The Effect on Serum Cholesterol Levels of Coffee Brewed by Filtering or Boiling
Abstract
Previous reports have indicated that coffee consumption may increase serum cholesterol levels. We studied the effects of coffee prepared by two common brewing methods (filtering and boiling) on serum lipid levels in a 12-week randomized trial involving 107 young adult subjects with normal serum cholesterol levels. After a three-week run-in period during which they all consumed filtered coffee, the participants were randomly assigned to one of three groups receiving four to six cups of boiled coffee a day, four to six cups of filtered coffee a day, or no coffee, for a period of nine weeks. As compared with the change from base line in the filtered-coffee group, the serum total cholesterol level increased after the consumption of boiled coffee by 0.48 mmol per liter (95 percent confidence limits, 0.13 and 0.83), and the low-density lipoprotein cholesterol level increased by 0.39 mmol per liter (95 percent confidence limits, -0.04 and 0.82). There was no significant difference in the change in serum total or low-density lipoprotein cholesterol levels between the filtered-coffee group and the group that drank no coffee. The levels of high-density lipoprotein cholesterol and apolipoproteins were not affected by boiled or filtered coffee. We conclude that drinking filtered coffee does not affect serum lipid levels. The consumption of boiled coffee, however, has an effect on serum cholesterol levels amounting to a mean net increase of 10 percent of the base-line level after nine weeks.
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Drinking boiled coffee increases serum cholesterol, an important risk factor for CVD.
“It has been shown that drinking boiled coffee increases serum cholesterol, an important risk factor for CVD5.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [5]
Cites
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
Burstein, M., Scholnick, H. R., & Morfin, R. F. (1970) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42943-8 · Cited by 2,500 · see citing works
Thelle, D. S., Arnesen, E., & Førde, O. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198306163082405 · Cited by 493 · see citing works
The Measurement of Apolipoprotein A-I and A-II Levels in Men and Women by Immunoassay
Cheung, M. C., & Albers, J. J. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108767 · Cited by 381 · see citing works
Plasma Lipids and Lipoproteins in Vegetarians and Controls
Sacks, F. M., Castelli, W. P., Donner, A., & Kass, E. H. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505292922203 · Cited by 356 · see citing works
Coffee consumption and the incidence of coronary heart disease.
LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151601 · Cited by 183 · see citing works
Coffee and Cardiovascular Disease
Dawber, T. R., Kannel, W. B., & Gordon, T. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410242911703 · Cited by 183 · see citing works
Weksler, M. E., Kuntz, M. M., Lockshin, M., Kohn, R. M., & Eisenhauer, A. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90600-x · Cited by 174 · see citing works
Coffee and cardiovascular disease.
Yuan, S. (1977) · PubMed · Cited by 171 · see citing works
van Gent, C. M., van der Voort, H. A., Bruyn, A. M. D., & Klein, F. (1977) · Clinica Chimica Acta · doi:10.1016/0009-8981(77)90195-4 · Cited by 131 · see citing works
Independence of serum lipid levels and dietary habits. The Tecumseh study
Nichols, A. B. (1976) · JAMA · doi:10.1001/jama.236.17.1948 · Cited by 127 · see citing works
PHILLIPS, N. R., Havel, R. J., & Kane, J. P. (1981) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.1.1.13 · Cited by 121 · see citing works
Bioled coffee increases serum low density lipoprotein concentration
Aro, A., Tuomilehto, J., Kostiainen, E., Uusitalo, U. M., & Pietinen, P. (1987) · Metabolism · doi:10.1016/0026-0495(87)90021-7 · Cited by 108 · see citing works
Coffee and cholesterol in epidemiological and experimental studies
Thelle, D. S., Heyden, S., & FODOR, J. G. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90270-x · Cited by 104 · see citing works
Førde, O. H., Knutsen, S. F., Arnesen, E., & Thelle, D. S. (1985) · BMJ · doi:10.1136/bmj.290.6472.893 · Cited by 97 · see citing works
COFFEE CONSUMPTION AND MORTALITY IN THE CHICAGO WESTERN ELECTRIC COMPANY STUDY
Legrady, D., Dyer, A. R., Shekelle, R. B., Stamler, J., Liu, K., Paul, O., Lepper, M. H., & Shryock, A. M. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114717 · Cited by 93 · see citing works
The combined effect of smoking and coffee drinking on LDL and HDL cholesterol.
Heyden, S., HEISS, G. M., Manegold, C., Tyroler, H. A., Hames, C. G., Bartel, A. G., & Cooper, G. (1979) · Circulation · doi:10.1161/01.cir.60.1.22 · Cited by 81 · see citing works
COFFEE CONSUMPTION, DIET, AND LIPIDS
Haffner, S. M., KNAPP, J. A., D, M. P. S. M., Hazuda, H. P., Rosenthal, M., & Franco, L. J. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114067 · Cited by 78 · see citing works
Coffee Intake and Elevated Cholesterol and Apolipoprotein B Levels in Men
Williams, P. T. (1985) · JAMA · doi:10.1001/jama.1985.03350340059017 · Cited by 78 · see citing works
COFFEE DRINKING AND NONFATAL MYOCARDIAL INFARCTION IN MEN UNDER 55 YEARS OF AGE1
Rosenberg, L. A., Palmer, J. R., Kelly, J. P., Kaufman, D. W., & Shapiro, S. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115004 · Cited by 78 · see citing works
Coffee and cholesterol: is it all in the brewing? The Tromsø Study.
Bønaa, K. H., Arnesen, E., Thelle, D. S., & Førde, O. H. (1988) · BMJ · doi:10.1136/bmj.297.6656.1103 · Cited by 68 · see citing works
Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic prevalence study.
Kark, J. D., Friedlander, Y., KAUFMANN, N. A., & Stein, Y. (1985) · BMJ · doi:10.1136/bmj.291.6497.699 · Cited by 66 · see citing works
Hemodynamic and humoral effects of coffee after β1-selective and nonselective β-blockade
Smits, P., Hoffmann, H. J., Thien, T. A., Houben, H. H. M. L., & Laar, A. V. '. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.145 · Cited by 61 · see citing works
COLON CANCER AND BLOOD-CHOLESTEROL
Bjelke, E. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90601-1 · Cited by 58 · see citing works
Arnesen, E., Førde, O. H., & Thelle, D. S. (1984) · BMJ · doi:10.1136/bmj.288.6435.1960 · Cited by 58 · see citing works
COFFEE, CAFFEINE, AND SERUM CHOLESTEROL IN JAPANESE MEN IN HAWAII
Curb, J. D., REED, D. M., Kautz, J. A., & Yano, K. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114284 · Cited by 50 · see citing works
(1983) · New England Journal of Medicine · doi:10.1056/nejm198311173092012 · Cited by 50 · see citing works
DETERMINANTS OF CHANGE IN BLOOD PRESSURE DURING CHILDHOOD
Hofman, A., & Valkenburg, H. A. (1983) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113607 · Cited by 46 · see citing works
Coffee consumption is correlated with serum cholesterol in middle-aged Finnish men and women.
Tuomilehto, J. O., Tanskanen, A. J., Pietinen, P., Aro, A., SALONEN, J. T., Happonen, P., Nissinen, A. M., & Puska, P. (1987) · Journal of Epidemiology & Community Health · doi:10.1136/jech.41.3.237 · Cited by 45 · see citing works
COFFEE, DIETARY HABITS, AND SERUM CHOLESTEROL AMONG MEN AND WOMEN 35–49 YEARS OF AGE
Solvoll, K., Selmer, R. M., Løken, E. B., FOSS, O. P., & Trygg, K. U. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115247 · Cited by 45 · see citing works
Klatsky, A. L., Petitti, D. B., Armstrong, M. A., & FRIEDMAN, G. D. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90250-4 · Cited by 42 · see citing works
COFFEE, PLASMA CHOLESTEROL, AND LIPOPROTEINS A POPULATION STUDY IN AN ADULT COMMUNITY
MATHIAS, S., Garland, C. F., Barrett-Connor, E. L., & Wingard, D. L. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114059 · Cited by 37 · see citing works
COFFEE CONSUMPTION AND SERUM CHOLESTEROL IN THE HYPERTENSION DETECTION AND FOLLOW-UP PROGRAM1
Davis, B. R., Curb, J. D., Borhani, N. O., Prineas, R. J., Molteni, A., & FOR THE HYPERTENSION DETECTION AND FOLLOW-UP PROGRAM COOPERATIVE GROUP (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114935 · Cited by 37 · see citing works
Caffeine Consumption and Serum Cholesterol Levels
Shirlow, M., & Mathers, C. D. (1984) · International Journal of Epidemiology · doi:10.1093/ije/13.4.422 · Cited by 33 · see citing works
Association of serum lipids with coffee, tea, and egg consumption in free-living subjects.
Green, M. S., & JUCHA, E. (1986) · Journal of Epidemiology & Community Health · doi:10.1136/jech.40.4.324 · Cited by 30 · see citing works
Coffee Consumption and Serum Cholesterol: An Epidemiological Study in Belgium
PIETINE, P., Geboers, J., & Kesteloot, H. (1988) · International Journal of Epidemiology · doi:10.1093/ije/17.1.98 · Cited by 30 · see citing works
SOLLMANN, T., & PILCHER, J. D. (1911) · Journal of Pharmacology and Experimental Therapeutics · Cited by 21 · see citing works
Donahue, R. P., Orchard, T. J., Stein, E. A., & Kuller, L. H. (1987) · Preventive Medicine · doi:10.1016/0091-7435(87)90019-3 · Cited by 17 · see citing works
THE ACTIONS OF CAFFEIN ON THE MAMMALIAN CIRCULATION
SOLLMANN, T., & PILCHER, J. D. (1911) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03904-7 · Cited by 10 · see citing works
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Ding, M., Bhupathiraju, S. N., Satija, A., van Dam, R. M., & Hu, F. B. (2014) · Circulation · doi:10.1161/circulationaha.113.005925 · Cited by 565 · see citing works
“It has been shown that drinking boiled coffee increases serum cholesterol, an important risk factor for CVD.(5) Second, in earlier studies, the sample size was typically small, the measurement of baseline characteristics was typically crude, statistical control of confounders such as diet was inadequate, and the avera…”
InfluentialCoffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490 · see citing works
The lipid fraction of the coffee bean
Speer, K., & Kölling-Speer, I. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100014 · Cited by 382 · see citing works
O’Keefe, J. H., Bhatti, S. K., Patil, H., DiNicolantonio, J. J., Lucan, S. C., & Lavie, C. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.035 · Cited by 353 · see citing works
Landin‐Wllhelmsen, K., Wllhelmsen, L., Lappast, G., Rosén, T., Lindstedt, G., Lundberg, P., & Bengtsson, B. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02556.x · Cited by 340 · see citing works
Coffee, caffeine, and cardiovascular disease in men.
Grobbee, D. E., Rimm, E. B., Giovannucci, E., Colditz, G., Stampfer, M., & Willett, W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010113231504 · Cited by 322 · see citing works
Self-citationCoffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials
Jee, S. H., He, J., Appel, L. J., Whelton, P. K., Suh, II, & Klag, M. J. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.4.353 · Cited by 301 · see citing works
Tea drinking and bone mineral density in older women
Hegarty, V., May, H. M., & Khaw, K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.1003 · Cited by 293 · see citing works
Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality
Stensvold, I., Tverdal, A., Solvoll, K., & FOSS, O. P. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90062-m · Cited by 271 · see citing works
THE CHOLESTEROL-RAISING FACTOR FROM COFFEE BEANS
Urgert, R., & Katan, M. B. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.305 · Cited by 260 · see citing works
Ranheim, T., & Halvorsen, B. L. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400109 · Cited by 251 · see citing works
Sánchez-González, I., Jiménez‐Escrig, A., & Saura-Calixto, F. D. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.03.037 · Cited by 227 · see citing works
Caffeine and cardiovascular health
Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.025 · Cited by 216 · see citing works
Coffee Consumption and Coronary Heart Disease in Men and Women: A Prospective Cohort Study
Lopez-Garcia, E., van Dam, R. M., Willett, W. C., Rimm, E. B., Manson, J. E., Stampfer, M. J., Rexrode, K. M., & Hu, F. B. (2006) · Circulation · doi:10.1161/circulationaha.105.598664 · Cited by 215 · see citing works
Analysis of the content of the diterpenes cafestol and kahweol in coffee brews
Gross, G., Jaccaud, E., & Huggett, A. C. (1997) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(96)00123-8 · Cited by 213 · see citing works
The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials
Cai, L., Ma, D., Zhang, Y., Liu, Z., & Wang, P. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.68 · Cited by 205 · see citing works
Wouw, M. P. M. E. W.-V. D., Katan, M., Viani, R., Huggett, A. C., Liardon, R., Liardon, R., Lund‐Larsen, P. G., Thelle, D. S., Ahola, I., & Aro, A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41169-1 · Cited by 200 · see citing works
A meta‐analysis of coffee, myocardial infarction, and coronary death
Greenland, S. (1993) · Epidemiology · doi:10.1097/00001648-199307000-00013 · Cited by 163 · see citing works
Schoeneck, M., & Iggman, D. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.12.032 · Cited by 161 · see citing works
Coffee and incidence of diabetes in Swedish women: a prospective 18‐year follow‐up study
Rosengren, A., Dotevall, A., Wilhelmsen, L., Thelle, D. S., & Johansson, S. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01260.x · Cited by 157 · see citing works
Barrea, L., Pugliese, G., Frías-Toral, E., Ghoch, M. E., Castellucci, B., Chapela, S. P., Carignano, M. D. L. A., Laudisio, D., Savastano, S., Colao, A., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1963207 · Cited by 159 · see citing works
The Provincial Group for the Study of Chronic Liver Disease, Corrao, G., Lepore, A. R., Torchio, P., Valenti, M., GALATOLA, G., D’Amicis, A., Aricò, S., & di Orio, F. (1994) · European Journal of Epidemiology · doi:10.1007/bf01719277 · Cited by 132 · see citing works
Effect of a lipid-rich fraction from boiled coffee on serum cholesterol
Zock, P. L., Katan, M., Merkus, M. P., Dusseldorp, M., & Harryvan, J. L. (1990) · The Lancet · doi:10.1016/0140-6736(90)91302-q · Cited by 127 · see citing works
Lipid content and composition of coffee brews prepared by different methods
Ratnayake, W. M. N., Hollywood, R., O'Grady, E. B., & Stavrić, B. (1993) · Food and Chemical Toxicology · doi:10.1016/0278-6915(93)90076-b · Cited by 126 · see citing works
Wake up and smell the coffee. Caffeine, coffee, and the medical consequences.
Chou, T. M. (1992) · PubMed Central · Cited by 124 · see citing works
Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages
Uto‐Kondo, H., Ayaori, M., Ogura, M., Nakaya, K., Ito, M., Suzuki, A., Takiguchi, S., Yakushiji, E., Terao, Y., Ozasa, H., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.206615 · Cited by 119 · see citing works
Cholesterol-raising factor from boiled coffee does not pass a paper filter.
Dusseldorp, M., Katan, M., van Vliet, T., Demacker, P. N. M., & Stalenhoef, A. F. H. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.3.586 · Cited by 117 · see citing works
Extraction of coffee diterpenes and coffee oil using supercritical carbon dioxide
Araújo, J. M. A., & Sandi, D. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.03.008 · Cited by 107 · see citing works
Heterogeneity in Assessing Self-Reports of Caffeine Exposure
Bracken, M. B., Triche, E. W., Grosso, L. M., HELLENBRAND, K. G., Belanger, K. D., & Leaderer, B. P. (2002) · Epidemiology · doi:10.1097/00001648-200203000-00011 · Cited by 107 · see citing works
Effects of caffeine with repeated dosing
Denaro, C. P., Brown, C. R., Jacob, P., & Benowitz, N. L. (1991) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315208 · Cited by 106 · see citing works
Christensen, B., Mosdøl, A., Retterstøl, L., Landaas, S., & Thelle, D. S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.3.302 · Cited by 104 · see citing works
Rob Urgert, B., Essed, N., van der Weg, G., Kosmeijer‐Schuil, T. G., & Katan, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.2.519 · Cited by 100 · see citing works
Rob Urgert, B., Meyboom, S., Kuilman, M., Rexwinkel, H., Vissers, M. N., Klerk, M., & Katan, M. (1996) · BMJ · doi:10.1136/bmj.313.7069.1362 · Cited by 96 · see citing works
Caffeine and coffee: effects on health and cardiovascular disease
Chou, T. M., & Benowitz, N. L. (1994) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/0742-8413(94)00048-f · Cited by 95 · see citing works
Cardiovascular effects of caffeinated beverages
Voskoboinik, A., Koh, Y., & Kistler, P. M. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.09.019 · Cited by 92 · see citing works
How coffee affects metabolic syndrome and its components
Başpınar, B., Eskici, G., & Özçelik, A. Ö. (2017) · Food & Function · doi:10.1039/c7fo00388a · Cited by 90 · see citing works
Caffeine content in coffee as influenced by grinding and brewing techniques
Bell, L. N., Wetzel, C. R., & Grand, A. N. (1996) · Food Research International · doi:10.1016/s0963-9969(97)00002-1 · Cited by 88 · see citing works
Is habitual caffeine use a preventable cardiovascular risk factor?
James, J. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)04253-5 · Cited by 85 · see citing works
Brown, C. A., Bolton-Smith, C., Woodward, M., & Tunstall‐Pedoe, H. (1993) · Journal of Epidemiology & Community Health · doi:10.1136/jech.47.3.171 · Cited by 80 · see citing works
Rob Urgert, B., Schulz, A., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.1.149 · Cited by 80 · see citing works
The Cholesterol-Raising Factor from Coffee Beans
Rob Urgert, B., & Katan, M. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608901107 · Cited by 78 · see citing works
Post, S. M., de Wit, E. C. M., & Princen, H. M. G. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.3064 · Cited by 77 · see citing works
Superko, H. R., Bortz, W. M., Williams, P., Albers, J., & Wood, P. D. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.599 · Cited by 69 · see citing works
The hypercholesterolaemic factor in boiled coffee is retained by a paper filter
Ahola, I., Jauhiainen, M., & Aro, A. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00447.x · Cited by 70 · see citing works
Caffeine decreases exercise-induced myocardial flow reserve
Namdar, M., Koepfli, P., Grathwohl, R., Siegrist, P. T., Klainguti, M., Schepis, T., Delaloye, R., Wyss, C. A., Fleischmann, S. P., Gaemperli, O., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.064 · Cited by 60 · see citing works
A Comprehensive Overview of the Risks and Benefits of Coffee Consumption
Pourshahidi, L. K., Navarini, L., Petracco, M., & Strain, J. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12206 · Cited by 62 · see citing works
Aro, A., Teirilä, J., & Gref, C.-G. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90171-e · Cited by 59 · see citing works
Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials
Du, Y., Lv, Y., Zha, W., Hong, X., & Luo, Q. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.08.017 · Cited by 58 · see citing works
ROSENGREN, A., & WILHELMSEN, L. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00407.x · Cited by 54 · see citing works
Impact of Coffee Consumption on Cardiovascular Health
Mendoza, M. F., Sulague, R. M., Posas-Mendoza, T., & Lavie, C. J. (2023) · Ochsner Journal · doi:10.31486/toj.22.0073 · Cited by 54 · see citing works
van Rooij, J., van der Stegen, G. H. D., Schoemaker, R. C., Kroon, C., Burggraaf, J., Hollaar, L., Vroon, T., Smelt, A., & Cohen, A. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1277 · Cited by 51 · see citing works
Cardiovascular Effects of Coffee: Is It a Risk Factor?
Sudano, I., Binggeli, C., Spieker, L. E., Lüscher, T. F., Ruschitzka, F. T., Noll, G., & Corti, R. (2005) · Progress in Cardiovascular Nursing · doi:10.1111/j.0889-7204.2005.02477.x · Cited by 48 · see citing works
Coffee intake and coronary heart disease
Klag, M. J., Mead, L. A., Lacroix, A. Z., Wang, N.-Y., Coresh, J., Liang, K.-Y., Pearson, T. A., & Levine, D. M. (1994) · Annals of Epidemiology · doi:10.1016/1047-2797(94)90001-9 · Cited by 47 · see citing works
Zeldis, S. M. (1992) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)01126-6 · Cited by 48 · see citing works
Green, M. S., & Harari, G. (1992) · Preventive Medicine · doi:10.1016/0091-7435(92)90061-l · Cited by 47 · see citing works
Isolation of coffee diterpenes by means of high-speed countercurrent chromatography
Scharnhop, H., & Winterhalter, P. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.10.018 · Cited by 45 · see citing works
Coffee consumption and risk of heart failure in men: An analysis from the Cohort of Swedish Men
Ahmed, H. N., Levitan, E. B., Wolk, A., & Mittleman, M. A. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.07.006 · Cited by 45 · see citing works
Review of Analytical Methods to Detect Adulteration in Coffee
Wang, X., Lim, L., & Fu, Y. (2020) · Journal of AOAC International · doi:10.1093/jaocint/qsz019 · Cited by 45 · see citing works
Coffee drinking timing and mortality in US adults
Wang, X., Ma, H., Sun, Q., Li, J., Heianza, Y., van Dam, R. M., Hu, F. B., Rimm, E. B., Manson, J. E., & Qi, L. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehae871 · Cited by 48 · see citing works
Coffee and metabolic impairment: An updated review of epidemiological studies
Buscemi, S., Marventano, S., Antoci, M., Cagnetti, A., Castorina, G., Galvano, F., Marranzano, M., & Mistretta, A. (2016) · NFS Journal · doi:10.1016/j.nfs.2016.02.001 · Cited by 44 · see citing works
Coffee: One of the Most Consumed Beverages in the World
Lim, L., Zwicker, M., & Wang, X. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64046-8.00462-6 · Cited by 44 · see citing works
Rustan, A. C., Halvorsen, B. L., Huggett, A. C., Ranheim, T., & Drevon, C. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2140 · Cited by 44 · see citing works
Mensink, R. P., LEBBINK, W. J., LOBBEZOO, I. E., Wouw, M. P. M. E. W.-V. D., Zock, P. L., & Katan, M. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00883.x · Cited by 44 · see citing works
An update on research with coffee/caffeine (1989–1990)
Stavrić, B. (1992) · Food and Chemical Toxicology · doi:10.1016/0278-6915(92)90106-u · Cited by 43 · see citing works
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts
Halvorsen, B. L., Ranheim, T., Nenseter, M. S., Huggett, A. C., & Drevon, C. A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32576-1 · Cited by 43 · see citing works
Ekstrand, K., Boström, P. A., Arborelius, M., Nilsson, J., & Lindell, S. (1996) · Angiology · doi:10.1177/000331979604701109 · Cited by 42 · see citing works
Lindsted, K. D., Kuzma, J. W., & Anderson, J. L. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90051-n · Cited by 41 · see citing works
Relationship of Coffee Consumption with Serum Lipids and Lipoproteins in Japanese Men
Miyake, Y., Kono, S., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H., & Ogawa, S. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(98)00051-9 · Cited by 38 · see citing works
Coffee consumption and serum lipids: A randomized, crossover clinical trial
Rosmarin, P. C., Applegate, W. B., & Somes, G. W. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90488-y · Cited by 38 · see citing works
Boiled coffee and blood pressure. A 14-week controlled trial.
Dusseldorp, M., Smits, P., Lenders, J. W. M., Thien, T. A., & Katan, M. (1991) · Hypertension · doi:10.1161/01.hyp.18.5.607 · Cited by 37 · see citing works
Coffee consumption and health-related quality of life
López‐García, E., Guallar‐Castillón, P., León-Muñoz, L. M., Graciani, A., & Rodríguez‐Artalejo, F. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.04.004 · Cited by 35 · see citing works
Rob Urgert, B., der Wouw, M. W.-V., Hovenier, R., Meyboom, S., Beynen, A. C., & Katan, M. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600414 · Cited by 35 · see citing works
Coffee drinking and blood cholesterol—effects of brewing method, food intake and life style
Lindahl, B., Johansson, I., Huhtasaari, F., Hallmans, G., & Asplund, K. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00448.x · Cited by 32 · see citing works
Mo, L., Xie, W., Pu, X.-Q., & Ouyang, D. (2018) · Oncotarget · doi:10.18632/oncotarget.23947 · Cited by 31 · see citing works
Coffee Consumption and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis
Moua, E. D., Hu, C., Day, N. B., Hord, N. G., & Takata, Y. (2020) · Nutrients · doi:10.3390/nu12051349 · Cited by 31 · see citing works
Diet and lifestyle modification and its relationship to atherosclerosis
Denke, M. A. (1994) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30183-3 · Cited by 31 · see citing works
Coffee consumption and risk of physical function impairment, frailty and disability in older adults
Machado‐Fragua, M. D., Struijk, E. A., Graciani, A., Guallar‐Castillón, P., Rodríguez‐Artalejo, F., & López‐García, E. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1664-7 · Cited by 30 · see citing works
Caffeine, blood pressure, and serum lipids
Bak, A. A. A., & Grobbee, D. E. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.4.971 · Cited by 30 · see citing works
Self-citationJansen, D. F., Nedeljković, S., Feskens, E. J. M., Ostojić, M., Grujic, M. Z., Bloemberg, B. P. M., & Kromhout, D. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.15v11.1793 · Cited by 29 · see citing works
The impact of changes in coffee consumption on serum cholesterol
Wei, M., Macera, C. A., Hornung, C. A., & Blair, S. N. (1995) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00023-w · Cited by 29 · see citing works
Italian Style Brewed Coffee: Effect on Serum Cholesterol in Young Men
D’Amicis, A., Scaccini, C., Tomassi, G., ANACLERIO, M., Stornelli, R., & BERNINI, A. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.3.513 · Cited by 29 · see citing works
Relationship between lifestyle and serum lipid and lipoprotein levels in middle-aged Japanese men
Nakanishi, N., Nakamura, K., Ichikawa, S., Suzuki, K., & Tatara, K. (1999) · European Journal of Epidemiology · doi:10.1023/a:1007527111946 · Cited by 25 · see citing works
Lipid Analysis ofCoffea ArabicaLinn. Beans and Their Possible Hypercholesterolemic Effects
Al-Kanhal, M. A. (1997) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637489709006973 · Cited by 24 · see citing works
Acute Coffee Ingestion Does Not Affect LDL Cholesterol Level
Cheung, R. J., Gupta, E. K., & Ito, M. K. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1g005 · Cited by 24 · see citing works
Rodrigues, I. M., & Klein, L. C. (2006) · Toxicological Reviews · doi:10.2165/00139709-200625010-00004 · Cited by 23 · see citing works
Coffee and serum lipids: Findings from the Olivetti heart study
Jossa, F., Krogh, V., Farinaro, E., Panico, S., Giumetti, D., Galasso, R., Celentano, E., Mancini, M., & Trevisan, M. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90027-2 · Cited by 22 · see citing works
Boiled coffee fails to raise serum cholesterol in hamsters and rats
Beynen, A. C., Wouw, M. P. M. E. W.-V. D., de Roos, B., & Katan, M. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960081 · Cited by 22 · see citing works
Association between espresso coffee and serum total cholesterol: the Tromsø Study 2015–2016
Svatun, Å. L., Løchen, M., Thelle, D. S., & Wilsgaard, T. (2022) · Open Heart · doi:10.1136/openhrt-2021-001946 · Cited by 21 · see citing works
Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells.
Ranheim, T., Halvorsen, B. L., Huggett, A. C., Blomhoff, R., & Drevon, C. A. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39193-8 · Cited by 21 · see citing works
The cholesterol-raising effect of coffee in the Syrian hamster
Sanders, T. A. B., & Sandaradura, S. (1992) · British Journal Of Nutrition · doi:10.1079/bjn19920100 · Cited by 21 · see citing works
Coffee, caffeine and hemostasis: results from two randomized studies
Bak, A. A. A., van Vliet, H. H. D. M., & Grobbee, D. E. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90170-n · Cited by 20 · see citing works
Self-citationImpact of Coffee Consumption on Physiological Markers of Cardiovascular Risk: A Systematic Review
Daneschvar, H. L., Smetana, G. W., Brindamour, L. J., Bain, P. A., & Mukamal, K. J. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.09.036 · Cited by 18 · see citing works
Pathophysiology of Atherosclerosis
Prasad, K. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1190-7_6 · Cited by 18 · see citing works
Coffee: A Selected Overview of Beneficial or Harmful Effects on the Cardiovascular System?
Whayne, T. F. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161112666141002121429 · Cited by 18 · see citing works
Chemistry I: Non‐Volatile Compounds
Speer, K., & Kölling-Speer, I. (2001) · doi:10.1002/9780470690499.ch1c · Cited by 18 · see citing works
Association of Lifestyle with Serum Lipid Levels: a Study of Middle-Aged Japanese Men.
Nakanishi, N., Tatara, K., Nakamura, K., & SUZUKI, K. S. (2000) · Journal of Epidemiology · doi:10.2188/jea.10.216 · Cited by 17 · see citing works
Investigation of the effect of coffee lipids on serum cholesterol in hamsters
Ratnayake, W. M. N., Pelletier, G., Hollywood, R., Malcolm, S., & Stavrić, B. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)00131-7 · Cited by 17 · see citing works
Thompson, W. G. (1994) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199407000-00011 · Cited by 17 · see citing works
A Study of the Impact of Arabic Coffee Consumption on Serum Cholesterol
Ali, M. E. S., & Felimban, F. (1993) · Journal of the Royal Society of Health · doi:10.1177/146642409311300602 · Cited by 16 · see citing works
Coronary risk factors in middle-aged men as related to smoking, coffee intake and physical activity
Høstmark, A. T., Berg, J. E., Brudal, S., Berge, S. R., Kierulf, P., & Bjérkedal, T. (1992) · Scandinavian Journal of Social Medicine · doi:10.1177/140349489202000402 · Cited by 16 · see citing works
- Authors
- Bak, A. A. A., & Grobbee, D. E.
- Affiliations
- Erasmus MC (NL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1989-11-23
- Volume
- 321
- Issue
- 21
- Pages
- 1432-1437
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332265208
- Cited by
- 194
- References
- 38
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Keywords
- coffee, brewing technology, filtered coffee, boiled coffee, serum cholesterol, LDL cholesterol, serum lipids, HDL cholesterol, apolipoproteins, dietary fat intake
- MeSH terms
- Adult, Apolipoproteins, Cholesterol, Coffee, Cooking, Female, Filtration, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Random Allocation
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