Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep
Abstract
We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.
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After 24 h of sleep deprivation, decreases rather than increases in metabolic rates were observed.
“Moreover, decreases rather than increases in metabolic rates were observed after 24 h of sleep deprivation (1186, 1336), although it cannot be excluded that distinctly extended periods of wakefulness trigger separate compensatory processes characterized by the occurrence of local slow waves in the waking state and by reduced metabolic demands (1204, 1267).”
From About Sleep's Role in Memory (2013) · cites this paper as [1336]
The After Sleep Deprivation section reports significant decreases and no significant increases in absolute glucose metabolism, supporting the direction of the claim. However, Subjects and Methods says participants were sleep deprived for 29–34 hours, not 24 hours. The paper also reports relative metabolic increases in some regions. (LLM, conf=0.90)
Experimental — accuracy not yet measuredPET studies of sleep deprivation have consistently reported significant reductions in metabolic rates in the thalamic, parietal, and prefrontal regions after sleep loss, which correlated with declines of cognitive performance and alertness.
“PET studies of sleep deprivation have consistently reported significant reductions in metabolic rates in the thalamic, parietal, and prefrontal regions after sleep loss, which correlated with declines of cognitive performance and alertness.186–189”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [187]
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- Authors
- Wu, J. C., Gillin, J. C., Buchsbaum, M. S., Chen, P., Keator, D. B., Khosla Wu, N., Darnall, L. A., Fallon, J. H., & Bunney, W. E.
- Affiliations
- University of California, Irvine (US)
- University of California San Diego (US)
- Corresponding author
- Wu, Joseph C
- Venue
- Neuropsychopharmacology
- Published
- 2006-07-26
- Volume
- 31
- Issue
- 12
- Pages
- 2783-2792
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W1976843844
- Cited by
- 157
- References
- 44
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 8
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep deprivation, recovery sleep, brain glucose metabolism, frontal cortex, thalamus, striatum, sleep restoration
- MeSH terms
- Adult, Brain Mapping, Cognition, Cognition Disorders, Corpus Striatum, Energy Metabolism, Female, Frontal Lobe, Humans, Functional Laterality, Male, Middle Aged, Neuropsychological Tests, Sleep, Sleep Deprivation, Thalamus, Recovery of Function, Positron-Emission Tomography
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