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Sirtuins as regulators of metabolism and healthspan
Open accessAbstract
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.
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“Regarding mammals, several studies have shown that several of the seven mammalian sirtuins can delay various parameters of aging in mice (Houtkooper et al., 2012; Sebastian et al., 2012).”
From The Hallmarks of Aging (2013) · cites this paper as Houtkooper et al., 2012
In the citing paper
“sirtuins can regulate gene expression by deacetylating histone and non-histone substrates, and this activity depends on a cofactor linked to the cellular energy status, NAD+ (nicotinamide adenine dinucleotide) (Houtkooper et al., 2012).”
From The Aging Epigenome (2016) · cites this paper as Houtkooper et al., 2012
In the citing paper
“The SIRT family of NAD+-dependent deacylases, comprising seven members that vary in tissue specificity, subcellular localization, enzymatic activity, and targets, mediates metabolic flexibility in animal models (42).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [42]
In the citing paper
“Nicotinamide mononucleotide conversion to NAD+ activates SIRT1 and improves glucose homeostasis in mice (42).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [42]
In the citing paper
“SIRT3, which is localized in the mitochondrial matrix, targets many proteins involved in metabolic homeostasis, including OXPHOS subunits (42).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [42]
In the citing paper
“SIRT1 controls the activity of transcription factors and cofactors such as p53, MEF2, FOXO, and PGC1α, which govern mitochondrial biogenesis and activity and lipid and glucose metabolism (42).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [42]
In the citing paper
“This is due to changes in the balances between acetylation and deacetylation rates, for instance involving the mitochondrial NAD+-dependent deacetylase SIRT3 (Houtkooper et al, 2012).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Houtkooper et al, 2012
In the citing paper
“Indeed, different situations of energy restriction, including fasting and exercise, increase NAD+ levels and trigger SIRT1/PGC-1α-dependent mitochondrial adaptation (Lin et al, 2000; Houtkooper et al, 2012).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Houtkooper et al, 2012
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1 retracted
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Metadata
- Authors
- Houtkooper, R. H., Pirinen, E., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- University of Eastern Finland (FI)
- Corresponding author
- Auwerx, Johan
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2012-03-07
- Volume
- 13
- Issue
- 4
- Pages
- 225-238
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC4872805
- OpenAlex
- W2028178274
- Cited by
- 2,008
- References
- 160
- Citations by year
- 2026: 109 · 2025: 114 · 2024: 137 · 2023: 147 · 2022: 132 · 2021: 159 · 2020: 169 · 2019: 140 · 2018: 175 · 2017: 145 · 2016: 122 · 2015: 144 · 2014: 126 · 2013: 131 · 2012: 57
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (125487, 124713)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- sirtuins, histone deacetylation, energy homeostasis, glucose metabolism, lipid metabolism, healthspan, aging, transcriptional regulation
- MeSH terms
- Resveratrol, Insulin Secretion, Aging, Animals, Energy Metabolism, Multigene Family, Glucose, Histones, Homeostasis, Humans, Insulin, Longevity, NAD, Phylogeny, Protein Processing, Post-Translational, Stilbenes, Sirtuins, Lipid Metabolism
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