Distinct contributions of the hippocampus and medial prefrontal cortex to the “what–where–when” components of episodic-like memory in mice
Open accessAbstract
There is a current controversy regarding whether non-human animals have a capacity for episodic memory, defined by the ability to remember what happened and where and when it occurred. It is also unclear which brain structures support the "what," "where," and "when" aspects of episodic memory. Here we addressed these issues by testing episodic memory in mice, using an object recognition task that has previously been employed to assess the "what," "where," and "when" components of recognition memory. Whereas intact mice remembered which objects they had explored, as well as when and where they were experienced, mice with damage to the hippocampus were impaired on all three components of the task. In contrast, animals with medial prefrontal cortical lesions were selectively impaired on the "where" component of the task, but had intact memory for "what" and "when." These results are consistent with the hypothesis that the hippocampus integrates the "what," "where," and "when" features of unique experiences, whereas the prefrontal cortex makes a more selective contribution to retrieving source information about where events occurred.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rodents with hippocampal lesions fail in both what-where-when tasks and incidental encoding tasks.
“These observations are supported by research using established episodic-like memory paradigms, showing that rodents with hippocampal lesions fail in both what–where–when tasks [70,72] as well as incidental encoding tasks [82].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [72]
Mice with lesion of the mPFC show impaired where, but not what or when, component assessed in the ELM2-1 test.
“Mice with lesion of the mPFC showed the impaired where, but not what or when, component assessed in the ELM2–1 test (DeVito and Eichenbaum, 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as DeVito and Eichenbaum, 2010
Mice with hippocampal lesions were impaired in the what, where and when components in the ELM2-1 paradigm.
“Mice with hippocampal lesions were impaired in the what, where and when components in the ELM2–1 paradigm”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as DeVito and Eichenbaum, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580 · see citing works
Self-citationEpisodic-like memory during cache recovery by scrub jays
Clayton, N. S., & Dickinson, A. (1998) · Nature · doi:10.1038/26216 · Cited by 1,464 · see citing works
Prefrontal and medial temporal lobe interactions in long-term memory
Simons, J. S., & Spiers, H. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1178 · Cited by 961 · see citing works
Critical role of the hippocampus in memory for sequences of events
Fortin, N. J., Agster, K. L., & Eichenbaum, H. B. (2002) · Nature Neuroscience · doi:10.1038/nn834 · Cited by 881 · see citing works
Self-citationIntegration of What and Where in the Primate Prefrontal Cortex
Rao, S. C., Rainer, G., & Miller, E. K. (1997) · Science · doi:10.1126/science.276.5313.821 · Cited by 877 · see citing works
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714 · see citing works
Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-06.2007 · Cited by 691 · see citing works
Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes
Slotnick, S. D., Moo, L. R., Segal, J. B., & Hart, J. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00082-x · Cited by 654 · see citing works
Executive Control during Episodic Retrieval
Dobbins, I. G., Foley, H. A., Schacter, D. L., & Wagner, A. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00858-9 · Cited by 501 · see citing works
On the delay-dependent involvement of the hippocampus in object recognition memory
HAMMOND, R. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.03.005 · Cited by 476 · see citing works
Recollection-like memory retrieval in rats is dependent on the hippocampus
Fortin, N. J., Wright, S. P., & Eichenbaum, H. (2004) · Nature · doi:10.1038/nature02853 · Cited by 460 · see citing works
Self-citationRobust Conjunctive Item–Place Coding by Hippocampal Neurons Parallels Learning What Happens Where
Komorowski, R. W., Manns, J. R., & Eichenbaum, H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1378-09.2009 · Cited by 372 · see citing works
Self-citationPerspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356 · see citing works
Nyberg, L. H., McIntosh, A. R., Cabeza, R. E. L., Habib, R., Houle, S., & Tulving, E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11280 · Cited by 346 · see citing works
Integrated Memory for Object, Place, and Context in Rats: A Possible Model of Episodic-Like Memory?
Eacott, M. J., & Norman, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2975-03.2004 · Cited by 344 · see citing works
The Hippocampus and Memory for “What,” “Where,” and “When”
Ergorul, C., & Eichenbaum, H. (2004) · Learning & Memory · doi:10.1101/lm.73304 · Cited by 294 · see citing works
Self-citationRossato, J. I., Bevilaqua, L. R. M., Myskiw, J. C., Medina, J. H., Izquierdo, I., & Cammarota, M. (2007) · Learning & Memory · doi:10.1101/lm.422607 · Cited by 282 · see citing works
Memory fields of neurons in the primate prefrontal cortex
Rainer, G., Asaad, W. F., & Miller, E. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15008 · Cited by 280 · see citing works
The Role of the Prefrontal Cortex in Recognition Memory and Memory for Source: An fMRI Study
Rugg, M. D., Fletcher, P. C., Chua, P. M.-L., & Dolan, R. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0488 · Cited by 275 · see citing works
Glutamate-receptor-mediated encoding and retrieval of paired-associate learning
Day, M., Langston, R. F., & Morris, R. (2003) · Nature · doi:10.1038/nature01769 · Cited by 259 · see citing works
Integrated memory for objects, places, and temporal order: Evidence for episodic-like memory in mice
Dere, E., Huston, J. P., & De Souza Silva, M. A. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.07.002 · Cited by 243 · see citing works
Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.08.001 · Cited by 242 · see citing works
Hannesson, D. K., Howland, J. G., & Phillips, A. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5517-03.2004 · Cited by 231 · see citing works
Episodic memory: what can animals remember about their past?
Griffiths, D., Dickinson, A., & Clayton, N. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01272-8 · Cited by 228 · see citing works
Mitchell, J. B. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00032-1 · Cited by 212 · see citing works
The case for episodic memory in animals
Dere, E., KARTTEKE, E., Huston, J. P., & DESOUZASILVA, M. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.09.005 · Cited by 202 · see citing works
Contrasting Hippocampal and Perirhinalcortex Function using Immediate Early Gene Imaging
Aggleton, J. P., & Brown, M. W. (2005) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990444000131 · Cited by 158 · see citing works
Effects of Unilateral Prefrontal Lesions on Familiarity, Recollection, and Source Memory
Duarte, A., Ranganath, C., & Knight, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1392-05.2005 · Cited by 153 · see citing works
Jenkins, T. A., Amin, E., Pearce, J. M. S., Brown, M. W., & Aggleton, J. P. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.024 · Cited by 128 · see citing works
The Medial Prefrontal Cortex Is Involved in Spatial Memory Retrieval under Partial-Cue Conditions
Jo, Y. S., Park, E., Kim, I. H., Park, S. K., Kim, H., Kim, H. T., & Choi, J.-S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3589-07.2007 · Cited by 123 · see citing works
Medial prefrontal cortex supports recollection, but not familiarity, in the rat
Farovik, A., Dupont, L. M., Arce, M., & Eichenbaum, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3662-08.2008 · Cited by 121 · see citing works
Self-citationHannesson, D. K., Vacca, G., Howland, J. G., & Phillips, A. G. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.004 · Cited by 115 · see citing works
The role of prefrontal cortex in object‐in‐place learning in monkeys
Browning, P. G. F., Easton, A., Buckley, M. J., & Gaffan, D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04477.x · Cited by 73 · see citing works
Prefrontal Cortex Lesions Modify the Spatial Properties of Hippocampal Place Cells
Kyd, R. J. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.5.444 · Cited by 72 · see citing works
Episodic memory, semantic memory, and amnesia
Squire, L. R., & Zola, S. M. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:3
Flagged first, then by citations
Cited by
Sorted by citations
One-trial object recognition in rats and mice: Methodological and theoretical issues
Ennaceur, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.036 · Cited by 676 · see citing works
Sleep for Preserving and Transforming Episodic Memory
Inostroza, M., & Jan Born, A. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170429 · Cited by 265 · see citing works
The medial temporal lobe and the attributes of memory
Wixted, J., & Squire, L. R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.03.005 · Cited by 19 · see citing works
Pascual, M., Baliño, P., Alfonso-Loeches, S., Aragón, C. M. G., & Guerri, C. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.012 · Cited by 213 · see citing works
Miedel, C. J., Patton, J. M., Miedel, A. N., Miedel, E. S., & Levenson, J. M. (2017) · Journal of Visualized Experiments · doi:10.3791/55523 · Cited by 192 · see citing works
Huffman, W. J., Subramaniyan, S., Rodriguiz, R. M., Wetsel, W. C., Grill, W. M., & Terrando, N. (2019) · Brain Stimulation · doi:10.1016/j.brs.2018.10.005 · Cited by 181 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Churchwell, J. C., & Kesner, R. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.045 · Cited by 143 · see citing works
Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
Malik, R., Li, Y., Schamiloglu, S., & Sohal, V. S. (2022) · Cell · doi:10.1016/j.cell.2022.04.001 · Cited by 138 · see citing works
Higher Body Mass Index is Associated with Episodic Memory Deficits in Young Adults
Cheke, L. G., Simons, J. S., & Clayton, N. S. (2015) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470218.2015.1099163 · Cited by 134 · see citing works
Separate elements of episodic memory subserved by distinct hippocampal-prefrontal connections
Barker, G. R. I., Banks, P. J., Scott, H., Ralph, G. S., Mitrophanous, K. A., Wong, L.-F., Bashir, Z. I., Uney, J. B., & Warburton, E. C. (2017) · Nature Neuroscience · doi:10.1038/nn.4472 · Cited by 124 · see citing works
Medial prefrontal cortex role in recognition memory in rodents
Morici, J. F., Bekinschtein, P., & Weisstaub, N. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.030 · Cited by 119 · see citing works
Recessive Mutations in SPTBN2 Implicate β-III Spectrin in Both Cognitive and Motor Development
Lise, S., Clarkson, Y. L., Perkins, E., Kwasniewska, A., Akha, E. S., Schnekenberg, R. P., Šuminaite, D., Hope, J. E., Baker, I., Gregory, L., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003074 · Cited by 111 · see citing works
Chao, O. Y.-H., Huston, J. P., Li, J., Wang, A., & Silva, M. A. D. S. (2015) · Hippocampus · doi:10.1002/hipo.22547 · Cited by 110 · see citing works
Inostroza, M., Brotons‐Mas, J. R., Laurent, F., Cid, E., & de la Prida, L. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0957-13.2013 · Cited by 101 · see citing works
O’Tuathaigh, C. M. P., Hryniewiecka, M., Behan, Á. T., Tighe, O., Coughlan, C. A., Desbonnet, L., Cannon, M. D., Karayiorgou, M., Gogos, J. A., Cotter, D., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.100 · Cited by 103 · see citing works
Sleep-dependency of episodic-like memory consolidation in rats
Inostroza, M., Binder, S., & Jan Born, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.011 · Cited by 99 · see citing works
Tuscher, J. J., Taxier, L. R., Fortress, A. M., & Frick, K. M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.002 · Cited by 88 · see citing works
Hippocampus and neocortex: recognition and spatial memory
Vann, S. D., & Albasser, M. M. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.02.002 · Cited by 86 · see citing works
Terry, A. V., Kutiyanawalla, A., & Pillai, A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.005 · Cited by 88 · see citing works
Barbosa, F. F., Santos, J. R., Meurer, Y. S. R., Macêdo, P. T., Ferreira, L. M. S., Pontes, I. M. O., Ribeiro, A. M., & Silva, R. H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00112 · Cited by 79 · see citing works
“For example, while HP and mPFC are essential to spatiotemporal processing, they do not seem to be involved in the novel item recognition process (Hoge and Kesner, 2007; DeVito and Eichenbaum, 2010; Aggleton et al., 2012).”
BackgroundNeurobehavioral alterations in HIV-1 transgenic rats: Evidence for dopaminergic dysfunction
Moran, L. M., Booze, R. M., Webb, K. M., & Mactutus, C. F. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.008 · Cited by 76 · see citing works
Remembering to attend: The anterior cingulate cortex and remote memory
Weible, A. P. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.010 · Cited by 78 · see citing works
CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing
Lehr, A. B., Kumar, A., Tetzlaff, C., Hafting, T., Fyhn, M., & Stöber, T. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.020 · Cited by 74 · see citing works
Yang, M., Lewis, F. C., Sarvi, M. S., Foley, G. M., & Crawley, J. N. (2015) · Learning & Memory · doi:10.1101/lm.039602.115 · Cited by 70 · see citing works
Barcoding of episodic memories in the hippocampus of a food-caching bird
Chettih, S. N., Mackevicius, E. L., Hale, S., & Aronov, D. (2024) · Cell · doi:10.1016/j.cell.2024.02.032 · Cited by 74 · see citing works
Barbosa, F. F., de Oliveira Pontes, I. M., Ribeiro, S., Ribeiro, A. M., & Silva, R. H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.022 · Cited by 71 · see citing works
Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy
Crimins, J. L., Rocher, A. B., Peters, A., Shultz, P. L., Lewis, J. M., & Luebke, J. I. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0877-0 · Cited by 71 · see citing works
de Bruin, N. M. W. J., Prickaerts, J., van Loevezijn, A., Venhorst, J., de Groote, L., Houba, P., Reneerkens, O. A. H., Akkerman, S., & Kruse, C. G. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.06.015 · Cited by 68 · see citing works
Salwiczek, L. H., Watanabe, A., & Clayton, N. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.011 · Cited by 65 · see citing works
Binder, S., Dere, E., & Zlomuzica, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.04.002 · Cited by 53 · see citing works
Zlomuzica, A., Preusser, F., Totzeck, C., Dere, E., & Margraf, J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.037 · Cited by 55 · see citing works
Võikar, V., Krackow, S., Lipp, H., Rau, A., Colacicco, G., & Wolfer, D. P. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.048 · Cited by 57 · see citing works
Rocha, M., Wang, D., Avila-Quintero, V. J., Bloch, M. H., & Kaffman, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01352-4 · Cited by 56 · see citing works
Slowing of the Hippocampal θ Rhythm Correlates with Anesthetic-induced Amnesia
Perouansky, M. A., Rau, V., Ford, T., Oh, S. I., Perkins, M. G., Eger, E. I., & Pearce, R. A. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f90ccc · Cited by 55 · see citing works
Castilla-Ortega, E., Pedraza, C., Chun, J., Fonseca, F. R. D., Estivill-Torrús, G., & Santín, L. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.018 · Cited by 50 · see citing works
Visual perception and memory systems: from cortex to medial temporal lobe
Khan, Z. U., Martín‐Montañez, E., & Baxter, M. G. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0641-6 · Cited by 51 · see citing works
Nash, M. I., Hodges, C. B., Muncy, N. M., & Kirwan, C. B. (2021) · Hippocampus · doi:10.1002/hipo.23299 · Cited by 49 · see citing works
Léger, M., Quiedeville, A., Païzanis, E., Natkunarajah, S., Fréret, T., Boulouard, M., & Schumann‐Bard, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048043 · Cited by 48 · see citing works
García-Baos, A., Puig-Reyné, X., García‐Algar, Ó., & Valverde, O. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111813 · Cited by 46 · see citing works
A bird-brain view of episodic memory
Rattenborg, N. C., & Martinez-Gonzalez, D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.030 · Cited by 45 · see citing works
Pharmacological rescue of cognitive function in a mouse model of chemobrain
Nguyen, L. D., Fischer, T. T., & Ehrlich, B. E. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00463-2 · Cited by 45 · see citing works
Chronic alcohol-induced liver injury correlates with memory deficits: Role for neuroinflammation
King, J. A., Nephew, B. C., Choudhury, A., Poirier, G. L., Lim, A., & Mandrekar, P. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.07.005 · Cited by 45 · see citing works
Sleep benefits in parallel implicit and explicit measures of episodic memoryPreprint
Weber, F. D., Wang, J., Jan Born, A., & Inostroza, M. (2014) · Learning & Memory · doi:10.1101/lm.033530.113 · Cited by 45 · see citing works
Prefrontal cortex stroke induces delayed impairment in spatial memory
Zhou, L. Y. Y., Wright, T. E., & Clarkson, A. N. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.08.022 · Cited by 44 · see citing works
Zhang, Z., Ma, Q., Velagapudi, R., Barclay, W. E., Rodriguiz, R. M., Wetsel, W. C., Yang, T., Shinohara, M. L., & Terrando, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856254 · Cited by 44 · see citing works
What , where and when : deconstructing memory
Marshall, R. E. S., Hurly, T. A., Sturgeon, J., Shuker, D. M., & Healy, S. D. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.2194 · Cited by 43 · see citing works
Castilla-Ortega, E., Rosell-Valle, C., Pedraza, C., Rodríguez de Fonseca, F., Estivill-Torrús, G., & Santín, L. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.001 · Cited by 41 · see citing works
de Souza Silva, M. A., Huston, J. P., Wang, A.-L., Petri, D., & Chao, O. Y.-H. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv112 · Cited by 41 · see citing works
Object/Context Specific Memory Deficits following Medial Frontal Cortex Damage in Mice
Spanswick, S. C., & Dyck, R. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043698 · Cited by 40 · see citing works
Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice
Tong, J., Chen, G.-H., Wang, F., Li, X., Cao, L., Sui, X., Tao, F., Yan, W.-W., & Wei, Z. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.052 · Cited by 39 · see citing works
Rising, A. C., Xu, J., Carlson, A. M., Napoli, V. V., Denovan‐Wright, E. M., & Mandel, R. J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.017 · Cited by 37 · see citing works
Cognitive mechanisms of memory for order in rhesus monkeys (Macaca mulatta)
Templer, V. L., & Hampton, R. R. (2012) · Hippocampus · doi:10.1002/hipo.22082 · Cited by 36 · see citing works
Miller‐Rhodes, P., Kong, C., Baht, G. S., Saminathan, P., Rodriguiz, R. M., Wetsel, W. C., Gelbard, H. A., & Terrando, N. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1582-5 · Cited by 32 · see citing works
Recognition memory reconsolidation requires hippocampal Zif268
Gonzalez, M. C., Rossato, J. I., Radiske, A., Pádua Reis, M., & Cammarota, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-53005-8 · Cited by 35 · see citing works
Terry, A. V., Buccafusco, J. J., Gearhart, D. A., Beck, W. D., Risher, M., Truan, J. N., Schwarz, G. M., Xu, M., Bartlett, M. G., Kutiyanawala, A., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.031 · Cited by 33 · see citing works
PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory
Rossato, J. I., González, M. C., Radiske, A., Apolinário, G., Conde‐Ocazionez, S., Bevilaqua, L. R., & Cammarota, M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2270-18.2018 · Cited by 32 · see citing works
CA1 inactivation impairs episodic-like memory in rats
Drieskens, D. C., Neves, L. R., Pugliane, K. C., de Souza, I. B. M. B., Lima, Á. D. C., Salvadori, M. G. D. S. S., Ribeiro, A. M., Silva, R. H., & Barbosa, F. F. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.08.008 · Cited by 31 · see citing works
Beyond hippocampus: Thalamic and prefrontal contributions to an evolving memory
Yadav, N., Toader, A. C., & Rajasethupathy, P. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.021 · Cited by 31 · see citing works
Lost in Transition: Aging-Related Changes in Executive Control by the Medial Prefrontal Cortex
Caetano, M. S., Horst, N. K., Harenberg, L., Liu, B., Arnsten, A. F. T., & Laubach, M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6011-11.2012 · Cited by 30 · see citing works
Stressors impair odor recognition memory via an olfactory bulb-dependent noradrenergic mechanism
Manella, L. C., Alperin, S., & Linster, C. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00097 · Cited by 29 · see citing works
Age-related spatial working memory deficits in homing pigeons (Columba livia).
Coppola, V. J., Hough, G. E., & Bingman, V. P. (2014) · Behavioral Neuroscience · doi:10.1037/bne0000013 · Cited by 29 · see citing works
Massand, E., & Bowler, D. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1869-9 · Cited by 28 · see citing works
Is episodic-like memory <i>like</i> episodic memory?
Davies, J. R., & Clayton, N. S. (2024) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2023.0397 · Cited by 27 · see citing works
Challenges and advanced concepts for the assessment of learning and memory function in mice
Lang, B., Kahnau, P., Hohlbaum, K., Mieske, P., Andresen, N., Boon, M. N., Thöne‐Reineke, C., Lewejohann, L., & Diederich, K. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1230082 · Cited by 27 · see citing works
Lander, S. S., Chornyy, S., Safory, H., Gross, A., Wolosker, H., & Gaisler‐Salomon, I. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12636 · Cited by 27 · see citing works
Cressant, A., Dubreuil, V., Kong, J., Kranz, T. M., Lazarini, F., Launay, J., Callebert, J., Sap, J., Malaspina, D., Granon, S., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4490-8 · Cited by 27 · see citing works
Chen, G., Tong, J., Wang, F., Hu, X., Li, X., Tao, F., & Wei, Z. (2015) · AGE · doi:10.1007/s11357-015-9839-0 · Cited by 26 · see citing works
Canto‐de‐Souza, L., & Mattioli, R. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.01.012 · Cited by 26 · see citing works
Flexible use of memory by food-caching birds
Applegate, M. C., & Aronov, D. (2021) · eLife · doi:10.7554/elife.70600 · Cited by 25 · see citing works
Breeden, P., Dere, D., Zlomuzica, A., & Dere, E. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0053 · Cited by 25 · see citing works
Rossato, J. I., Köhler, C. A., Radiske, A., Bevilaqua, L. R., & Cammarota, M. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.09.001 · Cited by 22 · see citing works
Making a case for endovascular approaches for neural recording and stimulation
Thielen, B., Xu, H., Fujii, T., Rangwala, S. D., Jiang, W., Lin, M., Kammen, A., Liu, C. Y., Selvan, P., Song, D. B., et al. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acb086 · Cited by 24 · see citing works
Sex differences in adult cognitive deficits after adolescent nicotine exposure in rats
Pickens, L. R. G., Rowan, J. D., Bevins, R. A., & Fountain, S. B. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.05.001 · Cited by 24 · see citing works
Testing long-term memory in animal models of schizophrenia: Suggestions from CNTRICS
Bussey, T. J., Barch, D. M., & Baxter, M. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.005 · Cited by 23 · see citing works
Trigiani, L. J., Royea, J., Tong, X., & Hamel, É. (2019) · The FASEB Journal · doi:10.1096/fj.201901002r · Cited by 23 · see citing works
Miedel, C. J., Patton, J. M., Miedel, A. N., Miedel, E. S., & Levenson, J. M. (2017) · Journal of Visualized Experiments · doi:10.3791/55523-v · Cited by 23 · see citing works
Time, memory, and the legacy of Howard Eichenbaum
Ranganath, C. (2018) · Hippocampus · doi:10.1002/hipo.23007 · Cited by 26 · see citing works
Schulz, D., Smith, D., Yu, M., Lee, H., & Henn, F. A. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001994 · Cited by 22 · see citing works
Tanqueiro, S. R., Mouro, F. M., Ferreira, C. B., Freitas, C. F., Fonseca‐Gomes, J., do Couto, F. S., Sebastião, A. M., Dawson, N., & Diógenes, M. J. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211008560 · Cited by 22 · see citing works
Coppola, V. J., Spencer, J. M., Peterson, R. M., & Bingman, V. P. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.038 · Cited by 20 · see citing works
Episodic-like memory impairment induced by sub-anaesthetic doses of ketamine
de Souza, I. B. M. B., Meurer, Y. D. S. R., Tavares, P. M., Pugliane, K. C., Lima, R. H., Silva, R. H., & Barbosa, F. F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.10.031 · Cited by 19 · see citing works
Morè, L., Lauterborn, J. C., Papaleo, F., & Brambilla, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.003 · Cited by 19 · see citing works
Olson, C. A., Hale, L. R., Hamilton, N., Powell, J. N., Martin, L. E., & Savage, C. R. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.08.031 · Cited by 17 · see citing works
Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
De Castro, V., & Girard, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-88357-7 · Cited by 17 · see citing works
Belblidia, H., Abdelouadoud, A., Jozet-Alves, C., Dumas, H., Freret, T., Leger, M., & Schumann-Bard, P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.043 · Cited by 17 · see citing works
Malkov, A., Shevkova, L., Latyshkova, A., & Kitchigina, V. F. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114110 · Cited by 17 · see citing works
How does episodic memory develop in adolescence?Preprint
Mechie, I. R., Plaisted-Grant, K. C., & Cheke, L. G. (2021) · Learning & Memory · doi:10.1101/lm.053264.120 · Cited by 17 · see citing works
Probing the nature of episodic memory in rodents
Huston, J. P., & Chao, O. Y.-H. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104930 · Cited by 16 · see citing works
Rashid, H., & Ahmed, T. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.02.004 · Cited by 16 · see citing works
Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development
Fischer, T. T., Nguyen, L. D., & Ehrlich, B. E. (2021) · The FASEB Journal · doi:10.1096/fj.202100731r · Cited by 16 · see citing works
Tam, S. K. E., Robinson, J., Jennings, D. J., & Bonardi, C. (2014) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000003 · Cited by 15 · see citing works
The Futures of the Past The Evolution of Imaginative Animals
Zacks, O., Ginsburg, S., & Jablonka, E. (2022) · Journal of Consciousness Studies · doi:10.53765/20512201.29.3.029 · Cited by 15 · see citing works
Towards an animal model of consciousness based on the platform theory
Zlomuzica, A., & Dere, E. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113695 · Cited by 17 · see citing works
Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging
Paban, V., Billard, J., Bouët, V., Fréret, T., Boulouard, M., Chambon, C., Loriod, B., & Alescio‐Lautier, B. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0472-8 · Cited by 16 · see citing works
The role of PPAR-γ in memory deficits induced by prenatal and lactation alcohol exposure in mice
García-Baos, A., Pastor, A., Gallego‐Landin, I., de la Torre, R., Sanz, F., & Valverde, O. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02191-z · Cited by 14 · see citing works
Xu, Z., Shen, B., Taji, W., Sun, P., & Naya, Y. (2020) · Human Brain Mapping · doi:10.1002/hbm.24953 · Cited by 14 · see citing works
Role of PFC during retrieval of recognition memory in rodents
Bekinschtein, P., & Weisstaub, N. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.03.001 · Cited by 13 · see citing works
Episodic-like memory in wild free-living blue tits and great tits
Davies, J. R., Keuneke, L. S., Clayton, N. S., & Davidson, G. L. (2024) · Current Biology · doi:10.1016/j.cub.2024.06.029 · Cited by 12 · see citing works
Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice
Bent, M. A. M., Pais, A. C., & Wolstenholme, J. T. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113703 · Cited by 12 · see citing works
- Authors
- DeVito, L. M., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Eichenbaum, Howard
- ORCID
- Eichenbaum, Howard
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 215
- Issue
- 2
- Pages
- 318-325
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC2891645
- OpenAlex
- W2102411019
- Cited by
- 164
- References
- 38
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 30 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 16 · 2014: 5 · 2013: 14 · 2012: 12
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH060450, R01MH059357)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- episodic-like memory, hippocampus, medial prefrontal cortex, object recognition memory, source memory, hippocampal lesions, prefrontal cortex lesions, mice, recognition memory
- MeSH terms
- Animals, Hippocampus, Ibotenic Acid, Male, Mice, Inbred C57BL, Microinjections, Mental Recall, N-Methylaspartate, Prefrontal Cortex, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
