The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
How NF-κB is activated: the role of the IκB kinase (IKK) complex
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Citations
Cites
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125
Self-citationLiu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Self-citationA CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836 · cited 1×
“This pathway is used both to activate innate immune responses to various pathogens (Ho mann et al., 1999) and to control developmental decisions (Belvin and Anderson, 1996).”
Background
Cited by
Activators and target genes of Rel/NF-κB transcription factors
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Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
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Chen, L., Mu, Y., & Greene, W. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf660 · Cited by 827
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.004 · Cited by 762
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Murakami, A., & Ohigashi, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.23161 · Cited by 478
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Tacke, F., Luedde, T., & Trautwein, C. (2009) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-008-8091-0 · Cited by 393
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Edwards, M. R., Bartlett, N. W., Clarke, D., Birrell, M., Belvisi, M., & Johnston, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.003 · Cited by 375
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Silva, R., Vilas-Boas, V., Carmo, H., Dinis-Oliveira, R. J., Carvalho, F., de Lourdes Bastos, M., & Remião, F. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.013 · Cited by 339
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Harmer, D., Falank, C., & Reagan, M. R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00788 · Cited by 307
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(2001) · Advances in Cancer Research · doi:10.1016/s0065-230x(01)83007-4 · Cited by 299
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Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., & Wang, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508125200 · Cited by 214
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Megías, J., Busserolles, J., & Alcaraz, M. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707184 · Cited by 117
Rodríguez-Calvo, R., Tajes, M., & Vázquez-Carrera, M. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1279146 · Cited by 117
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Hayashi, K., Taura, M., & Iwasaki, A. (2018) · Science Signaling · doi:10.1126/scisignal.aan4144 · Cited by 76
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Moreno-Ley, C. M., Osorio-Revilla, G., Hernández-Martínez, D. M., Ramos-Monroy, O. A., & Gallardo-Velázquez, T. (2021) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2021.200126 · Cited by 70
Xu, C.-X., Jin, H., Chung, Y.-S., Shin, J.-Y., Woo, M.-A., Lee, K.-H., Palmos, G. N., Choi, B.-D., & Cho, M.-H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.01.022 · Cited by 59
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma
Riganti, C., Orecchia, S., Pescarmona, G., Betta, P. G., Ghigo, D., & Bosia, A. (2006) · International Journal of Cancer · doi:10.1002/ijc.21832 · Cited by 48
Liu, W., Tzeng, T.-F., & Liu, I.-M. (2016) · Molecules · doi:10.3390/molecules21121708 · Cited by 30
WSTF nuclear autophagy regulates chronic but not acute inflammation
Wang, Y., Eapen, V. V., Liang, Y., Kournoutis, A., Sherman, M. S., Xu, Y., Onorati, A., Li, X., Zhou, X., Corey, K. E., et al. (2025) · Nature · doi:10.1038/s41586-025-09234-1 · Cited by 30
Xu, C.-X., Jin, H., Chung, Y.-S., Shin, J.-Y., Lee, K.-H., Beck, G. R., Palmos, G. N., Choi, B.-D., & Cho, M.-H. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801578x · Cited by 24
Choi, M.-K., Kim, J., Park, H.-M., Lim, C.-M., Pham, T.-H., Shin, H. Y., Kim, S.-E., Oh, D.-K., & Yoon, D.-Y. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113252 · Cited by 16
Metadata
- Authors
- Karin, M.
- Venue
- Oncogene
- Published
- 1999-11-22
- Volume
- 18
- Issue
- 49
- Pages
- 6867-6874
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2129242841
- Cited by
- 1,156
- References
- 4
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
