, N. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.045 · Cited by 20

How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy

Ropert, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2959-9 · Cited by 20

Xylose rich heteroglycan from flaxseed gum mediates the immunostimulatory effects on macrophages via TLR2 activation

Liu, J., Wu, C., Li, X., Yan, Q., Reaney, M. J. T., & Jiang, Z. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.02.080 · Cited by 20

SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4

Wong, D. V. T., Filho, H. V. R., Wanderley, C. W. S., Leite, C. A., Lima, J. B., Assef, A. N. B., Cajado, A. G., Batista, G. D. O., González, R. H., Silva, K. O., et al. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03844-z · Cited by 20

Synthetic Toll-like Receptors 7 and 8 Agonists: Structure–Activity Relationship in the Oxoadenine Series

Evans, J. T., Bess, L. S., Mwakwari, S. C., Livesay, M. T., Li, Y., Cybulski, V., Johnson, D. A., & Bazin, H. G. (2019) · ACS Omega · doi:10.1021/acsomega.9b02138 · Cited by 20

Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus

Yuan, P., Aipire, A., Yi, Y., Wei, X., Fu, C., Zhou, F., Mahabati, M., Li, J., & Li, J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104050 · Cited by 20

Autophagy in the control and pathogenesis of parasitic infections

Ghartey‐Kwansah, G., Adu‐Nti, F., Aboagye, B., Ankobil, A., Essuman, E. E., Opoku, Y. K., Abokyi, S., Abu, E. K., & Boampong, J. N. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00464-6 · Cited by 20

Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

O’Donovan, D. H., Gregson, C. L., Packer, M. J., Greenwood, R. D. R., Pike, K. G., Kawatkar, S. P., Bloecher, A., Robinson, J. D., Read, J. A., Code, E. L., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.127904 · Cited by 20

Structure of vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif

Kim, Y., Lee, H., Heo, L., Seok, C., & Choe, J. (2014) · Protein Science · doi:10.1002/pro.2472 · Cited by 20

Effects of dietary n-3 fatty acids on Toll-like receptor activation in primary leucocytes from Atlantic salmon (Salmo salar)

Arnemo, M., Kavaliauskis, A., Andresen, A. M. S., Bou, M., Berge, G. M., Ruyter, B., & Gjøen, T. (2017) · Fish Physiology and Biochemistry · doi:10.1007/s10695-017-0353-4 · Cited by 20

The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease

Smith, S. A., Samokhin, A. O., Alfaidi, M., Murphy, E., Rhodes, D., Holcombe, W. M. L., Kiss‐Toth, E., Storey, R. F., Yee, S., Francis, S., et al. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.03.014 · Cited by 20

Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis

Geng, X., Xia, X., Liang, Z., Li, S., Yue, Z., Zhang, H., Guo, L., Ma, S., Jiang, S., Lian, X., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05424-8 · Cited by 19

Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications

Vafaeian, A., Rajabi, F., & Rezaei, N. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42226 · Cited by 19

From bench to bedside, boswellic acids in anti-inflammatory therapy — mechanistic insights, bioavailability challenges, and optimization approaches

Peng, C., Yang, Y., Wang, Y., Gong, B., Sun, X., & Yang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1692443 · Cited by 21

CD46 accelerates macrophage‐mediated host susceptibility to meningococcal sepsis in a murine model

Wang, X., Zhang, D., Sjölinder, M., Wan, Y., & Sjölinder, H. (2016) · European Journal of Immunology · doi:10.1002/eji.201646397 · Cited by 19

Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP / PS1 ‐transgenic mice

Quan, W., Luo, Q., Hao, W., Tomic, I., Furihata, T., Schulz‐Schaeffer, W., Menger, M. D., Fassbender, K. C., & Liu, Y. (2021) · Glia · doi:10.1002/glia.24007 · Cited by 20

Bacterial and viral coinfection in idiopathic pulmonary fibrosis patients: the prevalence and possible role in disease progression

Moghoofei, M., Mostafaei, S., Kondori, N., Armstrong, M. E., & Babaei, F. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-01853-y · Cited by 20

Nile tilapia TLR3 recruits MyD88 and TRIF as adaptors and is involved in the NF-κB pathway in the immune response

Gao, F., Pang, J.-C., Lu, M., Liu, Z., Wang, M., Ke, X., Yi, M., & Cao, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.201 · Cited by 19

Identification of Biomarkers Related to M2 Macrophage Infiltration in Alzheimer’s Disease

Lin, C., Xu, C., Zhou, Y., Chen, A., & Jin, B. (2022) · Cells · doi:10.3390/cells11152365 · Cited by 20

Self‐Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design

Bookstaver, M. L., Zeng, Q., Oakes, R. S., Kapnick, S. M., Saxena, V., Edwards, C., Venkataraman, N., Black, S. K., Zeng, X., Froimchuk, E., et al. (2022) · Advanced Science · doi:10.1002/advs.202202393 · Cited by 19

Human toll-like receptor 8 (TLR8) in NK cells: Implication for cancer immunotherapy

Veneziani, I., Alicata, C., Moretta, L., & Maggi, E. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.07.003 · Cited by 19

Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection

Janssen, H. L. A., Lim, Y., Kim, H. J., Sowah, L. A., Tseng, C., Coffin, C. S., Elkhashab, M., Ahn, S. H., Nguyen, A., Chen, D. A., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100975 · Cited by 19

Computational Modelling of NF-κB Activation by IL-1RI and Its Co-Receptor TILRR, Predicts a Role for Cytoskeletal Sequestration of IκBα in Inflammatory Signalling

Rhodes, D. M., Smith, S. A., Holcombe, M., & Qwarnström, E. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129888 · Cited by 19

New Insights into the Role of Histone Deacetylases as Coactivators of Inflammatory Gene Expression

Schmitz, M. L., & de la Vega, L. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5750 · Cited by 20

Dendritic cells during Staphylococcus aureus infection: subsets and roles

Wu, X., & Xu, F. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0358-z · Cited by 19

Antiviral innate immunity through the lens of systems biology

Tripathi, S., & García‐Sastre, A. (2015) · Virus Research · doi:10.1016/j.virusres.2015.11.024 · Cited by 19

Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response

Bösl, K., Giambelluca, M. S., Haug, M., Bugge, M., Espevik, T., Kandasamy, R. K., & Bergstrøm, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00618 · Cited by 19

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis

Sisti, F., Wang, S., Brandt, S. L., Glosson, N. L., Mayo, L. D., Son, Y. M., Sturgeon, S. M., Filgueiras, L. R., Jancar, S., Wong, H. R., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aai9085 · Cited by 19

Semisynthesis and Inhibitory Effects of Solidagenone Derivatives on TLR-Mediated Inflammatory Responses

Cuadrado, I., Amesty, Á., Cedrón, J. C., Oberti, J. C., Estévez‐Braun, A., Hortelano, S., & Heras, B. D. L. (2018) · Molecules · doi:10.3390/molecules23123197 · Cited by 19

Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1

Park, E., Sang-ngern, M., Chang, L. C., & Pezzuto, J. M. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.8b00861 · Cited by 19

Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols

Lefort, C., Hul, M. V., Delzenne, N. M., Everard, A., & Cani, P. D. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00082.2019 · Cited by 19

The Next Generation of Pattern Recognition Receptor Agonists: Improving Response Rates in Cancer Immunotherapy

O’Donovan, D. H., Mao, Y., & Mele, D. A. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190620103105 · Cited by 19

Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions

Alshammari, T. K., Alghamdi, H., Green, T. A., Niazy, A. A., Alkahdar, L., Al-Rasheed, N. M., Al-Hosaini, K. A., Alswayyed, M., Elango, R., Laezza, F., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222818 · Cited by 19

Pathogenesis of Gingivitis

Preethanath, R. S., Ibraheem, W., & Anil, A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91614 · Cited by 19

Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice

Hathaway‐Schrader, J. D., Aartun, J. D., Poulides, N. A., Kuhn, M. B., McCormick, B. E., Chew, M. E., Huang, E., Darveau, R. P., Westwater, C., & Novince, C. M. (2022) · JCI Insight · doi:10.1172/jci.insight.140738 · Cited by 19

The ECSIT Mediated Toll3-Dorsal-ALFs Pathway Inhibits Bacterial Amplification in Kuruma Shrimp

Ding, D., Sun, X.-J., Yan, M., Chen, Q., Gao, L., & Kang, C.-J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.807326 · Cited by 19

Trend in biodegradable porous nanomaterials for a nticancer drug delivery

Le, B. Q. G., & Đoàn, T. L. H. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1874 · Cited by 19

Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells

Matsuzaki, H., Mikami, Y., Makita, K., Takeshima, H., Horie, M., Noguchi, S. F., Jo, T., Narumoto, O., Kohyama, T., Takizawa, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141746 · Cited by 19

Viral Enhancer Mimicry of Host Innate-Immune Promoters

Kropp, K. A., Angulo, A., & Ghazal, P. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003804 · Cited by 23

Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration

Patil, H. P., Murugappan, S., de Vries-Idema, J. J., Meijerhof, T., de Haan, A., Frijlink, H. W., Wilschut, J., Hinrichs, W. L. J., & Huckriede, A. L. W. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.04.004 · Cited by 19

S-Adenosylmethionine attenuates lipopolysaccharide-induced liver injury by downregulating the Toll-like receptor 4 signal in Kupffer cells

Li, P., Zhang, Z., Gong, J., Zhang, Y., & Zhu, X. (2014) · Hepatology International · doi:10.1007/s12072-014-9528-6 · Cited by 19

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity

Noya, V., Brossard, N., Rodríguez, E., Dergan-Dylon, L. S., Carmona, C., Rabinovich, G. A., & Freire, T. (2017) · Scientific Reports · doi:10.1038/srep40615 · Cited by 19

The dual role of type I interferons in bacterial infections: from immune defense to pathogenesis

Qiu, M., Li, J., Wu, W., Ren, J., & Wu, X. (2025) · mBio · doi:10.1128/mbio.01481-25 · Cited by 20

Antigen distribution of TMUV and GPV are coincident with the expression profiles of CD8α-positive cells and goose IFNγ

Zhou, H., Chen, S., Wang, M., Jia, R., Zhu, D., Liu, M., Liu, F., Yang, Q., Wu, Y., Sun, K., et al. (2016) · Scientific Reports · doi:10.1038/srep25545 · Cited by 18

Challenges in the identification of microbe‐associated molecular patterns in plant and animal innate immunity: a case study with bacterial lipopolysaccharide

Ranf, S., Scheel, D., & Lee, J. (2016) · Molecular Plant Pathology · doi:10.1111/mpp.12452 · Cited by 18

Site-specific effect of polar functional group-modification in lipids of TLR2 ligands for modulating the ligand immunostimulatory activity

Arai, Y., Inuki, S., & Fujimoto, Y. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.03.042 · Cited by 18

ING4 alleviated lipopolysaccharide‐induced inflammation by regulating the NF‐κB pathway via a direct interaction with SIRT1

Yang, Y., Yang, L., He, X. F., Yang, F., Han, S., Qin, A., Wu, G., Liu, M., Li, Z., Wang, J., et al. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12308 · Cited by 21

Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response

Kim, S., Lee, S.-Y., Bae, S., Lee, J., Hwang, K., Go, H., & Lee, C. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00489-4 · Cited by 18

Conciliatory Anti-Allergic Decoction Attenuates Pyroptosis in RSV-Infected Asthmatic Mice and Lipopolysaccharide (LPS)-Induced 16HBE Cells by Inhibiting TLR3/NLRP3/NF-κB/IRF3 Signaling Pathway

Chen, Y., Zhou, Y., Wang, Q.-L., Chen, J., Chen, H., Xie, H., & Li, L. (2022) · Journal of Immunology Research · doi:10.1155/2022/1800401 · Cited by 18

MiR-124 Reduced Neuroinflammation after Traumatic Brain Injury by Inhibiting TRAF6

Yang, Y., Ye, Y., Fan, K., Luo, J., Yang, Y., & Ma, Y. (2023) · NeuroImmunoModulation · doi:10.1159/000528502 · Cited by 18

Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota

Wen, M., Li, Y., Qin, X., Qin, B., & Wang, Q. A. (2023) · Cells · doi:10.3390/cells12141882 · Cited by 20

Immunomodulator-Mediated Suppressive Tumor Immune Microenvironment Remodeling Nanoplatform for Enhanced Immuno/Chemo/Photothermal Combination Therapy of Triple Negative Breast Cancer

Wang, A., Yang, X., Li, R., Shao, L., Zhao, W., Hu, X., Fang, K., Chai, K., Shi, S., & Dong, C. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c14137 · Cited by 18

A noncanonical IRAK4-IRAK1 pathway counters DNA damage–induced apoptosis independently of TLR/IL-1R signaling

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