Cited by 34Birth, Development, and HealthGestational Diabetes Research and ManagementPregnancy and preeclampsia studies

Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course

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Gaillard, Romy, Jaddoe, Vincent W. V.·2023·Nature Reviews Cardiology

Abstract

Obesity, hypertension, type 2 diabetes mellitus and dyslipidaemia are highly prevalent among women of reproductive age and contribute to complications in >30% of pregnancies in Western countries. An accumulating body of evidence suggests that these cardiovascular disorders in women, occurring before and during their pregnancy, can affect the development of the structure, physiology and function of cardiovascular organ systems at different stages during embryonic and fetal development. These developmental adaptations might, in addition to genetics and sociodemographic and lifestyle factors, increase the susceptibility of the offspring to cardiovascular disease throughout the life course. In this Review, we discuss current knowledge of the influence of maternal cardiovascular disorders, occurring before and during pregnancy, on offspring cardiovascular development, dysfunction and disease from embryonic life until adulthood. We discuss findings from contemporary, large-scale, observational studies that provide insights into specific critical periods, evidence for causality and potential underlying mechanisms. Furthermore, we focus on priorities for future research, including defining optimal cardiovascular and reproductive health in women and men before their pregnancy and identifying specific embryonic, placental and fetal molecular developmental adaptations from early pregnancy onwards. Together, these approaches will help stop the intergenerational cycle of cardiovascular disease.

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Crossref · 10.1038/s41569-023-00869-z

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  1. Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines. Weight Gain During Pregnancy: Reexamining the Guidelines (eds Rasmussen, K.M. & Yaktine, A.L.) (National Academies Press US, 2009).

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Authors
Gaillard, R., & Jaddoe, V. W. V.
Affiliations
Erasmus MC (NL)
Corresponding author
Gaillard, Romy
Venue
Nature Reviews Cardiology
Published
2023-05-11
Volume
20
Issue
9
Pages
617-630
ISSN
  • 1759-5002 (ISSN-L)
  • 1759-5010
OpenAlex
W4376149544
Cited by
34
References
137
Citations by year
2026: 12 · 2025: 10 · 2024: 10 · 2023: 2
FWCI
2.65
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
Funders
  • ZonMw (05430052110007, ERC-2014-CoG-648916, 09150172110034, 543003109, 727565, 529051026, 2017.81.002)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (ZonMW 543003109, 05430052110007, ERC-2014-CoG-648916, 09150172110034, 2017.81.002, 543003109)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
pregnancy, offspring cardiovascular risk, fetal programming, developmental origins of health and disease, obesity, hypertension, type 2 diabetes, dyslipidemia, placental development, embryonic development, preconception health, infancy, life course
MeSH terms
Heart Disease Risk Factors, Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Life Change Events, Male, Placenta, Pregnancy, Risk Factors

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