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Ubiquitin-binding domains — from structures to functions

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Dikic, Ivan, Wakatsuki, Soichi, Walters, Kylie J.·2009·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2767
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Abstract

Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Recent atomic-level resolution structures of ubiquitin–UBD complexes have revealed some of the mechanisms that underlie the versatile functions of ubiquitin in vivo. The preferences of UBDs for ubiquitin chains of specific length and linkage are central to these functions. These preferences originate from multimeric interactions, whereby UBDs synergistically bind multiple ubiquitin molecules, and from contacts with regions that link ubiquitin molecules into a polymer. The sequence context of UBDs and the conformational changes that follow their binding to ubiquitin also contribute to ubiquitin signalling. These new structure-based insights provide strategies for controlling cellular processes by targeting ubiquitin–UBD interfaces.

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Metadata

Authors
Dikic, I., Wakatsuki, S., & Walters, K. J.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-10
Volume
10
Issue
10
Pages
659-671
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm2767
OpenAlex
W2055390996
Cited by
859
References
2
FWCI
3.89
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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