The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Multiorgan and Renal Tropism of SARS-CoV-2
Open accessAbstract
Multiorgan and Renal Tropism of SARS-CoV-2 In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The finding of coronavirus RNA in brain tissue of deceased patients raised the possibility of a direct brain injury mechanism [153].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [153]
In the citing paper
“a study detected SARS-CoV-2 in 8 of 21 postmortem brain tissues, based on reverse transcriptase polymerase chain reaction [25].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [25]
In the citing paper
“In addition, human CSF samples have failed thus far to reveal CoV-2 RNA (73, 77), and autopsies from human patients have found that the brain contains the lowest levels of CoV-2 across organs sampled (78).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [78]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Zou, L., Ruan, F., Huang, M.-X., Liang, L.-J., Huang, H., Hong, Z.-S., Yu, J.-X., Kang, M., Song, Y.-C., Xia, J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001737 · Cited by 4,590
HCA Lung Biological Network, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0868-6 · Cited by 2,501
Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China
Su, H., Yang, M., Wan, C., Yi, L.-X., Tang, F., Zhu, H.-Y., Yi, F., Yang, H.-C., Fogo, A. B., Nie, X., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.04.003 · Cited by 1,763
Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia
Pei, G., Zhang, Z., Peng, J., Liu, L., Zhang, C., Yu, C., Ma, Z., Huang, Y., Liu, W., Yao, Y., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020030276 · Cited by 777
Flagged first, then by citations
Cited by
Sorted by citations
Extrapulmonary manifestations of COVID-19
Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0968-3 · Cited by 3,185
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
Cantuti-Castelvetri, L., Ojha, R., Pedro, L. D., Djannatian, M., Franz, J., Kuivanen, S., van der Meer, F., Kallio, K., Kaya, T., Anastasina, M., et al. (2020) · Science · doi:10.1126/science.abd2985 · Cited by 1,925
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud, G., Lee, S., Alfaro-Almagro, F., Arthofer, C., Wang, C., McCarthy, P., Lange, F., Andersson, J. L. R., Griffanti, L., Duff, E., et al. (2022) · Nature · doi:10.1038/s41586-022-04569-5 · Cited by 1,646
Meinhardt, J., Radke, J., Dittmayer, C., Franz, J., Thomas, C., Mothes, R., Laue, M., Schneider, J., Brünink, S., Greuel, S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00758-5 · Cited by 1,458
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
Nishiga, M., Wang, D. W., Han, Y., Lewis, D. B., & Wu, J. C. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0413-9 · Cited by 1,436
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
Matschke, J., Lütgehetmann, M., Hagel, C., Sperhake, J. P., Schröder, A. S., Edler, C., Mushumba, H., Fitzek, A., Allweiss, L., Dandri, M., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30308-2 · Cited by 1,300
Self-citationBrann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Van den Berge, K., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5801 · Cited by 1,198
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., et al. (2020) · doi:10.1101/2020.06.25.169946 · Cited by 1,064
Immunological considerations for COVID-19 vaccine strategies
Jeyanathan, M., Afkhami, S., Smaill, F., Miller, M. S., Lichty, B. D., & Xing, Z. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-00434-6 · Cited by 1,015
Aging in COVID-19: Vulnerability, immunity and intervention
Chen, Y., Klein, S. L., Garibaldi, B. T., Li, H., Wu, C., Osevala, N. M., Li, T., Margolick, J. B., Pawelec, G., & Leng, S. X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101205 · Cited by 1,007
“While SARS-CoV-2 has been characterized regarding its neurotrophic and neuroinvasive properties (Baig et al., 2020; Puelles et al., 2020), inflammatory cytokine release and immunopathology caused by this”
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
Stein, S. R., Ramelli, S. C., Grazioli, A., Chung, J., Singh, M., Yinda, C. K., Winkler, C. W., Sun, J., Dickey, J. M., Ylaya, K., et al. (2022) · Nature · doi:10.1038/s41586-022-05542-y · Cited by 1,001
Lamers, M. M., & Haagmans, B. L. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00713-0 · Cited by 1,066
Koehler, P. A., Bassetti, M., Chakrabarti, A., Chen, S. C. ‐., Colombo, A. L., Hoenigl, M., Климко, Н. Н., Lass‐Flörl, C., Oladele, R. O., Vinh, D. C., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30847-1 · Cited by 956
Beyerstedt, S., Casaro, E. B., & Rangel, É. B. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-04138-6 · Cited by 897
“Pre-existing comorbidities may also be directly associated to higher rates of SARS-CoV-2 organ tropism, as demonstrated in post-mortem analyses of the lungs, pharynx, kidneys, liver, and heart [35].”
BackgroundMethodSARS-CoV-2 viral load is associated with increased disease severity and mortality
Fajnzylber, J. M., Regan, J., Coxen, K., Corry, H., Wong, C., Rosenthal, A., Worrall, D. P., Giguel, F. F., Trocha, A. K., Atyeo, C. G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19057-5 · Cited by 903
Proal, A. D., & VanElzakker, M. B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.698169 · Cited by 921
Leisman, D. E., Ronner, L., Pinotti, R., Taylor, M. D., Sinha, P., Calfee, C. S., Hirayama, A. V. V., Mastroianni, F., Turtle, C. J., Harhay, M. O., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30404-5 · Cited by 874
Myocarditis With COVID-19 mRNA Vaccines
Bozkurt, B., Kamat, I., & Hotez, P. J. (2021) · Circulation · doi:10.1161/circulationaha.121.056135 · Cited by 859
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
Delorey, T. M., Ziegler, C. G. K., Heimberg, G., Normand, R., Yang, Y., Segerstolpe, Å., Abbondanza, D., Fleming, S. J., Subramanian, A., Montoro, D. T., et al. (2021) · Nature · doi:10.1038/s41586-021-03570-8 · Cited by 827
Karagiannidis, C., Mostert, C., Hentschker, C., Voshaar, T., Malzahn, J., Schillinger, G., Klauber, J., Janssens, U., Marx, G., Weber‐Carstens, S., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30316-7 · Cited by 792
Self-citationHalpin, D. M. G., Criner, G. J., Papi, A. A., Singh, D., Anzueto, A., Martínez, F. J., Agusti, A. A., & Vogelmeier, C. F. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202009-3533so · Cited by 793
“Compared with lung viral load, lower levels of SARS-CoV-2 have been reported in the kidneys, liver, heart, and brain (122), suggesting secondary rather”
BackgroundNadim, M. K., Forni, L. G., Mehta, R. L., Connor, M. J., Jr., Liu, K. D., Ostermann, M., Rimmele, T. R., Zarbock, A., Bell, S., Bihorac, A., et al. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00356-5 · Cited by 701
A molecular single-cell lung atlas of lethal COVID-19
Melms, J. C., Biermann, J., Huang, H., Wang, Y., Nair, A., Tagore, S., Katsyv, I., Rendeiro, A. F., Amin, A. D., Schapiro, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03569-1 · Cited by 685
Dysregulation of brain and choroid plexus cell types in severe COVID-19
Yang, A. C., Kern, F., Losada, P. M., Agam, M. R., Maat, C. A., Schmartz, G. P., Fehlmann, T., Stein, J. A., Schaum, N., Lee, D. P., et al. (2021) · Nature · doi:10.1038/s41586-021-03710-0 · Cited by 620
The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections
Machhi, J., Herskovitz, J., Senan, A. M., Dutta, D., Nath, B., Oleynikov, M. D., Blomberg, W. R., Meigs, D. D., Hasan, M., Patel, M., et al. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09944-5 · Cited by 642
“SARS-CoV-2 is known to infect podocytes and tubular epithelial cells, which could further contribute to renal abnormalities (Martinez-Rojas et al. 2020; Puelles et al. 2020).”
Backgroundβ-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway
Ghosh, S., Dellibovi-Ragheb, T. A., Kerviel, A., Pak, E., Qiu, Q., Fisher, M., Takvorian, P. M., Bleck, C. K. E., Hsu, V. W., Fehr, A. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.039 · Cited by 628
“The ability of these viruses to infect many different cell types, including those of the pulmonary, cardiovascular, hepatic, gastrointestinal, central nervous, and immune systems, results in complex multi-organ disease manifestations that can vary from individual to individual (Puelles et al., 2020; Ziegler et al., 20…”
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
Perico, L., Benigni, A., Casiraghi, F., Ng, L. F. P., Rénia, L., & Remuzzi, G. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00357-4 · Cited by 616
Raman, B., Cassar, M. P., Tunnicliffe, E. M., Filippini, N., Griffanti, L., Alfaro‐Almagro, F., Okell, T. W., Sheerin, F., Xie, C., Mahmod, M., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100683 · Cited by 625
“[5] An exaggerated and dysregulated immune response, endothelial damage, thromboinflammation and coagulopathy have also been implicated in causing injury to these organs.”
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
Chen, R., Wang, K., Yu, J., Howard, D., French, L., Chen, Z., Wen, C., & Xu, Z. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.573095 · Cited by 570
“found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, liver, heart, and brain (5).”
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
Müller, J. A., Groß, R. M., Conzelmann, C., Krüger, J., Merle, U., Steinhart, J., Weil, T., Koepke, L., Bozzo, C. P., Read, C., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00347-1 · Cited by 564
Pellegrini, L., Albecka, A., Mallery, D. L., Kellner, M. J., Paul, D., Carter, A. P., James, L. C., & Lancaster, M. A. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.10.001 · Cited by 562
Acute kidney injury in critically ill patients with COVID-19
Gabarre, P., Dumas, G., Dupont, T., Darmon, M., Azoulay, É., & Zafrani, L. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06153-9 · Cited by 541
“Interestingly, multiple underlying conditions were associated with SARS-CoV-2 kidney tropism [30].”
BackgroundSARS‐CoV‐2 targets neurons of 3D human brain organoids
Ramani, A., Müller, L., Ostermann, P. N., Gabriel, E., Abida‐Islam, P., Müller‐Schiffmann, A., Mariappan, A., Goureau, O., Gruell, H., Walker, A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020106230 · Cited by 518
“It is indeed intriguing that even a low level of ACE-2 is sufficient for the viral entry, and this could explain why SARS-CoV-2 has a broad spectrum of target organs and cell types (Puelles et al , 2020).”
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
Osuchowski, M. F., Winkler, M. S., Skirecki, T., Cajander, S., Shankar‐Hari, M., Lachmann, G., Monneret, G., Venet, F., Bauer, M. W., Brunkhorst, F. M., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00218-6 · Cited by 528
Schurink, B., Roos, E., Radonic, T., Barbé, E., Bouman, C. S. C., de Boer, H. H., de Bree, G. J., Bulle, E., Aronica, E., Florquin, S., et al. (2020) · The Lancet Microbe · doi:10.1016/s2666-5247(20)30144-0 · Cited by 517
Organ-specific manifestations of COVID-19 infection
Gavriatopoulou, M., Korompoki, E., Fotiou, D., Ntanasis‐Stathopoulos, I., Ψαλτοπούλου, Θ., Kastritis, E., Terpos, E., & Dimopoulos, M. A. (2020) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00648-x · Cited by 501
“This enrichment may explain the relevant affinity that induces SARS-CoV-2 kidney injury [3].”
BackgroundMethodde Melo, G. D., Lazarini, F., Levallois, S., Hautefort, C., Michel, V., Larrous, F., Vérillaud, B., Aparicio, C., Wagner, S., Gheusi, G., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf8396 · Cited by 516
Wang, S., Qiu, Z., Hou, Y., Deng, X., Xu, W., Zheng, T., Wu, P., Xie, S., Bian, W., Zhang, C., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00460-y · Cited by 497
Pathophysiology of COVID-19-associated acute kidney injury
Legrand, M. M., Bell, S., Forni, L. G., Joannidis, M., Koyner, J. L., Liu, K. D., & Cantaluppi, V. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00452-0 · Cited by 527
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19
Stefan, N., Birkenfeld, A. L., & Schulze, M. B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00462-1 · Cited by 452
Lifting the mask on neurological manifestations of COVID-19
Pezzini, A., & Padovani, A. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0398-3 · Cited by 447
COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation
Miesbach, W., & Makris, M. (2020) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029620938149 · Cited by 456
“In another case series of 27 autopsies, SARS-CoV-2 was detected in the endothelial cells of several organs, with the highest concentrations found in the respiratory tract and lower concentrations in the kidneys, liver, heart, brain, and blood.(42) Therefore, tissues beyond the respiratory tract may be affected, which…”
BackgroundJacob, F., Pather, S. R., Huang, W., Zhang, F., Wong, S. Z. H., Zhou, H., Cubitt, B., Fan, W., Chen, C. Z., Xu, M., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.09.016 · Cited by 443
“A substantial portion of patients with COVID-19 exhibit various neurological symptoms, which are highly variable, probably due to many factors (Helms et al., 2020; Moriguchi et al., 2020; Puelles et al., 2020; Solomon et al., 2020; Virani et al., 2020).”
COVID-19-associated coagulopathy and disseminated intravascular coagulation
Asakura, H., & Ogawa, H. (2020) · International Journal of Hematology · doi:10.1007/s12185-020-03029-y · Cited by 452
“The site of SARS-CoV-2 has been examined at autopsy [34].”
BackgroundCardiac Troponin for Assessment of Myocardial Injury in COVID-19
Sandoval, Y. B., Januzzi, J. L., & Jaffe, A. S. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.06.068 · Cited by 447
“Although SARS-CoV-2 appears to have renal tropism (28) and COVID-19 patients with increased cTn concentrations have higher rates of kidney injury (5), it is important to note that at high concentrations, cTn is mainly cleared through extrarenal mechanisms (29).”
Evans, P. C., Rainger, G. E., Mason, J. C., Guzik, T. J., Osto, E., Stamataki, Z., Neil, D., Hoefer, I. E., Fragiadaki, M., Waltenberger, J. L., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa230 · Cited by 446
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein
Toelzer, C., Gupta, K., Yadav, S. K. N., Borucu, U., Davidson, A. D., Williamson, M. K., Shoemark, D. K., Garzoni, F., Staufer, O., Milligan, R., et al. (2020) · Science · doi:10.1126/science.abd3255 · Cited by 427
Edler, C., Schröder, A. S., Aepfelbacher, M., Fitzek, A., Heinemann, A., Heinrich, F., Klein, A., Langenwalder, F., Lütgehetmann, M., Meißner, K., et al. (2020) · International Journal of Legal Medicine · doi:10.1007/s00414-020-02317-w · Cited by 425
Self-citationSARS-CoV-2 viral load and shedding kinetics
Puhach, O., Meyer, B., & Eckerle, I. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00822-w · Cited by 462
COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment
Arastehfar, A. A., Carvalho, A., van de Veerdonk, F. L., Jenks, J. D., Koehler, P. A., Krause, R., Cornely, O. A., Perlin, D. S., Lass‐Flörl, C., & Hoenigl, M. (2020) · Journal of Fungi · doi:10.3390/jof6020091 · Cited by 429
“This concern is particularly relevant for patients infected by SARS-CoV-2 which has shown renal tropism and been described as a frequent cause of kidney injury [87].”
BackgroundMagleby, R., Westblade, L. F., Trzebucki, A. M., Simon, M. S., Rajan, M., Park, J. C., Goyal, P., Safford, M. M., & Satlin, M. J. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa851 · Cited by 429
“A recent autopsy study demonstrated that SARS-CoV-2 frequently directly infects both the heart and kidney [27] and that kidney injury and myocardial injury are commonly re-ported complications of severe COVID-19 [28, 29].”
Kidney Biopsy Findings in Patients with COVID-19
Kudose, S., Batal, I., Santoriello, D., Xu, K. H., Barasch, J. M., Peleg, Y. A., Canetta, P. A., Ratner, L. E., Marasà, M., Gharavi, A. G., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020060802 · Cited by 418
Painter, W., Holman, W., Bush, J. A., Almazedi, F., Malik, H., Eraut, N. C. J. E., Morin, M. J., Szewczyk, L. J., & Painter, G. R. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02428-20 · Cited by 401
Pathophysiological mechanisms of liver injury in COVID‐19
Nardo, A. D., Schneeweiss‐Gleixner, M., Bakail, M., Dixon, E. D., Lax, S., & Trauner, M. (2020) · Liver International · doi:10.1111/liv.14730 · Cited by 400
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital
Thakur, K. T., Miller, E. H., Glendinning, M. D., Al‐Dalahmah, O., Banu, M. A., Boehme, A. K., Boubour, A., Bruce, S. S., Chong, A. M., Claassen, J., et al. (2021) · Brain · doi:10.1093/brain/awab148 · Cited by 396
Hoffmann, M., Hofmann-Winkler, H., Smith, J. C., Krüger, N., Arora, P., Sørensen, L. K., Søgaard, O. S., Hasselstrøm, J. B., Winkler, M., Hempel, T., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103255 · Cited by 397
“A recent study provided evidence for extrapulmonary replication of SARS-CoV-2 in liver, colon, heart, kidney and blood in some patients [17].”
The complement system in COVID-19: friend and foe?
Java, A., Apicelli, A. J., Liszewski, M. K., Coler-Reilly, A. L. G., Atkinson, J. P., Kim, A. H. J., & Kulkarni, H. S. (2020) · JCI Insight · doi:10.1172/jci.insight.140711 · Cited by 392
“This may be a result of the broad organ tropism of SARS-CoV-2 (46) and resultant damage induced by both the virus and the immune response to it, which is especially true in the lung.”
BackgroundAKI in Hospitalized Patients with and without COVID-19: A Comparison Study
Fisher, M. C., Neugarten, J., Bellin, E. Y., Yunes, M., Stahl, L., Johns, T. S., Abramowitz, M. K., Levy, R. V., Kumar, N., Mokrzycki, M. H., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020040509 · Cited by 376
Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA
Ortíz, A., Cozzolino, M. G., Fliser, D., Fouque, D. P., Goumenos, D. S., Massy, Z. A., Rosenkranz, A. R., Rychlík, I., Soler, M. J., Stevens, K., et al. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa314 · Cited by 370
“These data also indicate that SARS-CoV-2 has multiorgan tropism that includes glomerular and, as was later shown, tubular cells [28, 29].”
ResultSARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment
Wu, C.-T., Lidsky, P. V., Xiao, Y., Lee, I. T., Cheng, R., Nakayama, T., Jiang, S., Demeter, J., Bevacqua, R. J., Chang, C., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.013 · Cited by 385
COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings
Sharma, P., Uppal, N. N., Wanchoo, R., Shah, H. H., Yang, Y., Parikh, R., Khanin, Y., Madireddy, V., Larsen, C. P., Jhaveri, K. D., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020050699 · Cited by 368
Goldman, I. A., Ye, K. Q., & Scheinfeld, M. H. (2020) · Radiology · doi:10.1148/radiol.2020202348 · Cited by 384
Neurological Involvement in COVID-19 and Potential Mechanisms: A Review
Aghagoli, G., Gallo Marin, B., Katchur, N. J., Chaves-Sell, F., Asaad, W. F., & Murphy, S. A. (2021) · Neurocritical Care · doi:10.1007/s12028-020-01049-4 · Cited by 357
“This report has been followed by a second, identifying and quantifying SARS-CoV-2 virus in brain tissue samples from 8 of 22 patients (36%) who died from COVID-19 infection [12], more firmly establishing COVID-19’s neurotropic potential.”
MethodLessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic
To, K. K., Sridhar, S., Chiu, K. H., Hung, D. L. L., Li, X., Hung, I. F., Tam, A. R., Chung, T. W., Chan, J. F., Zhang, J., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1898291 · Cited by 359
“Multiple microscopic ischaemic infarct with or without antigen expression at endothelium [174-179]”
BackgroundCOVID-19, immunothrombosis and venous thromboembolism: biological mechanisms
Loo, J., Spittle, D. A., & Newnham, M. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-216243 · Cited by 346
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.032 · Cited by 341
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00653-w · Cited by 364
Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., von Wenserski, L., Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.024 · Cited by 329
Schwabenland, M., Salié, H., Tanevski, J., Killmer, S., Lago, M. S., Schlaak, A. E., Mayer, L., Matschke, J., Püschel, K., Fitzek, A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.06.002 · Cited by 326
Self-citationRoles of flavonoids against coronavirus infection
Russo, M., Moccia, S., Spagnuolo, C., Tedesco, I., & Russo, G. L. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109211 · Cited by 330
“Here, SARS-CoV-2 can target different tissues at multiple levels, starting from the cells of nose and throat down to the lung, invading, perhaps, through vasal endothelium, kidneys and nervous system where it can cause severe illness and death [4,5].”
BackgroundTissue-Specific Immunopathology in Fatal COVID-19
Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., Millar, T., Lerpiniere, C. E. B., Tagliavini, G., Hartley, C. S., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202008-3265oc · Cited by 321
“Although COVID-19 is principally thought of as a pulmonary disease, increasing evidence shows that SARS-CoV-2 also has extrapulmonary tissue tropism (16) and that dysfunction of multiple organs occurs in COVID-19 (17).”
BackgroundWalsh, C., Tafforeau, P., Wagner, W. L., Jafree, D. J., Bellier, A., Werlein, C., Kühnel, M., Boller, E., Walker‐Samuel, S., Robertus, J. L., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01317-x · Cited by 332
SARS-CoV-2 infects human neural progenitor cells and brain organoids
Zhang, B., Chu, H., Han, S., Shuai, H., Deng, J. M., Hu, Y., Gong, H., Lee, A. C.-Y., Zou, Z., Yau, T. C. C., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0390-x · Cited by 322
Lessons for COVID-19 immunity from other coronavirus infections
Sariol, A., & Perlman, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.005 · Cited by 317
Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
Sharma, A., Garcia, G., Wang, Y., Plummer, J., Morizono, K., Arumugaswami, V., & Svendsen, C. N. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100052 · Cited by 313
“(legend continued on next page) 2 Cell Reports Medicine 1, 100052, July 21, 2020 infection and resulting fulminant myocarditis.11–13 A recent multiorgan autopsy study of COVID-19 patients detected SARSCoV-2 viral RNA in the heart via PCR.14 However, the gold standard for confirming SARS-CoV-2 localization in CMs is en…”
InfluentialAutoinflammatory and autoimmune conditions at the crossroad of COVID-19
Rodríguez, Y., Novelli, L., Rojas, M., Santis, M. D., Acosta‐Ampudia, Y., Monsalve, D. M., Ramírez-Santana, C., Costanzo, A., Ridgway, W. M., Ansari, A. A., et al. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102506 · Cited by 319
Postmortem Kidney Pathology Findings in Patients with COVID-19
Santoriello, D., Khairallah, P., Bomback, A. S., Xu, K. H., Kudose, S., Batal, I., Barasch, J. M., Radhakrishnan, J., D’Agati, V. D., & Markowitz, G. S. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020050744 · Cited by 321
SARS-CoV-2 renal tropism associates with acute kidney injury
Braun, F., Lütgehetmann, M., Pfefferle, S., Wong, M. N., Carsten, A., Lindenmeyer, M. T., Nörz, D. S., Heinrich, F., Meißner, K., Wichmann, D., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31759-1 · Cited by 308
Self-citationCytokine Storm—Definition, Causes, and Implications
Jarczak, D., & Nierhaus, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911740 · Cited by 336
Calabrese, F., Pezzuto, F., Fortarezza, F., Hofman, P. M., Kern, I., Panizo, Á., von der Thüsen, J. H., Timofeev, S., Gorkiewicz, G., & Lunardi, F. (2020) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02886-6 · Cited by 311
“A few authors have quantified viral load in several types of tissues, finding lower levels of SARS-CoV-2 in the kidneys, liver, heart, and brain [74], thus supporting secondary rather than primary involvement.”
BackgroundPatients with COVID-19: in the dark-NETs of neutrophils
Ackermann, M., Anders, H., Bilyy, R. O., Bowlin, G. L., Daniel, C., LORENZO, R. D., Egeblad, M., Henneck, T., Hidalgo, A., Hoffmann, M. H., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00805-z · Cited by 312
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice
Kumari, P., Rothan, H. A., Natekar, J. P., Stone, S., Pathak, H., Strate, P. G., Arora, K., Brinton, M. A., & Kumar, M. (2021) · Viruses · doi:10.3390/v13010132 · Cited by 289
“Several human autopsy reports have documented the presence of SARS-CoV-2 RNA in brain tissues [16,17].”
BackgroundZhang, L., Zhou, L., Bao, L., Liu, J., Zhu, H., Lv, Q., Liu, R., Chen, W., Tong, W., Wei, Q., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00719-9 · Cited by 302
“Huber and colleagues detected SARS-CoV-2 RNA in multiple organs, including post-mortem brain tissue of patients with COVID19.”
BackgroundA systematic review of neurological symptoms and complications of COVID-19
Chen, X., Laurent, S. A., Onur, O. A., Kleineberg, N. N., Fink, G. R., Schweitzer, F., & Warnke, C. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10067-3 · Cited by 314
A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City
Frontera, J. A., Sabadia, S. B., Lalchan, R., Fang, T., Flusty, B., Vernetti, P. M., Snyder, T. E., Berger, S. L., Yang, D., Granger, A., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010979 · Cited by 288
“Acute renal failure 167/606 (28) 479/3,885 (12) <0.”
Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis
Ramasamy, S., & Subbian, S. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00299-20 · Cited by 307
“spleen, intestine, brain, and blood (54, 55).”
AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL 1 High-Risk Genotype
Wu, H., Larsen, C. P., Hernandez-Arroyo, C. F., Mohamed, M. M. B., Caza, T. N., Sharshir, M. A., Chughtai, A., Xie, L., Gimenez, J. M., Sandow, T. A., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020050558 · Cited by 283
Trougakos, I. P., Stamatelopoulos, K. S., Terpos, E., Tsitsilonis, O., Aivalioti, E., Paraskevis, D. N., Kastritis, E., Pavlakis, G. N., & Dimopoulos, M. A. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-020-00703-5 · Cited by 305
“heart, liver, brain, and kidneys further supporting the broad organotropism of the virus [31, 32].”
BackgroundSARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Jansen, J., Reimer, K. C., Nagai, J. S., Varghese, F. S., Overheul, G. J., de Beer, M., Roverts, R., Daviran, D., Fermin, L. A. S., Willemsen, B., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2021.12.010 · Cited by 259
Self-citationSARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes
Bojkova, D., Wagner, J. U. G., Shumliakivska, M., Aslan, G. S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M. D., Krishnan, J., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa267 · Cited by 257
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19
Zipeto, D., Palmeira, J. D. F., Argañaraz, G. A., & Argañaraz, E. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576745 · Cited by 269
“ACE2, TMPRSS2, and cathepsin L are highly expressed and active in the kidney (89, 90).”
BackgroundHigh-Flow Nasal Cannula in Critically III Patients with Severe COVID-19
Demoule, A., Vieillard‐Baron, A., Darmon, M., Beurton, A., Géri, G., Voiriot, G., Dupont, T., Zafrani, L., Girodias, L., Labbé, V., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202005-2007le · Cited by 256
“Moreover, the proportion of pulmonary embolism and acute kidney and myocardial injury are reported in much higher proportions than in typical acute respiratory distress syndrome (9).”
BackgroundWenzel, J., Lampe, J., Müller‐Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00926-1 · Cited by 259
“6, 7).”
Self-citationA Single-Cell RNA Expression Map of Human Coronavirus Entry Factors
Singh, M., Bansal, V., & Feschotte, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108175 · Cited by 241
Gaziano, L., Giambartolomei, C., Pereira, A. C., Gaulton, A., Posner, D. C., Swanson, S. A., Ho, Y.-L. A., Iyengar, S. K., Kosik, N., Vujković, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01310-z · Cited by 231
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
Ramakrishnan, R. K., Kashour, T., Hamid, Q. A., Halwani, R., & Tleyjeh, I. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686029 · Cited by 246
“This widespread damage in turn can be due to the wide distribution pattern of ACE2 (33), the cellular entry receptor for”
BackgroundInfluentialFrere, J. J., Serafini, R. A., Pryce, K. D., Zazhytska, M., Oishi, K., Golynker, I., Panis, M., Zimering, J. H., Horiuchi, S., Hoagland, D. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq3059 · Cited by 239
“These findings are consistent with reports of human patients displaying SARS-CoV-2 RNAemia and systemic detection of SARS-CoV-2 RNA that could reflect deposition of viral-derived inflammatory material (26, 55).”
ResultSARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule
Wérion, A., Belkhir, L., Perrot, M., Schmit, G., Aydın, S., Chen, Z., Penaloza, A., Greef, J. D., Yıldız, H., Pothen, L., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.07.019 · Cited by 233
Identifying who has long COVID in the USA: a machine learning approach using N3C data
Pfaff, E., Girvin, A. T., Bennett, T. D., Bhatia, A., Brooks, I. M., Deer, R., Dekermanjian, J., Jolley, S. E., Kahn, M. G., Kostka, K., et al. (2022) · The Lancet Digital Health · doi:10.1016/s2589-7500(22)00048-6 · Cited by 223
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
Krasemann, S., Haferkamp, U., Pfefferle, S., Woo, M. S., Heinrich, F., Schweizer, M., Appelt‐Menzel, A., Cubukova, A., Barenberg, J., Leu, J., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.011 · Cited by 232
“307 C BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). and findings remain controversial (Matschke et al., 2020; Meinhardt et al., 2021; Puelles et al., 2020; Song et al., 2021).”
InfluentialSelf-citation
Metadata
- Authors
- Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., Braun, F., Lu, S., Pfefferle, S., Schröder, A. S., Edler, C., Gross, O., Glatzel, M., Wichmann, D., Wiech, T., Kluge, S., Pueschel, K., Aepfelbacher, M., & Huber, T. B.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Huber, Tobias B.
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-08-06
- Volume
- 383
- Issue
- 6
- Pages
- 590-592
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7240771
- OpenAlex
- W3024126428
- Cited by
- 1,775
- References
- 4
- Citations by year
- 2026: 26 · 2025: 73 · 2024: 138 · 2023: 214 · 2022: 338 · 2021: 595 · 2020: 390
- FWCI
- 50.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- SARS-CoV-2, COVID-19 pandemic, kidney, heart, liver, brain, autopsy findings, viral tissue distribution
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, Autopsy, Brain, Female, Heart, Humans, Kidney, Liver, Lung, Male, Middle Aged, Pharynx, Pneumonia, Viral, Coronavirus Infections, Viral Load, Viral Tropism, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
