Impairments in the Initiation of Maternal Behavior in Oxytocin Receptor Knockout Mice
Open accessAbstract
Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care. Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Oxt knockout (Oxt -/-) mice, forebrain conditional Oxtr knockout (Oxtr FB/FB) mice, and total body Oxtr knockout (Oxtr -/-) mice. Since Oxtr -/- mice are unable to lactate, maternal behavior has only been examined in virgin females, or in dams within a few hours of parturition, and there have been no studies that have examined their anxiety-like and depression-like behavior following parturition. To improve our understanding of how the absence of Oxt signaling affects maternal behavior, mood and anxiety, we designed a study using Oxtr -/- mice that separated nursing behavior from other aspects of maternal care, such as licking and grooming by thelectomizing (i.e. removing the nipples) of Oxtr +/+ mice and sham-thelectomizing Oxtr -/- mice, and pairing both genotypes with a wet nurse. We then measured pup abandonment, maternal behavior, and postpartum anxiety-like and depression-like behaviors. We hypothesized that genetic disruption of the Oxtr would impact maternal care, mood and anxiety. Specifically, we predicted that Oxtr -/- dams would have impaired maternal care and increased anxiety-like and depression-like behaviors in the postpartum period. We found that Oxtr -/- dams had significantly higher levels of pup abandonment compared to controls, which is consistent with previous work in Oxtr FB/FB mice. Interestingly, Oxtr -/- dams that initiated maternal care did not differ from wildtype controls in measures of maternal behavior. We also did not find any evidence of altered anxiety-like or depressive-like behavior in the postpartum period of Oxtr -/- dams. Thus, our data suggest that Oxt lowers the threshold for the initiation of maternal behavior.
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Silencing of OT-PVN cells had little effect after virgins began retrieving.
“However, silencing of OT-PVN cells had little effect after virgins began retrieving (Extended Data Fig. 4b), similar to primiparous dams17.”
From Oxytocin neurons enable social transmission of maternal behaviour (2021) · cites this paper as [17]
Oxytocin signaling is important for normal displays of alloparental care.
“Thus, it appears that Oxt signaling is important for normal displays of alloparental care, which is consistent with its role in lowering the threshold for maternal care in rodents (53–56).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [53]
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- Authors
- Rich, M. E., deCárdenas, E. J., Lee, H.-J., & Caldwell, H. K.
- Affiliations
- Kent State University (US)
- Kyungpook National University (KR)
- Corresponding author
- Caldwell, Heather K.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-06-03
- Volume
- 9
- Issue
- 6
- Pages
- e98839
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4044031
- OpenAlex
- W2042123980
- Cited by
- 105
- References
- 83
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 14 · 2020: 7 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 13 · 2015: 13 · 2014: 3
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Kent State University
- King Saud University
- Directorate for Biological Sciences
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, oxytocin receptor, maternal behavior, maternal care, childbirth, knockout mice, nursing behavior
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Female, Maternal Behavior, Receptors, Oxytocin, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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