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Multiorgan and Renal Tropism of SARS-CoV-2
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Multiorgan and Renal Tropism of SARS-CoV-2 In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
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“The finding of coronavirus RNA in brain tissue of deceased patients raised the possibility of a direct brain injury mechanism [153].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [153]
Experimental — accuracy not yet measuredIn the citing paper
“a study detected SARS-CoV-2 in 8 of 21 postmortem brain tissues, based on reverse transcriptase polymerase chain reaction [25].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [25]
In the citing paper
“In addition, human CSF samples have failed thus far to reveal CoV-2 RNA (73, 77), and autopsies from human patients have found that the brain contains the lowest levels of CoV-2 across organs sampled (78).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [78]
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Citations
Cites
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Zou, L., Ruan, F., Huang, M.-X., Liang, L.-J., Huang, H., Hong, Z.-S., Yu, J.-X., Kang, M., Song, Y.-C., Xia, J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001737 · Cited by 4,590
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Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China
Su, H., Yang, M., Wan, C., Yi, L.-X., Tang, F., Zhu, H.-Y., Yi, F., Yang, H.-C., Fogo, A. B., Nie, X., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.04.003 · Cited by 1,763
Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia
Pei, G., Zhang, Z., Peng, J., Liu, L., Zhang, C., Yu, C., Ma, Z., Huang, Y., Liu, W., Yao, Y., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020030276 · Cited by 777
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Saeed, U., Uppal, S. R., Piracha, Z. Z., Khan, A. A., Rasheed, A., Zaheer, H., Aftab, Z., & Uppal, R. (2021) · Research Square · doi:10.21203/rs.3.rs-315851/v1 · Cited by 13
Progress report on the coronavirus pandemic
(2020) · Nature · doi:10.1038/d41586-020-02414-1 · Cited by 12
Association between smoking and COVID-19 severity: A multicentre retrospective observational study
He, Y., He, Y., Hu, Q., Yang, S., Li, J., Liu, Y., & Hu, J. (2022) · Medicine · doi:10.1097/md.0000000000029438 · Cited by 12
“Because of the cell specificity of ACE2 and host cell protease, the affinity of SARSCoV-2 to different organs varies.[7,8] Smoking seriously damages human health and is the main risk factor for respiratory and cardiovascular diseases.”
BackgroundOutcomes of COVID‐19–Positive Donor Heart Transplantation in the United States
Kim, S. T., Iyengar, A., Helmers, M. R., Weingarten, N., Rekhtman, D., Song, C., Shin, M., Cevasco, M., & Atluri, P. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.029178 · Cited by 12
Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147
Habeichi, N. J., Amin, G., Lakkis, B., Kataya, R., Mericskay, M., Booz, G. W., & Zouein, F. A. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2901008 · Cited by 11
“No-tably, another autopsy study performed on six COVID-19 patients observed SARS-CoV-2 in the glomerulus [25].”
ResultCOVID-19: a multi-organ perspective
Guarienti, F. A., Gonçalves, J. I. B., Gonçalves, J. B., Xavier, F. A. C., Marinowic, D. R., & Machado, D. C. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1425547 · Cited by 14
Mellors, J., Dhaliwal, R., Longet, S., Tipton, T., McInnes, I. B., Siebert, S., Kearns, P. R., Rea, D., Cook, G., Willicombe, M. K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57947-8 · Cited by 12
A 21st Century Evil: Immunopathology and New Therapies of COVID-19
Silva, T. F., Tomiotto‐Pellissier, F., Sanfelice, R. A., Gonçalves, M. D., Bortoleti, B. T. D. S., Detoni, M. B., Rodrigues, A. C. J., Carloto, A. C. M., Concato, V. M., Siqueira, E. D. S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.562264 · Cited by 12
“It has been reported that ACE2, TMPRSS2, and cathepsin L can be expressed on glial cells and neurons, cardiomyocytes, liver cells, bile duct cells, and renal tubular cells (90, 91).”
BackgroundNachweismethoden von SARS-CoV-2 in Gewebe
von Stillfried, S. F., & Boor, P. (2021) · Der Pathologe · doi:10.1007/s00292-021-00919-8 · Cited by 13
Egilmezer, E., & Rawlinson, W. D. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2227 · Cited by 11
“brain, heart, liver and kidneys, suggesting viral tropism in these organs.(48) Additionally, monocultures have been utilised to model and establish SARS‐CoV‐2 tropism in cell lines representative of different”
MethodCurrent Understanding of Clinical Manifestations of COVID-19 in Glomerular Disease
Shimmel, A., Shaikhouni, S., & Mariani, L. H. (2021) · Glomerular Diseases · doi:10.1159/000518276 · Cited by 12
Dash, R., & Mohapatra, S. (2021) · Minerva Biotechnology and Biomolecular Research · doi:10.23736/s2724-542x.21.02765-8 · Cited by 12
The Biopsychosocial Impact of COVID-19 on Older Adults
Laher, N., Bocchinfuso, S., Chidiac, M., Doherty, C., Persson, A., & Warren, E. (2021) · Gerontology and Geriatric Medicine · doi:10.1177/23337214211034274 · Cited by 10
Oral lesions and SARS‐CoV‐2: A postmortem study
Zarpellon, A., Matuck, B. F., Dolhnikoff, M., Duarte‐Neto, A. N., Maia, G., Gomes, S. C., Sendyk, D. I., de Souza, S. C. O. M., Mauad, T., Saldiva, P. H. N., et al. (2021) · Oral Diseases · doi:10.1111/odi.14047 · Cited by 12
Molecular mechanisms of vasculopathy and coagulopathy in COVID-19
Al-Gburi, S., Beissert, S., & Günther, C. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0245 · Cited by 12
A Peek into Pandora’s Box: COVID-19 and Neurodegeneration
Chandra, A., & Johri, A. (2022) · Brain Sciences · doi:10.3390/brainsci12020190 · Cited by 14
Stakišaitis, D., Kapočius, L., Valančiūtė, A., Balnytė, I., Tamošuitis, T., Vaitkevičius, A., Sužiedėlis, K., Urbonienė, D., Tatarūnas, V., Kilimaitė, E., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050962 · Cited by 12
Desquilles, L., Cano, L., Ghukasyan, G., Mouchet, N., Landreau, C., Corlu, A., Clément, B., Turlin, B., Désert, R., & Musso, O. C. (2022) · Scientific Reports · doi:10.1038/s41598-021-03710-0 · Cited by 12
Smith, C. J., Renshaw, P. F., Yurgelun-Todd, D. A., & Sheth, C. S. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.772335 · Cited by 12
Falcón, V., González, T. M., Acosta-Medina, E. F., Guillén, G. E., Berlanga‐Acosta, J., Fernández‐Ortega, C., Alfonso-Falcón, A., Gilva-Rodríguez, N., López-Nocedo, L., Cremata-García, D., et al. (2023) · Archives of Virology · doi:10.1007/s00705-023-05711-y · Cited by 12
Elemam, N. M., Talaat, I. M., Maghazachi, A. A., & Saber-Ayad, M. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12052067 · Cited by 13
“Hepatocytes and cholangiocytes did not contain SARS-CoV-2 RNAs, according to in-situ hybridization.”
BackgroundInfluentialZhou, S., Yu, Z., Chen, Z., Ning, F., Hu, X., Wu, T., Li, M., Xin, H., Reilly, S. N., & Zhang, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1187818 · Cited by 13
“have shown that SARS-CoV-2 has renal tropism and can infect the kidney directly to cause renal damage, especially renal-tubule injury and fibrosis (Braun et al., 2020; Puelles et al., 2020; Jansen et al., 2022).”
BackgroundInfluentialIntrinsic factors behind long COVID: III. Persistence of SARS‐CoV‐2 and its components
El‐Baky, N. A., Amara, A. A. A. F., Uversky, V. N., & Redwan, E. M. M. M. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30514 · Cited by 11
“76 Even neurons in the brain were found to be infected by SARS ‐ CoV ‐ 2 and could express ACE2 at low levels or use other coreceptors.”
BackgroundRationale for Medium Cutoff Membranes in COVID-19 Patients Requiring Renal Replacement Therapy
Ronco, C., Reis, T. D. A., & Cozzolino, M. G. (2020) · The Nephron journals/Nephron journals · doi:10.1159/000509807 · Cited by 12
da Silva, J. F., Hernández-Romieu, A. C., Browning, S. D., Bruce, B. B., Natarajan, P., Morris, S. B., Gold, J. A. W., Fanfair, R. N., Rogers-Brown, J. S., Rossow, J. A., et al. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa596 · Cited by 12
“This finding is consistent with those from other reports [3, 10, 13], which suggest that SARS-CoV-2 may have a specific tropism for renal tissue [2].”
ResultKoeppen, M., Rosenberger, P., & Magunia, H. (2021) · Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine · doi:10.1177/1179548421992327 · Cited by 13
“Studies that met the following criteria were considered eligible for inclusion: (1) original articles, research letters and letters to the editor reporting on the prevalence of cardiovascular disease and complications; (2) studies of critically ill patients; (3) studies with adult patients (age ⩾18 years); (4) studies…”
BackgroundViral Nephropathies, Adding SARS-CoV-2 to the List
Pramod, S., Kheetan, M., Ogu, I., Alsanani, A., & Khitan, Z. J. (2021) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s303080 · Cited by 12
Bayrakçı, N., Özkan, G., Şakacı, M., Sedef, S., Erdem, İ., Tuna, N., Mutlu, L. C., Yıldırım, İ., Kiraz, N., Erdal, B., et al. (2022) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.13790 · Cited by 12
“As indirect factors such as the cytokine storm, coagulopathy, sepsis, hemodynamic instability, and drug toxicity seen in the course of COVID-19 constitute a risk in terms of AKI development, it has been speculated that the virus exhibits renal tropism [11, 12].”
BackgroundSiegerist, F., Hay, E., Dikou, J. S., Pollheimer, M. J., Büscher, A. K., Oh, J. S., Ribback, S., Zimmermann, U., Bräsen, J. H., Lenoir, O., et al. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17392 · Cited by 12
“15 On the functional side, it has been shown that the degree of albuminuria can predict disease severity in COVID-19 patients.”
BackgroundInfluentialAutopsy of patients with COVID-19: A balance of fear and curiosity
Hirschbühl, K., Schaller, T., Kling, E., Märkl, B., & Claus, R. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153039 · Cited by 12
Balakrishnan, B., & Lai, K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.04.429769 · Cited by 12
“the kidney cells, as well as the enhanced expression of transmembrane serine protease 2 (TMPRSS2) and cathepsin L (CTSL), which are also considered to facilitate SARSCoV-2 infection in multiple kidney-cell types from fetal development through adulthood [27].”
BackgroundNeuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mousePreprint
Seehusen, F., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., Subramaniam, K. S., Wunderlin, S., Hughes, G. L., Patterson, E. I., Michael, B. D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.16.440173 · Cited by 12
Pflegende Angehörige in der COVID-19-Krise
Budnick, A., Eggert, S., Gellert, P. R., Kuhlmey, A., & Teubner, C. (2020) · doi:10.71059/qrzs6582 · Cited by 12
Organoids: physiologically relevant ex vivo models for viral disease research
Wang, Y., Peng, D., Li, M., Meng, Y., Li, T., Li, S., Qiu, H., & Li, L. (2025) · Journal of Virology · doi:10.1128/jvi.01132-25 · Cited by 11
“Examples include SARS-CoV-2 (43), ZIKV (44), influenza virus (45), and MPXV (46).”
Bucurica, S., Radu, F. I., Bucurica, A., Socol, C., Prodan, I., Tudor, I., Sîrbu, C. A., Pleşa, C., & Jinga, M. (2022) · Medicina · doi:10.3390/medicina59010062 · Cited by 11
“When comparing the level of RNA between airway cells and hepatic cells, there is a similar range but a lower median viral RNA in hepatic cells [68].”
BackgroundMahé, D., Bourgeau, S., Silva, J., Schlederer, J., Satié, A.-P., Kuassivi, N. O., Mathiéu, R., Guillou, Y.-M., Tortorec, A. L., Guivel‐Benhassine, F., et al. (2023) · Journal of Virology · doi:10.1128/jvi.01104-23 · Cited by 11
“tissues such as kidney (6, 7), capillary (6), gastro-intestinal organs (8, 9), and brain (4).”
BackgroundSardarni, U. K., Ambikan, A. T., Acharya, A., Johnson, S. D., Avedissian, S. N., Végvári, Á., Neogi, U., & Byrareddy, S. N. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.032 · Cited by 11
Coelho, S. V. A., Souza, G. L. E., Bezerra, B. B., Lima, L. R., Corrêa, I. A., de Almeida, D. V., Silva-Aguiar, R. P., Pinheiro, A. A. S., Sirois, P., Caruso‐Neves, C., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125540 · Cited by 11
“Positive PCR results, dsRNA, and S staining in brain autopsies suggest virus invasion [59,60], and viral RNA has been detected in the brain later, after the acute symptoms [24].”
Diabetes and Novel Coronavirus Infection: Implications for Treatment
Williams, D. M., Nawaz, A., & Evans, M. (2020) · Diabetes Therapy · doi:10.1007/s13300-020-00858-2 · Cited by 11
“Interestingly, one recent study concluded that SARS-CoV-2 may cause acute kidney injury via the ACE2 receptor, as the virus was detected within human glomerular cells at autopsy [27].”
BackgroundCharacteristics of patients with kidney injury associated with COVID-19
Ke, C., Xiao, J., Wang, Z., Yu, C., Yang, C., & Hu, Z. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107794 · Cited by 12
Imaging in the COVID-19 era: Lessons learned during a pandemic
Sideris, G. A., Nikolakea, M., Karanikola, A.-E., Konstantinopoulou, S., Giannis, D., & Modahl, L. E. (2021) · World Journal of Radiology · doi:10.4329/wjr.v13.i6.192 · Cited by 10
Cobos, T. L. (2021) · Revista de Comunicación · doi:10.26441/rc20.2-2021-a6 · Cited by 11
Neurological Presentations in Patients with COVID-19 in Cytokine Storm
Gürsoy, G. T., Yüksel, H., ŞİMŞEK, İ. M., Oral, S., KÜÇÜKDAĞLI, F. E., Karaman, A., Akıncı, E., Baştuğ, A., Güner, R., & Bektaş, H. (2021) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2021.247 · Cited by 11
Urinary Tract Virome as an Urgent Target for Metagenomics
Salabura, A., Łuniewski, A., Kucharska, M., Myszak, D., Dołęgowska, B., Ciechanowski, K., Kędzierska-Kapuza, K., & Wojciuk, B. (2021) · Life · doi:10.3390/life11111264 · Cited by 12
“What is more, in the same study, other tropisms have been identified as high viral-load was detected in other organs such as the pharynx, heart, liver, and brain [59].”
BackgroundThe Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients
Diniz, F., Hipkiss, A. R., & Ferreira, G. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.898735 · Cited by 11
Acute kidney injury and electrolyte disorders in COVID-19
Nogueira, G., Silva, N. L. O. R., Moura, A. F., Silveira, M. A. D., & Moura-Neto, J. A. (2022) · World Journal of Virology · doi:10.5501/wjv.v11.i5.283 · Cited by 11
SARS-CoV-2 and HIV-1: So Different yet so Alike. Immune Response at the Cellular and Molecular Level
Demoliou, C. D., Papaneophytou, C. P., & Nicolaidou, V. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.73134 · Cited by 12
Mahajan, S., Sen, D., Sunil, A., Srikanth, P., Marathe, S. D., Shaw, K., Sahare, M., Galande, S., & Abraham, N. M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1180868 · Cited by 11
COVID-19 and Chronic Kidney Disease: A Narrative Review
Martins, M., & de Oliveira, R. B. (2023) · COVID · doi:10.3390/covid3080080 · Cited by 12
Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
Xu, Z., Wang, H., Jiang, S., Teng, J., Zhou, D., Chen, Z., Wen, C., & Xu, Z. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01110-0 · Cited by 10
“As SARS-CoV-2 has been shown to cause damage and dysregulation in other systems [80], its detection in the brain by polymerase chain reaction [81] and immunohistochemistry [82] suggests that it may also harm brain cells and tissues.”
Persistent bilateral Tapia syndrome following critical COVID-19
Yatim, N., Bonnet, N., Tin, S. N. W., Cohen, Y., & Degos, B. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.12.007 · Cited by 11
Generalić, A., Davidović, M., Kos, I., Vrljičak, K., & Lamot, L. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.760070 · Cited by 11
“On the other hand, the respiratory mucosal epithelium is most commonly the entry point of virus in adults (41), and therefore, it is fair to mark the lung as a “primary battle zone.”
BackgroundCarter, M., Casey, S., O’Keeffe, G. W., Gibson, L., Gallagher, L., & Murray, D. M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.823096 · Cited by 14
“Viral RNA has been isolated in clinical CSF samples in those with COVID-19 and neurological symptoms (143), and post-mortem examination of brain tissue has identified both viral RNA and neutrophilic infiltrates suggestive of aberrant immune response (144).”
MethodChen, W., Liu, H., Yang, G., Wang, W., Liu, Q., Huang, C., Zou, Z., Liu, Y., Zhuang, G., & Zhang, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.843505 · Cited by 11
“SARS-CoV-2 mainly attacks the lungs, but it can also cause severe damage to the liver, kidneys, intestines, heart and the central nervous system via the ubiquitous distribution of the viral entry receptor Angiotensin-converting enzyme 2 (ACE2) (5, 6).”
BackgroundFlores‐León, M., Lázaro, D. F., Shvachiy, L., Kriško, A., & Outeiro, T. F. (2021) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2021.140693 · Cited by 11
Kalejaiye, T. D., Bhattacharya, R., Burt, M. A., Travieso, T., Okafor, A. E., Mou, X., Blasi, M., & Musah, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.16.468893 · Cited by 11
Bengsch, B., Schwabenland, M., Salié, H., Tanevski, J., Killmer, S., Matschke, J., Püschel, K., Mei, H. E., Boettler, T., Neumann‐Haefelin, C., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-63687/v1 · Cited by 9
Self-citationRazu, M. H., Hossain, M. I., Ahmed, Z. B., Bhowmik, M., Hasan, M. K. E., Kibria, M. K., Moni, D. A., & Khan, M. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01187-0 · Cited by 10
“Introduction Since the emergence of the COVID-19 pandemic, an exponentially growing dataset shows that SARS-CoV-2 infection affects multiple organs with short- and longterm consequences [1].”
BackgroundMei, S., Zou, Y., Jiang, S., Lü, X., Wang, Y., Han, J. D. J., Yang, P., Niu, M., Li, J., Yuan, K., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115908 · Cited by 10
Long COVID: From olfactory dysfunctions to viral Parkinsonism
Pandey, S., Bapat, V., Abraham, J. N., & Abraham, N. M. (2024) · World Journal of Otorhinolaryngology - Head and Neck Surgery · doi:10.1002/wjo2.175 · Cited by 10
“14,47,60 Prevalent neurological concerns of COVID ‐ 19 include chronic taste and smell disturbances, vertigo, myalgia, fatigue, attention ‐ related problems, and memory impairments.”
The alarmin IL-33 exacerbates pulmonary inflammation and immune dysfunction in SARS-CoV-2 infection
Wang, H., Hosakote, Y. M., Boor, P. J., Yang, J., Zhang, Y., Yu, X., Gonzales, C., Levine, C. B., McLellan, S., Cloutier, N., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110117 · Cited by 10
SARS-CoV-2 Omicron subvariants progressively adapt to human cells with altered host cell entry
Sakurai, Y., Okada, S., Ozeki, T., Yoshikawa, R., Kinoshita, T., & Yasuda, J. (2024) · mSphere · doi:10.1128/msphere.00338-24 · Cited by 12
“SARS-CoV-2 infection has also been detected in human non-respiratory tissues such as the heart, kidney, and intestines (23, 24).”
Evidence-Based Management of the Critically Ill Adult With SARS-CoV-2 Infection
Chivukula, R. R., Maley, J. H., Dudzinski, D. M., Hibbert, K. A., & Hardin, C. C. (2020) · Journal of Intensive Care Medicine · doi:10.1177/0885066620969132 · Cited by 10
SARS-CoV-2 Infections among Recent Organ Recipients, March–May 2020, United States
Jones, J. M., Kracalik, I. T., Rana, M. M., Nguyen, A., Keller, B. C., Mishkin, A. D., Hoopes, C. W., Kaleekal, T. S., Humar, A., Vilaro, J. R., et al. (2021) · Emerging infectious diseases · doi:10.3201/eid2702.204046 · Cited by 10
COVID-19; Immunology, pathology, severity and immunosuppressants
Safwat, M.-A., Abdul-Rahman, A., Forsan, H. F., Abduljabar, R. S., & Riad, O. K. M. (2021) · Azhar International Journal of Pharmaceutical and Medical Sciences/Azhar International Journal of Pharmaceutical and Medical Sciences · doi:10.21608/aijpms.2021.50103.1005 · Cited by 10
Praktische Aspekte von COVID-19-Obduktionen
Boor, P., Eichhorn, P., Hartmann, A., Lax, S., Märkl, B., Menter, T., Skok, K., Slotta‐Huspenina, J., von Stillfried, S. F., Tzankov, A., et al. (2021) · Der Pathologe · doi:10.1007/s00292-021-00925-w · Cited by 11
COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences
Sanchez-Russo, L., Billah, M., Chancay, J., Hindi, J., & Cravedi, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10050900 · Cited by 11
“In a series of autopsies from COVID-positive patients, Puelles and collaborators detected viral load in kidney tissue using quantitative polymerase chain reaction (PCR) specific for SARS-CoV-2 in 13 out of 21 cases [62].”
Paranjpe, I., Chaudhary, K., Johnson, K. W., Jaladanki, S. K., Zhao, S., Freitas, J. K. D., Pujadas, E., Chaudhry, F. F., Böttinger, E. P., Levin, M. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247366 · Cited by 10
Enikeev, D. V., Taratkin, M. S., Efetov, S. K., Shlomina, A., Boldyreva, M. N., Galkina, I., Spivak, L., Gitel, E., Мэлсовна, К. А., Mikhailov, V., et al. (2021) · Current Opinion in Urology · doi:10.1097/mou.0000000000000901 · Cited by 11
Nakel, J., Robitaille, A., Günther, T., Rosenau, L., Czech‐Sioli, M., Plenge‐Bönig, A., Bühler, S., Wille, A., Jakubowski, E., Pruskil, S., et al. (2022) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2022.113928 · Cited by 10
Self-citationAcute Kidney Injury in Critically-Ill COVID-19 Patients
Arrestier, R., Gendreau, S., Mokrani, D., Bastard, J., Fellahi, S., Bagate, F., Masi, P., d’Humières, T., Razazi, K., Carteaux, G., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11072029 · Cited by 10
“detected SARS-Cov2 RNA and protein in glomerular epithelial and tubular cells extracted from autopsy samples [45].”
BackgroundRoguljić, H., Arambašić, J., Ninčević, V., Kuna, L., Šesto, I., Tabll, A. A., Smolić, R., Včev, A., Primorac, D., Wu, G. Y., et al. (2022) · Croatian Medical Journal · doi:10.3325/cmj.2022.63.287 · Cited by 10
Modeling infectious diseases of the central nervous system with human brain organoids
Priyathilaka, T. T., Laaker, C. J., Herbáth, M., Fábry, Z., & Sándor, M. (2022) · Translational research · doi:10.1016/j.trsl.2022.06.013 · Cited by 11
Does covid-19 impair endogenous neurogenesis?
Kumaria, A., Noah, M. A., & Kirkman, M. A. (2022) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2022.09.006 · Cited by 9
Balan, C. I., Ciuhodaru, T., & Bubenek-Turconi, Ş.-I. (2023) · The Journal of Critical Care Medicine · doi:10.2478/jccm-2023-0023 · Cited by 10
Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2
Duloquin, G., Pommier, T., Georges, M., Giroud, M., Guénancia, C., Béjot, Y., Laurent, G., & Rabec, C. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051397 · Cited by 12
“Viral inclusion particles were visualized by electron microscopy in the tubular epithelium and glomerular capillary loops [105].”
Taramasso, L., Vena, A., Bovis, F., Portunato, F., Mora, S., Dentone, C., Delfino, E., Mikulska, M., Giacobbe, D. R., Maria, A. D., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8122010 · Cited by 10
“not only experience respiratory illness, but also immunologic dysregulation [3] and heart [4], kidney [5] and liver [6,7] involvement in a systemic disease involving multiple organs.”
BackgroundAllogeneic stem cell transplantation in acute leukemia patients after COVID-19 infection
Christopeit, M., Reichard, M., Niederwieser, C., Massoud, R., Klyuchnikov, E., Haase, N., Wolschke, C., Ayuk, F. A., Heidenreich, S., & Kröger, N. M. (2021) · Bone Marrow Transplantation · doi:10.1038/s41409-021-01225-w · Cited by 10
Störungen der Chemosensorik bei Covid-19: Pathomechanismen und klinische Relevanz
Isenmann, S., Haehner, A., & Hummel, T. R. (2021) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-1375-0761 · Cited by 10
“SARS-CoV-2 wurde in Autopsien im menschlichen Gehirn nachgewiesen [16].”
BackgroundImpact of Cardiovascular Diseases on COVID-19: A Systematic Review
Cao, Q., Lei, H., Yang, M., Wei, L., Dong, Y., Xu, J., Nasser, M., Liu, M., Zhu, P., Xu, L., et al. (2021) · Medical Science Monitor · doi:10.12659/msm.930032 · Cited by 10
“4% (8/22) of COVID-19 cases [22], the virions are likely to infect the central nervous system (CNS) directly.”
BackgroundAge and Sex Modulate SARS-CoV-2 Viral Load Kinetics: A Longitudinal Analysis of 1735 Subjects
Caputo, V., Termine, A., Fabrizio, C., Calvino, G., Luzzi, L., Fusco, C., Ingrascì, A., Peconi, C., D'Alessio, R., Mihali, S., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090882 · Cited by 10
Evolutionary genetics and acclimatization in nephrology
Adeyemo, A., Shriner, D., Bentley, A. R., Gbadegesin, R., & Rotimi, C. N. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00483-7 · Cited by 12
Takeshita, Y., Terada, J., Hirasawa, Y., Kinoshita, T., Tajima, H., Koshikawa, K., Kinouchi, T., Isaka, Y., Shionoya, Y., Fujikawa, A., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010134 · Cited by 10
“is concentrated in the lungs, and the angiotensin-converting enzyme 2 (ACE2) receptor, which plays an important role in host cell invasion by SARS-CoV-2, is highly expressed in the lungs [17].”
BackgroundIn Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor
Wang, H., Li, C. L., Obadan, A. O., Frizzell, H., Hsiang, T.-Y., Gil, S., Germond, A., Fountain, C., Baldessari, A. E., Roffler, S. R., et al. (2022) · Human Gene Therapy · doi:10.1089/hum.2021.295 · Cited by 10
“The widespread tissue distribution of ACE2 16 and the presence of virus in other tissues 17,18 argue for the first one.”
Veyrenche, N., Pisoni, A., Debiesse, S., Bolloré, K., Bedin, A., Makinson, A., Niel, C., Cordellat, C. A., Mondain, A. M., Moing, V. L., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac073 · Cited by 11
“most frequently affected extrapulmonary organs during SARS-CoV-2 infection, and varying degrees of renal damage have been reported in Covid-19 patients [34,35].”
BackgroundZhang, G. F., Meng, W., Chen, L., Ding, L., Sun, S., Wang, X., Huang, Y., Guo, H., & Gao, S. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28437 · Cited by 9
“While patient tissue analysis or tropism studies indicates that SARS‐ CoV‐2 WT has multiorgan tropism, the tropism of VOCs has rarely been reported.(11,12) Our results of enhanced infectivity of VOCs in different cell types from numerous organs compared with that of WT”
BackgroundResultA specific molecular signature in SARS-CoV-2–infected kidney biopsies
Isnard, P., Vergnaud, P., Garbay, S., Jamme, M., Eloudzeri, M., Karras, A., Anglicheau, D., Galantine, V., Eddine, A. J., Gosset, C., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.165192 · Cited by 10
“Although a recent publication has shown a direct SARS-CoV-2 infection of kidney epithelial cells (21), several other studies argue against this result (13, 22–26).”
The Long Story of Ebselen: From about One Century of its Synthesis to Clinical Trials
Nogara, P. A., Pereira, M. E., Oliveira, C. S., Orian, L., & da Rocha, J. B. T. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167386-00567 · Cited by 10
Recent Advances of COVID-19 Modeling Based on Regenerative Medicine
Larijani, B. A., Heravani, N. F., Abedi, M., Tayanloo-Beik, A., Rezaei–Tavirani, M., Adibi, H., & Arjmand, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683619 · Cited by 9
“Due to its multi-organ tropism, a spectrum of pathologic symptoms from neurological, cardiac, pancreatic, digestive, and renal to the most common one, respiratory signs can be presented (Alsaad et al., 2020; Puelles et al., 2020; Qin and Zhao, 2020; Simoneau and Ott, 2020; Wiersinga et al., 2020; Yang et al., 2020).”
BackgroundHistopathological pulmonary findings of survivors and autopsy COVID-19 cases: A bi-center study
Chrabańska, M., Mazur, A., & Stęplewska, K. (2022) · Medicine · doi:10.1097/md.0000000000032002 · Cited by 9
Labach, D. S., Kohio, H. P., Tse, E. A., Paparisto, E., Friesen, N. J., Pankovich, J., Bazett, M., & Barr, S. D. (2023) · Biomolecules · doi:10.3390/biom13071095 · Cited by 9
Zhang, C., Gerzanich, V., Cruz‐Cosme, R., Zhang, J., Tsymbalyuk, O., Tosun, Ç., Sallapalli, B. T., Liu, D., Keledjian, K. M., Papadimitriou, J. C., et al. (2024) · mBio · doi:10.1128/mbio.02308-24 · Cited by 9
“A comparable percentage of kidney complications is found among critically ill COVID-19 patients (10), with nearly half of those with AKI not fully recovered by discharge (7).”
Ivković, V., Anandh, U., Bell, S., Kronbichler, A., Soler, M. J., & Bruchfeld, A. N. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00997-4 · Cited by 9
Falach, R., Bar‐On, L., Lazar, S., Kadar, T., Mazor, O., Aftalion, M., Gur, D., Evgy, Y., Shifman, O., Aminov, T., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.145916 · Cited by 9
“This finding is of considerable clinical relevance because autopsy samples obtained from COVID-19 patients revealed the presence of the virus in organs other than the lungs, including the heart, brain, and blood (23).”
ResultCoronavirus disease 2019 and kidney injury
Punj, S., Eng, E., & Shetty, A. A. (2021) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000718 · Cited by 8
“Histological findings of virus-like particles on electron microscopy in tubular epithelial cells [4 & ,19], podocytes [20], and endothelial cells [21] along with evidence of SARS-CoV-2 viral ribonucleic acid in micro-dissected kidney compartments in an autopsy series support the direct viral invasion hypothesis [22].”
BackgroundMulti-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19
Woo, M. S., Haag, F., Nierhaus, A., Jarczak, D., Roedl, K., Mayer, C., Brehm, T. T., van der Meirschen, M., Hennigs, A., Christopeit, M., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102752 · Cited by 9
Self-citationConvalescent plasma treatment for early post‐kidney transplant acquired COVID‐19
Kluger, M. A., Czogalla, J., Schmidt‐Lauber, C., Peine, S., Schmiedel, S., Bangert, K., Kluge, S., Huber, S., Puelles, V. G., Fischer, L., et al. (2021) · Transplant Infectious Disease · doi:10.1111/tid.13685 · Cited by 9
Self-citationMalik, P., Patel, K., Akrmah, M., Donthi, D., Patel, U. K., Khader, S. N., & Asiry, S. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-01029-5 · Cited by 9
“region and an increased RNA expression of genes [32, 34].”
BackgroundInfluentialLong-term effects of Covid-19 on the kidney
Svetitsky, S., Shuaib, R., McAdoo, S. P., & Thomas, D. (2021) · QJM · doi:10.1093/qjmed/hcab061 · Cited by 9
Immunotherapy Summary for Cytokine Storm in COVID-19
Li, Y., Zhao, W., Liu, J., Chen, Z., Lv, Q., & Zhang, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.731847 · Cited by 10
“If the immune cascade cannot be properly controlled, the immune response may have adverse effects on the host, and remodeling the balance between inflammation and antiinflammation may be a more effective method for the treatment of infection (Puelles et al., 2020).”
Background
Metadata
- Authors
- Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., Braun, F., Lu, S., Pfefferle, S., Schröder, A. S., Edler, C., Gross, O., Glatzel, M., Wichmann, D., Wiech, T., Kluge, S., Pueschel, K., Aepfelbacher, M., & Huber, T. B.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Huber, Tobias B.
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-08-06
- Volume
- 383
- Issue
- 6
- Pages
- 590-592
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7240771
- OpenAlex
- W3024126428
- Cited by
- 1,775
- References
- 4
- Citations by year
- 2026: 26 · 2025: 73 · 2024: 138 · 2023: 214 · 2022: 338 · 2021: 595 · 2020: 390
- FWCI
- 50.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- SARS-CoV-2, COVID-19 pandemic, kidney, heart, liver, brain, autopsy findings, viral tissue distribution
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Autopsy, Brain, Female, Heart, Humans, Kidney, Liver, Lung, Male, Middle Aged, Pharynx, Pneumonia, Viral, Coronavirus Infections, Viral Load, Viral Tropism, Pandemics
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