The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
American Gastroenterological Association Technical Review on Constipation
Open accessAbstract
Constipation is a very common symptom. Prompted by several advances since the last technical review 15 years ago,1 this update will identify a rational, efficacious, and ideally cost-effective approach to patients with constipation. Toward those objectives, the epidemiology, clinical assessment, diagnostic testing, and management of constipation will be discussed, primarily from the perspective of a practicing gastroenterologist. Constipation in children and secondary constipation (eg, due to spinal cord injury) in adults will not be specifically addressed. This review was prepared by updating the previous technical review with material sourced from recent reviews on chronic constipation,2–4 supplemented by selected and focused literature searches of peer-reviewed, published studies. Although recommendations are graded based on US Preventive Services Task Force (USPSTF) ratings, formal cost-effectiveness analyses have not been performed. Comparisons of diagnostic approaches, with precise estimates of specificity and sensitivities, also have not been published. Indeed, in some instances, individual diagnostic techniques have not even been standardized.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Simplified assessment of segmental colonic transit
Metcalf, A. M., Phillips, S. F., Zinsmeister, A. R., MacCarty, R. L., Beart, R. W., & Wolff, B. G. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90837-7 · Cited by 928
Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man
Mekhjian, H. S., Phillips, S. F., & Hofmann, A. F. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106644 · Cited by 584
A placebo-controlled trial of prucalopride for severe chronic constipation
Camilleri, M., Kerstens, R., Rykx, A., & Vandeplassche, L. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800670 · Cited by 576
Physical Activity Improves Symptoms in Irritable Bowel Syndrome: A Randomized Controlled Trial
Johannesson, E., Simrén, M., Strid, H., Bajor, A., & Sadik, R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.480 · Cited by 431
DROSSMAN, D. A., CHEY, W. D., JOHANSON, J. F., FASS, R., SCOTT, C., PANAS, R., & UENO, R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03881.x · Cited by 399
Two randomized trials of linaclotide for chronic constipation
Lembo, A. J., Schneier, H. A., Shiff, S. J., Kurtz, C. B., MacDougall, J. E., Jia, X. D., Shao, J. Z., Lavins, B. J., Currie, M. G., Fitch, D. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1010863 · Cited by 373
QUIGLEY, E. M. M., VANDEPLASSCHE, L., KERSTENS, R., & AUSMA, J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03884.x · Cited by 344
Cited by
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866
Gastrointestinal Dysfunction in Parkinson’s Disease
Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016
Mechanisms, evaluation, and management of chronic constipation
Bharucha, A. E., & Lacy, B. E. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.034 · Cited by 655
Self-citationManagement of functional constipation in children and adults
Vriesman, M. H., Koppen, I. J. N., Camilleri, M., Di Lorenzo, C., & Benninga, M. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0222-y · Cited by 457
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396
Self-citationProbiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT
Barichella, M., Pacchetti, C., Bolliri, C., Cassani, E., Iorio, L., Pusani, C., Pinelli, G., Privitera, G., Cesari, I., Faierman, S. A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003127 · Cited by 390
Rao, S. S. C., Yu, S., & Fedewa, A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13167 · Cited by 343
Diagnosis and management of chronic constipation in adults
Rao, S. S. C., Rattanakovit, K., & Patcharatrakul, T. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.53 · Cited by 337
Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases
Spielman, L. J., Gibson, D. L., & Klegeris, A. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.005 · Cited by 266
Bharucha, A. E., Kudva, Y. C., & Prichard, D. O. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00161 · Cited by 252
Self-citationSerra, J., Pohl, D., Azpiroz, F., Chiarioni, G., Ducrotté, P., Gourcerol, G., Hungin, A. P. S., Layer, P., Mendive, J., Pfeifer, J., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13762 · Cited by 244
Bharucha, A. E., & Wald, A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.031 · Cited by 238
Self-citationGe, X., Zhao, W., Ding, C., Tian, H., Xu, L., Wang, H., Ni, L., Jiang, J., Gong, J., Zhu, W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00612-y · Cited by 232
Role of gut microbiota in functional constipation
Zhang, S., Wang, R., Li, D., Zhao, L., & Zhu, L. (2021) · Gastroenterology Report · doi:10.1093/gastro/goab035 · Cited by 175
“Other treatment options with evidence for efficacy include biofeedback therapy [13], transanal irrigation [14], surgical interventions [15, 16], and neuromodulation [14].”
BackgroundPsychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158
Miner, P. B., Koltun, W. D., Wiener, G. J., De La Portilla, M., Prieto, B., Shailubhai, K., Layton, M. B., Barrow, L., Magnus, L., & Griffin, P. H. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.611 · Cited by 141
Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy.
(2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8807 · Cited by 132
Bifidobacteria exert species-specific effects on constipation in BALB/c mice
Wang, L., Hu, L., Xu, Q., Jiang, T., Fang, S., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2017) · Food & Function · doi:10.1039/c6fo01641c · Cited by 115
Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation
Wang, J.-K., & Yao, S.-K. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/5560310 · Cited by 98
Elobixibat and its potential role in chronic idiopathic constipation
Acosta, A., & Camilleri, M. (2014) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x14528269 · Cited by 91
Sharma, A., Rao, S. S. C., Kearns, K., Orleck, K. D., & Waldman, S. A. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16369 · Cited by 84
Harris, L. A., Horn, J., Kissous-Hunt, M., Magnus, L., & Quigley, E. M. M. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0633-5 · Cited by 75
Cinca, R., Chera, D., Gruss, H. ‐., & Halphen, M. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12278 · Cited by 73
Analysis of gut microbiome and metabolite characteristics in patients with slow transit constipation
Tian, H., Chen, Q., Yang, B., Qin, H., & Li, N. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06500-2 · Cited by 68
Ding, C., Fan, W., Gu, L., Tian, H., Ge, X., Gong, J., Nie, Y., & Li, N. (2018) · Gastroenterology report · doi:10.1093/gastro/gox036 · Cited by 65
Taba Taba Vakili, S., Nezami, B. G., Shetty, A., Chetty, V. K., & Srinivasan, S. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12630 · Cited by 63
Araújo, M. M., & Botelho, P. B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.935830 · Cited by 58
Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial
Ding, C., Ge, X., Zhang, X., Tian, H., Wang, H., Gu, L., Gong, J., Zhu, W., & Li, N. (2016) · Nutrients · doi:10.3390/nu8100605 · Cited by 55
McRorie, J. W., Fahey, G. C., Gibb, R. D., & Chey, W. D. (2020) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000346 · Cited by 48
Mori, S., Tomita, T., Fujimura, K., Asano, H., Ogawa, T., Yamasaki, T., Kondo, T., Kono, T., Tozawa, K., Oshima, T., et al. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18194 · Cited by 47
Clinical practice guidelines for irritable bowel syndrome in Korea, 2017 revised edition
Song, K. H., Jung, H.-K., Kim, H. J., Koo, H. S., Kwon, Y. H., Shin, H. D., Lim, H. C., Shin, J. E., Kim, S. E., Cho, D. H., et al. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17145 · Cited by 47
“Previous nonselective 5-HT4 agonists (cisapride and tegaserod) are associated with significant interactions with other receptors, leading to adverse cardiovascular events and resulting in withdrawal of these drugs from the market.(86) However, serious cardiac toxicity has not been reported in patients taking prucalopr…”
BackgroundLim, Y. J., Jamaluddin, R., Hazizi, A. S., & Chieng, J. Y. (2018) · Nutrients · doi:10.3390/nu10070824 · Cited by 37
Nakajima, A., Taniguchi, S., Kurosu, S., Gillberg, P., Mattsson, J. P., & Camilleri, M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13571 · Cited by 33
Consistently inconsistent, the posterior vaginal wall
Hale, D. S., & Fenner, D. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.001 · Cited by 26
Woo, H.-I., Kwak, S. H., Lee, Y., Choi, J. H., Cho, Y. M., & Om, A.-S. (2015) · Journal of Cancer Prevention · doi:10.15430/jcp.2015.20.1.64 · Cited by 22
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14040 · Cited by 20
The Sweet Side of Constipation: Colonic Motor Dysfunction in Diabetes Mellitus
De Fano, M., Baluganti, S., Manco, M., Porcellati, F., Fanelli, C. G., & Bassotti, G. (2025) · Nutrients · doi:10.3390/nu17193038 · Cited by 4
Metadata
- Authors
- Bharucha, A. E., Pemberton, J. H., & Locke, G. R.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 144
- Issue
- 1
- Pages
- 218-238
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2026414358
- Cited by
- 909
- References
- 20
- FWCI
- 30.84
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.