The gut microbiome and obesity

John, George Kunnackal; Mullin, Gerard E.

doi:10.1007/s11912-016-0528-7

Cited by 304Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

The gut microbiome and obesity

John, George Kunnackal, Mullin, Gerard E.·2016·Current Oncology Reports

DOI 10.1007/s11912-016-0528-7

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Abstract

The gut microbiome consists of trillions of bacteria which play an important role in human metabolism. Animal and human studies have implicated distortion of the normal microbial balance in obesity and metabolic syndrome. Bacteria causing weight gain are thought to induce the expression of genes related to lipid and carbohydrate metabolism thereby leading to greater energy harvest from the diet. There is a large body of evidence demonstrating that alteration in the proportion of Bacteroidetes and Firmicutes leads to the development of obesity, but this has been recently challenged. It is likely that the influence of gut microbiome on obesity is much more complex than simply an imbalance in the proportion of these phyla of bacteria. Modulation of the gut microbiome through diet, pre- and probiotics, antibiotics, surgery, and fecal transplantation has the potential to majorly impact the obesity epidemic.

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Adult GF mice that received normal cecal microbiota maintained a 60% increase in body insulin resistance and fat two weeks later despite a reduction in food intake.
“Two weeks later, despite a reduction in food intake, adult GF mice maintained a 60% increase in body insulin resistance and fat [83].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [83]

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Demırci, M., Tokman, H. B., Taner, Z., Keskin, F. E., Çağatay, P., Bakar, Y. O., Özyazar, M., Kiraz, N., & Kocazeybek, B. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.107449 · Cited by 75 · see citing works

Authors: John, G. K., & Mullin, G. E.
Affiliations: Johns Hopkins University (US)
Corresponding author: Mullin, Gerard E.
ORCID: John, George Kunnackal
Mullin, Gerard E.
Venue: Current Oncology Reports
Publisher: Springer Science and Business Media LLC
Published: 2016-06-02
Volume: 18
Issue: 7
Pages: 45-45
ISSN: 1523-3790 (ISSN-L)
1534-6269
DOI: 10.1007/s11912-016-0528-7
OpenAlex: W2413207665
Cited by: 304
References: 71
Citations by year: 2026: 9 · 2025: 30 · 2024: 36 · 2023: 41 · 2022: 49 · 2021: 44 · 2020: 31 · 2019: 23 · 2018: 17 · 2017: 18 · 2016: 6
FWCI: 1.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Current Oncology Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, obesity, metabolic syndrome, Bacteroidetes, Firmicutes, dysbiosis, lipid metabolism, carbohydrate metabolism, energy harvesting, diet, probiotics, prebiotics, antibiotics, bariatric surgery, fecal microbiota transplantation
MeSH terms: Gastrointestinal Microbiome, Animals, Humans, Obesity, Probiotics

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