Cited by 1,765Immune Response and InflammationImmune responses and vaccinationsInvertebrate Immune Response Mechanisms

The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.

The history of toll-like receptors - redefining innate immunity

O'Neill, Luke A. J., Golenbock, Douglas, Bowie, Andrew G.·2013·Nature reviews. Immunology

Open this paper in CoChat — free account

Abstract

The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research.

Integrity signals

Registry

Crossref · 10.1038/nri3446

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444

Flagged first, then by citations

Show all 119 references

1 of the 119 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 1,001

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators
Huppertsberg, A., Kaps, L., Zhong, Z., Schmitt, S., Stickdorn, J., Deswarte, K., Combes, F., Czysch, C., Vrieze, J. D., Kasmi, S., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03772 · Cited by 69
Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition
Yuan, S., Balaji, S., Lomakin, I. B., & Xiong, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.752214 · Cited by 69
Engineering nanomaterial physical characteristics for cancer immunotherapy
Lee, D., Huntoon, K. M., Lux, J., Kim, B. Y. S., & Jiang, W. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00047-3 · Cited by 71
BDCA3+CLEC9A+ human dendritic cell function and development
van der Aa, E., van Montfoort, N., & Woltman, A. M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.05.016 · Cited by 76
Contribution of Ninjurin1 to Toll-Like Receptor 4 Signaling and Systemic Inflammation
Jennewein, C., Sowa, R., Faber, A. C., Dildey, M., von Knethen, A., Meybohm, P., Scheller, B., Dröse, S., & Zacharowski, K. D. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0354oc · Cited by 72
Modulation of Innate Immune Responses via Covalently Linked TLR Agonists
Tom, J. K., Dotsey, E. Y., Wong, H. Y., Stutts, L., Moore, T., Davies, D. H., Felgner, P. L., & Esser-Kahn, A. P. (2015) · ACS Central Science · doi:10.1021/acscentsci.5b00274 · Cited by 69
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses
Song, Y., Lai, L., Chong, Z., He, J., Zhang, Y., Xue, Y., Xie, Y., Chen, S., Dong, P., Chen, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14654 · Cited by 69
Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
Qie, J., Liu, Y., Wang, Y., Zhang, F., Qin, Z., Tian, S., Liu, M., Li, K., Shi, W., Song, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35095-7 · Cited by 75
Cross‐talk between pathogen recognizing Toll‐like receptors and immunoglobulin Fc receptors in immunity
van Egmond, M., Vidarsson, G., & Bakema, J. E. (2015) · Immunological Reviews · doi:10.1111/imr.12333 · Cited by 69
MicroRNA regulation of Toll-like receptor signaling pathways in teleost fish
Zhou, Z., Lin, Z., Pang, X., Shan, P., & Wang, J. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.01.036 · Cited by 68
Polyomavirus‐driven Merkel cell carcinoma: Prospects for therapeutic vaccine development
Tabachnick‐Cherny, S., Pulliam, T., Church, C. D., Koelle, D. M., & Nghiem, P. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23190 · Cited by 69
TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection
Nazmi, A., Mukherjee, S., Kundu, K., Dutta, K., Mahadevan, A., Shankar, S. K., & Basu, A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.036 · Cited by 69
Digital signaling decouples activation probability and population heterogeneity
Kellogg, R., Tian, C., Tomasz Lipniacki, B., Quake, S. R., & Tay, S. (2015) · eLife · doi:10.7554/elife.08931 · Cited by 69
Transcriptome Analysis of the Sydney Rock Oyster, Saccostrea glomerata: Insights into Molluscan Immunity
Ertl, N. G., O’Connor, W. A., Papanicolaou, A., Wiegand, A. N., & Elizur, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156649 · Cited by 67
How Mitochondrial Metabolism Contributes to Macrophage Phenotype and Functions
Benmoussa, K., Garaude, J., & Acín‐Pérez, R. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.07.003 · Cited by 69
A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
Northfelt, D., Ramanathan, R. K., Cohen, P. A., Hoff, D. D. V., Weiss, G. J., Dietsch, G. N., Manjarrez, K. L., Randall, T. D., & Hershberg, R. M. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0392 · Cited by 66
Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells
Eslamloo, K., Xue, X., Hall, J. R., Smith, N. C. P., Caballero‐Solares, A., Parrish, C. C., Taylor, R. G., & Rise, M. L. (2017) · BMC Genomics · doi:10.1186/s12864-017-4099-2 · Cited by 67
Molecular determinants of disease severity in urinary tract infection
Ambite, I., Butler, D. S. C., Wan, M. L. Y., Rosenblad, T., Tran, T. H., Chao, S. M., & Svanborg, C. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00477-x · Cited by 67
Toll-like receptors and their role in neuropathic pain and migraine
Liu, X., Yang, W., Zhu, C., Sun, S., Wu, S., Wang, L., Wang, Y., & Ge, Z. (2022) · Molecular Brain · doi:10.1186/s13041-022-00960-5 · Cited by 66
Emerging functional principles of tRNA-derived small RNAs and other regulatory small RNAs
Chen, Q., & Zhou, T. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105225 · Cited by 70
Lessons learned from the study of human inborn errors of innate immunity
Bucciol, G., Moens, L., Bosch, B., Bossuyt, X., Casanova, J., Puel, A., & Meyts, I. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.013 · Cited by 69
Cnidarian Immunity and the Repertoire of Defense Mechanisms in Anthozoans
Parisi, M. G., Parrinello, D., Stabili, L., & Cammarata, M. (2020) · Biology · doi:10.3390/biology9090283 · Cited by 67
Immune Intervention in Sepsis
Chen, J., & Wei, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.718089 · Cited by 66
Friend or Foe? Recent Strategies to Target Myeloid Cells in Cancer
Chaib, M., Chauhan, S. C., & Makowski, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00351 · Cited by 65
Immunostimulatory Activities of CpG-Oligodeoxynucleotides in Teleosts: Toll-Like Receptors 9 and 21
Lai, C.-Y., Yu, G., Luo, Y., Xiang, R., & Chuang, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00179 · Cited by 65
Innate Immune Functions of Astrocytes are Dependent Upon Tumor Necrosis Factor-Alpha
Rodgers, K. R., Lin, Y., Langan, T. J., Iwakura, Y., & Chou, R. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-63766-2 · Cited by 64
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation
Couto, M., Vasconcelos, D. P., Sousa, D. M., Sousa, B., Conceição, F., Neto, E., Lamghari, M., & Alves, C. J. (2020) · Frontiers in Materials · doi:10.3389/fmats.2020.00274 · Cited by 64
The microRNAs Let7c and miR21 are recognized by neuronal Toll-like receptor 7 to restrict dendritic growth of neurons
Liu, H.-Y., Huang, C.-M., Hung, Y.-F., & Hsueh, Y.-P. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.011 · Cited by 59
Small-Molecule Targets in Immuno-Oncology
Dhanak, D., Edwards, J. P., Nguyen, A., & Tummino, P. J. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.08.019 · Cited by 65
Cell-free fetal DNA and spontaneous preterm birth
van Boeckel, S. R., Davidson, D. J., Norman, J. E., & Stock, S. J. (2017) · Reproduction · doi:10.1530/rep-17-0619 · Cited by 68
Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus
Ban, T., Sato, G. R., & Tamura, T. (2018) · International Immunology · doi:10.1093/intimm/dxy032 · Cited by 66
Role of neutrophils in CVB3 infection and viral myocarditis
Rivadeneyra, L., Charó, N. L., Kviatcovsky, D., de la Barrera, S., Gomez, R. M., & Schattner, M. A. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.08.029 · Cited by 64
The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells
Li, J., Li, J., & Fuchun, Z. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.05.050 · Cited by 64
Long noncoding RNA: Novel links between gene expression and innate immunity
Carpenter, S. B. (2015) · Virus Research · doi:10.1016/j.virusres.2015.08.019 · Cited by 63
Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses.
Szabó, A., & Rajnavölgyi, É. (2013) · Europe PMC (PubMed Central) · Cited by 63
Interferons in Sjögren’s Syndrome: Genes, Mechanisms, and Effects
Li, H., Ice, J. A., Lessard, C. J., & Sivils, K. L. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00290 · Cited by 64
Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis
Wasko, N. J., Nichols, F. C., & Clark, R. B. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102430 · Cited by 65
Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses
Salerno, F., Heeren, J. J. F., Guislain, A., Nicolet, B. P., & Wolkers, M. C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1801026 · Cited by 62
Swine Enteric Coronavirus: Diverse Pathogen–Host Interactions
Yan, Q., Liu, X., Sun, Y., Zeng, W., Li, Y., Zhao, F., Wu, K., Fan, S., Zhao, M., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073953 · Cited by 64
Tumor-associated macrophages employ immunoediting mechanisms in colorectal tumor progression: Current research in Macrophage repolarization immunotherapy
Cheruku, S., Rao, V., Pandey, R., Chamallamudi, M. R., Ravichandiran, V., & Kumar, N. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109569 · Cited by 63
Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2
Bai, Y., Min, R., Chen, P., Mei, S., Deng, F., Zheng, Z., Jiang, C., Miao, R., Wu, Z., Zhang, P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306399120 · Cited by 64
Understanding the impact of in vitro transcription byproducts and contaminants
Lenk, R., Kleindienst, W., Szabó, G. T., Baiersdörfer, M., Boros, G., Keller, J. M., Mahiny, A. J., & Vlatkovic, I. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1426129 · Cited by 63
Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection
Franco, L. H., Fleuri, A. K. A., Pellison, N. C., Quirino, G. F. S., Horta, C. V., de Carvalho, R. A., Oliveira, S. C., & Zamboni, D. S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780981 · Cited by 62
Small-Molecule TLR8 Antagonists via Structure-Based Rational Design
Hu, Z., Tanji, H., Jiang, S., Zhang, S., Koo, K., Chan, J. H., Sakaniwa, K., Ohto, U., Candia, A. F., Shimizu, T., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.07.004 · Cited by 62
Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor‐conditioned macrophages
Maeda, A., Digifico, E., Andon, F. T., Mantovani, A., & Allavena, P. (2019) · European Journal of Immunology · doi:10.1002/eji.201847888 · Cited by 64
Various Forms of Tissue Damage and Danger Signals Following Hematopoietic Stem-Cell Transplantation
Ramadan, A. M., & Paczesny, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00014 · Cited by 65
HIV, Inflammation, and Calcium in Atherosclerosis
Shrestha, S., Irvin, M. R., Grünfeld, C., & Arnett, D. K. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302191 · Cited by 61
Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy
Liu, Y. U., Leslie, P. L., & Zhang, Y. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.10.005 · Cited by 61
Reviewing the importance of TLR‐NLRP3‐pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitors
Kinra, M., Nampoothiri, M., Arora, D. S., & Mudgal, J. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13124 · Cited by 60
Toll-like receptor agonists as cancer vaccine adjuvants
Jeon, D., Hill, E., & McNeel, D. G. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2297453 · Cited by 60
Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease
Mullen, L., Chamberlain, G., & Sacre, S. M. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0645-y · Cited by 61
Current knowledge and future directions of TLR and NOD signaling in sepsis
Foley, N. M., Wang, J., Redmond, H. P., & Wang, J. H. (2015) · Military Medical Research · doi:10.1186/s40779-014-0029-7 · Cited by 63
MicroRNA-146a-5p Mediates High Glucose-Induced Endothelial Inflammation via Targeting Interleukin-1 Receptor-Associated Kinase 1 Expression
Lo, W., Peng, C., & Wang, H.-J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00551 · Cited by 60
Addressing viral and bacterial threats to salmon farming in Chile: historical contexts and perspectives for management and control
Figueroa, J. E., Cárcamo, J. G., Yáñez, A. J., Olavarría, V. H., Ruíz, P., Manríquez, R. A., Muñoz, C., Romero, A., & Avendaño-Herrera, R. E. (2019) · Reviews in Aquaculture · doi:10.1111/raq.12333 · Cited by 60
E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses
Medvedev, A. E., Murphy, M., Zhou, H., & Li, X. (2015) · Immunological Reviews · doi:10.1111/imr.12298 · Cited by 60
Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
Owens, R., Grabert, K., Davies, C. L., Alfieri, A., Antel, J. P., Healy, L. M., & McColl, B. W. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00056 · Cited by 62
Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling
Kiyan, Y., Tkachuk, S., Kuršelis, K., Shushakova, N., Stahl, K., Dawodu, D., Kiyan, R. V., Chichkov, B. N., & Haller, H. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-50068-5 · Cited by 59
The Role of Toll-like Receptors in Atherothrombotic Cardiovascular Disease
Zhou, Y., Little, P. J., Downey, L., Afroz, R., Wu, Y., Ta, H. T., Xu, S., & Kamato, D. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00100 · Cited by 59
Dietary Component-Induced Inflammation and Its Amelioration by Prebiotics, Probiotics, and Synbiotics
Bilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
Adamovský, O., Moosová, Z., Pekarová, M., Basu, A., Babica, P., Sindlerova, L. S., Kubala, L., & Bláha, L. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b02049 · Cited by 58
BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells
Georg, I., Díaz-Barreiro, A., Morell, M. H., Pey, A. L., & Alarcón-Riquelme, M. E. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0254-9 · Cited by 58
Novel insights: Dynamic foam cells derived from the macrophage in atherosclerosis
Li, J., Meng, Q., Fu, Y., Yu, X., Ji, T., Chao, Y., Chen, Q., Li, Y., & Bian, H. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30300 · Cited by 59
HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis
Zhang, F., Qi, L., Feng, Q., Zhang, B., Li, X., Liu, C. X., Li, W., Liu, Q., Yang, D., Yin, Y., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021798118 · Cited by 58
An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants
Kayesh, M. E. H., Kohara, M., & Tsukiyama–Kohara, K. (2021) · Viruses · doi:10.3390/v13112302 · Cited by 59
Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments
Liu, Z., Yang, M., Yu, K., Lian, Z., & Deng, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.989664 · Cited by 58
Bioorthogonal Activation of TLR7 Agonists Provokes Innate Immunity to Reinforce Aptamer-Based Checkpoint Blockade
Yue, W., Qin, G., Wang, Z., Zhao, C., Ren, J., & Qu, X. (2023) · ACS Nano · doi:10.1021/acsnano.2c12313 · Cited by 58
Sensors of Infection: Viral Nucleic Acid PRRs in Fish
Poynter, S. J., Lisser, G. J., Monjo, A. L.-A., & DeWitte‐Orr, S. J. (2015) · Biology · doi:10.3390/biology4030460 · Cited by 58
Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response
O'Callaghan, P. W., Li, J., Lannfelt, L., Lindahl, U., & Zhang, X. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.634337 · Cited by 58
Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome
Kiripolsky, J., & Kramer, J. M. (2018) · Journal of Immunology Research · doi:10.1155/2018/1246818 · Cited by 58
The immunotoxicity and neurobehavioral toxicity of zebrafish induced by famoxadone-cymoxanil
Cheng, B., Zhang, H., Hu, J., Peng, Y., Yang, J., Liao, X., Liu, F., Guo, J., Hu, C., & Lu, H. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.125870 · Cited by 58
TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism
Shepard, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.613639 · Cited by 62
Trained Immunity: An Overview and the Impact on COVID-19
Brueggeman, J., Zhao, J., Schank, M., Yao, Z. Q., & Moorman, J. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837524 · Cited by 58
Helicobacter pylori-Associated Iron Deficiency Anemia in Childhood and Adolescence-Pathogenesis and Clinical Management Strategy
Kato, S., Gold, B. D., & Kato, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247351 · Cited by 57
TLR3 drives IRF6‐dependent IL‐23p19 expression and p19/EBI3 heterodimer formation in keratinocytes
Ramnath, D., Tunny, K. A., Hohenhaus, D. M., Pitts, C. M., Bergot, A., Hogarth, P. M., Hamilton, J. A., Kapétanovic, R., Sturm, R. A., Scholz, G. M., et al. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.77 · Cited by 57
Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity
Murphy, M. B., & Medvedev, A. E. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ru1215-575r · Cited by 57
Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs)
Deng, S., Jia, P., Zhang, J., Junaid, M., Niu, A., Ma, Y., Fu, A., & Pei, D. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.05.063 · Cited by 57
Redox Signaling from Mitochondria: Signal Propagation and Its Targets
Ježek, P., Holendová, B., & Plecitá‐Hlavatá, L. (2020) · Biomolecules · doi:10.3390/biom10010093 · Cited by 59
Atractylenolide-I Suppresses Tumorigenesis of Breast Cancer by Inhibiting Toll-Like Receptor 4-Mediated Nuclear Factor-κB Signaling Pathway
Long, F., Lin, H., Zhang, X., Zhang, J., Xiao, H., & Wang, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.598939 · Cited by 57
Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches
Hasan, A., Al‐Ozairi, E., Albaqsumi, Z., Ahmad, R., & Al‐Mulla, F. (2021) · ImmunoTargets and Therapy · doi:10.2147/itt.s280706 · Cited by 56
Vitamin D inhibits lipopolysaccharide-induced inflammatory response potentially through the Toll-like receptor 4 signalling pathway in the intestine and enterocytes of juvenile Jian carp (Cyprinus carpiovar. Jian)
Jiang, J., Shi, D., Zhou, X., Yin, L. W., Feng, L., Jiang, W., Liu, Y., Tang, L., Wu, P., & Zhao, Y. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003256 · Cited by 56
Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip
Liu, Y., Zhang, Q., Ding, Y., Li, X., Zhao, D., Zhao, K., Guo, Z., & Cao, X. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402087 · Cited by 56
Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis
Li, Y., Jin, S., Lei, L., Pan, Z., & Zou, X. (2015) · Scientific Reports · doi:10.1038/srep09283 · Cited by 56
Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery
Narasimhan, B., Goodman, J. T., & Ramirez, J. E. V. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-082615-030519 · Cited by 57
Worldwide malaria incidence and cancer mortality are inversely associated
Li, Q., Chen, C., Chen, L., Xue, R., Ouyang, M., Zhou, C., Zhao, S., He, Z., Xia, Y., He, J., et al. (2017) · Infectious Agents and Cancer · doi:10.1186/s13027-017-0117-x · Cited by 57
Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs
Chang, M. Y., Kang, I., Gale, M., Manicone, A. M., Kinsella, M. G., Braun, K. R., Wigmosta, T., Parks, W. C., Altemeier, W. A., Wight, T. N., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00353.2017 · Cited by 56
miR-195 inhibits macrophages pro-inflammatory profile and impacts the crosstalk with smooth muscle cells
Bras, J. P., Silva, A. M., Calin, G. A., Barbosa, M. A., Santos, S. G., & Almeida, M. I. (2017) · PLOS ONE · doi:10.1371/journal.pone.0188530 · Cited by 58
NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop
DeFelice, M. M., Clark, H. R., Hughey, J., Maayan, I., Kudo, T., Gutschow, M. V., Covert, M. W., & Regot, S. (2019) · Science Signaling · doi:10.1126/scisignal.aau3568 · Cited by 59
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition
Bai, X., Fu, R., Duan, Z., Liu, Y., Zhu, C., & Fan, D. (2021) · Food & Function · doi:10.1039/d1fo00242b · Cited by 57
Human Endotoxin Administration as an Experimental Model in Drug Development
Suffredini, A. F., & Noveck, R. J. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2014.146 · Cited by 55
Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers
Ma, G., Pan, Z., Kong, L., & Du, G. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107216 · Cited by 57
Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease
Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.015 · Cited by 54
Roles of Host Immunity in Viral Myocarditis and Dilated Cardiomyopathy
Zhao, L., & Fu, Z. (2018) · Journal of Immunology Research · doi:10.1155/2018/5301548 · Cited by 55
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management
Saleki, K., Alijanizadeh, P., Javanmehr, N., & Rezaei, N. (2024) · Medicinal Research Reviews · doi:10.1002/med.22012 · Cited by 56
Radionanomedicine: Widened perspectives of molecular theragnosis
Lee, D. S., Im, H., & Lee, Y. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.12.010 · Cited by 54
Plant lectins and Toll-like receptors: implications for therapy of microbial infections
da Silva, L. C. N., & Correia, M. T. D. S. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00020 · Cited by 54
Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia
Tran, D. Q., Tse, E. K., Kim, M. H., & Belsham, D. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.015 · Cited by 55
Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88
Shao, F., Tan, T., Tan, Y., Sun, Y., Wu, X., & Xu, Q. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.06.001 · Cited by 54
Enterobacteria and host resistance to infection
Kang, E., Crouse, A., Chevallier, L., Pontier, S. M., Zahrani, A. J. A., Silué, N., Campbell‐Valois, F., Montagutelli, X., Gruenheid, S., & Malo, D. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9749-4 · Cited by 55
PRR Function of Innate Immune Receptors in Recognition of Bacteria or Bacterial Ligands
Gulati, A., Kaur, D., Prasad, G. V. R. K., & Mukhopadhaya, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3065-0_18 · Cited by 61
Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish
Jia, P., Junaid, M., Wen, P.-P., Yang, Y., Li, W.-G., Yang, X., & Pei, D. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116925 · Cited by 54

Authors: O'Neill, L. A. J., Golenbock, D., & Bowie, A. G.
Affiliations: Trinity College Dublin (IE)
University of Massachusetts Chan Medical School (US)
Corresponding author: O'Neill, Luke A. J.
Golenbock, Douglas
ORCID: O'Neill, Luke A. J.
Golenbock, Douglas
Bowie, Andrew G.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-05-17
Volume: 13
Issue: 6
Pages: 453-460
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3446
OpenAlex: W1995586746
Cited by: 1,765
References: 119
Citations by year: 2026: 72 · 2025: 98 · 2024: 102 · 2023: 126 · 2022: 145 · 2021: 147 · 2020: 159 · 2019: 150 · 2018: 171 · 2017: 161 · 2016: 156 · 2015: 140 · 2014: 108 · 2013: 27
FWCI: 12.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords: Toll-like receptors, innate immunity, pattern recognition receptors, innate-adaptive immune crosstalk, history of immunology, Nobel Prize in Physiology or Medicine, dendritic cells
MeSH terms: Animals, Humans, Immunity, Innate, Signal Transduction, Cytokines, NF-kappa B, Cyclic AMP Response Element-Binding Protein, Models, Immunological, Transcription Factor AP-1, Inflammation Mediators, Protein Isoforms, Mitogen-Activated Protein Kinases, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Toll-Like Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The history of toll-like receptors - redefining innate immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks