Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 20

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain

Spann, Marisa N., Alleyne, Kiarra, Holland, Cristin M., Davids, Antonette, Pierre-Louis, Arline, Bang, Claire, Oyeneye, Victoria, Kiflom, Rebecca, Shea, Eileen, Cheng, Bin, Peterson, Bradley S., Monk, Catherine, Scheinost, Dustin·2024·Neuropsychopharmacology
DOI 10.1038/s41386-023-01765-3
Open this paper in CoChat — free account

Abstract

The experience of ethnic, racial, and structural inequalities is increasingly recognized as detrimental to health, and early studies suggest that its experience in pregnant mothers may affect the developing fetus. We characterized discrimination and acculturation experiences in a predominantly Hispanic sample of pregnant adolescent women and assessed their association with functional connectivity in their neonate’s brain. We collected self-report measures of acculturation, discrimination, maternal distress (i.e., perceived stress, childhood trauma, and depressive symptoms), and socioeconomic status in 165 women. Then, we performed a data-driven clustering of acculturation, discrimination, perceived stress, depressive symptoms, trauma, and socioeconomic status variables during pregnancy to determine whether discrimination or acculturation clustered into distinct factors. Discrimination and acculturation styles loaded onto different factors from perceived stress, depressive symptoms, trauma, and socioeconomic status, suggesting that they were distinct from other factors in our sample. We associated these data-driven maternal phenotypes (discrimination and acculturation styles) with measures of resting-state functional MRI connectivity of the infant amygdala (n = 38). Higher maternal report of assimilation was associated with weaker connectivity between their neonate’s amygdala and bilateral fusiform gyrus. Maternal experience of discrimination was associated with weaker connectivity between the amygdala and prefrontal cortex and stronger connectivity between the amygdala and fusiform of their neonate. Cautiously, the results may suggest a similarity to self-contained studies with adults, noting that the experience of discrimination and acculturation may influence amygdala circuitry across generations. Further prospective studies are essential that consider a more diverse population of minoritized individuals and with a comprehensive assessment of ethnic, racial, and structural factors.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41386-023-01765-3

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 71

  1. Krieger N. ENOUGH: COVID-19, structural racism, police brutality, plutocracy, climate change-and time for health justice, democratic governance, and an equitable, sustainable future. Am J Public Health. 2020;110:1620–23. · DOI
  2. Gover AR, Harper SB, Langton L. Anti-Asian hate crime during the COVID-19 pandemic: exploring the reproduction of inequality. Am J Crim Justice. 2020;45:647–67. · DOI
  3. Tessler H, Choi M, Kao G. The anxiety of being Asian American: hate crimes and negative biases during the COVID-19 pandemic. Am J Crim Justice. 2020;45:636–46. · DOI · Paper page
  4. Frey WH. The growing diversity of the US population. Futuribles. 2020;439:35–46. · DOI
  5. Vernice NA, Pereira NM, Wang A, Demetres M, Adams LV. The adverse health effects of punitive immigrant policies in the United States: a systematic review. PLoS ONE. 2020;15:e0244054. · DOI
  6. Association AP. Discrimination: what it is, and how to cope. Psychology Help Center. 2019;10:a0016059.
  7. Berry JW. Acculturation: A Conceptual Overview. In: Bornstein MH, Cote LR, editors. Acculturation and parent-child relationships: Measurement and development. Lawrence Erlbaum Associates Publishers; 2006. pp. 13–30. · DOI
  8. Lara M, Gamboa C, Kahramanian MI, Morales LS, Bautista DE. Acculturation and Latino health in the United States: a review of the literature and its sociopolitical context. Annu Rev Public Health. 2005;26:367–97. · DOI · Paper page
  9. Sluiter F, Incollingo Rodriguez AC, Nephew BC, Cali R, Murgatroyd C, Santos HP Jr. Pregnancy associated epigenetic markers of inflammation predict depression and anxiety symptoms in response to discrimination. Neurobiol Stress. 2020;13:100273. · DOI
  10. Collins JW Jr, David RJ. Racial disparity in low birth weight and infant mortality. Clin Perinatol. 2009;36:63–73. · DOI
  11. Earnshaw VA, Rosenthal L, Lewis JB, Stasko EC, Tobin JN, Lewis TT, et al. Maternal experiences with everyday discrimination and infant birth weight: a test of mediators and moderators among young, urban women of color. Ann Behav Med. 2013;45:13–23. · DOI
  12. Giurgescu C, Engeland CG, Zenk SN, Kavanaugh K. Stress, inflammation and preterm birth in African American women. Newborn Infant Nurs Rev. 2013;13:171–7. · DOI
  13. Calzada EJ, Sales A. Depression among Mexican-origin mothers: exploring the immigrant paradox. Cultur Divers Ethnic Minor Psychol. 2019;25:288. · DOI
  14. Capielo Rosario C, Dillon F. Ni de aquí, ni de allá: Puerto Rican acculturation-acculturative stress profiles and depression. Cultur Divers Ethnic Minor Psychol. 2020;26:42. · DOI
  15. Hill DJ, Blanco Martinez S, Mejia Y, Kulish AL, Cavanaugh AM, Stein GL. Depressive symptoms in Latina mothers in an emerging immigrant community. Cult Divers Ethnic Minor Psychol. 2019;25:397–402. · DOI
  16. Walker JL, Ruiz RJ, Chinn JJ, Marti N, Ricks TN. Discrimination, acculturation and other predictors of depression among pregnant Hispanic women. Ethn Dis. 2012;22:497–503.
  17. Barcelona de Mendoza V, Harville E, Theall K, Buekens P, Chasan-Taber L. Effects of acculturation on prenatal anxiety among Latina women. Arch Womens Ment Health. 2016;19:635–44. · DOI
  18. D’Anna-Hernandez KL, Garcia E, Coussons-Read M, Laudenslager ML, Ross RG. Sleep moderates and mediates the relationship between acculturation and depressive symptoms in pregnant Mexican-American women. Matern Child Health J. 2016;20:422–33. · DOI
  19. Chasan-Taber L, Kini N, Harvey MW, Pekow P, Dole N. The association between acculturation and prenatal psychosocial stress among Latinas. J Immigr Minor Health. 2020;22:534–44. · DOI
  20. Caplan S. Latinos, acculturation, and acculturative stress: a dimensional concept analysis. Policy Polit Nurs Pract. 2007;8:93–106. · DOI
  21. Sifers SK, Puddy RW, Warren JS, Roberts MC. Reporting of demographics, methodology, and ethical procedures in journals in pediatric and child psychology. J Pediatr Psychol. 2002;27:19–25. · DOI
  22. Geronimus AT, Hicken M, Keene D, Bound J. Weathering” and age patterns of allostatic load scores among blacks and whites in the United States. Am J Public Health. 2006;96:826–33. · DOI · Paper page
  23. Carter SE, Ong ML, Simons RL, Gibbons FX, Lei MK, Beach SRH. The effect of early discrimination on accelerated aging among African Americans. Health Psychol. 2019;38:1010–13. · DOI
  24. Bradford DE, DeFalco A, Perkins ER, Carbajal I, Kwasa J, Goodman FR, et al. Whose signals are being amplified? Toward a more equitable clinical psychophysiology. Clin Psychol Sci. 2022;1–16. · DOI
  25. Webb EK, Weis CN, Huggins AA, Fitzgerald JM, Bennett K, Bird CM, et al. Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults. Neurobiol Stress. 2021;15:100385. · DOI
  26. Harnett NG, Wheelock MD, Wood KH, Goodman AM, Mrug S, Elliott MN, et al. Negative life experiences contribute to racial differences in the neural response to threat. Neuroimage. 2019;202:116086. · DOI
  27. Carter SE, Mekawi Y, Harnett NG. It’s about racism, not race: a call to purge oppressive practices from neuropsychiatry and scientific discovery. Neuropsychopharmacology. 2022;47:2179–80. · DOI
  28. Williams DR. Race, socioeconomic status, and health. The added effects of racism and discrimination. Ann N Y Acad Sci. 1999;896:173–88. · DOI · Paper page
  29. Berger M, Sarnyai Z. “More than skin deep”: stress neurobiology and mental health consequences of racial discrimination. Stress. 2015;18:1–10. · DOI · Paper page
  30. Masten CL, Telzer EH, Eisenberger NI. An FMRI investigation of attributing negative social treatment to racial discrimination. J Cogn Neurosci. 2011;23:1042–51. · DOI
  31. Wright KD, Jack AI, Friedman JP, Jones LM, Sattar A, Fresco DM, et al. Neural processing and perceived discrimination stress in African Americans. Nurs Res. 2020;69:331–38. · DOI
  32. Clark US, Miller ER, Hegde RR. Experiences of discrimination are associated with greater resting amygdala activity and functional connectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3:367–78.
  33. Kubota JT, Banaji MR, Phelps EA. The neuroscience of race. Nat Neurosci. 2012;15:940–8. · DOI · Paper page
  34. Qiu, Anh TT, Li Y, Chen H, Rifkin-Graboi A, Broekman BF, et al. Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants. Transl Psychiatry. 2015;5:e508. · DOI · Paper page
  35. Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, et al. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clin. 2016;12:381–88. · DOI · Paper page
  36. Monk C, Sloan RP, Myers MM, Ellman L, Werner E, Jeon J, et al. Fetal heart rate reactivity differs by women’s psychiatric status: an early marker for developmental risk? J Am Acad Child Adolesc Psychiatry. 2004;43:283–90. · DOI
  37. Abraído-Lanza AF, Echeverría SE, Flórez KR. Latino immigrants, acculturation, and health: promising new directions in research. Annu Rev Public Health. 2016;37:219–36. · DOI
  38. Krieger N. Racial and gender discrimination: risk factors for high blood pressure?. Soc Sci Med. 1990;30:1273–81. · DOI · Paper page
  39. Spann MN, Scheinost D, Feng T, Barbato K, Lee S, Monk C, et al. Association of maternal prepregnancy body mass index with fetal growth and neonatal thalamic brain connectivity among adolescent and young women. JAMA Netw Open. 2020;3:e2024661. · DOI
  40. Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, et al. GABA, resting-state connectivity and the developing brain. Neonatology. 2014;106:149–55. · DOI
  41. Kwon SH, Scheinost D, Lacadie C, Sze G, Schneider KC, Dai F, et al. Adaptive mechanisms of developing brain: cerebral lateralization in the prematurely-born. Neuroimage. 2015;108:144–50. · DOI
  42. Joshi A, Scheinost D, Okuda H, Belhachemi D, Murphy I, Staib LH, et al. Unified framework for development, deployment and robust testing of neuroimaging algorithms. Neuroinformatics. 2011;9:69–84. · DOI
  43. Cox RW, Chen G, Glen DR, Reynolds RC, Taylor PA. fMRI clustering and false-positive rates. Proc Natl Acad Sci USA. 2017;114:E3370–71. · DOI · Paper page
  44. Cox RW, Chen G, Glen DR, Reynolds RC, Taylor PA. FMRI clustering in AFNI: false-positive rates redux. Brain Connect. 2017;7:152–71. · DOI
  45. Hart AJ, Whalen PJ, Shin LM, McInerney SC, Fischer H, Rauch SL. Differential response in the human amygdala to racial outgroup vs ingroup face stimuli. Neuroreport. 2000;11:2351–5. · DOI
  46. Golby AJ, Gabrieli JDE, Chiao JY, Eberhardt JL. Differential responses in the fusiform region to same-race and other-race faces. Nat Neurosci. 2001;4:845–50. · DOI
  47. Zhou G, Liu J, Xiao NG, Wu SJ, Li H, Lee K. The fusiform face area plays a greater role in holistic processing for own-race faces than other-race faces. Front Hum Neurosci. 2018;12:220. · DOI
  48. Farmer H, Hewstone M, Spiegler O, Morse H, Saifullah A, Pan X, et al. Positive intergroup contact modulates fusiform gyrus activity to black and white faces. Sci Rep. 2020;10:2700. · DOI
  49. Kesner L, Fajnerová I, Adámek P, Buchtík M, Grygarová D, Hlinka J, et al. Fusiform activity distinguishes between subjects with low and high xenophobic attitudes toward refugees. Front Behav Neurosci. 2020;14:98. · DOI
  50. Brosch T, Bar-David E, Phelps EA. Implicit race bias decreases the similarity of neural representations of black and white faces. Psychol Sci. 2013;24:160–6. · DOI
  51. Herrington JD, Taylor JM, Grupe DW, Curby KM, Schultz RT. Bidirectional communication between amygdala and fusiform gyrus during facial recognition. Neuroimage. 2011;56:2348–55. · DOI
  52. Kelly DJ, Quinn PC, Slater AM, Lee K, Ge L, Pascalis O. The other-race effect develops during infancy: evidence of perceptual narrowing. Psychol Sci. 2007;18:1084–9. · DOI
  53. Kelly DJ, Quinn PC, Slater AM, Lee K, Gibson A, Smith M, et al. Three‐month‐olds, but not newborns, prefer own‐race faces. Dev Sci. 2005;8:F31–6. · DOI
  54. Bar-Haim Y, Ziv T, Lamy D, Hodes RM. Nature and nurture in own-race face processing. Psychol Sci. 2006;17:159–63. · DOI
  55. Quinn PC, Lee K, Pascalis O. Perception of face race by infants: five developmental changes. Child Dev Perspect. 2018;12:204–09. · DOI
  56. Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, et al. Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation. Proc Natl Acad Sci USA. 2013;110:15638–43. · DOI · Paper page
  57. Posner J, Cha J, Roy AK, Peterson BS, Bansal R, Gustafsson HC, et al. Alterations in amygdala-prefrontal circuits in infants exposed to prenatal maternal depression. Transl Psychiatry. 2016;6:e935. · DOI · Paper page
  58. Park AT, Leonard JA, Saxler PK, Cyr AB, Gabrieli JDE, Mackey AP. Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood. Soc Cogn Affect Neurosci. 2018;13:430–39. · DOI
  59. Nieves GM, Bravo M, Baskoylu S, Bath KG. Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development. Elife. 2020;9:e55263. · DOI
  60. Hay RE, Reynolds JE, Grohs MN, Paniukov D, Giesbrecht GF, Letourneau N, et al. Amygdala-prefrontal structural connectivity mediates the relationship between prenatal depression and behavior in preschool boys. J Neurosci. 2020;40:6969. · DOI
  61. Phillips ML, Schmithorst VJ, Banihashemi L, Taylor M, Samolyk A, Northrup JB, et al. Patterns of infant amygdala connectivity mediate the impact of high caregiver affect on reducing infant smiling: discovery and replication. Biol Psychiatry. 2021;90:342–52. · DOI
  62. Dufford AJ, Spann M, Scheinost D. How prenatal exposures shape the infant brain: insights from infant neuroimaging studies. Neurosci Biobehav Rev. 2021;131:47–58. · DOI
  63. Johnson KJ, Fredrickson BL. We all look the same to me: positive emotions eliminate the own-race in face recognition. Psychol Sci. 2005;16:875–81. · DOI · Paper page
  64. Telzer EH, Humphreys KL, Shapiro M, Tottenham N. Amygdala sensitivity to race is not present in childhood but emerges over adolescence. J Cogn Neurosci. 2013;25:234–44. · DOI
  65. Berboth S, Morawetz C. Amygdala-prefrontal connectivity during emotion regulation: a meta-analysis of psychophysiological interactions. Neuropsychologia. 2021;153:107767. · DOI
  66. DuPlessis HM, Bell R, Richards T. Adolescent pregnancy: understanding the impact of age and race on outcomes. J Adolesc Health. 1997;20:187–97. · DOI
  67. Aguirre BE, Saenz R, Hwang S-S. Discrimination and the assimilation and ethnic competition perspectives. Soc Sci Q. 1989;70:594.
  68. Michelson MR. The corrosive effect of acculturation: how Mexican Americans lose political trust. Soc Sci Q. 2003;84:918–33. · DOI
  69. Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8:383–95. · DOI · Paper page
  70. Ellison J, Jandorf L, Duhamel K. Assessment of the Short Acculturation Scale for Hispanics (SASH) among low-income, immigrant Hispanics. J Cancer Educ. 2011;26:478–83. · DOI
  71. Unger JGP, Shakib S, Ritt-Olson A, Palmer P, Johnson C. The AHIMSA Acculturation Scale: a new measure of acculturation for adolescents in a multicultural society. J Early Adolesc. 2002;22:225–51. · DOI

Cited by

See all 20

Metadata

Authors
Spann, M. N., Alleyne, K., Holland, C. M., Davids, A., Pierre-Louis, A., Bang, C., Oyeneye, V., Kiflom, R., Shea, E., Cheng, B., Peterson, B. S., Monk, C., & Scheinost, D.
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2023-11-15
Volume
49
Issue
2
Pages
476-485
ISSN
  • 0893-133X
  • 1740-634X
DOI
10.1038/s41386-023-01765-3
Cited by
20
References
18
Language
en
Update notices
correction (2024-01-11)
Licence
Funders
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (K24MH127381)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.