Nutrition modulation of human aging: The calorie restriction paradigm

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Adiponectin: More Than Just Another Fat Cell Hormone?

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Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

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Proteostasis and aging

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Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

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The GH/IGF-1 axis in ageing and longevity

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Aging, adiposity, and calorie restriction

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Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects

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A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity

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Biomarkers of Caloric Restriction May Predict Longevity in Humans

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Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

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Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

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Long‐term effects of calorie or protein restriction on serum IGF‐1 and IGFBP‐3 concentration in humans

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INTERMITTENT FASTING AND HUMAN METABOLIC HEALTH

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Long-term caloric restriction ameliorates the decline in diastolic function in humans

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Nutrition and Aging: Changes in the Regulation of Energy Metabolism With Aging

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Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging: The Diet of the World's Longest‐Lived People and Its Potential Impact on Morbidity and Life Span

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Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss

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Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

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Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial

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Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.

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Calorie Restriction in Biosphere 2: Alterations in Physiologic, Hematologic, Hormonal, and Biochemical Parameters in Humans Restricted for a 2-Year Period

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Metabolic reprogramming, caloric restriction and aging

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Effect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution

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Calorie restriction as an intervention in ageing

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Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial

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The aging process and potential interventions to extend life expectancy.

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Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat

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Calorie restriction in rhesus monkeys

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One Year of Caloric Restriction in Humans: Feasibility and Effects on Body Composition and Abdominal Adipose Tissue

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Effect of calorie restriction on resting metabolic rate and spontaneous physical activity.

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Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

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Caloric Restriction in Primates and Relevance to Humans

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Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals

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Effect of 6‐Month Calorie Restriction and Exercise on Serum and Liver Lipids and Markers of Liver Function

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Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

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Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults

Martin, C. K., Bhapkar, M. V., Pittas, A. G., Pieper, C. F., Das, S. K., Williamson, D. A., Scott, T. M., Redman, L. M., Stein, R. I., Gilhooly, C. H., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.1189 · Cited by 209 · see citing works

Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy

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Restriction of energy intake, energy expenditure, and aging

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Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial

Villareal, D. T., Fontana, L., Das, S. K., Redman, L., Smith, S. R., Saltzman, E., Bales, C., Rochon, J., Pieper, C., Huang, M., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2701 · Cited by 191 · see citing works

Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis

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Autophagy in the heart and liver during normal aging and calorie restriction

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Effects of 2‐year calorie restriction on circulating levels of IGF‐1, IGF‐binding proteins and cortisol in nonobese men and women: a randomized clinical trial

Fontana, L., Villareal, D. T., Das, S. K., Smith, S. R., Meydani, S. N., Pittas, A. G., Klein, S., Bhapkar, M. V., Rochon, J., Ravussin, É., et al. (2015) · Aging Cell · doi:10.1111/acel.12400 · Cited by 174 · see citing works

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

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Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle

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Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

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The CALERIE Study: Design and methods of an innovative 25% caloric restriction intervention

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A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial

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What are the roles of calorie restriction and diet quality in promoting healthy longevity?

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Caloric restriction and human longevity: what can we learn from the Okinawans?

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Effect of Long-Term Calorie Restriction With Adequate Protein and Micronutrients on Thyroid Hormones

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Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk

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Caloric Restriction Mimetics: Metabolic Interventions

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The caloric restriction paradigm: Implications for healthy human aging

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Does calorie restriction induce mitochondrial biogenesis? A reevaluation

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Will calorie restriction work in humans?

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Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans

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Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction

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Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes

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Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

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Autophagy in ageing and ageing-associated diseases

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Influence of Weekend Lifestyle Patterns on Body Weight

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Calorie Restriction and Aging in Nonhuman Primates

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Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study

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Calorie Restriction and Bone Health in Young, Overweight Individuals

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Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr

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Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk

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Long‐term effects of calorie restriction on serum sex‐hormone concentrations in men

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Examination of Cognitive Function During Six Months of Calorie Restriction: Results of a Randomized Controlled Trial

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The Effects of the Dietary Glycemic Load on Type 2 Diabetes Risk Factors during Weight Loss

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