The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Inflammatory cortical demyelination in early multiple sclerosis.
Open accessAbstract
BACKGROUND: Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonance imaging studies indicate that cortical damage occurs early in the disease. METHODS: We evaluated the prevalence and character of demyelinating cortical lesions in patients with multiple sclerosis. Cortical tissues were obtained in passing during biopsy sampling of white-matter lesions. In most cases, biopsy was done with the use of stereotactic procedures to diagnose suspected tumors. Patients with sufficient cortex (138 of 563 patients screened) were evaluated for cortical demyelination. Using immunohistochemistry, we characterized cortical lesions with respect to demyelinating activity, inflammatory infiltrates, the presence of meningeal inflammation, and a topographic association between cortical demyelination and meningeal inflammation. Diagnoses were ascertained in a subgroup of 77 patients (56%) at the last follow-up visit (at a median of 3.5 years). RESULTS: Cortical demyelination was present in 53 patients (38%) (104 lesions and 222 tissue blocks) and was absent in 85 patients (121 tissue blocks). Twenty-five patients with cortical demyelination had definite multiple sclerosis (81% of 31 patients who underwent long-term follow-up), as did 33 patients without cortical demyelination (72% of 46 patients who underwent long-term follow-up). In representative tissues, 58 of 71 lesions (82%) showed CD3+ T-cell infiltrates, and 32 of 78 lesions (41%) showed macrophage-associated demyelination. Meningeal inflammation was topographically associated with cortical demyelination in patients who had sufficient meningeal tissue for study. CONCLUSIONS: In this cohort of patients with early-stage multiple sclerosis, cortical demyelinating lesions were frequent, inflammatory, and strongly associated with meningeal inflammation. (Funded by the National Multiple Sclerosis Society and the National Institutes of Health.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“This may well reflect the greater microglia and astrocyte activity in the white matter; pure cortical lesions in post-mortem tissues show little or no inflammation (Bo et al., 2004; Brink et al., 2005; van Horssen et al., 2007), although early lesions have been associated with prominent microglial activation (Lucchinetti et al., 2011).”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Lucchinetti et al., 2011
In the citing paper
“Biopsies taken from early MS patients with cortical demyelination were more likely to have leptomeningeal inflammation, consisting of effector T cells and IgA B cells infiltrates, than those without cortical demyelination.”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Lucchinetti et al., 2011
In the citing paper
“The leptomeninges are now recognized as a key player in multiple sclerosis (MS), an inflammatory CNS autoimmune disorder characterized by axon demyelination”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Lucchinetti et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Revised diagnostic criteria for neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Neurology · doi:10.1212/01.wnl.0000216139.44259.74 · Cited by 2,568
Self-citationCortical demyelination and diffuse white matter injury in multiple sclerosis
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836
Self-citationMagliozzi, R., Howell, O. W., Vora, A., Serafini, B., Nicholas, R. S., Puopolo, M., Reynolds, R., & Aloisi, F. (2006) · Brain · doi:10.1093/brain/awm038 · Cited by 1,486
Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403
Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E., & Aloisi, F. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00049.x · Cited by 1,208
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206
Cortical lesions in multiple sclerosis
Kidd, D., Barkhof, F., McConnell, R., Algra, P. R., Allen, I. V., & Revesz, T. (1999) · Brain · doi:10.1093/brain/122.1.17 · Cited by 766
Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis Patients
Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D., & Mørk, S. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.7.723 · Cited by 757
Research works printed but not linked: 1
- Tardif CL, 2010, Med Image Comput Assist Interv, 13, 181
Cited by
Sorted by citations
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Self-citationNeurofilaments as biomarkers in neurological disorders
Khalil, M., Teunissen, C. E., Otto, M., Piehl, F., Sormani, M. P., Gattringer, T., Barro, C., Kappos, L., Comabella, M., Fazekas, F., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0058-z · Cited by 1,988
How neuroinflammation contributes to neurodegeneration
Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967
Self-citationDiagnosis and Treatment of Multiple Sclerosis: A Review
McGinley, M. P., Goldschmidt, C. H., & Rae-Grant, A. D. (2021) · JAMA · doi:10.1001/jama.2020.26858 · Cited by 1,205
Astrocyte barriers to neurotoxic inflammation
Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202
Pathological mechanisms in progressive multiple sclerosis
Mahad, D., Trapp, B. D., & Lassmann, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70256-x · Cited by 1,198
Self-citationProgressive multiple sclerosis: pathology and pathogenesis
Lassmann, H., van Horssen, J., & Mahad, D. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.168 · Cited by 1,033
Self-citationMultiple Sclerosis: Current Knowledge and Future Outlook
Kamm, C. P., Uitdehaag, B. M. J., & Polman, C. H. (2014) · European Neurology · doi:10.1159/000360528 · Cited by 1,011
The anatomical and cellular basis of immune surveillance in the central nervous system
Ransohoff, R. M., & Engelhardt, B. (2012) · Nature reviews. Immunology · doi:10.1038/nri3265 · Cited by 1,029
Self-citationMultiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938
Lassmann, H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028936 · Cited by 937
Self-citationCapture, crawl, cross: the T cell code to breach the blood–brain barriers
Engelhardt, B., & Ransohoff, R. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.07.004 · Cited by 686
Self-citationPathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis
Lassmann, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03116 · Cited by 711
Self-citationNeuronal vulnerability and multilineage diversity in multiple sclerosis
Schirmer, L., Velmeshev, D., Holmqvist, S., Kaufmann, M., Werneburg, S., Jung, D., Vistnes, S., Stockley, J. H., Young, A., Steindel, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1404-z · Cited by 638
Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
Friese, M. A., Schattling, B., & Fugger, L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.37 · Cited by 628
Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0213-2 · Cited by 610
Progressive multiple sclerosis: from pathogenic mechanisms to treatment
Correale, J. D., Gaitán, M. I., Ysrraelit, M. C., & Fiol, M. P. (2016) · Brain · doi:10.1093/brain/aww258 · Cited by 609
Multiple sclerosis: experimental models and reality
Lassmann, H., & Bradl, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1631-4 · Cited by 525
Self-citationThe epidemiology of multiple sclerosis
Goodin, D. S. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802973-2.00011-2 · Cited by 517
Association between pathological and MRI findings in multiple sclerosis
Filippi, M., Rocca, M. A., Barkhof, F., Brück, W., Chen, J. T., Comı, G., DeLuca, G. C., Stefano, N. D., Erickson, B. J., Evangelou, N., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70003-0 · Cited by 499
Self-citationLifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain
Hill, R. A., Li, A. M., & Grutzendler, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0120-6 · Cited by 467
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 477
The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
Savio, L. E. B., de Andrade Mello, P., da Silva, C. G., & Coutinho-Silva, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00052 · Cited by 437
Astrocytes in human central nervous system diseases: a frontier for new therapies
Verkhratsky, A., Butt, A., Li, B., Illes, P., Zorec, R., Semyanov, A., Tang, Y., & Sofroniew, M. V. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01628-9 · Cited by 428
Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies
Wingerchuk, D. M., & Carter, J. L. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.11.002 · Cited by 416
Exploring the origins of grey matter damage in multiple sclerosis
Calabrese, M., Magliozzi, R., Ciccarelli, O., Geurts, J. J. G., Reynolds, R., & Martin, R. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3900 · Cited by 414
The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain
Haider, L., Zrzavy, T., Hametner, S., Höftberger, R., Bagnato, F., Grabner, G., Trattnig, S., Pfeifenbring, S., Brück, W., & Lassmann, H. (2016) · Brain · doi:10.1093/brain/awv398 · Cited by 400
Self-citationReassessing B cell contributions in multiple sclerosis
Li, R., Patterson, K. R., & Bar‐Or, A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0135-x · Cited by 417
Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.
Choi, S. R., Howell, O. W., Carassiti, D., Magliozzi, R., Gveric, D., Muraro, P. A., Nicholas, R., Roncaroli, F., & Reynolds, R. (2012) · Brain · doi:10.1093/brain/aws189 · Cited by 386
Karussis, D. M. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.022 · Cited by 398
Höftberger, R., Guo, Y. X., Flanagan, E. P., Lopez-Chiriboga, A. S., Endmayr, V., Hochmeister, S., Joldic, D., Pittock, S. J., Tillema, J. M., Gorman, M., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02132-y · Cited by 379
Self-citationAnimal models of multiple sclerosis: the good, the bad and the bottom line
Ransohoff, R. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3168 · Cited by 379
Self-citationEffector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
Schläger, C., Körner, H., Krueger, M., Vidoli, S., Haberl, M., Mielke, D., Brylla, E., Issekutz, T., Cabañas, C., Nelson, P. J., et al. (2016) · Nature · doi:10.1038/nature16939 · Cited by 372
Teriflunomide and Its Mechanism of Action in Multiple Sclerosis
Bar‐Or, A., Pachner, A. R., Menguy-Vacheron, F., Kaplan, J. M., & Wiendl, H. (2014) · Drugs · doi:10.1007/s40265-014-0212-x · Cited by 372
Haider, L., Simeonidou, C., Steinberger, G., Hametner, S., Grigoriadis, N., Deretzi, G., Kovács, G. G., Kutzelnigg, A., Lassmann, H., & Frischer, J. M. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-307712 · Cited by 365
Self-citationSankowski, R., Mader, S., & Valdés-Ferrer, S. I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00028 · Cited by 351
An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis
Garg, N., & Smith, T. W. (2015) · Brain and Behavior · doi:10.1002/brb3.362 · Cited by 398
B cells in autoimmune and neurodegenerative central nervous system diseases
Sabatino, J. J., Pröbstel, A., & Zamvil, S. S. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0233-2 · Cited by 361
Simon, M. J., & Iliff, J. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.014 · Cited by 349
Multiple sclerosis—a quiet revolution
Ransohoff, R. M., Hafler, D. A., & Lucchinetti, C. F. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.14 · Cited by 342
Self-citationImmunologic Privilege in the Central Nervous System and the Blood–Brain Barrier
Muldoon, L. L., Alvarez, J. I., Begley, D. J., Boado, R. J., del Zoppo, G. J., Doolittle, N. D., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.153 · Cited by 342
The thalamus and multiple sclerosis
Minagar, A., Barnett, M. H., Benedict, R. H. B., Pelletier, D., Pirko, I., Sahraian, M. A., Frohman, E., & Zivadinov, R. (2013) · Neurology · doi:10.1212/wnl.0b013e31827b910b · Cited by 323
Disease-specific molecular events in cortical multiple sclerosis lesions
Fischer, M. T., Wimmer, I., Höftberger, R., Gerlach, S., Haider, L., Zrzavy, T., Hametner, S., Mahad, D., Binder, C. J., Krumbholz, M., et al. (2013) · Brain · doi:10.1093/brain/awt110 · Cited by 311
Self-citationPathology of multiple sclerosis and related inflammatory demyelinating diseases
Kutzelnigg, A., & Lassmann, H. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52001-2.00002-9 · Cited by 315
Self-citationInflammatory intrathecal profiles and cortical damage in multiple sclerosis
Magliozzi, R., Howell, O. W., Nicholas, R. S., Cruciani, C., Castellaro, M., Romualdi, C., Rossi, S., Pitteri, M., Benedetti, M. D., Gajofatto, A., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25197 · Cited by 307
Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function
Ontaneda, D., Thompson, A. J., Fox, R. J., & Cohen, J. A. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31320-4 · Cited by 298
Measurement and clinical effect of grey matter pathology in multiple sclerosis
Geurts, J. J. G., Calabrese, M., Fisher, E., & Rudick, R. A. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70230-2 · Cited by 304
Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis
Absinta, M., Vuolo, L., Rao, A., Nair, G., Sati, P., Cortese, I. C. M., Ohayon, J., Fenton, K., Reyes-Mantilla, M. I., Maric, D., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001587 · Cited by 296
Neurodegeneration in multiple sclerosis and neuromyelitis optica
Kawachi, I., & Lassmann, H. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-313300 · Cited by 294
Self-citationMacrophage subsets and microglia in multiple sclerosis
Bogie, J. F. J., Stinissen, P., & Hendriks, J. J. A. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1310-2 · Cited by 251
B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies
Cencioni, M. T., Mattoscio, M., Magliozzi, R., Bar‐Or, A., & Muraro, P. A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00498-5 · Cited by 284
Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis
Witte, M. E., Mahad, D., Lassmann, H., & van Horssen, J. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.11.007 · Cited by 286
Self-citationA large fraction of neocortical myelin ensheathes axons of local inhibitory neurons
Micheva, K. D., Wolman, D. N., Mensh, B. D., Pax, E., Buchanan, J., Smith, S. J., & Bock, D. D. (2016) · eLife · doi:10.7554/elife.15784 · Cited by 291
B‐cell Therapy for Multiple Sclerosis: Entering an era
Greenfield, A. L., & Hauser, S. L. (2017) · Annals of Neurology · doi:10.1002/ana.25119 · Cited by 278
B cells and antibodies in multiple sclerosis pathogenesis and therapy
Krumbholz, M., Derfuss, T. J., Hohlfeld, R., & Meinl, E. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.203 · Cited by 270
Pathology of Multiple Sclerosis: Where Do We Stand?
Popescu, B. F. G., Pirko, I., & Lucchinetti, C. F. (2013) · Continuum · doi:10.1212/01.con.0000433291.23091.65 · Cited by 261
Self-citationPathology and disease mechanisms in different stages of multiple sclerosis
Lassmann, H. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.05.010 · Cited by 224
Self-citationDisease-modifying therapies and infectious risks in multiple sclerosis
Winkelmann, A., Loebermann, M., Reisinger, E. C., Hartung, H., & Zettl, U. K. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.21 · Cited by 259
Association between pathological and MRI findings in multiple sclerosis
Filippi, M., Brück, W., Chard, D., Fazekas, F., Geurts, J. J. G., Enzinger, C., Hametner, S., Kuhlmann, T., Preziosa, P., Rovira, À., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30451-4 · Cited by 263
Self-citationOverview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis.
Tullman, M. J. (2013) · PubMed · Cited by 251
Relapsing and progressive forms of multiple sclerosis
Dutta, R., & Trapp, B. D. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000094 · Cited by 252
Mundt, S., Mrdjen, D., Utz, S. G., Greter, M., Schreiner, B., & Becher, B. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau8380 · Cited by 235
Pikor, N. B., Astarita, J. L., Summers-Deluca, L., Galicia, G., Qu, J., Ward, L. A., Armstrong, S., Dominguez, C. X., Malhotra, D., Heiden, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.010 · Cited by 229
Multiple sclerosis animal models: a clinical and histopathological perspective
Kipp, M., Nyamoya, S., Hochstrasser, T., & Amor, S. (2017) · Brain Pathology · doi:10.1111/bpa.12454 · Cited by 226
Cognitive Impairment in Multiple Sclerosis: Clinical, Radiologic and Pathologic Insights
DeLuca, G. C., Yates, R. L., Beale, H., & Morrow, S. A. (2014) · Brain Pathology · doi:10.1111/bpa.12220 · Cited by 228
Microglia in multiple sclerosis: Friend or foe
Guerrero, B. L., & Sicotte, N. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00374 · Cited by 215
Petrou, P., Kassis, I., Levin, N., Paul, F., Backner, Y., Benoliel, T., Oertel, F. C., Scheel, M., Halimi, M., Yaghmour, N. E., et al. (2020) · Brain · doi:10.1093/brain/awaa333 · Cited by 218
Imaging chronic active lesions in multiple sclerosis: a consensus statement
Bagnato, F. R., Sati, P., Hemond, C. C., Elliott, C., Gauthier, S. A., Harrison, D. M., Mainero, C., Oh, J., Pitt, D., Shinohara, R. T., et al. (2024) · Brain · doi:10.1093/brain/awae013 · Cited by 207
The role of microglia in multiple sclerosis
Luo, C., Jian, C., Liao, Y., Huang, Q., Wu, Y., Liu, X., Zou, D., & Wu, Y. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s140634 · Cited by 187
Schattling, B., Steinbach, K., Thies, E., Kruse, M., Menigoz, A., Ufer, F., Flockerzi, V., Brück, W., Pongs, O., Vennekens, R., et al. (2012) · Nature Medicine · doi:10.1038/nm.3015 · Cited by 205
Self-citationMeningeal and cortical grey matter pathology in multiple sclerosis
Popescu, B. F. G., & Lucchinetti, C. F. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-11 · Cited by 208
Self-citationNeuroinflammatory component of gray matter pathology in multiple sclerosis
Herranz, E., Giannì, C., Louapre, C., Treaba, C. A., Govindarajan, S. T., Ouellette, R., Loggia, M. L., Sloane, J. A., Madigan, N. K., Izquierdo‐Garcia, D., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24791 · Cited by 209
Schain, A. J., Hill, R., & Grutzendler, J. (2014) · Nature Medicine · doi:10.1038/nm.3495 · Cited by 200
Multiple Sclerosis and T Lymphocytes: An Entangled Story
Legroux, L., & Arbour, N. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9614-0 · Cited by 206
The neuropathobiology of multiple sclerosis
Woo, M. S., Engler, J. B., & Friese, M. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00823-z · Cited by 205
Mechanisms of white matter damage in multiple sclerosis
Lassmann, H. (2014) · Glia · doi:10.1002/glia.22597 · Cited by 191
Self-citationImmune cell compartmentalization for brain surveillance and protection
Croese, T., Castellani, G., & Schwartz, M. (2021) · Nature Immunology · doi:10.1038/s41590-021-00994-2 · Cited by 197
Epidemiology and Pathophysiology of Multiple Sclerosis
Ward, M., & Goldman, M. D. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001136 · Cited by 185
Granberg, T., Fan, Q., Treaba, C. A., Ouellette, R., Herranz, E., Mangeat, G., Louapre, C., Cohen-Adad, J., Klawiter, E. C., Sloane, J. A., et al. (2017) · Brain · doi:10.1093/brain/awx247 · Cited by 184
B cells in central nervous system disease: diversity, locations and pathophysiology
Jain, R. W., & Yong, V. W. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00652-6 · Cited by 185
Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
Lisak, R. P., Benjamins, J. A., Nedelkoska, L., Barger, J. L., Ragheb, S., Fan, B., Ouamara, N., Johnson, T., Rajasekharan, S., & Bar‐Or, A. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.02.015 · Cited by 179
Lazari, A., & Lipp, I. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117744 · Cited by 176
Cognitive impairment and cortical degeneration in neuromyelitis optica
Saji, E., Arakawa, M., Yanagawa, K., Toyoshima, Y., Yokoseki, A., Okamoto, K., Otsuki, M., Akazawa, K., Kakita, A., Takahashi, H., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23721 · Cited by 176
Michel, L., Touil, H., Pikor, N. B., Gommerman, J. L., Prat, A., & Bar‐Or, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00636 · Cited by 180
Jürgens, T., Jafari, M., Kreutzfeldt, M., Bahn, E., Brück, W., Kerschensteiner, M., & Merkler, D. (2016) · Brain · doi:10.1093/brain/awv353 · Cited by 175
Self-citationMechanisms underlying progression in multiple sclerosis
Absinta, M., Lassmann, H., & Trapp, B. D. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000818 · Cited by 175
Self-citationKilsdonk, I. D., Jonkman, L. E., Klaver, R., van Veluw, S. J., Zwanenburg, J. J. M., Kuijer, J. P. A., Pouwels, P. J. W., Twisk, J. W. R., Wattjes, M. P., Luijten, P. R., et al. (2016) · Brain · doi:10.1093/brain/aww037 · Cited by 176
Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis
Yong, H. Y. F., & Yong, V. W. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00581-x · Cited by 170
Mechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis
Correale, J., Marrodan, M., & Ysrraelit, M. C. (2019) · Biomedicines · doi:10.3390/biomedicines7010014 · Cited by 167
Advances in the immunopathogenesis of multiple sclerosis
Yadav, S. K., Mindur, J. E., Ito, K., & Dhib-Jalbut, S. S. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000205 · Cited by 173
Promotion and prevention of autoimmune disease by CD8+ T cells
Gravano, D. M., & Hoyer, K. K. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.06.004 · Cited by 166
Absinta, M., Sati, P., Gaitán, M. I., Maggi, P., Cortese, I. C. M., Filippi, M., & Reich, D. S. (2013) · Annals of Neurology · doi:10.1002/ana.23959 · Cited by 165
Christy, A. L., Walker, M. E., Hessner, M. J., & Brown, M. A. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.11.003 · Cited by 172
Dellarole, A., Morton, P. D., Brambilla, R., Walters, W. M., Summers, S. H., Bernardes, D., Grilli, M., & Bethea, J. R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.003 · Cited by 170
A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging
Mainero, C., Louapre, C., Govindarajan, S. T., Giannì, C., Nielsen, A. S., Cohen‐Adad, J., Sloane, J. A., & Kinkel, R. P. (2015) · Brain · doi:10.1093/brain/awv011 · Cited by 167
Magnetic Resonance Imaging in Multiple SclerosisPreprint
Hemond, C. C., & Bakshi, R. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028969 · Cited by 172
Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI
Sethi, V., Yousry, T. A., Muhlert, N., Ron, M., Golay, X., Wheeler-Kingshott, C., Miller, D. H., & Chard, D. T. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303023 · Cited by 163
Guglielmetti, C., Veraart, J., Roelant, E., Mai, Z., Daans, J., Audekerke, J. V., Naeyaert, M., Vanhoutte, G., y Palacios, R. D., Praet, J., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.052 · Cited by 160
When encephalitogenic T cells collaborate with microglia in multiple sclerosis
Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 169
Bălașa, R., Bărcuţean, L., Mosora, O., & Manu, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168370 · Cited by 169
Metadata
- Authors
- Lucchinetti, C. F., Popescu, B. F. G., Bunyan, R. F., Moll, N. M., Roemer, S. F., Lassmann, H., Brück, W., Parisi, J. E., Scheithauer, B. W., Giannini, C., Weigand, S. D., Mandrekar, J., & Ransohoff, R. M.
- Affiliations
- Mayo Clinic (US)
- Cleveland Clinic Research (US)
- Medical University of Vienna (AT)
- Universitätsmedizin Göttingen (DE)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-12-08
- Volume
- 365
- Issue
- 23
- Pages
- 2188-2197
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3282172
- OpenAlex
- W2113948549
- Cited by
- 1,103
- References
- 50
- Citations by year
- 2026: 37 · 2025: 44 · 2024: 69 · 2023: 70 · 2022: 68 · 2021: 104 · 2020: 75 · 2019: 83 · 2018: 64 · 2017: 72 · 2016: 75 · 2015: 84 · 2014: 89 · 2013: 100 · 2012: 67
- FWCI
- 58.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- National Multiple Sclerosis Society (RG3185-B-3)
- Multiple Sclerosis Society
- National Institutes of Health (P50NS38667)
- National Institute of Neurological Disorders and Stroke (P50NS38667, P50NS038667, R01NS049577)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- multiple sclerosis, cortical demyelination, inflammatory demyelination, meningeal inflammation, cortical lesions, early multiple sclerosis, white matter lesions, stereotactic biopsy, disease progression
- MeSH terms
- Biopsy, Cerebral Cortex, Humans, Inflammation, Multiple Sclerosis, Prevalence, Logistic Models, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
