p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

Jimenez, Gretchen S; Khan, Shireen H; Stommel, Jayne M; Wahl, Geoffrey M

doi:10.1038/sj.onc.1203013

Cited by 177

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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

Jimenez, Gretchen S, Khan, Shireen H, Stommel, Jayne M, Wahl, Geoffrey M·1999·Oncogene

DOI 10.1038/sj.onc.1203013

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Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 1×
“As MDM2 also targets p53 for degradation (Haupt et al., 1997; Kubbutat et al., 1997, 1998), this region is crucial to the concurrent regulation of p53 transactivation and stability.”
Background
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · cited 2×
“…mutated in patients with ataxia telangiectasia), and ATR (the ataxia telangiectasia related kinase), have been proposed as upstream activators of p53 (Banin et al., 1998; Canman et al., 1998; Kastan et al., 1992; Shieh et al., 1997; Siliciano et al., 1997; Tibbetts et al., 1999; Woo et al., 1998).”
Background
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80416-x · Cited by 2,100
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53
Pomerantz, J., Schreiber-Agus, N., Liégeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81400-2 · Cited by 1,521

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See all 177

Authors: Jimenez, G. S., Khan, S. H., Stommel, J. M., & Wahl, G. M.
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 1999-12-13
Volume: 18
Issue: 53
Pages: 7656-7665
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1203013
OpenAlex: W2072940800
Cited by: 177
References: 17
FWCI: 6.44
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)

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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

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