The history of toll-like receptors - redefining innate immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444

Extracellular nucleoprotein exacerbates influenza virus pathogenesis by activating Toll-like receptor 4 and the NLRP3 inflammasome

Kim, C.-U., Jeong, Y. L., Lee, P., Lee, M., Park, J., Kim, Y., & Kim, D. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00862-5 · Cited by 35

Mitochondrial DNA Is a Vital Driving Force in Ischemia‐Reperfusion Injury in Cardiovascular Diseases

Liu, H., Liu, X., Zhou, J., & Li, T. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6235747 · Cited by 35

Advances in Cancer Vaccine Research

Liu, N., Xiao, X., Zhang, Z.-Q., Mao, C., Wan, M., & Shen, J. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01154 · Cited by 35

The emerging role of mTOR signalling in antibacterial immunity

Abdel‐Nour, M., Tsalikis, J., Kleinman, D. R., & Girardin, S. E. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.3 · Cited by 33

Inflammation and Immunity: From an Adipocyte's Perspective

Chan, C. C., Damen, M. S. M. A., Alarcon, P. C., Sánchez-Gurmaches, J., & Divanovic, S. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2019.0014 · Cited by 35

Receptor basis of biological activity of polysaccharides

Generalov, E. A., & Yakovenko, L. V. (2023) · Biophysical Reviews · doi:10.1007/s12551-023-01102-4 · Cited by 33

TLR signaling controls lethal encephalitis in WNV-infected brain

Sabouri, A. H., Marcondes, M. C. G., Flynn, C. T., Berger, M., Xiao, N., Fox, H. S., & Sarvetnick, N. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.049 · Cited by 32

Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats

Goulopoulou, S., Wenceslau, C. F., McCarthy, C. G., Matsumoto, T., & Webb, R. C. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00834.2015 · Cited by 32

Matricellular Proteins: Functional Insights From Non-mammalian Animal Models

Adams, J. C. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.003 · Cited by 33

Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9

Martínez-Colón, G. J., Warheit-Niemi, H. I., Gurczynski, S. J., Taylor, Q. M., Wilke, C. A., Podsiad, A. B., Crespo, J., Bhan, U., & Moore, B. B. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007560 · Cited by 34

Transcriptomic Profiling of the Adaptive and Innate Immune Responses of Atlantic Salmon to Renibacterium salmoninarum Infection

Eslamloo, K., Caballero‐Solares, A., Inkpen, S. M., Emam, M., Kumar, S., Bouniot, C., Avendaño-Herrera, R. E., Jakob, E., & Rise, M. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.567838 · Cited by 32

Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis

Thada, S., Horvath, G. L., Müller, M. M., Dittrich, N., Conrad, M. L., Sur, S., Hussain, A., Pelka, K., Gaddam, S., Latz, E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041560 · Cited by 33

Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics

Huang, X., Zhang, X., & Lu, M. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1898369 · Cited by 32

Mitochondrial metabolism in macrophages

Nassef, M. Z., Hanke, J. E., & Hiller, K. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00126.2021 · Cited by 32

Emerging roles of TRIM27 in cancer and other human diseases

Yu, C., Rao, D., Wang, T., Song, J., Zhang, L., & Huang, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1004429 · Cited by 32

The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2

Pattabiraman, G., Panchal, R., & Medvedev, A. E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784470 · Cited by 32

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

Dickinson, S. E., & Wondrak, G. T. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170828125328 · Cited by 32

Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging

Lopez, E. M., Leclerc, K., Ramsukh, M., Parente, P. E., Patel, K., Aranda, C. J., Josephson, A. M., Remark, L. H., Kirby, D. J., Buchalter, D. B., et al. (2022) · Bone · doi:10.1016/j.bone.2021.116324 · Cited by 31

Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Liu, H., Xu, J., Wang, L., Guo, P., Tang, Z., Sun, X., Tang, X., Wang, W., Wang, L., Cao, Y., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011740 · Cited by 31

Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice

Yang, Y., Fang, H., Xie, Z., Ren, F., Yan, L., Zhang, M., Xu, G., Song, Z., Chen, Z., Sun, W., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01734-6 · Cited by 31

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity

Humphries, F., & Moynagh, P. N. (2015) · Immunological Reviews · doi:10.1111/imr.12306 · Cited by 31

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

Cao, L., Ji, Y., Zeng, L., Liu, Q., Zhang, Z., Guo, S., Guo, X., Tong, Y., Zhao, X., Li, C., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008079 · Cited by 31

Platelets and extracellular traps in infections

Gomez, R. M., Ortiz, A. O. L., & Schattner, M. A. (2020) · Platelets · doi:10.1080/09537104.2020.1718631 · Cited by 31

Vγ9Vδ2 T Cells: Can We Re-Purpose a Potent Anti-Infection Mechanism for Cancer Therapy?

Künkele, K., Wesch, D., Oberg, H., Aichinger, M., Supper, V., & Baumann, C. (2020) · Cells · doi:10.3390/cells9040829 · Cited by 31

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate Immunity

Lin, Z., Wang, J., Zhu, W., Yu, X., Wang, Z., Ma, J., Wang, H., Yan, Y., Sun, J., & Cheng, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742074 · Cited by 31

Intracellular mono-ADP-ribosyltransferases at the host–virus interphase

Lüscher, B., Verheirstraeten, M., Krieg, S., & Korn, P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04290-6 · Cited by 33

Rational Vaccinology: Harnessing Nanoscale Chemical Design for Cancer Immunotherapy

Huang, Z. N., Callmann, C. E., Wang, S., Vasher, M. K., Evangelopoulos, M., Petrosko, S. H., & Mirkin, C. A. (2022) · ACS Central Science · doi:10.1021/acscentsci.2c00227 · Cited by 31

Icaritin and intratumoral injection of CpG treatment synergistically promote T cell infiltration and antitumor immune response in mice

Dongye, Z., Wu, X., Wen, Y., Ding, X., Wang, C., Zhao, T., Li, J., & Wu, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109093 · Cited by 31

Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway

Sun, H.-Y., Wu, J. H., Wang, R., Zhang, S., Xu, H., Kaznacheyeva, E. V., Lu, X., Ren, H., & Wang, G. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01030-1 · Cited by 31

Protein targeting by the itaconate family in immunity and inflammation

Day, E. A., & O'Neill, L. A. J. (2022) · Biochemical Journal · doi:10.1042/bcj20220364 · Cited by 32

Inhibitory Effects of Ginsenoside Compound K on Lipopolysaccharide-Stimulated Inflammatory Responses in Macrophages by Regulating Sirtuin 1 and Histone Deacetylase 4

Kang, H., Kim, S., Lee, J., & Kim, B. (2023) · Nutrients · doi:10.3390/nu15071626 · Cited by 32

A short history of innate immunity

Martins, Y. C., Ribeiro-Gomes, F. L., & Daniel‐Ribeiro, C. T. (2023) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760230023 · Cited by 31

Identification of Immune-Related Genes and Development of SSR/SNP Markers from the Spleen Transcriptome of Schizothorax prenanti

Luo, H., Xiao, S., Ye, H., Zhang, Z., Lv, C., Zheng, S., Wang, Z., & Wang, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152572 · Cited by 31

Danger of frustrated sensors: Role of Toll-like receptors and NOD-like receptors in aseptic and septic inflammations around total hip replacements

Takagi, M., Takakubo, Y., Pajarinen, J., Naganuma, Y., Oki, H., Maruyama, M., & Goodman, S. B. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.004 · Cited by 31

CD11b-activated Src signal attenuates neuroinflammatory pain by orchestrating inflammatory and anti-inflammatory cytokines in microglia

Yang, M., Xu, W., Wang, Y., Jiang, X., Li, Y., Yang, Y., & Yuan, H. (2018) · Molecular Pain · doi:10.1177/1744806918808150 · Cited by 35

Genome-wide identification of Toll-like receptors in the Chinese soft-shelled turtle Pelodiscus sinensis and expression analysis responding to Aeromonas hydrophila infection

Liu, T., Han, Y., Chen, S., & Zhao, H. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.01.052 · Cited by 31

The Role of PKM2 in Multiple Signaling Pathways Related to Neurological Diseases

Zhang, X., Lei, Y., Zhou, H., Liu, H., & Xu, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03901-y · Cited by 30

Structurally diverse genes encode Tlr2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro

Brietzke, A., Arnemo, M., Gjøen, T., Rebl, H., Korytář, T., Goldammer, T., Rebl, A., & Seyfert, H. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.08.012 · Cited by 30

The crucial role of l-arginine in macrophage activation: What you need to know about it

Pekarová, M., & Lojek, A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.07.012 · Cited by 30

Diagnostic and prognostic roles of IRAK1 in hepatocellular carcinoma tissues: an analysis of immunohistochemistry and RNA-sequencing data from the cancer genome atlas

Ye, Z., Gao, L., Wen, D., He, Y., Pang, Y., & Chen, G. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s132120 · Cited by 30

Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia

da Guarda, C. C., Santiago, R. P., Fiuza, L. M., Aleluia, M. M., Ferreira, J. R. D., Figueiredo, C. V. B., Yahouédéhou, S. C. M. A., de Oliveira, R. M., Lyra, I. M., & Gonçalves, M. D. S. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1327809 · Cited by 30

Self‐Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation

Bookstaver, M. L., Hess, K. L., & Jewell, C. M. (2018) · Small · doi:10.1002/smll.201802202 · Cited by 30

GABAAR α2-activated neuroimmune signal controls binge drinking and impulsivity through regulation of the CCL2/CX3CL1 balance

Aurelian, L., & Balan, I. S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05220-4 · Cited by 31

Transcriptome Analyses of Immune System Behaviors in Primary Polyp of Coral Acropora digitifera Exposed to the Bacterial Pathogen Vibrio coralliilyticus under Thermal Loading

Takagi, T., Yoshioka, Y., Zayasu, Y., Satoh, N., & Shinzato, C. (2020) · Marine Biotechnology · doi:10.1007/s10126-020-09984-1 · Cited by 30

Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages

Kang, H., Park, Y., & Lee, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158838 · Cited by 30

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Deliyannis, G., Wong, C. Y., McQuilten, H. A., Bachem, A., Clarke, M. V., Jia, X., Horrocks, K. J., Zeng, W., Girkin, J. L. N., Scott, N. E., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.140267 · Cited by 30

Toll-like receptor 7 regulates cardiovascular diseases

Shafeghat, M., Kazemian, S., Aminorroaya, A., Aryan, Z., & Rezaei, N. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109390 · Cited by 31

Covalent Conjugation of Small-Molecule Adjuvants to Nanoparticles Induces Robust Cytotoxic T Cell Responses via DC Activation

Kim, W. G., Choi, B., Yang, H.-J., Han, J., Jung, H., Cho, H., Kang, S., & Hong, S. Y. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00277 · Cited by 30

Influence of particle size, an elongated particle geometry, and adjuvants on dendritic cell activation

Mathaes, R., Winter, G., Siahaan, T. J., Besheer, A., & Engert, J. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.06.015 · Cited by 30

Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Liang, Z., Wang, Y., Lai, Y., Zhang, J., Yin, L., Yu, X., Zhou, Y.-Q., Li, X., & Song, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1050396 · Cited by 29

Structural characterization of macro domain–containing Thoeris antiphage defense systems

Shi, Y. Y., Masic, V., Mosaiab, T., Rajaratman, P., Hartley‐Tassell, L. E., Sorbello, M., Goulart, C. C., Vasquez, E., Mishra, B. P., Holt, S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn3310 · Cited by 29

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Crouch, L. I., Rodrigues, C. S., Bakshani, C. R., Tavares-Gomes, L., Gaifem, J., & Pinho, S. S. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101891 · Cited by 29

The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds

Khan, I., Maldonado, E., Silva, L., Almeida, D., Johnson, W. E., O’Brien, S. J., Zhang, G., Jarvis, E. D., Gilbert, M. T. P., & Antunes, A. (2019) · Diversity · doi:10.3390/d11080131 · Cited by 29

TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection

Aldrich, A. L., Heim, C. E., Shi, W., Fallet, R. W., Duan, B., & Kielian, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01793-6 · Cited by 29

Systematic Optimization of Potent and Orally Bioavailable Purine Scaffold as a Dual Inhibitor of Toll-Like Receptors 7 and 9

Kundu, B., Raychaudhuri, D., Mukherjee, A., Sinha, B. P., Sarkar, D., Bandopadhyay, P., Pal, S., Das, N., Dey, D., Ramarao, K., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00532 · Cited by 29

A reverse vaccinology and immunoinformatics approach for designing a multiepitope vaccine against SARS-CoV-2

Jahangirian, E., Jamal, G. A., Nouroozi, M., & Mohammadpour, A. (2021) · Immunogenetics · doi:10.1007/s00251-021-01228-3 · Cited by 29

TLR5 recognizes Aeromonas hydrophila flagellin and interacts with MyD88 in Nile tilapia

Gao, F., Pang, J.-C., Lu, M., Liu, Z., Wang, M., Ke, X., Yi, M., & Cao, J. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104409 · Cited by 29

STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant

Gallovic, M. D., Junkins, R. D., Sandor, A., Pena, E. S., Sample, C. J., Mason, A. K., Arwood, L., Sahm, R. A., Bachelder, E. M., Ainslie, K. M., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.017 · Cited by 29

CpG 1018® adjuvant enhances Tdap immune responses against Bordetella pertussis in mice

DeJong, M. A., Wolf, M. A., Bitzer, G. J., Hall, J. M., Sen-Kilic, E., Blake, J. M., Petty, J. E., Wong, T. Y., Barbier, M., Campbell, J. D., et al. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.07.030 · Cited by 29

Of Flies and Men—The Discovery of TLRs

Weiss, H. J., & O'Neill, L. A. J. (2022) · Cells · doi:10.3390/cells11193127 · Cited by 29

Polyguanine alleviated autoimmune hepatitis through regulation of macrophage receptor with collagenous structure and TLR4‐TRIF‐NF‐κB signalling

Cai, T., Xu, L., Xia, D., Zhu, L., Lin, Y., Yu, S., Zhu, K., Wang, X., Pan, C., Chen, Y., et al. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17599 · Cited by 29

Cathelicidin Antimicrobial Peptide LL37 Induces Toll-Like Receptor 8 and Amplifies IL-36γ and IL-17C in Human Keratinocytes

Miura, S., Garcet, S., Li, X., Cueto, I., Salud-Gnilo, C., Kunjravia, N., Yamamura, K., Gonzalez, J., Murai‐Yamamura, M., Rambhia, D., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.10.017 · Cited by 29

Signaling Mediated by Toll-Like Receptor 5 Sensing of Pseudomonas aeruginosa Flagellin Influences IL-1β and IL-18 Production by Primary Fibroblasts Derived from the Human Cornea

Cendra, M. D. M., Christodoulides, M., & Hossain, P. N. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00130 · Cited by 29

Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species

Hamonic, G., Pasternak, J. A., & Wilson, H. L. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2767-9 · Cited by 31

Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1

Kim, A.-Y., Shim, H., Shin, H., Lee, Y. J., Nam, H., Kim, S. Y., & Youn, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.02.019 · Cited by 29

Cnidaria: Anthozoans in the Hot Seat

Palmer, C. V., & Traylor‐Knowles, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-76768-0_3 · Cited by 31

Dual Targeting of Toll-Like Receptor 4 and Angiotensin-Converting Enzyme 2: A proposed Approach to SARS-CoV-2 Treatment

Gadanec, L. K., Qaradakhi, T., McSweeney, K. R., Ali, B. A., Zulli, A., & Apostolopoulos, V. (2021) · Future Microbiology · doi:10.2217/fmb-2021-0018 · Cited by 29

Breaking Boundaries: The Perpetual Interplay Between Tobamoviruses and Plant Immunity

Spiegelman, Z., & Dinesh‐Kumar, S. P. (2023) · Annual Review of Virology · doi:10.1146/annurev-virology-111821-122847 · Cited by 28

Modulation of Alzheimer’s disease brain pathology in mice by gut bacterial depletion: the role of IL-17a

Hao, W., Luo, Q., Tomic, I., Quan, W., Hartmann, T., Menger, M. D., Fassbender, K. C., & Liu, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363014 · Cited by 29

Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer

Lanki, M., Seppänen, H. E., Mustonen, H. K., Böckelman, C., Juuti, A., Hagström, J., & Haglund, C. H. (2018) · Tumor Biology · doi:10.1177/1010428318801188 · Cited by 28

Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer’s Disease

Yousefi, N., Sotoodehnejadnematalahi, F., Heshmati-Fakhr, N., Sayyah, M., Hoseini, M., Ghassemi, S., Aliakbari, S., & Pourbadie, H. G. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1249-1 · Cited by 28

Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis

Li, M., Li, C., Wu, X., Chen, T., Ren, L., Xu, B., & Cao, J. (2020) · Critical Care · doi:10.1186/s13054-020-02977-5 · Cited by 29

The S(c)ensory Immune System Theory

Veiga‐Fernandes, H., & Freitas, A. A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.02.007 · Cited by 28

Glial TLR2‐driven innate immune responses and CD8+ T cell activation against brain tumor

Chang, C. Y., Jeon, S., Yoon, H. J., Choi, B., Kim, S. S., Oshima, M., & Park, E. J. (2019) · Glia · doi:10.1002/glia.23597 · Cited by 28

Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity

Jiang, M., Taghizadeh, F., & Steyger, P. S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00362 · Cited by 27

Polyplex interaction strength as a driver of potency during cancer immunotherapy

Tsai, S. J., Andorko, J. I., Zeng, X., Gammon, J. M., & Jewell, C. M. (2018) · Nano Research · doi:10.1007/s12274-018-2181-y · Cited by 27

Characterization of Spz5 as a novel ligand for Drosophila Toll-1 receptor.

Nonaka, S., Kawamura, K., Hori, A., Salim, E., Fukushima, K., Nakanishi, Y., & Kuraishi, T. (2018) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2018.10.096 · Cited by 23

Overexpression of Toll-Like Receptor 4 Affects Autophagy, Oxidative Stress, and Inflammatory Responses in Monocytes of Transgenic Sheep

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