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Cited by 35Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Recognition memory reconsolidation requires hippocampal Zif268

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Gonzalez, Maria Carolina, Rossato, Janine I., Radiske, Andressa, Pádua Reis, Marina, Cammarota, Martín·2019·Scientific Reports
DOI 10.1038/s41598-019-53005-8PMC PMC6851087
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Abstract

Object recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.

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  • SGK1 increases neuronal plasticity by modulating SRF and CREB1, allowing transition of stored information from short-term to long-term memories.

    “Specifically, SGK1 increases neuronal plasticity by modulating the activity of transcription factors SRF and CREB1. This process allows transitioning stored information from short-term memories to long-term memories”

    From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Gonzalez et al., 2019

    The Introduction (page not available) discusses Zif268 and object-recognition memory reconsolidation, not SGK1. Searches for SGK1, SRF, CREB1, and short-term-to-long-term memory transition found no passage in our copy addressing the attributed mechanism. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Gonzalez, M. C., Rossato, J. I., Radiske, A., Pádua Reis, M., & Cammarota, M.
Affiliations
Universidade Federal do Rio Grande do Norte (BR)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2019-11-12
Volume
9
Issue
1
Pages
16620-16620
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-019-53005-8
PMC
PMC6851087
OpenAlex
W2984078984
Cited by
35
References
9
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 3 · 2019: 1
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Universidade Federal do Rio Grande do Norte
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
object recognition memory, memory reconsolidation, Zif268, hippocampus, long-term potentiation, transcription factors, antisense oligonucleotides, memory updating, memory retrieval, memory traces
MeSH terms
Memory Consolidation, Animals, Fluorescent Antibody Technique, Hippocampus, Male, Rats, Wistar, Maze Learning, Recognition, Psychology, Rats, Early Growth Response Protein 1, Gene Knockdown Techniques

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