Cited by 1,775COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19

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Multiorgan and Renal Tropism of SARS-CoV-2

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Puelles, Victor G., Lütgehetmann, Marc, Lindenmeyer, Maja T., Sperhake, Jan P., Wong, Milagros N., Allweiss, Lena, Chilla, Silvia, Heinemann, Axel, Wanner, Nicola, Liu, Shuya, Braun, Fabian, Lu, Shun, Pfefferle, Susanne, Schröder, Ann S., Edler, Carolin, Gross, Oliver, Glatzel, Markus, Wichmann, Dominic, Wiech, Thorsten, Kluge, Stefan, Pueschel, Klaus, Aepfelbacher, Martin, Huber, Tobias B.·2020·New England Journal of Medicine

DOI 10.1056/nejmc2011400PMC PMC7240771

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Multiorgan and Renal Tropism of SARS-CoV-2 In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...

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Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology
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Background
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Background
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Background
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Background
Livedo reticularis as a presenting sign of severe acute respiratory syndrome coronavirus 2 infection
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“and cell types, including lung, gut, kidney, and brain.(14,15) There is increasing suspicion for direct endothelial cell infection by SARS-CoV-2,(16) and one study has observed SARS-CoV-2 spike protein directly within the endothelial cell cytoplasm in COVID-19eassociated chilblains lesions.”
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“In line with this, SARS-CoV-2 was detected in some, but not all, autopsy liver samples of COVID-19patients (5).”
Result
Acute Kidney Injury is Associated with Worse Prognosis In COVID-19 Patients: A Systematic Review and Meta-analysis.
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“, [35] recently demonstrated that the RNA for angiotensin-converting enzyme 2 (ACE2), the receptor that is considered to facilitate SARS-CoV-2 infection is enriched in multiple kidney-cell types from fetal development through adulthood [35].”
BackgroundResult
Higher prevalence of pulmonary macrothrombi in SARS‐CoV ‐2 than in influenza A: autopsy results from ‘Spanish flu’ 1918/1919 in Switzerland to Coronavirus disease 2019
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“Endothelial cells play a central role in the vascular phase of COVID-19 [14,34,35].”
Background
Role of serum albumin and proteinuria in patients with SARS‐CoV‐2 pneumonia
Bassoli, C. R., Oreni, L. M., Ballone, E., Foschi, A., Perotti, A., Mainini, A., Casalini, G., Galimberti, L., Meroni, L., Antinori, S., et al. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13946 · Cited by 29
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“the isolation of SARS-CoV-2 RNA from kidney glomeruli.(2,4) However, published in situ hybridization”
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“These results are consistent with previous observations [54].”
Result

Authors: Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., Braun, F., Lu, S., Pfefferle, S., Schröder, A. S., Edler, C., Gross, O., Glatzel, M., Wichmann, D., Wiech, T., Kluge, S., Pueschel, K., Aepfelbacher, M., & Huber, T. B.
Affiliations: University Medical Center Hamburg-Eppendorf (DE)
Universitätsmedizin Göttingen (DE)
Corresponding author: Huber, Tobias B.
ORCID: Puelles, Victor G.
Lütgehetmann, Marc
Lindenmeyer, Maja T.
Wong, Milagros N.
Allweiss, Lena
Wanner, Nicola
Liu, Shuya
Braun, Fabian
Lu, Shun
Pfefferle, Susanne
Edler, Carolin
Gross, Oliver
Glatzel, Markus
Wichmann, Dominic
Wiech, Thorsten
Kluge, Stefan
Aepfelbacher, Martin
Huber, Tobias B.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2020-08-06
Volume: 383
Issue: 6
Pages: 590-592
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmc2011400
PMC: PMC7240771
OpenAlex: W3024126428
Cited by: 1,775
References: 4
Citations by year: 2026: 26 · 2025: 73 · 2024: 138 · 2023: 214 · 2022: 338 · 2021: 595 · 2020: 390
FWCI: 50.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: New England Journal of Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords: SARS-CoV-2, COVID-19 pandemic, kidney, heart, liver, brain, autopsy findings, viral tissue distribution
MeSH terms: Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Autopsy, Brain, Female, Heart, Humans, Kidney, Liver, Lung, Male, Middle Aged, Pharynx, Pneumonia, Viral, Coronavirus Infections, Viral Load, Viral Tropism, Pandemics

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Multiorgan and Renal Tropism of SARS-CoV-2

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