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Cited by 72Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsProtein Kinase Regulation and GTPase Signaling

Synaptic memory requires CaMKII

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Tao, Wucheng, Lee, Joel, Chen, Xiumin, Díaz-Alonso, Javier, Zhou, Jing, Pleasure, Samuel, Nicoll, Roger A·2021·eLife
DOI 10.7554/elife.60360PMC PMC8798046
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Abstract

Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained contentious over the last 20 years. Here, we find that Ca 2+ -calmodulin-dependent kinase II (CaMKII) contributes to synaptic transmission and is required LTP maintenance. Acute inhibition of CaMKII erases LTP and transient inhibition of CaMKII enhances subsequent LTP. These findings strongly support the role of CaMKII as a molecular storage device.

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Crossref · 10.7554/elife.60360

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  • The slow time course of inhibition is not due to slow access of the inhibitors to the site of action, since paAIP2 acts within seconds and has the same slow time course.

    “The slow time course is not due to slow access of the inhibitors to the site of action, since paAIP2, a photoactivatable peptide inhibitor (203) that acts within seconds of light exposure, has the same slow time course (361).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [361]

    In Results (Blocking CaMKII inhibits synaptic transmission; page not specified), blue light rapidly exposes paAIP2, yet inhibition develops slowly, with kinetics similar to myr-CN27 and myr-AIP. The authors say this *suggests* slow access is not the cause; the citing sentence states that conclusion as fact. The copy describes rapid activation but does not specify that paAIP2 acts within seconds. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Transiently inhibiting CaMKII and reducing baseline transmission results in a larger magnitude of LTP.

    “Thus, if one were to transiently inhibit CaMKII and reduce baseline transmission, the magnitude of LTP should be larger. Again, experiments confirm this prediction (361).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [361]

  • Chelating postsynaptic Ca2+ has no effect on CaMKII constitutive activity.

    “Chelating postsynaptic Ca2+ has no effect on this CaMKII constitutive activity (361).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [361]

  • After transient inhibition of CaMKII with the photoactivatable inhibitor paAIP2, there is no recovery of synaptic responses.

    “After the transient inhibition of CaMKII with the photoactivatable inhibitor (paAIP2) (203), there is no recovery (361).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [361]

  • Deleting NMDARs in individual neurons or replacing GluN1 with a pore-dead mutant in utero, thus preventing NMDAR-dependent LTP, prevents generation of constitutive CaMKII activity.

    “Deleting NMDARs in individual neurons or replacing GluN1 with a pore-dead mutant in utero, thus preventing NMDAR-dependent LTP, should prevent generation of constitutive CaMKII activity. This indeed is the case (361).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [361]

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Cited by

Sorted by citations

Authors
Tao, W., Lee, J., Chen, X., Díaz-Alonso, J., Zhou, J., Pleasure, S., & Nicoll, R. A.
Affiliations
  • Fujian Medical University (CN)
  • University of California, San Francisco (US)
Corresponding author
Nicoll, Roger A
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2021-12-15
Volume
10
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.60360
PMC
PMC8798046
OpenAlex
W4200085151
Cited by
72
References
16
Citations by year
2026: 11 · 2025: 13 · 2024: 18 · 2023: 21 · 2022: 9
FWCI
5.51
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (MH070957)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
CaMKII, long-term potentiation, synaptic memory, LTP maintenance, synaptic transmission, memory storage, learning and memory, calcium/calmodulin-dependent protein kinase
MeSH terms
Animals, Synaptic Transmission, Long-Term Potentiation, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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