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Mutant Mammalian Cells as Tools to Delineate the Sterol Regulatory Element-Binding Protein Pathway for Feedback Regulation of Lipid Synthesis

Goldstein, Joseph L., Rawson, Robert B., Brown, Michael S.·2002·Archives of Biochemistry and Biophysics
DOI 10.1006/abbi.2001.2615
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Abstract

The tools of somatic cell genetics have been instrumental in unraveling the pathway by which sterol regulatory element-binding proteins (SREBPs) control lipid metabolism in animal cells. SREBPs are membrane-bound transcription factors that enhance the synthesis and uptake of cholesterol and fatty acids. The activities of the SREBPs are controlled by the cholesterol content of cells through feedback inhibition of proteolytic processing. When cells are replete with sterols, SREBPs remain bound to membranes of the endoplasmic reticulum (ER) and are therefore inactive. When cells are depleted of sterols, the SREBPs move to the Golgi complex where two proteases release the active portions of the SREBPs, which then enter the nucleus and activate transcription of target genes. This processing requires three membrane proteins-a sterol-sensing escort protein (SCAP) that transports SREBPs from the ER to the Golgi and two Golgi-located proteases (S1P and S2P) that release SREBPs from membranes. The existence of all three proteins was revealed through analysis of mutant mammalian cells in tissue culture. Their cDNAs and genes were isolated by genetic complementation or by expression cloning. The somatic cell genetic approach described in this article should prove useful for unraveling other complex biochemical pathways in animal cells.

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  • The strongest negative regulator of SQLE-mNeon found in the screen was the E3 ubiquitin ligase MARCH6 and its cognate E2 partner UBE2J2.

    “Conversely, the strongest negative regulator of SQLE-mNeon found in our screen was the E3 ubiquitin ligase MARCH6, and its cognate E2 partner UBE2J2, which we have recently reported to be critical determinants of cholesterol-dependent degradation of SQLE25–27.”

    From Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism (2020) · cites this paper as [26]

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Metadata

Authors
Goldstein, J. L., Rawson, R. B., & Brown, M. S.
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
2002-01
Volume
397
Issue
2
Pages
139-148
ISSN
0003-9861
DOI
10.1006/abbi.2001.2615
Cited by
214
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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