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The BCM theory of synapse modification at 30: interaction of theory with experiment

Cooper, Leon N, Bear, Mark F.·2012·Nature Reviews Neuroscience

DOI 10.1038/nrn3353

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Abstract

Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro's 'Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.

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Authors: Cooper, L. N., & Bear, M. F.
Affiliations: Brown University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Cooper, Leon N
Bear, Mark F.
ORCID: Bear, Mark F.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2012-10-19
Volume: 13
Issue: 11
Pages: 798-810
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3353
OpenAlex: W2045432657
Semantic Scholar: cfe0b925a6405a864b9510c41cee6fc02dbda8d8
Cited by: 395
References: 194
Citations by year: 2026: 26 · 2025: 29 · 2024: 31 · 2023: 34 · 2022: 31 · 2021: 34 · 2020: 32 · 2019: 34 · 2018: 32 · 2017: 32 · 2016: 25 · 2015: 22 · 2014: 16 · 2013: 17
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Dana Foundation
Ittleson Foundation
U.S. Air Force
Office of Naval Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: synaptic plasticity, Hebbian learning, learning and memory, orientation specificity, visual cortex, binocular interaction
MeSH terms: Animals, Humans, Models, Neurological, Neuronal Plasticity, Photic Stimulation, Synapses, Time Factors, Visual Cortex

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The BCM theory of synapse modification at 30: interaction of theory with experiment

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