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Multiorgan and Renal Tropism of SARS-CoV-2
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Multiorgan and Renal Tropism of SARS-CoV-2 In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
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“The finding of coronavirus RNA in brain tissue of deceased patients raised the possibility of a direct brain injury mechanism [153].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [153]
Experimental — accuracy not yet measuredIn the citing paper
“a study detected SARS-CoV-2 in 8 of 21 postmortem brain tissues, based on reverse transcriptase polymerase chain reaction [25].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [25]
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“In addition, human CSF samples have failed thus far to reveal CoV-2 RNA (73, 77), and autopsies from human patients have found that the brain contains the lowest levels of CoV-2 across organs sampled (78).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [78]
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SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Zou, L., Ruan, F., Huang, M.-X., Liang, L.-J., Huang, H., Hong, Z.-S., Yu, J.-X., Kang, M., Song, Y.-C., Xia, J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001737 · Cited by 4,590
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Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China
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Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia
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Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7
Ondruschka, B., Heinrich, F., Lindenmeyer, M. T., Edler, C., Möbius, D., Czogalla, J., Heinemann, A., Braun, F., Aepfelbacher, M., Lütgehetmann, M., et al. (2021) · International Journal of Legal Medicine · doi:10.1007/s00414-021-02691-z · Cited by 16
“Comparison of the given results to a former cohort of 27 SARS-CoV-2 deaths during the first wave in spring 2020 [3] showed resembling organ tropism (Fig.”
Self-citationCell-Free DNA: Potential Application in COVID-19 Diagnostics and Management
Stawski, R. S., Nowak, D., & Perdas, E. (2022) · Viruses · doi:10.3390/v14020321 · Cited by 17
“The presence of coronavirus has been confirmed in the heart, liver, and blood of many patients [106,107].”
BackgroundSARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients
Ji, N., Zhang, M., Ren, L., Wang, Y., Hu, B., Xiang, J., Gong, Y., Wu, C., Qu, G., Ding, W., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2059400 · Cited by 17
“SARSCoV-2 has been detected in respiratory system[16] and kidney [3] specimens.”
BackgroundHromić‐Jahjefendić, A., Barh, D., Pinto, C. H. R., Gomes, L. G. R., Machado, J. L. P., Afolabi, O. O., Tiwari, S., Aljabali, A. A. A., Tambuwala, M. M., Serrano‐Aroca, Á., et al. (2022) · Viruses · doi:10.3390/v14050910 · Cited by 17
“Since the start of the COVID-19 pandemic, a growing body of evidence suggests that SARSCoV-2 infection affects several organs, with both short- and long-term consequences [97].”
BackgroundYang, S., Tian, M., Dai, Y., Feng, S., Wang, Y., Chhangani, D., Ou, T., Li, W., Yang, Z. H., McAdow, J. F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.20.423533 · Cited by 17
Grin, P. M., Baid, K., de Jesus, H. C. R., Kozarac, N., Bell, P. A., Jiang, S. Z., Kappelhoff, R., Butler, G. S., Leborgne, N. G. F., Pan, C. L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115080 · Cited by 18
Roedl, K., Heidenreich, S., Pfefferle, S., Jarczak, D., Urbanowicz, T., Nörz, D. S., Aepfelbacher, M., Kröger, N. M., Kluge, S., Lütgehetmann, M., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202009-3386le · Cited by 16
“This is in line with postmortem data demonstrating viral RNA in plasma and diverse organs, such as the kidney and heart (7, 8).”
Self-citationCOVID-19-Auswirkungen auf die Niere
Amann, K., Boor, P., Wiech, T., Singh, J., Vonbrunn, E., Knöll, A., Hermann, M., Büttner-Herold, M. J., Daniel, C., & Hartmann, A. (2021) · Der Pathologe · doi:10.1007/s00292-020-00899-1 · Cited by 18
Self-citationNeurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction
Chung, T. W., Zhang, H., Wong, F. K.-C., Sridhar, S., Chan, K., Cheng, V. C., Yuen, K., Hung, I. F., & Mak, H. K. (2021) · Brain Sciences · doi:10.3390/brainsci11060686 · Cited by 17
Understanding structural malleability of the SARS-CoV-2 proteins and relation to the comorbidities
Sen, S., Dey, A., Bandhyopadhyay, S., Uversky, V. N., & Maulik, U. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab232 · Cited by 16
Hoffmann, C., Gerber, P. A., Cavelti‐Weder, C., Licht, L., Kotb, R. E., Dweik, R. A., Cherfane, M., Bornstein, S. R., & Perakakis, N. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1834-9008 · Cited by 16
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“In addition, a mechanism of the direct infection of renal cells by SARS-CoV-2 has been hypothesized, as the presence of SARS-CoV-2 was observed in various renal districts, but especially at the glomerular level [98].”
BackgroundUsing autopsies to dissect COVID-19 pathogenesis
Heinrich, F., Mertz, K. D., Glatzel, M., Beer, M., & Krasemann, S. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01488-7 · Cited by 18
“Although respiratory symptoms and pulmonary findings predominate in most autopsy studies, autopsies also identified COVID-19 as a multiorgan disease 13 .”
BackgroundInfluentialSelf-citationPrasanth, M. I., Wannigama, D. L., Reiersen, A. M., Thitilertdecha, P., Prasansuklab, A., Tencomnao, T., Brimson, S. J., & Brimson, J. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-64260-9 · Cited by 16
Upregulation of Neuroinflammation-Associated Genes in the Brain of SARS-CoV-2-Infected Mice
Oh, S. J., Kumari, P., Auroni, T. T., Stone, S., Pathak, H., Elsharkawy, A., Natekar, J. P., Shin, O. S., & Kumar, M. (2024) · Pathogens · doi:10.3390/pathogens13070528 · Cited by 16
“…infection is also associated with a wide variety of neurological manifestations, such as headache, loss of taste and smell, ataxia, meningitis, cognitive dysfunction, memory loss, seizures, and impaired consciousness, as well as long-term neurological problems in more than 30% of adults [3,4].”
BackgroundCOVID-19 in Solid Organ Transplantation: Disease Severity and Clinical Update
Arya, A., Li, M., Aburjania, N., Singh, P., Royer, T. L., Moss, S., & Belden, K. A. (2021) · Transplantation Proceedings · doi:10.1016/j.transproceed.2021.02.014 · Cited by 19
“Acute kidney injury, found in 46% of our patients, is likely multifactorial in COVID-19, especially in severe illness, with the roles of hypotension, viral-mediated nephrotoxicity, complement deposition, and microvascular thrombosis contributing [40,41].”
Giani, A. M., & Chen, S. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102207 · Cited by 16
“To date, SARS-CoV-2 RNA transcripts have been detected in human brain autopsies (Paniz-Mon-dolfi et al., 2020; Puelles et al., 2020) and in the cerebrospinal fluid (Moriguchi et al., 2020; Virhammar et al., 2020) of few COVID-19 patients.”
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids
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“Moreover, despite some reports of detection of SARS-CoV-2 in the brain and cerebrospinal fluid of patients with COVID-19 [55,57,111], it is still unclear whether the virus can infect the central nervous system.”
BackgroundDetection methods for SARS-CoV-2 in tissue
von Stillfried, S. F., & Boor, P. (2021) · Der Pathologe · doi:10.1007/s00292-021-00920-1 · Cited by 16
Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19
Ilias, Ι., Goulas, S., & Zabulienė, L. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i12.2711 · Cited by 15
Host proviral and antiviral factors for SARS-CoV-2
Lv, L., & Zhang, L. (2021) · Virus Genes · doi:10.1007/s11262-021-01869-2 · Cited by 16
Histopathologic findings on indication renal allograft biopsies after recovery from acute COVID‐19
Bašić‐Jukić, N., Ćorić, M., Bulimbašić, S., Dika, Ž., Jurić, I., Furić-Čunko, V., Katalinić, L., Kos, J., Fištrek, M., Kaštelan, Ž., et al. (2021) · Clinical Transplantation · doi:10.1111/ctr.14486 · Cited by 16
Invasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients
Raffaelli, F., Tanzarella, E. S., PASCALE, G. D., & Tumbarello, M. (2022) · Journal of Fungi · doi:10.3390/jof8040415 · Cited by 17
“This is particularly relevant for patients infected by SARS-CoV-2 which has shown renal tropism and been described as a frequent cause of kidney injury [63].”
BackgroundTwo DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters
Babuadze, G. G., Fausther‐Bovendo, H., Vega, M.-A. D. L., Lillie, B. N., Naghibosadat, M., Shahhosseini, N., Joyce, M., Saffran, H. A., Tyrrell, D. L., Falzarano, D., et al. (2022) · npj Vaccines · doi:10.1038/s41541-022-00461-5 · Cited by 16
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“, 2020a) and brain tissue of COVID19 patients (Puelles et al., 2020; Song et al., 2021), and the virus could cross the blood-brain barrier (BBB) in a transcellular pathway (Zhang et al.”
BackgroundSelf-citationCOVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD
Chen, H., & Chen, Q. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72461 · Cited by 16
“SARS-CoV-2 preferentially infects respiratory cells, but it can be detected in multiple other organs, including the liver [61-63], indicating a multiple-organ tropism of SARS-CoV-2.”
BackgroundNegron, S. G., Kessinger, C. W., Xu, B., Pu, W. T., & Lin, Z. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.20.448993 · Cited by 16
“SARS-CoV-2 (CoV-2) infects not only the respiratory tract but also the other major organs, including the heart (Puelles et al., 2020).”
Backgroundde Vries, M., Mohamed, A., Prescott, R. A., Valero-Jimenez, A. M., Desvignes, L., O’Connor, R., Steppan, C. M., Devlin, J. C., Ivanova, E. N., Herrera, A. M., et al. (2021) · PubMed Central · doi:10.1101/2020.08.28.272880 · Cited by 14
Ma, K., Sivalingam, A., & Haller, J. A. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.05.011 · Cited by 15
Quo vadis? Central Rules of Pathogen and Disease Tropism
McCall, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.640987 · Cited by 16
COVID-19: The Heart of the Matter—Pathological Changes and a Proposed Mechanism
Fox, S., & Heide, R. S. V. (2021) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248421995356 · Cited by 16
Free, R. J., Annambhotla, P. D., Hoz, R. M. L., Danziger‐Isakov, L. A., Jones, J. M., Wang, L., Sankthivel, S., Levi, M. E., Michaels, M. G., Kuhnert, W. L., et al. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac221 · Cited by 15
SARS-CoV-2 and Skin: New Insights and Perspectives
Cazzato, G., Cascardi, E., Colagrande, A., Foti, C., Stellacci, A., Marrone, M., Ingravallo, G., Arezzo, F., Loizzi, V., Solimando, A. G., et al. (2022) · Biomolecules · doi:10.3390/biom12091212 · Cited by 15
Peak Plasma Levels of mtDNA Serve as a Predictive Biomarker for COVID-19 in-Hospital Mortality
Edinger, F., Edinger, S., Koch, C., Markmann, M., Hecker, M., Sander, M., & Schneck, E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237161 · Cited by 15
“COVID-19 has been recognized as a systemic inflammatory disease affecting multiple organ systems, such as the lungs, heart, kidneys, liver, and brain [2].”
BackgroundThe genetic associations of COVID-19 on genitourinary symptoms
Chang, Z., An, L., Lei, M., Song, Z., Deng, J. M., Tang, R., Cheng, Z. J., Wu, W., & Sun, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1216211 · Cited by 15
COVID-19 and the brain: understanding the pathogenesis and consequences of neurological damage
Maliha, S. T., Fatemi, R., & Araf, Y. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09279-x · Cited by 16
“Because of the COVID-19 pandemic, both direct and indirect impacts on mental health have been reported, including neurological, neuropsychiatric, and neuropsychological symptoms with possible long-term effects [29, 30].”
Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model
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“Nevertheless, there have been other neuropathologic studies published recently that support our findings and provide insight into the neurotropism of SARS-COV-2 49 and the potential parainfec-tious processes affecting the neural tissue in COVID-19.”
ResultThe virus that shook the world: questions and answers about SARS-CoV-2 and COVID-19
Alexandrova, R., Beykov, P., Vassilev, D. I., Jukič, M., & Podlipnik, Č. (2020) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2020.1847683 · Cited by 16
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Rectifying COVID-19 disparities with treatment and vaccination
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“Although the pulmonary tract is the principal organ system affected by this virus and the site of viral pneumonia, other organ systems may also be sites of primary SARS-CoV-2 infection and others can be secondarily compromised with severe COVID-19 disease (2, 7, 8).”
Stang, M.-B. L., Desenclos, J., Flamant, M., Chousterman, B. G., & Tabibzadeh, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.613019 · Cited by 15
Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19
Paris, G. C., de Azevedo, A., Ferreira, A. L. P., Azevedo, Y. M. A. D., Rainho, M. D. A., de Oliveira, G. P., Silva, K. R., Cortez, E. A. C., Stumbo, A. C., de Carvalho, S. N., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119510 · Cited by 15
“types are enriched with ACE2, TMPRSS2, and cathepsin L (CTSL), a facilitator of SARS-CoV-2 infection [49,53,138,139].”
Rapid Antigen Test for Postmortem Evaluation of SARS-CoV-2 Carriage
Zacharias, M., Stangl, V., Thüringer, A., Loibner, M., Wurm, P., Wolfgruber, S., Zatloukal, K., Kashofer, K., & Gorkiewicz, G. (2021) · Emerging infectious diseases · doi:10.3201/eid2706.210226 · Cited by 15
“Jefferson T, Spencer EA, Brassey J, Heneghan C. Viral cultures for COVID-19 infectious potential assessment—a systematic review.”
BackgroundInfluential78-year-old woman with opsoclonus myoclonus ataxia syndrome secondary to COVID-19
Saha, B. K., Saha, S., & Chong, W. H. (2021) · BMJ Case Reports · doi:10.1136/bcr-2021-243165 · Cited by 15
ECG pathology and its association with death in critically ill COVID-19 patients, a cohort study
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“Myocarditis may be non-viral [38], as a part of the hyperinflammatory response reported in COVID-19, but also due to direct viral infiltration in myocardial cells [12, 47, 48].”
BackgroundSARS-CoV-2 Establishes a Productive Infection in Hepatoma and Glioblastoma Multiforme Cell Lines
Smirnova, O., Ivanova, O., Fedyakina, I., Yusubalieva, G., Baklaushev, V., Yanvarev, D., Kechko, O., Mitkevich, V., Vorobyev, P., Fedorov, V., et al. (2023) · Cancers · doi:10.3390/cancers15030632 · Cited by 14
“detected SARS-CoV-2 RNA in liver post-mortem samples [46].”
BackgroundSARS‐CoV‐2 as an extrahepatic precipitator of acute‐on‐chronic liver failure
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Neuropathology associated with SARS-CoV-2 infection
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Self-citationOlfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19Preprint
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“Angiotensin-converting enzyme inhibitor 65 (19) 57 (20) 8 (13) .”
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Chronic kidney disease and clinical outcomes in patients with COVID-19 in Japan
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“In addition, several postmortem studies have revealed the presence of viral particles in both the visceral and tubular epithelium [17, 18].”
BackgroundEmerging trends in management of long COVID with a focus on pulmonary rehabilitation: A review
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ACE2 and SARS-CoV-2: Tissue or Plasma, Good or Bad?
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Ventricular Assist Device for a Coronavirus Disease 2019-Affected Heart
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Outcomes of renal replacement therapy in the critically ill with COVID-19
Burke, E., Haber, E. N., Pike, C. W., & Sonti, R. (2021) · Medicina Intensiva · doi:10.1016/j.medin.2021.02.004 · Cited by 14
The COVID-Kidney Controversy: Can SARS-CoV-2 Cause Direct Renal Infection?
Lau, W. L., Zuckerman, J. E., Gupta, A., & Kalantar‐Zadeh, K. (2021) · The Nephron journals/Nephron journals · doi:10.1159/000513789 · Cited by 14
Sieracka, J., Sieracki, P., Kozera, G., Szurowska, E., Gulczyński, J., Sobolewski, P. K., Kloc, W., & Iżycka‐Świeszewska, E. (2021) · Folia Neuropathologica · doi:10.5114/fn.2021.105128 · Cited by 14
“[80] 27 Viral copies in the brain qRT-PCR positive in the frontal lobe and/or medulla”
BackgroundInfluentialLópez‐Cortés, A., Guerrero, S. X., Ortiz‐Prado, E., Yumiceba, V., Vera-Guapi, A., Cáceres, Á. L., Simbaña‐Rivera, K., Gómez-Jaramillo, A. M., Echeverría‐Garcés, G., García-Cárdenas, J. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.833174 · Cited by 15
“However, these studies were limited in their discovery potential due to tissue type, prolonged post-mortem intervals–affecting RNA quality–, and low-plex assays (Ackermann et al., 2020b; De Michele et al., 2020; Puelles et al., 2020).”
BackgroundFrom COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
Zhao, M., Tian, C., Cong, S., Di, X., & Wang, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.877303 · Cited by 14
SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis
Szlachcic, W. J., Dąbrowska, A., Milewska, A., Ziojla, N., Błaszczyk, K., Barreto-Durán, E., Sanak, M., Surmiak, M., Owczarek, K., Grzanka, D., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104594 · Cited by 16
“The systems most affected by SARS-CoV-2 include cardiovascular (Puelles et al., 2020; Tavazzi et al., 2020; Varga et al., 2020), gastrointestinal (Wang et al., 2020; Xiao et al., 2020; Zhang et al., 2020), renal (Puelles et al., 2020; Su et al., 2020), neurological (Di Carlo et al., 2020; Helms et…”
Remdesivir Administration in COVID-19 Patients With Renal Impairment: A Systematic Review
Davoudi-Monfared, E., Ahmadi, A., Karimpour‐Razkenari, E., Shahrami, B., Najmeddin, F., & Mojtahedzadeh, M. (2022) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001543 · Cited by 14
Ramezani, S., Ezzatifar, F., Hojjatipour, T., Hemmatzadeh, M., Shabgah, A. G., Navashenaq, J. G., Aslani, S., Shomali, N., Arabi, M., Babaie, F., et al. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07907-y · Cited by 14
“Moreover, virus particles have also been detected in the autopsy samples of brain in a subject [5].”
BackgroundElevated ubiquitination contributes to protective immunity against severe SARS‐CoV‐2 infection
Che, Y., Jiang, D., Zhang, Y., Zhang, J., Xu, T., Sun, Y., Fan, J., Wang, J., Chang, N., Wu, Y., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1103 · Cited by 14
COVID-19 Biogenesis and Intracellular Transport
Aa, M., Savin, M. A., & Beznoussenko, G. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054523 · Cited by 14
“Proteases facilitate the infectivity of SARS-CoV-2 [51,137].”
Dental diseases are associated with increased odds ratio for coronavirus disease 19
Katz, J., Yue, S., & Xue, W. (2020) · Oral Diseases · doi:10.1111/odi.13653 · Cited by 14
Neurological involvement in the respiratory manifestations of COVID-19 patients
Tan, B., Liu, J., Gui, Y., Wu, S., Suo, J., & Li, Y. (2021) · Aging · doi:10.18632/aging.202665 · Cited by 15
Freitas, N. L., Deus, J. V. C., Sampaio, K., Gomes, Y. C. P., Torres, R. C., Brandão, C. O., Soares, C., Silva, M. T. T., & Espíndola, O. D. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-08632-9 · Cited by 13
“Neuro-COVID-19 patients displayed elevated blood levels of TGF-α and VEGF, and high CSF levels of GM-CSF.”
InfluentialTargeting neuropilins as a viable SARS‐CoV‐2 treatment
Sarabipour, S., & Gabhann, F. M. (2021) · FEBS Journal · doi:10.1111/febs.16096 · Cited by 13
Limoges, M.-A., Quenum, A., Chowdhury, M. M. H., Rexhepi, F., Namvarpour, M., Akbari, S. A., Rioux‐Perreault, C., Nandi, M., Lucier, J., Lemaire‐Paquette, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1223936 · Cited by 14
“Despite low levels of viral copy numbers, SARS-CoV-2 has been detected in the brain, kidney, and other organs (Puelles et al., 2020; Stein et al., 2022).”
BackgroundPredictive Model for Mortality in Severe COVID-19 Patients across the Six Pandemic Waves
Casillas, N., Ramón, A., Torres, A., Blasco, P., & Mateo, J. (2023) · Viruses · doi:10.3390/v15112184 · Cited by 13
Kikinis, Z., Castañeyra-Perdomo, A., González–Mora, J. L., Rushmore, J., Toppa, P. H., Haggerty, K., Papadimitriou, G., Yogesh Rathi, A., Kubicki, M. R., Kikinis, R., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1337888 · Cited by 13
Rostami, M., Farahani, P., Esmaelian, S., Bahman, Z., Hussein, A. F., Alrikabi, H. A., Hooshiar, M. H., & Yasamineh, S. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10770-y · Cited by 13
“The findings suggest that SARS-CoV-2 can potentially infect several organs throughout the body [85].”
Immunity and Coagulation in COVID-19
Авдонин, П. П., Blinova, M. S., Serkova, A. A., Komleva, L. A., & Avdonin, P. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011267 · Cited by 17
MicroRNAs in long COVID: roles, diagnostic biomarker potential and detection
Pavăl, N.-E., Căliman-Sturdza, O. A., Lobiuc, A., Dimian, M., Sîrbu, I. O., & Covașă, M. (2025) · Human Genomics · doi:10.1186/s40246-025-00810-0 · Cited by 12
“SARS-CoV-2 has been shown to directly infect kidney cells, leading to cytopathic effects and persistent viral presence in renal tissue [104].”
Biodistribution and serologic response in SARS-CoV-2 induced ARDS: A cohort study
Schlesinger, T., Weißbrich, B., Wedekink, F., Notz, Q., Herrmann, J., Krone, M., Sitter, M., Schmid, B., Kredel, M., Stumpner, J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242917 · Cited by 13
“This could be an indication of a postulated renal tropism of SARS-CoV-2 [31].”
BackgroundGroß, O., Moerer, O., Rauen, T., Boeckhaus, J., Hoxha, E., Jörres, A., Kamm, M., Elfanish, A., Windisch, W., Dreher, M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143049 · Cited by 13
Self-citationLang, M., Li, M., Jiang, K., Yoon, B. C., Mendoza, D. P., Flores, E. J., Rincon, S., Mehan, W. A., Conklin, J., Huang, S. Y., et al. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7032 · Cited by 15
“089 Altered mental status 13 (54) 42 (61) Concern for stroke 10 (42) 14 (20) Trauma 0 (0) 10 (15) Seizure 1 (4) 1 (3) Headache 0 (0) 2 (1)”
BackgroundCOVID‐19 and care for patients with chronic kidney disease: Challenges and lessons
Divyaveer, S. S., & Jha, V. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00002 · Cited by 13
SARS‐CoV‐2 RNA screening in routine pathology specimens
von Stillfried, S. F., Villwock, S., Bülow, R. D., Djudjaj, S., Buhl, E. M., Maurer, A., Ortiz‐Brüchle, N., Celec, P., Klinkhammer, B. M., Wong, D. W. L., et al. (2021) · Microbial Biotechnology · doi:10.1111/1751-7915.13828 · Cited by 12
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19
Brain, D. E., Plant-Hately, A. J., Heaton, B. J., Arshad, U., David, C. A. W., Hedrich, C. M., Owen, A., & Liptrott, N. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113848 · Cited by 13
El-Solh, A., Lawson, Y., & El-Solh, D. A. (2021) · Internal and Emergency Medicine · doi:10.1007/s11739-021-02848-z · Cited by 13
Benedetti, F., Silvestri, G., Mavian, C. N., Weichseldorfer, M. R., Munawwar, A., Cash, M. N., Dulcey, M., Vittor, A. Y., Ciccozzi, M., Salemi, M., et al. (2021) · Viruses · doi:10.3390/v13112193 · Cited by 12
“SARS-CoV-2 RNA has also been detected in the brain tissue of deceased patients [4] and several in vitro experiments have previously shown that SARS-CoV-2 infects cell brain cultures [18–20], though productive in vivo infection has not been convincingly demonstrated yet.”
ResultSpike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2
Brady, M., McQuaid, C., Solorzano, A. G., Johnson, A., Combs, A. L., Venkatraman, C., Rahman, A., Leyva, H., Kwok, W. E., Wood, R. W., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02856-x · Cited by 12
“The distribution of SARS-CoV-2 RNA in a small group of autopsy tissue samples from COVID-19infected patients shows evidence of multiorgan tropism [55,60].”
BackgroundInfluentialAhmad, W., & Shabbiri, K. (2022) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-021-00092-7 · Cited by 13
“SARS‐CoV‐2 and kidney disease It is interesting to note that the SARS-CoV-2 was found in autopsy samples of the COVID-19 patients whether they had pre-kidney problems or not [52].”
BackgroundProteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells
Kohli, A., Sauerhering, L., Fehling, S. K., Klann, K., Geiger, H., Becker, S., Koch, B., Baer, P. C., Strecker, T., & Münch, C. (2022) · Life Science Alliance · doi:10.26508/lsa.202201371 · Cited by 13
“However, transmembrane serine protease 2 (TMPRSS2), cathepsin L, and furin proteases required for SARS-CoV-2 spike protein cleavage and viral entry are also abundantly expressed in DTC (59, 60, 61).”
BackgroundAcute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis
Silva, B. M., Assis, L. C. S. D., Júnior, M. D. C. B., Gonzalez, N. A. P., Anjos, S. B. D., & Góes, M. Â. (2022) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2022-0013en · Cited by 13
“AKI is common among critically ill COVID-19 patients 17-20 , of which 20 to 40% are admitted to intensive care units (ICUs) 21,2 5 .”
BackgroundKato, Y., Nishiyama, K., Lee, J. M., Ibuki, Y., Imai, Y., Noda, T., Kamiya, N., Kusakabe, T., Kanda, Y., & Nishida, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010102 · Cited by 13
“The tropism of organs has been studied from autopsy specimens: SARS-CoV-2 genomic RNA was highest in the lungs, but the heart, kidney, and liver also showed substantial amounts [6].”
BackgroundKidney Biopsy Findings in Patients with SARS-CoV-2 Infection or After COVID-19 Vaccination
Noriega, M., Husain‐Syed, F., Wulf, S., Csala, B., Krebs, C. F., Jabs, W. J., Zipfel, P. F., Gröne, H., Wiech, T., & the CoV-Kidney Investigators (2023) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000000000106 · Cited by 13
“4) 3551 (2175 –22,970) 31 (11 to 31) Positive circulating immune complexes: 1 (20) None: 4 (80) Noninvasive ventilation, critical illness: 2 (40) Piperacillin/tazobactam therapy; rhabdomyolysis: 1 (20) Frequent preadmission NSAID use; piperacillintazobactam therapy: 1 (20) None: 1 (20) Cs for COVID-19: 2 (40) None: 3…”
Self-citationPlatelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia
Hirsch, J., Uzun, G., Zlamal, J., Singh, A., & Bakchoul, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186000 · Cited by 13
Rapid antigen tests for SARS-CoV-2—a synopsis of the medical evidence
Wertenauer, C., Pfeifer, C., Roskos, M., & März, W. (2023) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2023.116027 · Cited by 13
S1-Leitlinie: Neurologische Manifestationen bei COVID-19
Berlit, P. (2020) · DGNeurologie · doi:10.1007/s42451-020-00254-x · Cited by 15
Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections
Tripathi, S. C., Deshmukh, V. R., Creighton, C. J., & Patil, A. L. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.579422 · Cited by 13
Pathogenesis of coronavirus disease 2019-associated kidney injury
Smith, K. D., & Akilesh, S. (2021) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000708 · Cited by 13
“ISH reported negative in 4 of 4 cases [11], and positive by RT-PCR in one case [3].”
BackgroundNeuropathology of COVID‐19: where are the neuropathologists?
Glatzel, M. (2020) · Brain Pathology · doi:10.1111/bpa.12871 · Cited by 13
Self-citation
Metadata
- Authors
- Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., Braun, F., Lu, S., Pfefferle, S., Schröder, A. S., Edler, C., Gross, O., Glatzel, M., Wichmann, D., Wiech, T., Kluge, S., Pueschel, K., Aepfelbacher, M., & Huber, T. B.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Huber, Tobias B.
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-08-06
- Volume
- 383
- Issue
- 6
- Pages
- 590-592
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7240771
- OpenAlex
- W3024126428
- Cited by
- 1,775
- References
- 4
- Citations by year
- 2026: 26 · 2025: 73 · 2024: 138 · 2023: 214 · 2022: 338 · 2021: 595 · 2020: 390
- FWCI
- 50.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- SARS-CoV-2, COVID-19 pandemic, kidney, heart, liver, brain, autopsy findings, viral tissue distribution
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Autopsy, Brain, Female, Heart, Humans, Kidney, Liver, Lung, Male, Middle Aged, Pharynx, Pneumonia, Viral, Coronavirus Infections, Viral Load, Viral Tropism, Pandemics
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