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The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk
Open accessAbstract
To address how the microbiome might modify the interaction between diet and cardiometabolic health, we analyzed longitudinal microbiome data from 307 male participants in the Health Professionals Follow-Up Study, together with long-term dietary information and measurements of biomarkers of glucose homeostasis, lipid metabolism and inflammation from blood samples. Here, we demonstrate that a healthy Mediterranean-style dietary pattern is associated with specific functional and taxonomic components of the gut microbiome, and that its protective associations with cardiometabolic health vary depending on microbial composition. In particular, the protective association between adherence to the Mediterranean diet and cardiometabolic disease risk was significantly stronger among participants with decreased abundance of Prevotella copri. Our findings advance the concept of precision nutrition and have the potential to inform more effective and precise dietary approaches for the prevention of cardiometabolic disease mediated through alterations in the gut microbiome.
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“Microbiome-mediated links between diet and health have been prevalently investigated by considering the role of the abiotic components of foods. 35-41”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [37]
Experimental — accuracy not yet measuredIn the citing paper
“The SCFAs produced by the gut microbiota during the fermentation of dietary fiber are critical in the reinforcement of the mucus layer”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [636]
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“High-fiber intake increases dietary fiber metabolizers and SCFAs producers, which in turn stimulates mucus secretion to maintain a well-structured and intact mucus layer.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [636]
In the citing paper
“whereas Mediterranean diets — abundant in vegetables, legumes, fruits, fish, and olive oil — increase Faecalibacterium prausnitzii, Bacteroides cellulosilyticus, and Roseburia spp., lower secondary BAs, attenuate systemic inflammation, and correlate with reduced risks of disease.70,85,86”
From Gut dysbiosis in oncology: a risk factor for immunoresistance (2026) · cites this paper as [86]
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Citations
Cites
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Fast and sensitive protein alignment using DIAMOND
Buchfink, B., Xie, C., & Huson, D. H. (2015) · Nature Methods · doi:10.1038/nmeth.3176 · Cited by 14,201
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Boerjan, W., Ralph, J., & Baucher, M. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.134938 · Cited by 4,504
Adherence to a Mediterranean diet and survival in a Greek population
Trichopoulou, A., Costacou, T., Bamia, C., & Trichopoulos, D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025039 · Cited by 4,397
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
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Self-citationMicrobiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
The gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817
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Ross, F. C., Patangia, D. V., Grimaud, G. M., Lavelle, A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01068-4 · Cited by 762
Targeting the gut and tumor microbiota in cancer
Park, E. M., Chelvanambi, M., Bhutiani, N., Kroemer, G., Zitvogel, L., & Wargo, J. A. (2022) · Nature Medicine · doi:10.1038/s41591-022-01779-2 · Cited by 496
Autism-related dietary preferences mediate autism-gut microbiome associations
Yap, C. X., Henders, A. K., Alvares, G. A., Wood, D., Krause, L., Tyson, G. W., Restuadi, R., Wallace, L. M., McLaren, T., Hansell, N. K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.015 · Cited by 371
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359
Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 322
Rethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252
Li, Z., Lai, J., Zhang, P., Ding, J., Jiang, J., Liu, C., Huang, H., Zhen, H., Xi, C., Sun, Y., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01569-9 · Cited by 227
Self-citationThe promise of the gut microbiome as part of individualized treatment strategies
Schupack, D. A., Mars, R. A. T., Voelker, D. H., Abeykoon, J. P., & Kashyap, P. C. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00499-1 · Cited by 217
Nesci, A., Carnuccio, C., Ruggieri, V., D’Alessandro, A., Giorgio, A. D., Santoro, L., Gasbarrini, A., Santoliquido, A., & Ponziani, F. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109087 · Cited by 235
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Mantovani, A., & Dalbeni, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052350 · Cited by 244
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Adolph, T. E., & Tilg, H. (2024) · Nature Medicine · doi:10.1038/s41591-024-03165-6 · Cited by 224
Jardon, K. M. C., Canfora, E. E., Goossens, G. H., & Blaak, E. E. (2022) · Gut · doi:10.1136/gutjnl-2020-323715 · Cited by 197
Diets intervene osteoporosis via gut-bone axis
Zhang, Y., Song, P., Wang, S., Liu, H., Shi, Z., & Su, J. (2024) · Gut Microbes · doi:10.1080/19490976.2023.2295432 · Cited by 188
Dietary regulation in health and disease
Wu, Q., Gao, Z., Yu, X., & Wang, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01104-w · Cited by 190
Rinott, E., Meir, A. Y., Tsaban, G., Zelicha, H., Kaplan, A., Knights, D., Tuohy, K. M., Scholz, M., Koren, O., Stampfer, M. J., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01015-z · Cited by 179
Self-citationRole of dietary fiber in promoting immune health—An EAACI position paper
Venter, C., Meyer, R. W., Greenhawt, M., Pali‐Schöll, I., Nwaru, B. I., Roduit, C., Untersmayr, E., Adel‐Patient, K., Agache, I. O., Agostoni, C. V., et al. (2022) · Allergy · doi:10.1111/all.15430 · Cited by 166
Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation
Deledda, A., Annunziata, G., Tenore, G. C., Palmas, V., Manzin, A., & Velluzzi, F. (2021) · Antioxidants · doi:10.3390/antiox10050708 · Cited by 163
Jiang, Z., Zhuo, L., He, Y., Fu, Y., Shen, L., Xu, F., Gou, W., Miao, Z., Shuai, M., Liang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30712-x · Cited by 161
Bourdeau‐Julien, I., Castonguay-Paradis, S., Rochefort, G., Perron, J., Lamarche, B., Flamand, N., Marzo, V. D., Veilleux, A., & Raymond, F. (2023) · Microbiome · doi:10.1186/s40168-023-01469-2 · Cited by 166
Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome.
Carlino, N., Blanco-Míguez, A., Punčochář, M., Mengoni, C., Pinto, F., Tatti, A., Manghi, P., Armanini, F., Avagliano, M., Barcenilla, C., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.039 · Cited by 146
K., V., Sharma, A. K., Mahajan, S., Dhakan, D. B., Maji, A., Scaria, J., & Sharma, V. K. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00248-x · Cited by 139
Lin, L., Yi, X., Liu, H., Meng, R., Li, S., Liu, X., Yang, J., Xu, Y., Li, C., Wang, Y., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02424-2 · Cited by 139
Mei, Z., Wang, F., Bhosle, A., Dong, D., Mehta, R. S., Ghazi, A. R., Zhang, Y., Liu, Y., Rinott, E., Ma, S., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03067-7 · Cited by 130
Self-citationThe role of the gut microbiota in health and cardiovascular diseases
Wang, L., Wang, S., Zhang, Q., He, C., Fu, C., & Wei, Q. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00091-2 · Cited by 132
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Shen, X., Kellogg, R., Panyard, D. J., Bararpour, N., Castillo, K. P. E., Lee‐McMullen, B., Delfarah, A., Ubellacker, J. M., Ahadi, S., Rosenberg‐Hasson, Y., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00999-8 · Cited by 126
Yassine, H. N., Samieri, C., Livingston, G., Glass, K., Wagner, M., Tangney, C., Plassman, B. L., Ikram, M. A., Voigt, R. M., Gu, Y., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00120-9 · Cited by 116
Research gaps and opportunities in precision nutrition: an NIH workshop report
Lee, B. Y., Ordovás, J. M., Parks, E. J., Anderson, C. A. M., Barabási, A.-Ĺ., Clinton, S. K., de la Haye, K., Duffy, V. B., Franks, P. W., Ginexi, E. M., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac237 · Cited by 132
Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective
Valles-Colomer, M., Menni, C., Berry, S. E., Valdes, A. M., Spector, T. D., & Segata, N. (2023) · Nature Medicine · doi:10.1038/s41591-023-02260-4 · Cited by 114
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Ojala, T., Kankuri, E. M., & Kankainen, M. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.02.002 · Cited by 113
Piperni, E., Nguyen, L. H., Manghi, P., Kim, H., Pasolli, E., Andreu‐Sánchez, S., Arrè, A., Bermingham, K. M., Blanco‐Míguez, A., Manara, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.018 · Cited by 108
Self-citationGut microbiota and microbiota-derived metabolites in cardiovascular diseases
Chen, X., Zhang, H., Ren, S., Ding, Y.-N., Remex, N. S., Bhuiyan, M. S., Qu, J.-H., & Tang, X. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002206 · Cited by 101
Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)
Hemmati, M., Kashanipoor, S., Mazaheri, P., Alibabaei, F., Babaeizad, A., Asli, S., Mohammadi, S., Gorgin, A. H., Ghods, K., Yousefi, B., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121947 · Cited by 105
Houttu, V., Csader, S., Nieuwdorp, M., Holleboom, A. G., & Schwab, U. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.716783 · Cited by 104
Diet-gut microbiota interactions on cardiovascular disease
Zhang, X., & Gérard, P. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.028 · Cited by 98
Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
Stražar, M., Temba, G. S., Vlamakis, H., Kullaya, V. I., Lyamuya, F., Mmbaga, B. T., Joosten, L. A. B., van der Ven, A. J. A. M., Netea, M. G., de Mast, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25213-2 · Cited by 91
Kimble, R., Gouinguenet, P., Ashor, A. W., Stewart, C. J., Deighton, K., Matu, J., Griffiths, A., Malcomson, F. C., Joel, A., Houghton, D., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2057416 · Cited by 100
Blanco‐Míguez, A., Beghini, F., Cumbo, F., McIver, L. J., Thompson, K. N., Zolfo, M., Manghi, P., Dubois, L., Huang, K. D., Thomas, A. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.22.504593 · Cited by 89
Self-citationMicrobiome epidemiology and association studies in human health
VanEvery, H., Franzosa, E. A., Nguyen, L. H., & Huttenhower, C. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00529-x · Cited by 86
Self-citationThe microbiome-driven impact of western diet in the development of noncommunicable chronic disorders
Severino, A., Tohumcu, E., Tamai, L., D’Argenio, P., Porcari, S., Rondinella, D., Venturini, I., Maida, M. F., Gasbarrini, A., Cammarota, G., et al. (2024) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2024.101923 · Cited by 102
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Wilkinson, J. E., Franzosa, E. A., Everett, C., Li, C., trainees, H. R. A., Bae, S., Berzansky, I., Bhosle, A., Bjørnevik, K., Brennan, C. A., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01258-0 · Cited by 92
Self-citationChu, C., Yu, L., Qi, G., Mi, Y., Wu, W., Lee, Y. K., Zhai, Q., Tian, F., & Chen, W. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104556 · Cited by 87
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Tarawneh, R. M., & Penhos, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104814 · Cited by 92
Ben-Yacov, O., Godneva, A., Rein, M., Shilo, S., Lotan‐Pompan, M., Weinberger, A., & Segal, E. (2023) · Gut · doi:10.1136/gutjnl-2022-329201 · Cited by 93
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Mousa, W. K., Chehadeh, F., & Husband, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.825338 · Cited by 91
Predicting drug-microbiome interactions with machine learning
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Miao, Z., Du, W., Xiao, C., Su, C., Gou, W., Shen, L., Zhang, J., Fu, Y., Jiang, Z., Wang, Z., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02402-4 · Cited by 83
Khavandegar, A., Heidarzadeh, A., Angoorani, P., Hasani‐Ranjbar, S., Ejtahed, H., Larijani, B. A., & Qorbani, M. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01861-3 · Cited by 91
Wang, T., Shi, Z., Ren, H., Xu, M., Lu, J., Yang, F., Ye, C., Wu, K., Chen, M., Xu, X., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03038-y · Cited by 81
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Li, F., Armet, A. M., Korpela, K., Liu, J., Quevedo, R. M., Asnicar, F., Seethaler, B., Rusnak, T., Cole, J. L., Zhang, Z., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.034 · Cited by 77
Wu, H., Lv, B., Zhi, L., Shao, Y., Liu, X., Mitteregger, M., Chakaroun, R., Tremaroli, V., Hazen, S. L., Wang, R., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03642-6 · Cited by 71
Yıldırım, S., Nalbantoğlu, Ö. U., Bayraktar, A., Ercan, F. B., Gündoğdu, A., Velioğlu, H. A., Göl, M. F., Ekinci, A., Koç, F., Aslan-Gülpınar, E., et al. (2022) · mSystems · doi:10.1128/msystems.00004-22 · Cited by 62
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van Olst, L., Roks, S. J. M., Kamermans, A., Verhaar, B. J. H., van der Geest, A. M., Muller, M., van der Flier, W. M., & de Vries, H. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683068 · Cited by 68
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Filippis, F. D., Esposito, A., & Ercolini, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04080-6 · Cited by 69
Hu, F. B., Drescher, G., Trichopoulou, A., Willett, W. C., & Martínez‐González, M. Á. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.036 · Cited by 64
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Sun, Z., Pan, X., Li, X., Jiang, L., Hu, P., Wang, Y., Ye, Y., Wu, P., Zhao, B., Xu, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202205289 · Cited by 61
Martinou, E., Stefanova, I., Iosif, E., & Angelidi, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063339 · Cited by 64
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Ser, H., Letchumanan, V., Goh, B. H., Wong, S. H., & Lee, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.519836 · Cited by 57
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Self-citationMartin, V., Virkud, Y. V., Dahan, E., Seay, H., Itzkovits, D., Vlamakis, H. C., Xavier, R. J., Shreffler, W. G., Yuan, Q., & Yassour, M. (2022) · Microbiome · doi:10.1186/s40168-022-01322-y · Cited by 52
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Asnicar, F., Manghi, P., Fackelmann, G., Baldanzi, G., Bakker, E., Ricci, L., Piccinno, G., Piperni, E., Mladenović, K., Amati, F., et al. (2025) · Nature · doi:10.1038/s41586-025-09854-7 · Cited by 69
Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy
Nakamura, M. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.12568 · Cited by 53
Fan, Y., Liu, Y., Shao, C., Jiang, C., Wu, L., Xiao, J., & Tang, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125486 · Cited by 57
Early-onset colorectal cancer as an emerging disease of metabolic dysregulation
Du, M., Drew, D. A., Goncalves, M. D., Cao, Y., & Chan, A. T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01159-z · Cited by 51
Self-citationPrecision nutrition for cardiometabolic diseases
Guasch‐Ferré, M., Wittenbecher, C., Palmnäs, M. S. A., Ben-Yacov, O., Blaak, E. E., Dahm, C. C., Fall, T., Heitmann, B. L., Licht, T. R., Löf, M., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03669-9 · Cited by 59
Self-citationGodny, L., Elial-Fatal, S., Arrouasse, J., Fischler, T. S., Reshef, L., Kutukov, Y., Cohen, S., Pfeffer‐Gik, T., Barkan, R., Shakhman, S. R., et al. (2025) · Gastroenterology · doi:10.1053/j.gastro.2024.12.031 · Cited by 51
Metagenomic analysis characterizes stage-specific gut microbiota in Alzheimer’s disease
Jia, L., Ke, Y., Zhao, S., Liu, J., Luo, X., Cao, J., Liu, Y., Guo, Q., Chen, W., Chen, F., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02973-7 · Cited by 52
Ticinesi, A., Nouvenne, A., Cerundolo, N., Parise, A., Mena, P. R., & Meschi, T. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-024-02707-9 · Cited by 54
Gut Microbiome and Common Variable Immunodeficiency: Few Certainties and Many Outstanding Questions
Varricchi, G., Poto, R., Ianiro, G., Punziano, A., Marone, G., Gasbarrini, A., & Spadaro, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.712915 · Cited by 45
The role of the Mediterranean diet in modulating the gut microbiome: A review of current evidence
Gündoğdu, A., & Nalbantoğlu, Ö. U. (2023) · Nutrition · doi:10.1016/j.nut.2023.112118 · Cited by 45
Wang, J., Zhang, H., Yuan, H., Chen, S., Yu, Y., Zhang, X., Gao, Z., Du, H., Li, W., Wang, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202307233 · Cited by 43
Dietary patterns to promote cardiometabolic health
Pagidipati, N. J., Taub, P. R., Ostfeld, R. J., & Kirkpatrick, C. F. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01061-7 · Cited by 46
Al‐Shaer, A. E., Buddenbaum, N., & Shaikh, S. R. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158936 · Cited by 47
Gut feelings: associations of emotions and emotion regulation with the gut microbiome in women
Ke, S., Guimond, A., Tworoger, S. S., Huang, T., Chan, A. T., Liu, Y., & Kubzansky, L. D. (2023) · Psychological Medicine · doi:10.1017/s0033291723000612 · Cited by 47
Self-citationSood, S., Feehan, J., Itsiopoulos, C., Wilson, K., Plebanski, M., Scott, D. S., Hébert, J. R., Shivappa, N., Mousa, A., George, E. S., et al. (2022) · Nutrients · doi:10.3390/nu14204437 · Cited by 46
Human microbiome variance is underestimated
Shanahan, F., Ghosh, T. S., & O’Toole, P. W. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102288 · Cited by 43
Hu, Y., Li, J., Wang, B., Zhu, L., Li, Y., Ivey, K. L., Lee, K. H., Eliassen, A. H., Chan, A. T., Huttenhower, C., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-330410 · Cited by 42
Self-citationRole of Gut Microbial Metabolites in Cardiovascular Diseases—Current Insights and the Road Ahead
Datta, S., Pasham, S., Sandeep, I. S., Boini, K. M., & Koka, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810208 · Cited by 42
Bae, M., Le, C., Mehta, R. S., Dong, X., Pieper, L. M., Ramirez, L., Alexander, M., Kiamehr, S., Turnbaugh, P. J., Huttenhower, C., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.10.002 · Cited by 42
Self-citationAssociation between dietary patterns and cardiovascular diseases: A review
Lu, L., Jing, W., Qian, W., Fan, L., & Cheng, J. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102412 · Cited by 42
Keshet, A., & Segal, E. (2024) · Nature Communications · doi:10.1038/s41467-024-53832-y · Cited by 44
Metagenomic estimation of dietary intake from human stool
Diener, C., Holscher, H. D., Filek, K., Corbin, K. D., Moissl‐Eichinger, C., & Gibbons, S. M. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01220-1 · Cited by 42
Bonaccio, M., Iacoviello, L., Donati, M. B., & de Gaetano, G. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00924-3 · Cited by 46
Shin, J., Li, T., Zhu, L., Wang, Q., Liang, X., Li, Y., Wang, X., Zhao, S., Li, L., & Li, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.859708 · Cited by 38
Self-citationWang, Q., Huang, H., Yang, Y., Yang, X., Li, X., Zhong, W., Wen, B., He, F., & Li, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1491821 · Cited by 51
Jiménez-González, C., Alonso‐Peña, M., Vélez, P. A., Crespo, J., & Iruzubieta, P. (2025) · Nutrients · doi:10.3390/nu17091580 · Cited by 40
Peters, B. A., Xing, J., Chen, G.-C., Usyk, M., Wang, Z., McClain, A. C., Thyagarajan, B., Daviglus, M. L., Sotres‐Alvarez, D., Hu, F. B., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2022.11.020 · Cited by 38
Self-citationvan den Bogaard, E. H. J., Esser, C., & Perdew, G. H. (2021) · Experimental Dermatology · doi:10.1111/exd.14409 · Cited by 35
Metadata
- Authors
- Wang, D. D., Nguyen, L. H., Li, Y., Yan, Y., Ma, W., Rinott, E., Ivey, K. L., Shai, I., Willett, W. C., Hu, F. B., Rimm, E. B., Stampfer, M. J., Chan, A. T., & Huttenhower, C.
- Affiliations
- Brigham and Women's Hospital (US)
- Massachusetts General Hospital (US)
- Harvard University (US)
- Ben-Gurion University of the Negev (IL)
- Broad Institute (US)
- Corresponding author
- Huttenhower, Curtis
- ORCID
- Venue
- Nature Medicine
- Published
- 2021-02
- Volume
- 27
- Issue
- 2
- Pages
- 333-343
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC8186452
- OpenAlex
- W3127664280
- Cited by
- 386
- References
- 75
- Citations by year
- 2026: 52 · 2025: 83 · 2024: 77 · 2023: 65 · 2022: 69 · 2021: 39
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services (U01CA152904, R00DK119412, K24DK098311, U54DE023798, U01 CA167552, R01 HL035464, R01CA202704, R01HL060712, P30 DK046200)
- Crohn's and Colitis Foundation (563526, 690389)
- National Heart, Lung, and Blood Institute (R01HL060712, R01HL035464)
- National Cancer Institute (R01CA202704, U01CA152904, U01CA167552)
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK125838, R00DK119412, P30DK046200, K99DK119412, K24DK098311, P30DK043351)
- National Institute of Dental and Craniofacial Research (U54DE023798)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- gut microbiota, Mediterranean diet, cardiometabolic risk, Prevotella copri, diet-microbiome interactions, personalized nutrition, glucose homeostasis, lipid metabolism, inflammation, Health Professionals Follow-up Study, male participants
- MeSH terms
- Gastrointestinal Microbiome, Cardiometabolic Risk Factors, Cardiovascular Diseases, Diet, Female, Follow-Up Studies, Humans, Male, Biomarkers, Prevotella, Diet, Mediterranean, Microbiota
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