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The cellular function of SCAP in metabolic signaling

Lee, Sun Hee, Lee, Jae-Ho, Im, Seung-Soon·2020·Experimental & Molecular Medicine
DOI 10.1038/s12276-020-0430-0PMC PMC7272406
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Abstract

Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP induces translocation of SREBP from the endoplasmic reticulum to the Golgi apparatus, allowing it to regulate cellular triglyceride and cholesterol levels. Previous studies have shown that suppression of SREBP activation in SCAP conditional knockout mice reduced the accumulation of intracellular triglycerides, which eventually causes the development of metabolic diseases such as atherosclerosis, diabetes, hepatic steatosis, and insulin resistance. However, despite the significance of SCAP as a regulator of SREBP, its function has not been thoroughly discussed. In this review, we have summarized the function of SCAP and its regulatory proteins. Furthermore, we discuss recent studies regarding SCAP as a possible therapeutic target for hypertriglyceridemia and hyperlipidemia.

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Metadata

Authors
Lee, S. H., Lee, J.-H., & Im, S.-S.
ORCID
Im, Seung-Soon
Venue
Experimental & Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2020-05
Volume
52
Issue
5
Pages
724-729
ISSN
  • 1226-3613
  • 2092-6413
DOI
10.1038/s12276-020-0430-0
PMC
PMC7272406
Cited by
96
References
4
Language
en
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