Cited by 116SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesSARS-CoV-2 detection and testing

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Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models

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Khoury, David S., Wheatley, Adam K., Ramuta, Mitchell D., Reynaldi, Arnold, Cromer, Deborah, Subbarao, Kanta, O’Connor, David H., Kent, Stephen J., Davenport, Miles P.·2020·Nature Reviews Immunology

DOI 10.1038/s41577-020-00471-1PMC PMC7605490

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Abstract

The rapid scale-up of research on coronavirus disease 2019 (COVID-19) has spawned a large number of potential vaccines and immunotherapies, accompanied by a commensurately large number of in vitro assays and in vivo models to measure their effectiveness. These assays broadly have the same end-goal - to predict the clinical efficacy of prophylactic and therapeutic interventions in humans. However, the apparent potency of different interventions can vary considerably between assays and animal models, leading to very different predictions of clinical efficacy. Complete harmonization of experimental methods may be intractable at the current pace of research. However, here we analyse a selection of existing assays for measuring antibody-mediated virus neutralization and animal models of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and provide a framework for comparing results between studies and reconciling observed differences in the effects of interventions. Finally, we propose how we might optimize these assays for better comparison of results from in vitro and animal studies to accelerate progress.

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Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
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See all 116

Authors: Khoury, D. S., Wheatley, A. K., Ramuta, M. D., Reynaldi, A., Cromer, D., Subbarao, K., O’Connor, D. H., Kent, S. J., & Davenport, M. P.
Affiliations: UNSW Sydney (AU)
The University of Melbourne (AU)
University of Wisconsin–Madison (US)
Corresponding author: Davenport, Miles P.
ORCID: Khoury, David S.
Wheatley, Adam K.
Ramuta, Mitchell D.
Reynaldi, Arnold
Cromer, Deborah
Subbarao, Kanta
O’Connor, David H.
Kent, Stephen J.
Davenport, Miles P.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2020-11-02
Volume: 20
Issue: 12
Pages: 727-738
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-020-00471-1
PMC: PMC7605490
OpenAlex: W3096510866
Cited by: 115
References: 83
Citations by year: 2026: 3 · 2025: 8 · 2024: 13 · 2023: 18 · 2022: 38 · 2021: 35
FWCI: 1.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Minerva Access (University of Melbourne) (submittedVersion)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion)
Funders: Wisconsin Alumni Research Foundation
World Health Organization (SARS-CoV-2, COVID-19)
Australian Government
National Institutes of Health (COVID-19, R24OD017850, P51OD011106)
Medical Research Council (COVID-19)
National Health and Medical Research Council (1136322, 1173027, 1173433, 1173528, 1177174, 1141921)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords: SARS-CoV-2, COVID-19 pandemic, neutralizing antibody assay, assay harmonization, immunotherapy efficacy
MeSH terms: COVID-19, COVID-19 Serological Testing, COVID-19 Drug Treatment, Animals, Disease Models, Animal, Humans, Immunoassay, Neutralization Tests, Pre-Exposure Prophylaxis

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Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models

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