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Conduct disorder and callous-unemotional traits in youth
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Children with repetitive rule-breaking, aggression, and disregard for others are at increased risk for substance abuse, educational disruption, and criminal behavior. Progress is being made toward understanding the clinical and neurocognitive features of callous youth.
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“These “emotional instability disorders” are characterized by emotional hyper-responsiveness in amygdala and insula, regions involved in shaping emotional responses and experience (Blair, 2010; Rubia, 2011; Blair et al., 2014; Glenn and Raine, 2014; Krause-Utz et al., 2014).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Blair et al., 2014
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“Structurally, the gray matter volumes of amygdala and insula are often reduced in such disorders (Blair, 2010; Rubia, 2011; Blair et al., 2014; Glenn and Raine, 2014; Krause-Utz et al., 2014).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Blair et al., 2014
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“…these disorders also include sub-populations with callousunemotional traits that are associated with decreased behavioral and neural responding to emotional stimuli, potentially confounding the contribution from emotional instability traits (Blair, 2010, 2013; Rubia, 2011; Blair et al., 2014).”
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Metadata
- Authors
- Blair, R. J. R., Leibenluft, E., & Pine, D. S.
- Affiliations
- National Institutes of Health (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-12-04
- Volume
- 371
- Issue
- 23
- Pages
- 2207-2216
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC6312699
- OpenAlex
- W2041104702
- Cited by
- 371
- References
- 75
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 27 · 2023: 30 · 2022: 43 · 2021: 34 · 2020: 50 · 2019: 33 · 2018: 28 · 2017: 35 · 2016: 35 · 2015: 17
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- conduct disorder, callous-unemotional traits, youth, aggression, rule violations, substance abuse risk, criminal behavior, educational disruption, clinical features
- MeSH terms
- Adolescent, Amygdala, Antisocial Personality Disorder, Child, Child Behavior Disorders, Cognition Disorders, Decision Making, Empathy, Humans, Magnetic Resonance Imaging, Psychotherapy, Social Environment, Conduct Disorder
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