Cited by 143Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationAlkaloids: synthesis and pharmacology

Dose-Related Enhancement of Mood and Cognition in Smokers Administered Nicotine Nasal Spray

Myers, Carol S, Taylor, Richard C, Moolchan, Eric T, Heishman, Stephen J·2008·Neuropsychopharmacology

Abstract

The discovery of the role of nicotinic receptors in attention and memory has led to the testing of nicotinic analogs as cognitive enhancing agents in patient populations. Empirical information about nicotine's ability to enhance elements of attention and memory in normal individuals might guide development of therapeutic uses of nicotine in cognitively impaired populations. The purpose of this study was to determine the effect of nicotine on continuous attention, working memory, and computational processing in tobacco-deprived and nondeprived smokers. A total of 28 smokers (14 men, 14 women) participated in a double-blind, placebo-controlled, within-subject study, in which they were overnight (12 h) tobacco deprived at one session and smoked ad libitum before the other session. At each session, participants received 0, 1, and 2 mg nicotine via nasal spray in random order at 90 min intervals. Before and after each dose, a battery of cognitive, subjective, and physiological measures was administered, and blood samples were taken for plasma nicotine concentration. Overnight tobacco deprivation resulted in impaired functioning on all cognitive tests and increased self-reports of tobacco craving and negative mood; nicotine normalized these deficits. In the nondeprived condition, nicotine enhanced performance on the continuous performance test (CPT) and an arithmetic test in a dose-related manner, but had no effect on working memory. In general, women were more sensitive than men to the subjective effects of nicotine. These results provide an unequivocal determination that nicotine enhanced attentional and computational abilities in nondeprived smokers and suggest these cognitive domains as substrates for novel therapeutic indications.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1301425

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Cognitive deficits manifest during nicotine withdrawal, including difficulty concentrating, increased reaction times in sustained attention tasks, and impaired episodic and working memory.

    “In addition, there are cognitive deficits that manifest during nicotine withdrawal, including difficulty concentrating, increased reaction times in tasks requiring sustained attention, and impaired episodic and working memory (Myers et al. 2008; Wesnes et al. 2013).”

    From Nicotine Withdrawal (2015) · cites this paper as Myers et al. 2008

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Myers, C. S., Taylor, R. C., Moolchan, E. T., & Heishman, S. J.
Affiliations
National Institutes of Health (US)
Corresponding author
Myers, Carol S
Venue
Neuropsychopharmacology
Published
2007-04-18
Volume
33
Issue
3
Pages
588-598
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W1997749834
Cited by
143
References
68
Citations by year
2026: 1 · 2025: 5 · 2024: 10 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 7 · 2014: 18 · 2013: 8 · 2012: 15
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
Keywords
nicotine, cognitive enhancement, attention, working memory, continuous performance test, nicotine craving, mood, sex differences, nicotinic acetylcholine receptors, dose-response relationship, smokers, plasma nicotine concentration
MeSH terms
Administration, Inhalation, Adult, Aerosols, Affect, Blood Pressure, Cognition, Dose-Response Relationship, Drug, Double-Blind Method, Female, Heart Rate, Humans, Male, Memory, Short-Term, Nicotine, Psychomotor Performance, Sex Characteristics, Smoking, Substance Withdrawal Syndrome, Smoking Cessation, Nicotinic Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review