Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,733

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Gene-Expression Profiles in Hereditary Breast Cancer

Hedenfalk, Ingrid, Duggan, David, Chen, Yidong, Radmacher, Michael, Bittner, Michael, Simon, Richard, Meltzer, Paul, Gusterson, Barry, Esteller, Manel, Raffeld, Mark, Yakhini, Zohar, Ben-Dor, Amir, Dougherty, Edward, Kononen, Juha, Bubendorf, Lukas, Fehrle, Wilfrid, Pittaluga, Stefania, Gruvberger, Sofia, Loman, Niklas, Johannsson, Oskar, Olsson, Håkan, Wilfond, Benjamin, Sauter, Guido, Kallioniemi, Olli-P., Borg, Åke, Trent, Jeffrey·2001·New England Journal of Medicine
DOI 10.1056/nejm200102223440801
Open this paper in CoChat — free account

Abstract

BACKGROUND: Many cases of hereditary breast cancer are due to mutations in either the BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often characteristic of the mutant gene. We hypothesized that the genes expressed by these two types of tumors are also distinctive, perhaps allowing us to identify cases of hereditary breast cancer on the basis of gene-expression profiles. METHODS: RNA from samples of primary tumor from seven carriers of the BRCA1 mutation, seven carriers of the BRCA2 mutation, and seven patients with sporadic cases of breast cancer was compared with a microarray of 6512 complementary DNA clones of 5361 genes. Statistical analyses were used to identify a set of genes that could distinguish the BRCA1 genotype from the BRCA2 genotype. RESULTS: Permutation analysis of multivariate classification functions established that the gene-expression profiles of tumors with BRCA1 mutations, tumors with BRCA2 mutations, and sporadic tumors differed significantly from each other. An analysis of variance between the levels of gene expression and the genotype of the samples identified 176 genes that were differentially expressed in tumors with BRCA1 mutations and tumors with BRCA2 mutations. Given the known properties of some of the genes in this panel, our findings indicate that there are functional differences between breast tumors with BRCA1 mutations and those with BRCA2 mutations. CONCLUSIONS: Significantly different groups of genes are expressed by breast cancers with BRCA1 mutations and breast cancers with BRCA2 mutations. Our results suggest that a heritable mutation influences the gene-expression profile of the cancer.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejm200102223440801

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 35

  1. 10.1126/science.7545954 · DOI
  2. 10.1038/378789a0 · DOI
  3. Easton DF, 1995, Am J Hum Genet, 56, 265, 10.1002/ajmg.1320560305 · DOI · Paper page
  4. 10.1086/301749 · DOI · Paper page
  5. 10.1016/S0140-6736(98)03300-5 · DOI
  6. Szabo CI, 1997, Am J Hum Genet, 60, 1013
  7. 10.1073/pnas.97.17.9603 · DOI
  8. 10.1038/sj.onc.1200881 · DOI
  9. 10.1093/jnci/90.15.1138 · DOI · Paper page
  10. 10.1002/(SICI)1097-0142(19980715)83:2<310::AID-CNCR15>3.0.CO;2-W · DOI
  11. 10.1016/S0959-8049(97)89007-7 · DOI · Paper page
  12. 10.1002/(SICI)1097-0142(19970801)80:3<435::AID-CNCR11>3.0.CO;2-Y · DOI
  13. 10.1016/S0168-9525(99)01930-7 · DOI · Paper page
  14. Yu VPCC, 2000, Genes Dev, 14, 1400, 10.1101/gad.14.11.1400 · DOI · Paper page
  15. Tirkkonen M, 1997, Cancer Res, 57, 1222
  16. Hakansson S, 1997, Am J Hum Genet, 60, 1068
  17. 10.1038/35020115 · DOI · Paper page
  18. Kahn J, 1998, Cancer Res, 58, 5009
  19. 10.1038/ng1296-457 · DOI
  20. 10.1117/12.281504 · DOI · Paper page
  21. 10.1038/nm0798-844 · DOI · Paper page
  22. 10.1016/0197-2456(93)90225-3 · DOI
  23. 10.1016/S0140-6736(96)10109-4 · DOI · Paper page
  24. Lakhani SR, 2000, Clin Cancer Res, 6, 782
  25. 10.1111/j.1365-2559.1991.tb00229.x · DOI
  26. 10.1002/(SICI)1097-0142(19960215)77:4<697::AID-CNCR16>3.0.CO;2-W · DOI
  27. 10.1023/A:1005830230664 · DOI
  28. 10.1023/A:1005853022804 · DOI
  29. 10.1089/106652700750050943 · DOI · Paper page
  30. 10.1101/gad.10.12.1433 · DOI · Paper page
  31. 10.1006/bbrc.1998.9893 · DOI
  32. 10.1074/jbc.274.52.37461 · DOI
  33. 10.1093/nar/26.21.4975 · DOI
  34. 10.1038/35021093 · DOI · Paper page
  35. 10.1001/jama.283.5.617 · DOI

Cited by

Metadata

Authors
Hedenfalk, I., Duggan, D., Chen, Y., Radmacher, M., Bittner, M., Simon, R., Meltzer, P., Gusterson, B., Esteller, M., Raffeld, M., Yakhini, Z., Ben-Dor, A., Dougherty, E., Kononen, J., Bubendorf, L., Fehrle, W., Pittaluga, S., Gruvberger, S., Loman, N., Johannsson, O., Olsson, H., Wilfond, B., Sauter, G., Kallioniemi, O.-P., Borg, Å., & Trent, J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2001-02-22
Volume
344
Issue
8
Pages
539-548
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm200102223440801
OpenAlex
W2008233728
Cited by
1,733
References
5
FWCI
91.62
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.