Cited by 160Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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Changes in Oxytocin Receptor mRNA in Rat Brain During Pregnancy and the Effects of Estrogen and Interleukin‐6

Young, Larry J., Muns, Scott, Wang, Zuoxin, Insel, Thomas R.·1997·Journal of Neuroendocrinology

DOI 10.1046/j.1365-2826.1997.00654.x

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Abstract

Changes in brain oxytocin receptor (OTR) binding sites during the course of pregnancy may influence the sudden onset of maternal behavior in female rats at parturition. In situ hybridization was used to identify changes in OTR messenger ribonucleic acid (mRNA) expression during pregnancy and parturition. Two patterns of mRNA regulation were observed. Relative to diestrus virgin control females, OTR mRNA was elevated in the lateral septum and medial preoptic area at days 13–15 of pregnancy but not on the morning of parturition. In the central nucleus of the amygdala and ventromedial nucleus of the hypothalamus (VMH), OTR mRNA was most abundant on the morning of parturition. Strong signals for OTR mRNA were detected in the bed nucleus of the stria terminalis, hypothalamic paraventricular nucleus, supraoptic nucleus and suprachiasmatic nucleus. However no group differences were detected in these areas. As estrogen and interleukin‐6 have been suggested to modulate OTR gene expression and both are elevated at the time of parturition, their effects on OTR mRNA in the brain were examined. Estrogen and interleukin‐6, given simultaneously, significantly elevated the concentration of OTR mRNA in the VMH, but not in the amygdala. The increase in the VMH was significantly greater than that produced by estrogen alone, and interleukin‐6 alone had no effects. These results demonstrate that transcriptional regulation of OTR gene expression mediates changes in receptor density in the brain in a region specific manner during pregnancy and suggests a potential mechanism for some of these changes.

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Authors: Young, L. J., Muns, S., Wang, Z., & Insel, T. R.
Affiliations: Emory University (US)
Corresponding author: Young, Larry J.
ORCID: Young, Larry J.
Insel, Thomas R.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 1997-11
Volume: 9
Issue: 11
Pages: 859-865
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1046/j.1365-2826.1997.00654.x
OpenAlex: W2115024338
Cited by: 160
References: 5
Citations by year: 2026: 2 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 11 · 2013: 7 · 2012: 5
FWCI: 7.80
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2190 d)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29mh054554-06)
National Institute of Mental Health (MH54554, MH 56538, R01MH056538)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin receptor, mRNA expression, pregnancy, childbirth, estrogen, interleukin-6, ventromedial hypothalamus, lateral septum, medial preoptic area, amygdala, transcriptional regulation, maternal behavior, rat brain
MeSH terms: Animals, Brain, Diestrus, Estradiol, Female, Hypothalamus, Labor, Obstetric, Ovariectomy, Pregnancy, Pregnancy, Animal, RNA, Messenger, Time Factors, Interleukin-6, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Oxytocin, Rats

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Changes in Oxytocin Receptor mRNA in Rat Brain During Pregnancy and the Effects of Estrogen and Interleukin‐6

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