A transient placental source of serotonin for the fetal forebrain
Open accessAbstract
Serotonin (5-hydroxytryptamine or 5-HT) is thought to regulate neurodevelopmental processes through maternal-fetal interactions that have long-term mental health implications. It is thought that beyond fetal 5-HT neurons there are significant maternal contributions to fetal 5-HT during pregnancy but this has not been tested empirically. To examine putative central and peripheral sources of embryonic brain 5-HT, we used Pet1(-/-) (also called Fev) mice in which most dorsal raphe neurons lack 5-HT. We detected previously unknown differences in accumulation of 5-HT between the forebrain and hindbrain during early and late fetal stages, through an exogenous source of 5-HT which is not of maternal origin. Using additional genetic strategies, a new technology for studying placental biology ex vivo and direct manipulation of placental neosynthesis, we investigated the nature of this exogenous source. We uncovered a placental 5-HT synthetic pathway from a maternal tryptophan precursor in both mice and humans. This study reveals a new, direct role for placental metabolic pathways in modulating fetal brain development and indicates that maternal-placental-fetal interactions could underlie the pronounced impact of 5-HT on long-lasting mental health outcomes.
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External neurotransmitter sources, such as the placenta, can play a role in the early shaping of cortical areas.
“External neurotransmitter sources, such as the placenta, can play a role in this early shaping of cortical areas [114, 118, 241, 242].”
From Development of prefrontal cortex (2022) · cites this paper as [118]
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Cites
p-CHLOROPHENYLALANINE: A SPECIFIC DEPLETOR OF BRAIN SEROTONIN
Koe, B. K., & Weissman, A. (1966) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27497-3 · Cited by 1,785 · see citing works
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269 · see citing works
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2173 · Cited by 586 · see citing works
Hendricks, T. J., Fyodorov, D., Wegman, L. J., Lelutiu, N. B., Pehek, E. A., Yamamoto, B., Silver, J., Weeber, E., Sweatt, J., & Deneris, E. S. (2003) · Neuron · doi:10.1016/s0896-6273(02)01167-4 · Cited by 486 · see citing works
Self-citationTaylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.019 · Cited by 432 · see citing works
Chen, J. C., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., & Gershon, M. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06348.2001 · Cited by 397 · see citing works
Maternal serotonin is crucial for murine embryonic development
Côté, F., Fligny, C., Bayard, E., Launay, J.-M., Gershon, M. D., Mallet, J., & Vodjdani, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606722104 · Cited by 381 · see citing works
Immunohistochemical study of the development of serotonergic neurons in the rat CNS
Lidov, H. G. W., & Molliver, M. E. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90164-2 · Cited by 376 · see citing works
Transient Uptake and Storage of Serotonin in Developing Thalamic Neurons
Lebrand, C., Cases, O., Adelbrecht, C., Doye, A., Alvarez, C., Mestikawy, S. E., Seif, I., & Gaspar, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80215-9 · Cited by 327 · see citing works
Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis
Buznikov, G. A., Lambert, H. W., & Lauder, J. M. (2001) · Cell and Tissue Research · doi:10.1007/s004410100408 · Cited by 274 · see citing works
Kanai, M., Funakoshi, H., Takahashi, H., Hayakawa, T., Mizuno, S., Matsumoto, K., & Nakamura, T. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-8 · Cited by 273 · see citing works
Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
Bonnin, A., Torii, M., Wang, L., RAKIC, P. T., & Levitt, P. R. (2007) · Nature Neuroscience · doi:10.1038/nn1896 · Cited by 249 · see citing works
Self-citationOberlander, T. F., Gingrich, J. A., & Ansorge, M. S. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.201 · Cited by 236 · see citing works
Aitken, A. R., & Törk, I. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740105 · Cited by 167 · see citing works
Animal Models in Diabetes and Pregnancy
Jawerbaum, A., & White, V. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0038 · Cited by 165 · see citing works
Evidence for an Imipramine-sensitive Serotonin Transporter in Human Placental Brush-border Membranes
Balkovetz, D. F., Tiruppathì, C., Leibach, F. H., Mahesh, V. B., & Ganapathy, V. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94161-x · Cited by 158 · see citing works
Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti.
Suzuki, S., Toné, S., Takikawa, O., Kubo, T., Kohno, I., & Minatogawa, Y. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3550425 · Cited by 148 · see citing works
Novel monoamine oxidase A knock out mice with human-like spontaneous mutation
Scott, A. L., Bortolato, M., Chen, K., & Shih, J. C. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282fd6e88 · Cited by 130 · see citing works
Self-citationBranchek, T. A., & Gershon, M. D. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902850208 · Cited by 129 · see citing works
Anderson, G. M., Gutknecht, L., Cohen, D. J., Brailly‐Tabard, S., Cohen, J. H. M., Ferrari, P., Roubertoux, P. L., & Tordjman, S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001099 · Cited by 127 · see citing works
Kuhn, D. M., Ruskin, B., & Lovenberg, W. M. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85644-2 · Cited by 118 · see citing works
Bonnin, A., Peng, W., Hewlett, W., & Levitt, P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.036 · Cited by 117 · see citing works
Self-citationCellular Expression of the Monocarboxylate Transporter (MCT) Family in the Placenta of Mice
Nagai, A., Takebe, K., Nio‐Kobayashi, J., Takahashi‐Iwanaga, H., & Iwanaga, T. (2009) · Placenta · doi:10.1016/j.placenta.2009.11.013 · Cited by 111 · see citing works
Serotonin uptake in the ectoplacental cone and placenta of the mouse
Yavarone, M., Shuey, D. L., Sadler, T. W., & Lauder, J. M. (1993) · Placenta · doi:10.1016/s0143-4004(05)80257-7 · Cited by 107 · see citing works
Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti
Suzuki, S., Toné, S., Takikawa, O., et al. (2001) · Biochemical Journal · doi:10.1042/bj3550425 · Cited by 79 · see citing works
Association of tryptophan 2,3 dioxygenase gene polymorphism with autism
Nabi, R., Serajee, F., Chugani, D. C., Zhong, H., & Huq, A. H. M. M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20147 · Cited by 78 · see citing works
Lynn‐Bullock, C. P., Welshhans, K., Pallas, S. L., et al. (2004) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2004.02.003 · Cited by 65 · see citing works
Miller, C. L., Murakami, P. N., Ruczinski, I., Ross, R. G., Sinkus, M. L., Sullivan, B. F., & Leonard, S. S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.05.014 · Cited by 55 · see citing works
Tryptophan Hydroxylase Is Phosphorylated by Protein Kinase A
Johansen, P. A., Jennings, I. G., Cotton, R. G. H., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020882.x · Cited by 53 · see citing works
Chen, K., Cases, O., Rebrin, I., Wu, W., Gallaher, T. K., Seif, I., & Shih, J. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609830200 · Cited by 50 · see citing works
Self-citationTHE 5‐HYDROXYTRYPTAMINE CONTENT OF THE PLACENTA AND FOETUS DURING PREGNANCY IN MICE
Robson, J. M., & Senior, J. (1964) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1964.tb02043.x · Cited by 33 · see citing works
L-tryptophan and rat fetal brain serotonin
Howd, R. A., Nelson, M. F., & Lytle, L. D. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90538-x · Cited by 18 · see citing works
An, X., Bandler, R., �ng�r, D., & Price, J. L. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981130)401:4
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Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Serotonin signalling in the gut: functions, dysfunctions and therapeutic targets
Mawe, G. M., & Hoffman, J. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.105 · Cited by 1,165 · see citing works
Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done
Glover, V. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.08.017 · Cited by 818 · see citing works
Neurodevelopmental model of schizophrenia: update 2012
Rapoport, J. L., Giedd, J. N., & Gogtay, N. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.23 · Cited by 790 · see citing works
Maltepe, E., & Fisher, S. J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125620 · Cited by 592 · see citing works
The serotonin system in autism spectrum disorder: From biomarker to animal models
Muller, C. L., Anacker, A. M. J., & Veenstra-VanderWeele, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.010 · Cited by 531 · see citing works
Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism
Patrick, R. P., & Ames, B. N. (2014) · The FASEB Journal · doi:10.1096/fj.13-246546 · Cited by 414 · see citing works
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
“External neurotransmitter sources, such as the placenta, can play a role in this early shaping of cortical areas [114, 118, 241, 242].”
BackgroundBlood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis
Gabriele, S., Sacco, R., & Persico, A. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.004 · Cited by 346 · see citing works
Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333 · see citing works
Self-citationBonnin, A., & Levitt, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.005 · Cited by 311 · see citing works
Self-citationNon-conventional features of peripheral serotonin signalling — the gut and beyond
Spohn, S. N., & Mawe, G. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.51 · Cited by 282 · see citing works
Glover, V., O'Donnell, K. J., O'Connor, T. G., & Fisher, J. (2018) · Development and Psychopathology · doi:10.1017/s095457941800038x · Cited by 271 · see citing works
Goeden, N., Velasquez, J., Arnold, K. A., Chan, Y., Lund, B. T., Anderson, G. M., & Bonnin, A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2534-15.2016 · Cited by 264 · see citing works
Rosenfeld, C. S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24603 · Cited by 280 · see citing works
Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.03.017 · Cited by 224 · see citing works
Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation
Migliarini, S., Pacini, G., Pelosi, B., Lunardi, G., & Pasqualetti, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.128 · Cited by 225 · see citing works
Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay
Harrington, R. A., Lee, L.-C., Crum, R. M., Zimmerman, A. W., & Hertz-Picciotto, I. (2014) · Pediatrics · doi:10.1542/peds.2013-3406 · Cited by 174 · see citing works
Exploring early human brain development with structural and physiological neuroimaging
Vasung, L., Abaci Turk, E., Ferradal, S. L., Sutin, J., Stout, J. N., Ahtam, B., Lin, P.-Y., & Grant, P. E. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2018.07.041 · Cited by 177 · see citing works
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.231 · Cited by 167 · see citing works
The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders
Pagan, C., Delorme, R., Callebert, J., Goubran-Botros, H., Amsellem, F., Drouot, X., Boudebesse, C., Le Dudal, K., Ngo-Nguyen, N., Laouamri, H., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.120 · Cited by 165 · see citing works
Viral infection, inflammation and schizophrenia
Kneeland, R. E., & Fatemi, S. H. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.001 · Cited by 152 · see citing works
Margolis, K. G., Li, Z., Stevanovic, K., Saurman, V., Israelyan, N., Anderson, G. M., Snyder, I., Veenstra-VanderWeele, J., Blakely, R. D., & Gershon, M. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84877 · Cited by 139 · see citing works
Self-citationYang, C.-J., Tan, H.-P., & Du, Y.-J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.021 · Cited by 132 · see citing works
Veenstra-VanderWeele, J., & Blakely, R. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.185 · Cited by 128 · see citing works
Self-citationde Bartolomeis, A., Barone, A., Vellucci, L., Mazza, B., Austin, M. C., Iasevoli, F., & Ciccarelli, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02976-3 · Cited by 113 · see citing works
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Love, C., Sominsky, L., O’Hely, M., Berk, M., Vuillermin, P., & Dawson, S. L. (2024) · BMC Medicine · doi:10.1186/s12916-024-03617-3 · Cited by 110 · see citing works
Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link
Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M., & Homberg, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165850 · Cited by 86 · see citing works
Blakeley, P. M., Capron, L. E., Jensen, A. B., O'Donnell, K. J., & Glover, V. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.07.002 · Cited by 63 · see citing works
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Gingrich, J. A., Malm, H., Ansorge, M. S., Brown, A., Sourander, A., Suri, D., Teixeira, C. M., Caffrey Cagliostro, M. K., Mahadevia, D., & Weissman, M. M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1085 · Cited by 53 · see citing works
Kinast, K., Peeters, D., Kolk, S. M., Schubert, D., & Homberg, J. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00072 · Cited by 57 · see citing works
Witteveen, J. S., Middelman, A., van Hulten, J. A., Martens, G. J. M., Homberg, J. R., & Kolk, S. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00143 · Cited by 53 · see citing works
Zhao, Q., Dai, W., Chen, H. Y., Jacobs, R. E., Zlokovic, B. V., Lund, B. T., Montagne, A., & Bonnin, A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113310119 · Cited by 52 · see citing works
Self-citationNomura, Y., Davey, K., Pehme, P. M., Finik, J., Glover, V., Zhang, W., Huang, Y., Buthmann, J., Dana, K., Yoshida, S., et al. (2019) · Infant Mental Health Journal · doi:10.1002/imhj.21766 · Cited by 51 · see citing works
Bronson, S. L., Chan, J. C., & Bale, T. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.025 · Cited by 49 · see citing works
Garcia, L. P., Witteveen, J. S., Middelman, A., van Hulten, J. A., Martens, G. J. M., Homberg, J. R., & Kolk, S. M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1105-x · Cited by 28 · see citing works
Garcia, L. P., Van de Wijer, L., Hanswijk, S. I., Rando, J., Witteveen, J. S., Middelman, A., ter Heine, R., de Mast, Q., Martens, G. J. M., van der Ven, A. J. A. M., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114050 · Cited by 6 · see citing works
- Authors
- Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., & Levitt, P.
- Affiliations
- University of Southern California (US)
- Vanderbilt University Medical Center (US)
- Case Western Reserve University (US)
- Corresponding author
- Bonnin, Alexandre
- Levitt, Pat
- ORCID
- Venue
- Nature
- Published
- 2011-04-20
- Volume
- 472
- Issue
- 7343
- Pages
- 347-350
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3084180
- OpenAlex
- W2055466946
- Cited by
- 608
- References
- 36
- Citations by year
- 2026: 38 · 2025: 40 · 2024: 47 · 2023: 35 · 2022: 48 · 2021: 49 · 2020: 37 · 2019: 40 · 2018: 39 · 2017: 29 · 2016: 33 · 2015: 36 · 2014: 44 · 2013: 30 · 2012: 42
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Vanderbilt University
- National Institute of Mental Health (R01 MH39085, R01MH039085, P50MH078028, 1P50MH078280A1)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD065287)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- serotonin, placenta, fetal brain development, maternal-fetal interaction, tryptophan metabolism, serotonin synthesis, dorsal raphe neurons, mental health
- MeSH terms
- Animals, Embryo, Mammalian, Female, Fetus, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Raphe Nuclei, Rhombencephalon, Serotonin, Time Factors, Transcription Factors, Prosencephalon, Mice, In Vitro Techniques
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