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Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

Dobrowolski, Radek, De Robertis, Edward M.·2012·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3244PMC PMC3374592
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  • Neurodegeneration is linked to impaired autophagy and trafficking.

    “Neurodegeneration is linked to impaired autophagy and trafficking (Dobrowolski and De Robertis 2011), (Sorkin and von Zastrow 2009), (Taelman et al. 2010), (Killisch et al. 1991), (Lipinski et al. 2010), (Nixon 2013).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Dobrowolski and De Robertis 2011

    The section “A broader role for sequestration?” discusses endosomal trafficking in growth-factor signalling, and the copy describes microautophagy in multivesicular endosomes. Neither passage links impaired autophagy or trafficking to neurodegeneration. Searches for “neurodegeneration” and related disease terms found no such link in our copy; page numbers were not provided. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

  • Impairment of the autophagosome-lysosomal system and the resulting disruption of intracellular signaling and trafficking are strongly linked to neurodegeneration.

    “Together, impairment of the autophagosome-lysosomal system and the resulting disruption of intracellular signaling and trafficking have been strongly linked to neurodegeneration (Sorkin and von Zastrow 2009;Dobrowolski and De Robertis 2011), (Taelman et al. 2010), (Killisch et al. 1991), (Lipinski et al. 2010), (Nixon 2013).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Dobrowolski and De Robertis 2011

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Research works printed but not linked: 83

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Cited by

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Metadata

Authors
Dobrowolski, R., & De Robertis, E. M.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2011-11-23
Volume
13
Issue
1
Pages
53-60
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm3244
PMC
PMC3374592
Cited by
170
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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