Cited by 1,765Immune Response and InflammationImmune responses and vaccinationsInvertebrate Immune Response Mechanisms

The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.

The history of toll-like receptors - redefining innate immunity

O'Neill, Luke A. J., Golenbock, Douglas, Bowie, Andrew G.·2013·Nature reviews. Immunology

Open this paper in CoChat — free account

Abstract

The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research.

Integrity signals

Registry

Crossref · 10.1038/nri3446

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444

Flagged first, then by citations

Show all 119 references

1 of the 119 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 1,001

S100A8 and S100A9 Are Induced by Decreased Hydration in the Epidermis and Promote Fibroblast Activation and Fibrosis in the Dermis
Zhong, A., Xu, W., Zhao, J., Xie, P., Jia, S., Sun, J., Galiano, R. D., Mustoe, T. A., & Hong, S. J. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.005 · Cited by 100
Tumor-associated macrophages: a short compendium
Prenen, H., & Mazzone, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2997-3 · Cited by 103
Regulation of lipid‐induced macrophage polarization through modulating peroxisome proliferator‐activated receptor‐gamma activity affects hepatic lipid metabolism via a Toll‐like receptor 4/NF‐κB signaling pathway
Wu, H., Ni, X., Xu, Q., Wang, Q., Li, X., & Hua, J. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15025 · Cited by 101
Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8 + T-cell axis
Brackett, C. M., Kojouharov, B., Veith, J. M., Greene, K. F., Burdelya, L. G., Gollnick, S. O., Abrams, S. I., & Gudkov, A. V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521359113 · Cited by 102
How Mouse Macrophages Sense What Is Going On
Ley, K. F., Pramod, A. B., Croft, M., Ravichandran, K. S., & Ting, J. P. ‐. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00204 · Cited by 101
Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug
Samarpita, S., Kim, J. Y., Rasool, M., & Kim, K. S. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-2097-2 · Cited by 98
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles
Wang, B., Herck, S. V., Chen, Y., Bai, X., Zhong, Z., Deswarte, K., Lambrecht, B. N., Sanders, N. N., Lienenklaus, S., Scheeren, H. W., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c01928 · Cited by 99
Phaseolus vulgaris lectins: A systematic review of characteristics and health implications
He, S., Simpson, B. K., Sun, H., Ngadi, M. O., Ma, Y., & Huang, T. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1096234 · Cited by 97
IMO-8400, a toll-like receptor 7, 8, and 9 antagonist, demonstrates clinical activity in a phase 2a, randomized, placebo-controlled trial in patients with moderate-to-severe plaque psoriasis
Balak, D., van Doorn, M. B. A., Arbeit, R. D., Rijneveld, R., Klaassen, E. S., Sullivan, T., Brevard, J. A., Thio, H. B., Prens, E. P., Burggraaf, J., et al. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.09.015 · Cited by 97
The IKK‐related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists
Bodur, Ç., Kazyken, D., Huang, K., Üstünel, B. E., Siroky, K. A., Tooley, A. S., Gonzalez, I. E., Foley, D. H., Acosta-Jaquez, H. A., Barnes, T. M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696164 · Cited by 100
Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond
Liu, S., Feng, M., & Guan, W. (2016) · International Journal of Cancer · doi:10.1002/ijc.30074 · Cited by 99
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma
Cho, J., Lee, H.-J., Ko, H., Yoon, B.-I., Choe, J., Kim, K., Hahn, T., Han, J. A., Choi, S. S., Jung, Y. M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15326 · Cited by 97
Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2
Gupta, K. D., Shakespear, M. R., Curson, J. E. B., Murthy, A. M. V., Iyer, A., Hodson, M. P., Ramnath, D., Tillu, V. A., von Pein, J. B., Reid, R. C., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.007 · Cited by 101
Toll-Like Receptor 2 at the Crossroad between Cancer Cells, the Immune System, and the Microbiota
Lorenzo, A. D., Bolli, E., Tarone, L., Cavallo, F., & Conti, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249418 · Cited by 96
DNA vaccination for finfish aquaculture
Collins, C., Lorenzen, N., & Collet, B. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.07.012 · Cited by 99
Titanium dioxide nanoparticles stimulate sea urchin immune cell phagocytic activity involving TLR/p38 MAPK-mediated signalling pathway
Pinsino, A., Russo, R., Bonaventura, R., Brunelli, A., Marcomini, A., & Matranga, V. (2015) · Scientific Reports · doi:10.1038/srep14492 · Cited by 99
Microbiome and intestinal ischemia/reperfusion injury
Nadatani, Y., Watanabe, T., Shimada, S., Otani, K., Tanigawa, T., & Fujiwara, Y. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-137 · Cited by 94
The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties
Panaro, M. A., Corrado, A., Benameur, T., Cantatore, F. P., Cici, D., & Porro, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072299 · Cited by 94
Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer
Cao, X., Li, B., Chen, J., Dang, J., Chen, S., Gunes, E. G., Xu, B., Tian, L., Muend, S., Raoof, M., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002022 · Cited by 97
Bioactive Injectable Hydrogel Dressings for Bacteria-Infected Diabetic Wound Healing: A “Pull–Push” Approach
Zhang, K., Yang, C., Cheng, C., Shi, C., Sun, M., Hu, H., Shi, T., Chen, X., He, X., Zheng, X., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c04300 · Cited by 96
Immunometabolism and immune response regulate macrophage function in atherosclerosis
Xue, S., Su, Z., & Liu, D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101993 · Cited by 97
The role of medicinal products in the treatment of inflammatory bowel diseases ( IBD ) through inhibition of TLR4 / NF‐kappaB pathway
Dejban, P., Nikravangolsefid, N., Chamanara, M., Dehpour, A. R., & Rashidian, A. (2020) · Phytotherapy Research · doi:10.1002/ptr.6866 · Cited by 94
Comparative studies of Toll-like receptor signalling using zebrafish
Kanwal, Z., Wiegertjes, G. F., Veneman, W. J., Meijer, A. H., & Spaink, H. P. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.02.003 · Cited by 95
Human antimicrobial peptides in ocular surface defense
Mohammed, I., Said, D. G., & Dua, H. S. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.03.004 · Cited by 94
Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy
Saylor, K., Gillam, F., Lohneis, T., & Zhang, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00283 · Cited by 92
Modularly Programmable Nanoparticle Vaccine Based on Polyethyleneimine for Personalized Cancer Immunotherapy
Nam, J., Son, S., Park, K. S., & Moon, J. J. (2021) · Advanced Science · doi:10.1002/advs.202002577 · Cited by 92
Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability
Pretorius, E., Olumuyiwa-Akeredolu, O.-O. O., Soma, P., & Kell, D. B. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216681549 · Cited by 93
Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis
Mahajan, S., Saini, A., Chandra, V., Nanduri, R., Kalra, R., Bhagyaraj, E., Khatri, N., & Gupta, P. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638064 · Cited by 92
The critical role of Toll-like receptor-mediated signaling in cancer immunotherapy
Chen, X., Zhang, Y., & Fu, Y. S. (2022) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2022.100122 · Cited by 92
The Alarmin Properties of DNA and DNA-associated Nuclear Proteins
Magna, M., & Pisetsky, D. S. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.02.029 · Cited by 90
Arginine and Polyamines Fate in Leishmania Infection
Muxel, S. M., Aoki, J. I., Fernandes, J. C. R., Laranjeira‐Silva, M. F., Zampieri, R. A., Acuña, S. M., Müller, K. E., Vanderlinde, R. H., & Floeter‐Winter, L. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02682 · Cited by 92
Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages
Leng, S., Zhang, X., Wang, S., Qin, J., Liu, Q., Liu, A., Sheng, Z., Feng, Q., Hu, X., & Peng, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.976482 · Cited by 89
Adjuvant physiochemistry and advanced nanotechnology for vaccine development
Ren, H., Jia, W., Xie, Y., Yu, M., & Chen, Y. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00848c · Cited by 91
From DNA Damage to Nucleic Acid Sensing: A Strategy to Enhance Radiation Therapy
Deng, L., Liang, H. L., Fu, S., Weichselbaum, R. R., & Fu, Y. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3110 · Cited by 87
Blocking Cold-Inducible RNA-Binding Protein Protects Liver From Ischemia-Reperfusion Injury
Godwin, A. K., Yang, W.-L., Sharma, A., Khader, A., Wang, Z., Zhang, F., Nicastro, J. M., Coppa, G. F., & Wang, P. (2014) · Shock · doi:10.1097/shk.0000000000000251 · Cited by 87
Role of Toll-like receptor mediated signaling in traumatic brain injury
Shi, H., Hua, X., Kong, D., Stein, D. G., & Hua, F. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.022 · Cited by 87
Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies
Eikmans, M., Gielis, E. M., Ledeganck, K. J., Yang, J., Abramowicz, D., & Claas, F. H. J. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2018.00358 · Cited by 91
Innate immune regulatory networks in hepatic lipid metabolism
Bai, L., & Li, H. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01765-1 · Cited by 86
TLR4-Associated IRF-7 and NFκB Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium
Hu, M., Zhang, Y., Li, X., Cui, P., Sferruzzi-Perri, A. N., Brännström, M., Shao, R., & Billig, H. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa951 · Cited by 86
Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells
Novoszel, P., Holcmann, M., Stulnig, G., Fernandes, C. D. S., Zyulina, V., Borek, I., Linder, M., Bogusch, A., Drobits, B., BAUER, T. L., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012409 · Cited by 86
Positive Correlation between Enhanced Expression of TLR4/MyD88/NF-κB with Insulin Resistance in Placentae of Gestational Diabetes Mellitus
Feng, H., Su, R., Song, Y., Wang, C., Lin, L., Ma, J., & Yang, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157185 · Cited by 86
Platelet toll-like receptors in thromboinflammation
Schattner, M. A. (2017) · Frontiers in bioscience · doi:10.2741/4576 · Cited by 85
Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
Rivera‐Correa, J., Guthmiller, J. J., Vijay, R., Fernández-Arias, C., Pardo-Ruge, M., González, S. M., Butler, N. S., & Rodrı́guez, A. (2017) · Nature Communications · doi:10.1038/s41467-017-01476-6 · Cited by 85
The Relationship between Toll-like Receptors and Helicobacter pylori -Related Gastropathies: Still a Controversial Topic
Meliţ, L. E., Mărginean, C. O., Mărginean, C. D., & Săsăran, M. O. (2019) · Journal of Immunology Research · doi:10.1155/2019/8197048 · Cited by 85
The functions and roles of sestrins in regulating human diseases
Chen, Y., Huang, T., Yu, Z., Yu, Q., Wang, Y., Hu, J., Shi, J., & Yang, G. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00302-8 · Cited by 85
The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation
Ahmad, R., Al-Roub, A., Kochumon, S., Akther, N., Thomas, R., Kumari, M., Koshy, M., Tiss, A., Hannun, Y. A., Tuomilehto, J., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701552 · Cited by 84
The gut microbiome and thromboembolism
Hasan, R. A., Koh, A. Y., & Zia, A. N. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.03.003 · Cited by 86
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
Mackman, R. L., Mish, M., Chin, G., Perry, J. K., Appleby, T. C., Aktoudianakis, V., Metobo, S. E., Pyun, P., Niu, C., Daffis, S., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00100 · Cited by 84
Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell Responses
Dar, A. A., Patil, R. S., & Chiplunkar, S. V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00366 · Cited by 93
Regulation of Th2 Cell Immunity by Dendritic Cells
Na, H., Cho, M., & Chung, Y. (2016) · Immune Network · doi:10.4110/in.2016.16.1.1 · Cited by 90
TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors
Francica, B. J., Ghasemzadeh, A., Desbien, A. L., Theodros, D., Sivick, K. E., Reiner, G. L., Glickman, L. H., Marciscano, A. E. E., Sharabi, A. B., Leong, M. L. L., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0263 · Cited by 83
Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway
Sun, Z., Ma, Y., Chen, F., Wang, S., Chen, B., & Shi, J. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.07.011 · Cited by 82
To TRIM the Immunity: From Innate to Adaptive Immunity
Yang, W., Gu, Z., Zhang, H., & Hu, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02157 · Cited by 82
Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies
Ntoufa, S., Vilia, M. G., Σταματόπουλος, Κ., Ghia, P., & Muzio, M. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.07.001 · Cited by 84
Toll-Like Receptor Signaling in Burn Wound Healing and Scarring
D’Arpa, P., & Leung, K. P. (2017) · Advances in Wound Care · doi:10.1089/wound.2017.0733 · Cited by 84
The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation
Vierbuchen, T., Bang, C., Rosigkeit, H., Schmitz, R. A., & Heine, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01535 · Cited by 83
Cardiac Damage in Anthracyclines Therapy: Focus on Oxidative Stress and Inflammation
Rocca, C., Pasqua, T., Cerra, M. C., & Angelone, T. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8016 · Cited by 83
The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence
Virtuoso, A., Giovannoni, R., Luca, C. D., Gargano, F., Cerasuolo, M., Maggio, N., Lavitrano, M., & Papa, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073301 · Cited by 83
Immunostimulation by Synthetic Lipopeptide-Based Vaccine Candidates: Structure-Activity Relationships
Zaman, M., & Toth, I. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00318 · Cited by 90
USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses
Yu, Z., Song, H., Jia, M., Zhang, J., Wang, W., Li, Q., Zhang, L., & Zhao, W. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170180 · Cited by 79
Hijacking of immune defences by biofilms: a multifront strategy
Campoccia, D., Mirzaei, R., Montanaro, L., & Arciola, C. R. (2019) · Biofouling · doi:10.1080/08927014.2019.1689964 · Cited by 81
Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling
Bellissimo, D. C., Chen, C.-H., Zhu, Q., Bagga, S., Lee, C.-T., He, B., Wertheim, G. B. W., Jordan, M. S., Tan, K., Worthen, G. S., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000785 · Cited by 78
Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
Yoo, E., Salunke, D. B., Sil, D., Guo, X., Salyer, A. C. D., Hermanson, A. R., Kumar, M., Malladi, S. S., Balakrishna, R., Thompson, W. H., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500744f · Cited by 78
The immunology of Plasmodium vivax malaria
Antonelli, L. R. D. V., Junqueira, C., Vinetz, J. M., Golenbock, D. T., Ferreira, M. U., & Gazzinelli, R. T. (2019) · Immunological Reviews · doi:10.1111/imr.12816 · Cited by 82
Self-citation
Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies
Bolli, E., Scherger, M., Arnouk, S. M., Antunes, A. R. P., Straßburger, D., Urschbach, M., Stickdorn, J., Vlaminck, K. D., Movahedi, K., Räder, H. J., et al. (2021) · Advanced Science · doi:10.1002/advs.202004574 · Cited by 77
Mitochondrial chaperone HSP‐60 regulates anti‐bacterial immunity via p38 MAP kinase signaling
Jeong, D., Lee, D.-Y., Hwang, S., Lee, Y., Lee, J., Seo, M., Hwang, W., Seo, K., Hwang, A. B., Artan, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201694781 · Cited by 77
The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus
de Castro-Jorge, L. A., de Carvalho, R. A., Klein, T. M., Hiroki, C. H., Lopes, A. H., Guimarães, R. M., Fumagalli, M. J., Floriano, V. G., Agostinho, M. R., Slhessarenko, R. D., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007934 · Cited by 76
The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes
Tai, N., Wong, F. S., & Li, W. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.03.006 · Cited by 77
A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
Iizumi, T., Takahashi, S., Mashima, K., Minami, K., Izawa, Y., Abe, T., Hishiki, T., Suematsu, M., Kajimura, M., & Suzuki, N. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0564-0 · Cited by 79
Interferons and inflammasomes: Cooperation and counterregulation in disease
Labzin, L. I., Lauterbach, M., & Latz, E. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.010 · Cited by 77
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions
Mansouri, L., Papakonstantinou, N., Ntoufa, S., Σταματόπουλος, Κ., & Rosenquist, R. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.07.005 · Cited by 78
Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections
Taghavi, M., Khosravi, A., Mortaz, E., Nikaein, D., & Athari, S. S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.013 · Cited by 79
Natural Products with Toll-Like Receptor 4 Antagonist Activity
Molteni, M., Bosi, A., & Rossetti, C. (2018) · International Journal of Inflammation · doi:10.1155/2018/2859135 · Cited by 76
Nano delivery systems and cancer immunotherapy
Le, Q., Choi, J.-J., & Oh, Y. (2018) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-018-0399-z · Cited by 74
A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism
Wen, Y., Peng, D., Li, C., Hu, X., Bi, S., Song, L., Bao, P., Zhu, J., Chen, Y., & Yu, R. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.171 · Cited by 74
The Role of Pattern-Recognition Receptors in Graft-Versus-Host Disease and Graft-Versus-Leukemia after Allogeneic Stem Cell Transplantation
Heidegger, S. M., van den Brink, M. R. M., Haas, T. L., & Poeck, H. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00337 · Cited by 74
In vitro and in vivo protective effect of arginine against lipopolysaccharide induced inflammatory response in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian)
Jiang, J., Shi, D., Zhou, X., Hu, Y., Feng, L., Liu, Y., Jiang, W., & Zhao, Y. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.11.030 · Cited by 74
Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells
Tanne, A., Muniz, L. R., Puzio-Kuter, A., Leonova, K. I., Gudkov, A. V., Ting, D. T., Monasson, R., Cocco, S., Levine, A. J., Bhardwaj, N., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517584112 · Cited by 74
Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages
Sacta, M. A., Tharmalingam, B., Coppo, M., Rollins, D. A., Deochand, D. K., Benjamin, B., Yu, L., Zhang, B., Hu, X., Li, R., et al. (2018) · eLife · doi:10.7554/elife.34864 · Cited by 77
A phytobacterial TIR domain effector manipulates NAD + to promote virulence
Eastman, S., Smith, T. G., Zaydman, M. A., Kim, P., Martinez, S., Damaraju, N., DiAntonio, A., Milbrandt, J., Clemente, T. E., Alfano, J. R., et al. (2021) · New Phytologist · doi:10.1111/nph.17805 · Cited by 73
Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors
Bloes, D. A., Kretschmer, D., & Peschel, A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3390 · Cited by 73
Synthetic high-density lipoprotein-like nanoparticles potently inhibit cell signaling and production of inflammatory mediators induced by lipopolysaccharide binding Toll-like receptor 4
Foit, L., & Thaxton, C. S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.021 · Cited by 75
THE INTESTINAL MICROBIOME IN HUMAN HEALTH AND DISEASE.
DuPont, H. L., Jiang, Z., Dupont, A. W., & Utay, N. S. (2020) · PubMed · Cited by 78
Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression
Gane, E. J., Dunbar, P. R., Brooks, A. E. S., Zhang, F., Chen, D. A., Wallin, J. J., van Buuren, N. J., Arora, P., Fletcher, S. P., Tan, S. K., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.09.027 · Cited by 72
Probiotics, prebiotics and the gastrointestinal tract in health and disease
Vitetta, L., Briskey, D. R., Alford, H., Hall, S., & Coulson, S. (2014) · Inflammopharmacology · doi:10.1007/s10787-014-0201-4 · Cited by 72
Innate antiviral signalling in the central nervous system
Carty, M., Reinert, L. S., Paludan, S. R., & Bowie, A. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.012 · Cited by 73
Self-citation
Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus
O’Gorman, W. E., Hsieh, E. W. Y., Savig, E. S., Gherardini, P. F., Hernandez, J. D., Hansmann, L., Balboni, I., Utz, P. J., Bendall, S. C., Fantl, W. J., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.008 · Cited by 72
Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells
Meng, Y., Wang, M., Xie, X., Di, T., Zhao, J., Lin, Y., Xu, X., Li, N., Zhai, Y., Wang, Y., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2930 · Cited by 72
Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism
Rong, B., Tianyu, X., Tiantian, Z., Feng, R., Huang, H., Wu, Q., & Sun, C. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.020 · Cited by 73
RNA‐Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators
Guan, C. M., Chernyak, N., Dominguez, D., Cole, L. E., Zhang, B., & Mirkin, C. A. (2018) · Small · doi:10.1002/smll.201803284 · Cited by 71
Toll-like receptors in Alzheimer's disease
Momtazmanesh, S., Perry, G. L., & Rezaei, N. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577362 · Cited by 73
Small-molecule agents for cancer immunotherapy
Wang, F., Fu, K., Wang, Y., Pan, C., Wang, X., Liu, Z., Yang, C., Zheng, Y. Y., Li, X., Lu, Y., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.010 · Cited by 71
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity
Ramirez‐Ortiz, Z. G., Prasad, A., Griffith, J. W., Pendergraft, W. F., Cowley, G. S., Root, D. E., Tai, M., Luster, A. D., Khoury, J. B. E., Hacohen, N., et al. (2015) · Nature Immunology · doi:10.1038/ni.3143 · Cited by 75
AKT-targeted anti-inflammatory activity of Panax ginseng calyx ethanolic extract
Han, S. Y., Kim, J., Kim, E., Kim, S. H., Seo, D. B., Kim, J., Shin, S. S., & Cho, J. Y. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.06.003 · Cited by 70
Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis
Shao, G., He, J., Meng, J., Ma, A., Geng, X., Zhang, S., Qiu, Z., Lin, D., Li, M., Zhou, H. Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910229 · Cited by 70
Regulation of Toll-like Receptor-Mediated Sestrin2 Induction by AP-1, Nrf2, and the Ubiquitin-Proteasome System in Macrophages
Kim, M. G., Yang, J. H., Kim, K. M., Jang, C. H., Jung, J. Y., Cho, I. J., Shin, S. M., & Ki, S. H. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv012 · Cited by 70
Danger signals in regulating the immune response to solid organ transplantation
Todd, J. L., & Palmer, S. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90594 · Cited by 72
Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides
Saravanan, R., Holdbrook, D. A., Petrlová, J., Singh, S., Berglund, N. A., Choong, Y. K., Kjellström, S., Bond, P. J., Malmsten, M., & Schmidtchen, A. (2018) · Nature Communications · doi:10.1038/s41467-018-05242-0 · Cited by 70
Recent Progress in the Synergistic Combination of Nanoparticle‐Mediated Hyperthermia and Immunotherapy for Treatment of Cancer
Stephen, Z. R., & Zhang, M. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001415 · Cited by 70
Regulation of Inflammatory Functions of Macrophages and T Lymphocytes by NFAT5
Aramburu, J. F., & López‐Rodríguez, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00535 · Cited by 72

Authors: O'Neill, L. A. J., Golenbock, D., & Bowie, A. G.
Affiliations: Trinity College Dublin (IE)
University of Massachusetts Chan Medical School (US)
Corresponding author: O'Neill, Luke A. J.
Golenbock, Douglas
ORCID: O'Neill, Luke A. J.
Golenbock, Douglas
Bowie, Andrew G.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-05-17
Volume: 13
Issue: 6
Pages: 453-460
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3446
OpenAlex: W1995586746
Cited by: 1,765
References: 119
Citations by year: 2026: 72 · 2025: 98 · 2024: 102 · 2023: 126 · 2022: 145 · 2021: 147 · 2020: 159 · 2019: 150 · 2018: 171 · 2017: 161 · 2016: 156 · 2015: 140 · 2014: 108 · 2013: 27
FWCI: 12.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords: Toll-like receptors, innate immunity, pattern recognition receptors, innate-adaptive immune crosstalk, history of immunology, Nobel Prize in Physiology or Medicine, dendritic cells
MeSH terms: Animals, Humans, Immunity, Innate, Signal Transduction, Cytokines, NF-kappa B, Cyclic AMP Response Element-Binding Protein, Models, Immunological, Transcription Factor AP-1, Inflammation Mediators, Protein Isoforms, Mitogen-Activated Protein Kinases, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Toll-Like Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The history of toll-like receptors - redefining innate immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks