Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
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The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and prognostic markers of renal disease. Type I interferon (IFN)-response signatures in tubular cells and keratinocytes distinguished patients with LN from healthy control subjects. Moreover, a high IFN-response signature and fibrotic signature in tubular cells were each associated with failure to respond to treatment. Analysis of tubular cells from patients with proliferative, membranous and mixed LN indicated pathways relevant to inflammation and fibrosis, which offer insight into their histologic differences. In summary, we applied scRNA-seq to LN to deconstruct its heterogeneity and identify novel targets for personalized approaches to therapy.
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Two studies demonstrated mesenchymal progenitor hierarchy, diversity in the pathophysiological roles of their progeny, and context-dependent fate determination.
“two studies, focussing on populations of hypermethylated in cancer protein (Hic1)+Pdgfrα+ lymphocyte antigen 6 complex (LY6A)+ MP populations in heart and skeletal muscle, have elegantly demonstrated MP hierarchy, diversity in the pathophysiological roles of their progeny, and how fate determination of MP is context dependent31,32.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
Although Hic1 inactivation in skeletal muscle results in marked expansion of Pdgfrα+LY6A+ cells during homeostasis, it does not increase skeletal muscle fibrosis and has no substantial effect on skeletal muscle regeneration.
“although Hic1 inactivation in skeletal muscle also resulted in a marked expansion of Pdgfrα+LY6A+ cells during homeostasis, this did not increase skeletal muscle fibrosis and had no substantial effect on skeletal muscle regeneration31”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
Conditional genetic inactivation of Hic1 in mice leads to activation and expansion of mesenchymal progenitors in both heart and skeletal muscle, demonstrating that Hic1 is required for maintaining mesenchymal progenitor quiescence.
“Conditional genetic inactivation of Hic1 in mice led to activation and expansion of MPs in both heart and skeletal muscle, demonstrating that Hic1 is required for maintaining MP quiescence.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799 · see citing works
KEGG: new perspectives on genomes, pathways, diseases and drugs
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1092 · Cited by 8,865 · see citing works
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814 · see citing works
KEGG as a reference resource for gene and protein annotation
Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1070 · Cited by 7,387 · see citing works
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.
Macosko, E. Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A. R., Kamitaki, N., Martersteck, E. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.002 · Cited by 7,110 · see citing works
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055 · see citing works
Tsokos, G. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37754-6.50094-4 · Cited by 3,990 · see citing works
The Reactome Pathway Knowledgebase
Fabregat, A., Jupe, S., Matthews, L. R., Sidiropoulos, K., Gillespie, M. E., Garapati, P. V., Haw, R., Jassal, B., Korninger, F., May, B., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1132 · Cited by 2,798 · see citing works
Tsokos, G. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100359 · Cited by 2,747 · see citing works
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358 · see citing works
The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Weening, J. J., D’Agati, V. D., Schwartz, M. M., Seshan, S. V., Alpers, C. E., Appel, G. B., Balow, J. E., Bruijn, J. A., Cook, T. H., Ferrario, F., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000108969.21691.5d · Cited by 2,005 · see citing works
The Reactome pathway knowledgebase
Croft, D., Mundo, A. F., Haw, R., Milacic, M., Weiser, J., Wu, G., Caudy, M., Garapati, P., Gillespie, M., Kamdar, M. R., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1102 · Cited by 1,889 · see citing works
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works
The Reactome pathway Knowledgebase
Fabregat, A., Sidiropoulos, K., Garapati, P., Gillespie, M., Hausmann, K., Haw, R., Jassal, B., Jupe, S., Korninger, F., McKay, S., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1351 · Cited by 1,201 · see citing works
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Park, J., Shrestha, R., Qiu, C., Kondo, A., Huang, S., Werth, M., Li, M., Barasch, J., & Suszták, K. (2018) · Science · doi:10.1126/science.aar2131 · Cited by 1,065 · see citing works
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Young, M. D., Mitchell, T. J., Vieira Braga, F. A., Tran, M. G. B., Stewart, B. J., Ferdinand, J. R., Collord, G., Botting, R. A., Popescu, D.-M., Loudon, K. W., et al. (2018) · Science · doi:10.1126/science.aat1699 · Cited by 762 · see citing works
Yang, J., & Liu, Y. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62533-3 · Cited by 751 · see citing works
Dermcidin: A novel human antibiotic peptide secreted by sweat glands
Schittek, B., Hipfel, R., Sauer, B., Bauer, J., Kalbacher, H., Stevanovic, S., Schirle, M., Schroeder, K., Blin, N., Meier, F., et al. (2001) · Nature Immunology · doi:10.1038/ni732 · Cited by 730 · see citing works
Predicting renal outcomes in severe lupus nephritis: Contributions of clinical and histologic data
Austin, H. A., Boumpas, D. T., Vaughan, E. M., & Balow, J. E. (1994) · Kidney International · doi:10.1038/ki.1994.70 · Cited by 406 · see citing works
Ng, Y.-Y., Huang, T., Yang, W.-C., Chen, Z.-P., Yang, A., Mu, W., Nikolic‐Paterson, D. J., Atkins, R. C., & Lan, H. Y. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00076.x · Cited by 396 · see citing works
Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
Mohan, C., & Putterman, C. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.33 · Cited by 376 · see citing works
Self-citationStephenson, W., Donlin, L. T., Butler, A., Rozo, C. T., Bracken, B., Rashidfarrokhi, A., Goodman, S. M., Ivashkiv, L. B., Bykerk, V. P., Orange, D. E., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02659-x · Cited by 367 · see citing works
Fibroblasts and myofibroblasts in renal fibrosis
Meran, S., & Steadman, R. (2011) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00764.x · Cited by 345 · see citing works
Yang, J., & Liu, Y. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v13196 · Cited by 324 · see citing works
Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring
Hsieh, C., Chang, A., Brandt, D. R., Guttikonda, R., Utset, T. O., & Clark, M. R. (2011) · Arthritis Care & Research · doi:10.1002/acr.20441 · Cited by 323 · see citing works
Du, J., Miller, A. J., Widlund, H. R., Horstmann, M. A., Ramaswamy, S., & Fisher, D. E. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63657-7 · Cited by 315 · see citing works
Pavličev, M., Wagner, G. P., Chavan, A. R., Owens, K. J., Maziarz, J. D., Dunn-Fletcher, C., Kallapur, S. G., Muglia, L. J., & Jones, H. N. (2017) · Genome Research · doi:10.1101/gr.207597.116 · Cited by 281 · see citing works
Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
Lan, H. Y. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200301000-00005 · Cited by 260 · see citing works
Yu, F., Wu, L., Tan, Y. C. R. S., Li, L., Wang, C., Wang, W., Qu, Z., Chen, M., Gao, J., Li, Z., et al. (2010) · Kidney International · doi:10.1038/ki.2010.13 · Cited by 250 · see citing works
Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis
Der, E. B., Ranabothu, S., Suryawanshi, H., Akat, K. M., Clancy, R. M., Morozov, P. S., Kustagi, M., Czuppa, M., Izmirly, P., Belmont, M. H., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93009 · Cited by 211 · see citing works
Self-citationKim, K.-T., Lee, H. W., Lee, H.-O., Song, H. J., Jeong, D. E., Shin, S., Kim, H., Shin, Y., Nam, D.-H., Jeong, B. C., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-0945-9 · Cited by 198 · see citing works
Strutz, F. M., Zeisberg, M., Hemmerlein, B., Sattler, B., Hummel, K. M., Becker, V., & Muller, G. A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00997.x · Cited by 183 · see citing works
Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time
Ofengeim, D., Γιαγτζόγλου, Ν., Huh, D., Zou, C., & Yuan, J. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.04.006 · Cited by 146 · see citing works
Type I Interferon and Systemic Lupus Erythematosus
Elkon, K. B., & Stone, V. V. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0045 · Cited by 131 · see citing works
Integrative Urinary Peptidomics in Renal Transplantation Identifies Biomarkers for Acute Rejection
Ling, X. B., Sigdel, T. K., Lau, K. H., Ying, L., Lau, I., Schilling, J., & Sarwal, M. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009080876 · Cited by 128 · see citing works
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Smith, E. R., Tan, S., Holt, S. G., & Hewitson, T. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-02709-w · Cited by 97 · see citing works
The lupus band test in systemic lupus erythematosus patients
Reich, A., Marcinow, K., & Białynicki‐Birula, R. (2011) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s10145 · Cited by 83 · see citing works
Castellano, G., Cafiero, C., Divella, C., Sallustio, F., Gigante, M., Pontrelli, P., Palma, G. D., Rossini, M., Grandaliano, G., & Gesualdo, L. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0588-3 · Cited by 78 · see citing works
Interstitial inflammation and long-term renal outcomes in lupus nephritis
Alsuwaida, A. (2013) · Lupus · doi:10.1177/0961203313507986 · Cited by 73 · see citing works
Misra, R., & Gupta, R. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12602 · Cited by 61 · see citing works
Zhang, X., Chen, X., Hong, Q., Lin, H., Zhu, H., Liu, Q., Wang, J., Xie, Y., Shang, X., Shi, S., et al. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1130 · Cited by 60 · see citing works
Renal tubular hypertrophy induced by angiotensin II.
Wolf, G., & Ziyadeh, F. N. (1997) · PubMed · Cited by 60 · see citing works
Su, Z., Wang, X., Gao, X., Liu, Y., Pan, C., Hu, H., Beyer, R. P., Shi, M. Y., Zhou, J., Zhang, J., et al. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12214 · Cited by 51 · see citing works
Stephenson, W., Donlin, L. T., Butler, A. W., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/140848 · Cited by 44 · see citing works
Molecular imaging of the kidney in lupus nephritis to characterize response to treatment
Parikh, S. V., Malvar, A., Song, H., Alberton, V. G., Lococo, B., Vance, J., Zhang, J., Yu, L., Birmingham, D. J., & Rovin, B. H. (2016) · Translational research · doi:10.1016/j.trsl.2016.10.010 · Cited by 36 · see citing works
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Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488 · see citing works
Self-citationFibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Confronting false discoveries in single-cell differential expression
Squair, J. W., Gautier, M., Kathe, C., Anderson, M. A., James, N. D., Hutson, T. H., Hudelle, R., Qaiser, T., Matson, K. J. E., Barraud, Q., et al. (2021) · doi:10.1101/2021.03.12.435024 · Cited by 1,017 · see citing works
Anders, H., Saxena, R., Zhao, M., Parodis, I., Salmon, J. E., & Mohan, C. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0141-9 · Cited by 998 · see citing works
Kidney fibrosis: from mechanisms to therapeutic medicines
Huang, R., Fu, P., & Ma, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01379-7 · Cited by 823 · see citing works
Autoimmunity and organ damage in systemic lupus erythematosus
Tsokos, G. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0677-6 · Cited by 589 · see citing works
Interferon target-gene expression and epigenomic signatures in health and disease
Barrat, F. J., Crow, M. K., & Ivashkiv, L. B. (2019) · Nature Immunology · doi:10.1038/s41590-019-0466-2 · Cited by 529 · see citing works
He, H., Suryawanshi, H., Morozov, P. S., Gay-Mimbrera, J., DUCA, E. D., Kim, H. J., Kameyama, N., Estrada, Y. D., Der, E. B., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.01.042 · Cited by 510 · see citing works
Self-citationApplications of single-cell RNA sequencing in drug discovery and development
de Sande, B. V., Lee, J. S., Mutasa-Gottgens, E., Naughton, B. J., Bacon, W., Manning, J. R., Wang, Y., Pollard, J. R., Mendez, M., Hill, J., et al. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00688-4 · Cited by 441 · see citing works
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
Crow, M. K. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223741 · Cited by 420 · see citing works
Peng, L., Li, W., Shi, Q.-F., Gao, F., Huang, B., Meng, J., Hu, C.-P., & Wang, C. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03178-2 · Cited by 387 · see citing works
Interferon pathway in SLE: one key to unlocking the mystery of the disease
Rönnblom, L., & Leonard, D. (2019) · Lupus Science & Medicine · doi:10.1136/lupus-2018-000270 · Cited by 362 · see citing works
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.012 · Cited by 314 · see citing works
PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-21
Bocharnikov, A. V., Keegan, J., Wacleche, V. S., Cao, Y., Fonseka, C. Y., Wang, G., Muise, E. S., Zhang, K. X., Arazi, A., Keras, G., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130062 · Cited by 318 · see citing works
Self-citationType I interferon in the pathogenesis of systemic lupus erythematosus
Postal, M., Vivaldo, J. F., Fernandez‐Ruiz, R., Paredes, J. L., Appenzeller, S., & Niewold, T. B. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.10.014 · Cited by 309 · see citing works
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
Mahmoudi, S., Mancini, E., Xu, L., Moore, A., Jahanbani, F., Hebestreit, K., Srinivasan, R., Li, X., Devarajan, K., Prélot, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1658-5 · Cited by 285 · see citing works
XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury
Zhao, Z., Wu, J., Xu, H., Zhou, C., Han, B., Zhu, H. J., Hu, Z., Ma, Z., Ming, Z., Yao, Y., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02871-6 · Cited by 225 · see citing works
Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus
Yu, H., Nagafuchi, Y., & Fujio, K. (2021) · Biomolecules · doi:10.3390/biom11070928 · Cited by 228 · see citing works
Balzer, M. S., Doke, T., Yang, Y., Aldridge, D. L., Hu, H., Mai, H., Mukhi, D., Ma, Z., Shrestha, R., Palmer, M. B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31772-9 · Cited by 204 · see citing works
Jayne, D. R. W., Rovin, B. H., Mysler, E., Furie, R. A., Houssiau, F., Trasieva, T., Knagenhjelm, J., Schwetje, E., Chia, Y. L., Tummala, R., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221478 · Cited by 207 · see citing works
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2715-9 · Cited by 156 · see citing works
Billi, A. C., Ma, F., Plazyo, O., Gharaee‐Kermani, M., Wasikowski, R., Hile, G. A., Xing, X., Yee, C. M., Rizvi, S. M., Maz, M. P., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn2263 · Cited by 152 · see citing works
Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond
Kwon, Y.-C., Chun, S., Kim, K.-W., & Mak, A. (2019) · Cells · doi:10.3390/cells8101180 · Cited by 148 · see citing works
Kim, J., Lee, J., Kim, H. J., Kameyama, N., Nazarian, R. S., Der, E. B., Cohen, S. R., Guttman‐Yassky, E., Putterman, C., & Krueger, J. G. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.04.021 · Cited by 144 · see citing works
Self-citationTreatment of lupus nephritis: consensus, evidence and perspectives
Mok, C. C., Teng, Y. K. O., Saxena, R., & Tanaka, Y. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00925-5 · Cited by 141 · see citing works
Liu, X., Chen, W., Zeng, Q., Ma, B., Li, Z., Meng, T., Chen, J., Yu, N., Zhou, Z., & Long, X. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.06.010 · Cited by 137 · see citing works
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus
Goel, R. R., Wang, X., O’Neil, L. J., Nakabo, S., Hasneen, K., Gupta, S., Wigerblad, G., Blanco, L. P., Kopp, J. B., Morasso, M. I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916897117 · Cited by 137 · see citing works
Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy
Zheng, Y., Lü, P., Deng, Y., Wen, L., Wang, Y., Ma, X., Wang, Z., Wu, L., Hong, Q., Duan, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108525 · Cited by 137 · see citing works
Prediction of prognosis and renal outcome in lupus nephritis
Parodis, I., Tamirou, F., & Houssiau, F. (2020) · Lupus Science & Medicine · doi:10.1136/lupus-2020-000389 · Cited by 134 · see citing works
Hong, X., Meng, S., Tang, D., Wang, T., Ding, L., Yu, H., Li, H., Liu, D. J., Dai, Y., & Yang, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594658 · Cited by 127 · see citing works
Skopelja‐Gardner, S., An, J., Tai, J., Tanaka, L., Sun, X., Hermanson, P., Baum, R., Kawasumi, M., Green, R. R., Gale, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64865-w · Cited by 127 · see citing works
Protecting the kidney in systemic lupus erythematosus: from diagnosis to therapy
Maria, N. I., & Davidson, A. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0401-9 · Cited by 121 · see citing works
Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation
Skopelja‐Gardner, S., Tai, J., Sun, X., Tanaka, L., Kuchenbecker, J. A., Snyder, J. M., Kubes, P., Mustelin, T., & Elkon, K. B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019097118 · Cited by 123 · see citing works
The Mesangial cell — the glomerular stromal cell
Avraham, S., Korin, B., Chung, J.-J., Oxburgh, L. H., & Shaw, A. S. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00474-8 · Cited by 122 · see citing works
Kidney dendritic cells: fundamental biology and functional roles in health and disease
Kurts, C., Ginhoux, F., & Panzer, U. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0272-y · Cited by 117 · see citing works
Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block
Suryawanshi, H., Clancy, R. M., Morozov, P. S., Halushka, M. K., Buyon, J. P., & Tuschl, T. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz257 · Cited by 116 · see citing works
Self-citationDistinct transcriptome architectures underlying lupus establishment and exacerbation
Nakano, M., Ota, M., Takeshima, Y., Iwasaki, Y., Hatano, H., Nagafuchi, Y., Itamiya, T., Maeda, J., Yoshida, R., Yamada, S., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.021 · Cited by 109 · see citing works
The CD6/ALCAM pathway promotes lupus nephritis via T cell–mediated responses
Chalmers, S. A., Ramachandran, R. A., Garcia, S. J., Der, E. B., Herlitz, L., Ampudia, J., Chu, D., Jordan, N., Zhang, T., Parodis, I., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci147334 · Cited by 104 · see citing works
Self-citationStanley, S. K., Vanarsa, K., Soliman, S., Habazi, D., Pedroza, C., Gidley, G., Zhang, T., Mohan, S., Der, E. B., Suryawanshi, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15986-3 · Cited by 103 · see citing works
Self-citationSingle-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Zheng, M., Hu, Z. Q., Mei, X., Ouyang, L., Song, Y., Zhou, W., Kong, Y., Wu, R., Rao, S., Long, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35209-1 · Cited by 103 · see citing works
Fava, A., Buyon, J. P., Mohan, C., Zhang, T., Belmont, H. M., Izmirly, P., Clancy, R. M., Trujillo, J. M. M., Fine, D. M., Zhang, Y., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138345 · Cited by 101 · see citing works
Self-citationDesign and application of single-cell RNA sequencing to study kidney immune cells in lupus nephritis
Rao, D. A., Arazi, A., Wofsy, D., & Diamond, B. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0232-6 · Cited by 96 · see citing works
Pathogenic cellular and molecular mediators in lupus nephritis
Mohan, C., Zhang, T., & Putterman, C. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00722-z · Cited by 92 · see citing works
Self-citationZheng, W., Wang, X., Liu, J., Yu, X., Lu, L., Wang, H., Yu, J., Pei, X., Li, C., Wang, Z., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204289119 · Cited by 94 · see citing works
The role of neutrophils in rheumatic disease-associated vascular inflammation
Wang, L., Luqmani, R. A., & Udalova, I. A. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00738-4 · Cited by 91 · see citing works
Interferon lambda in inflammation and autoimmune rheumatic diseases
Goel, R. R., Kotenko, S. V., & Kaplan, M. J. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00606-1 · Cited by 89 · see citing works
Type I Interferons in Autoimmunity
Fernandez‐Ruiz, R., & Niewold, T. B. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.11.031 · Cited by 88 · see citing works
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies
Allen, M. E., Rus, V., & Szeto, G. L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.09.009 · Cited by 89 · see citing works
The lupus nephritis management renaissance
Mejia-Vilet, J. M., Malvar, A., Arazi, A., & Rovin, B. H. (2021) · Kidney International · doi:10.1016/j.kint.2021.09.012 · Cited by 87 · see citing works
Dunlap, G. S., Billi, A. C., Xing, X., Ma, F., Maz, M. P., Tsoi, L. C., Wasikowski, R., Hodgin, J. B., Gudjonsson, J. E., Kahlenberg, J. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.156341 · Cited by 86 · see citing works
Clinical value of DNA methylation markers in autoimmune rheumatic diseases
Ballestar, E., Sawalha, A. H., & Lu, Q. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0470-9 · Cited by 84 · see citing works
Ramanujam, M., Steffgen, J., Visvanathan, S., Mohan, C., Fine, J. S., & Putterman, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102668 · Cited by 86 · see citing works
Self-citationIFN-I Mediates Lupus Nephritis From the Beginning to Renal Fibrosis
Ding, X., Ren, Y., & He, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676082 · Cited by 80 · see citing works
Alforaih, N., Whittall-García, L. P., & Touma, Z. (2022) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfac036 · Cited by 85 · see citing works
Immunology in the Era of Single-Cell Technologies
Efremova, M., Vento‐Tormo, R., Park, J.-E., Teichmann, S. A., & James, K. R. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090419-020340 · Cited by 77 · see citing works
The promise of precision medicine in rheumatology
Guthridge, J. M., Wagner, C. A., & James, J. A. (2022) · Nature Medicine · doi:10.1038/s41591-022-01880-6 · Cited by 77 · see citing works
Self-citationHong, S., Healy, H. G., & Kassianos, A. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.578952 · Cited by 76 · see citing works
Molecular mechanisms controlling age‐associated B cells in autoimmunity*
Phalke, S., Rivera‐Correa, J., Jenkins, D., Flores-Castro, D., Γιαννοπούλου, Ε., & Pernis, A. B. (2022) · Immunological Reviews · doi:10.1111/imr.13068 · Cited by 76 · see citing works
Lupus nephritis: challenges and progress
Davidson, A., Aranow, C. B., & Mackay, M. C. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000642 · Cited by 73 · see citing works
Mapping the human kidney using single-cell genomics
Schreibing, F., & Kramann, R. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00553-4 · Cited by 69 · see citing works
Transitioning single-cell genomics into the clinic
Lim, J. W. Y., Chin, V. T., Fairfax, K. A., Moutinho, C., Suan, D., Ji, H. P., & Powell, J. E. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00613-w · Cited by 72 · see citing works
Wang, R., Singaraju, A., Marks, K. E., Shakib, L., Dunlap, G. S., Adejoorin, I., Greisen, S. R., Chen, L., Tirpack, A., Aude, C. A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add1591 · Cited by 70 · see citing works
Vanarsa, K., Soomro, S., Zhang, T., Strachan, B. C., Pedroza, C., Nidhi, M., Cicalese, P. A., Gidley, G., Dasari, S., Mohan, S., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-216312 · Cited by 68 · see citing works
Self-citationRamaswamy, M., Tummala, R., Streicher, K. L., da Costa, A. N., & Brohawn, P. Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011286 · Cited by 69 · see citing works
Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis
Abraham, R., Durkee, M. S., Ai, J., Veselits, M., Casella, G., Asano, Y., Chang, A., Ko, K., Oshinsky, C., Peninger, E., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155350 · Cited by 66 · see citing works
Tertiary lymphoid structures in the choroid plexus in neuropsychiatric lupus
Stock, A. D., Der, E. B., Gelb, S., Huang, M. W., Weidenheim, K. M., Ben‐Zvi, A., & Putterman, C. (2019) · JCI Insight · doi:10.1172/jci.insight.124203 · Cited by 65 · see citing works
Self-citationCellular aspects of the pathogenesis of lupus nephritis
Chang, A., Clark, M. R., & Ko, K. (2020) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000777 · Cited by 65 · see citing works
Pathogenesis of lupus nephritis: the contribution of immune and kidney resident cells
Bhargava, R., Li, H., & Tsokos, G. C. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000887 · Cited by 66 · see citing works
Type I interferon–related kidney disorders
Lodi, L., Mastrolia, M. V., Bello, F., Rossi, G. M., Angelotti, M. L., Crow, Y. J., Romagnani, P., & Vaglio, A. (2022) · Kidney International · doi:10.1016/j.kint.2022.02.031 · Cited by 66 · see citing works
Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell, I. D., Steach, H. R., Gauld, S. B., Reinke-Breen, L., Kármán, J., Carr, T. L., Wetter, J. B., Phillips, L. A., Hinchcliff, M., & Flavell, R. A. (2022) · Science Immunology · doi:10.1126/sciimmunol.abq6691 · Cited by 65 · see citing works
Pregnancy-related complications in systemic lupus erythematosus
Tan, Y., Yang, S., Liu, Q., Li, Z., Mu, R., Qiao, J., & Cui, L. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102864 · Cited by 62 · see citing works
Using single-cell technologies to map the human immune system — implications for nephrology
Stewart, B. J., Ferdinand, J. R., & Clatworthy, M. R. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0227-3 · Cited by 60 · see citing works
Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus
Bolouri, N., Akhtari, M., Farhadi, E., Mansouri, R., Faezi, S. T., Jamshidi, A., & Mahmoudi, M. (2022) · Inflammation Research · doi:10.1007/s00011-022-01554-6 · Cited by 60 · see citing works
Schnepp, P. M., Shelley, G., Dai, J., Wakim, N. I., Jiang, H., Mizokami, A., & Keller, E. T. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0051 · Cited by 60 · see citing works
A hitchhiker's guide to single-cell transcriptomics and data analysis pipelines
Nayak, R., & Hasija, Y. (2021) · Genomics · doi:10.1016/j.ygeno.2021.01.007 · Cited by 58 · see citing works
Longitudinal Immune Cell Profiling in Patients With Early Systemic Lupus Erythematosus
Sasaki, T., Bracero, S., Keegan, J., Chen, L., Cao, Y., Stevens, E. F., Qu, Y., Wang, G., Nguyen, J. P., Sparks, J. A., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42248 · Cited by 55 · see citing works
Renal Fibrosis in Lupus Nephritis
Sciascia, S., Cozzi, M., Barinotti, A., Radin, M., Cecchi, I., Fenoglio, R., Mancardi, D., Jones, G. W., Rossi, D., & Roccatello, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214317 · Cited by 58 · see citing works
Martínez, B. A., Shrotri, S., Kingsmore, K. M., Bachali, P., Grammer, A. C., & Lipsky, P. E. (2022) · Science Advances · doi:10.1126/sciadv.abn4776 · Cited by 56 · see citing works
Leyva-Castillo, J. M., Sun, L., Wu, S.-Y., Rockowitz, S., Piotr Sliz, A., & Geha, R. S. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.03.002 · Cited by 56 · see citing works
Systemic lupus erythematosus genetics: insights into pathogenesis and implications for therapy
Ghodke‐Puranik, Y., Olferiev, M., & Crow, M. K. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01152-2 · Cited by 53 · see citing works
Zhao, M., Jiang, J., Zhao, M., Chang, C., Wu, H., & Lu, Q. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08813-6 · Cited by 50 · see citing works
Lupus Nephritis Risk Factors and Biomarkers: An Update
Renaudineau, Y., Brooks, W. H., & Bellière, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914526 · Cited by 52 · see citing works
Risk of Renal Failure Within 10 or 20 Years of Systemic Lupus Erythematosus Diagnosis
Petri, M., Barr, E. A., & Magder, L. S. (2020) · The Journal of Rheumatology · doi:10.3899/jrheum.191094 · Cited by 50 · see citing works
Liu, X., Yuan, M., Xiang, Q., Li, Z., Xu, F., Chen, W., Chen, J., Huang, J., Yu, N., Zhou, Z., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00402-5 · Cited by 51 · see citing works
Xu, J., Shen, C., Lin, W., Meng, T., Ooi, J. D., Eggenhuizen, P. J., Tang, R., Xiao, G., Jin, P., Ding, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683330 · Cited by 50 · see citing works
Update on the cellular and molecular aspects of lupus nephritis
Frangou, E. A., Georgakis, S., & Bertsias, G. K. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108445 · Cited by 50 · see citing works
Lupus Nephritis Biomarkers: A Critical Review
Alduraibi, F. K., & Tsokos, G. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020805 · Cited by 48 · see citing works
Anti-Cytokine Autoantibodies in Systemic Lupus Erythematosus
Howe, H. S., & Leung, B. P. L. (2019) · Cells · doi:10.3390/cells9010072 · Cited by 48 · see citing works
Theocharidis, G., Tekkela, S., Veves, A., McGrath, J. A., & Onoufriadis, A. (2022) · Experimental Dermatology · doi:10.1111/exd.14547 · Cited by 47 · see citing works
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
Chen, W., Jin, B., Cheng, C., Peng, H., Zhang, X., Tan, W., Tang, R., Lian, X., Diao, H., Luo, N., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224788 · Cited by 46 · see citing works
Deleersnijder, D., Callemeyn, J., Arijs, I., Naesens, M., Craenenbroeck, A. H. V., Lambrechts, D., & Sprangers, B. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021020157 · Cited by 46 · see citing works
Belimumab or anifrolumab for systemic lupus erythematosus? A risk-benefit assessment
Kirou, K. A., Dall’Era, M., Aranow, C. B., & Anders, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.980079 · Cited by 45 · see citing works
Burja, B., Paul, D., Tastanova, A., Edalat, S. G., Gerber, R., Houtman, M., Elhaï, M., Bürki, K., Staeger, R., Restivo, G., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.872688 · Cited by 45 · see citing works
Zeng, L., Yang, K., Zhang, T., Zhu, X., Hao, W., Chen, H., & Ge, J. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102919 · Cited by 45 · see citing works
Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus
Xiong, H., Cui, M., Kong, N., Jing, J., Xu, Y., Liu, X., Yang, F., Xu, Z., Yan, Y., Zhao, D., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104507 · Cited by 43 · see citing works
Fenton, K. A., & Pedersen, H. L. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1183535 · Cited by 43 · see citing works
Danaher, P. J., Hasle, N., Nguyen, E. D., Roberts, J. E., Rosenwasser, N. L., Rickert, C., Hsieh, E. W. Y., Hayward, K. N., Okamura, D. M., Alpers, C. E., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adl1666 · Cited by 43 · see citing works
Insights into rheumatic diseases from next-generation sequencing
Donlin, L. T., Park, S. H., Γιαννοπούλου, Ε., Ivovic, A., Park‐Min, K., Siegel, R. M., & Ivashkiv, L. B. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0217-7 · Cited by 42 · see citing works
Wu, C., Jiang, S., Chen, Z., Li, T., Gu, X., Dai, M., Du, F., Ye, Y., Tang, L., Wang, M., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-225876 · Cited by 40 · see citing works
Are lupus animal models useful for understanding and developing new therapies for human SLE?
Moore, E., & Putterman, C. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102490 · Cited by 40 · see citing works
Self-citation
- Authors
- the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Der, E., Suryawanshi, H., Morozov, P., Kustagi, M., Goilav, B., Ranabothu, S., Izmirly, P., Clancy, R., Belmont, H. M., Koenigsberg, M., Mokrzycki, M., Rominieki, H., Graham, J. A., Rocca, J. P., Bornkamp, N., Jordan, N., Schulte, E., Wu, M., Pullman, J., Slowikowski, K., Raychaudhuri, S., Guthridge, J., James, J., Buyon, J., Tuschl, T., & Putterman, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Rockefeller University (US)
- Arkansas Children's Hospital (US)
- New York University (US)
- Montefiore Medical Center (US)
- Broad Institute (US)
- Oklahoma Medical Research Foundation (US)
- Corresponding author
- Buyon, Jill
- Tuschl, Thomas
- Putterman, Chaim
- ORCID
- Venue
- Nature Immunology
- Published
- 2019-05-20
- Volume
- 20
- Issue
- 7
- Pages
- 915-927
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC6584054
- OpenAlex
- W2944872709
- Cited by
- 403
- References
- 52
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 61 · 2023: 44 · 2022: 86 · 2021: 56 · 2020: 64 · 2019: 25
- FWCI
- 44.01
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-10-11)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR003167, UL1TR000371)
- National Human Genome Research Institute (U01HG009379, T32HG002295)
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR067679, UH2AR067677, UH2AR067685, UH2AR067681, UH2AR067689, F31AR070582, UH2AR067676, UH2AR067694, UH2AR067691, UH2AR067690, UH2AR067688, UM2AR067678)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- lupus nephritis, type I interferon response, renal tubular epithelial cells, keratinocytes, renal fibrosis, treatment non-response, skin biopsy, disease heterogeneity, membranous lupus nephritis, proliferative lupus nephritis, single-cell transcriptomics, personalized treatment
- MeSH terms
- Biopsy, Fibrosis, Humans, Interferon Type I, Kidney Tubules, Lupus Nephritis, Protein Binding, Skin, Signal Transduction, Keratinocytes, Extracellular Matrix Proteins, Cell Lineage, Computational Biology, Gene Expression Profiling, Single-Cell Analysis, Transcriptome
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