New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

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The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

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A System for the Surgical Staging of Musculoskeletal Sarcoma

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414 · see citing works

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393 · see citing works

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391 · see citing works

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909 · see citing works

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

Tawbi, H. A., Burgess, M., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Hu, J., D'Angelo, S., Attia, S., Riedel, R. F., Priebat, D. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30624-1 · Cited by 1,452 · see citing works

Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

Wilhelm, S. M., Dumas, J., Adnane, L., Lynch, M., Carter, C. A., Schütz, G., Thierauch, K., & Zopf, D. (2011) · International Journal of Cancer · doi:10.1002/ijc.25864 · Cited by 1,355 · see citing works

The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity

Link, M. P., Goorin, A. M., Miser, A. W., Green, A. A., Pratt, C. B., Belasco, J. B., Pritchard, J., Malpas, J. S., Baker, A. R., Kirkpatrick, J. A., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142502 · Cited by 1,203 · see citing works

Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

Ahmed, N., Brawley, V. S., Hegde, M., Robertson, C., Ghazi, A., Gerken, C., Liu, E., Dakhova, O., Ashoori, A., Corder, A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.0225 · Cited by 1,004 · see citing works

Primary Metastatic Osteosarcoma: Presentation and Outcome of Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Kager, L., Zoubek, A., Pötschger, U., Kastner, U., Flege, S., Kempf-Bielack, B., Branscheid, D., Kotz, R., Salzer-Kuntschik, M., Winkelmann, W., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.08.132 · Cited by 934 · see citing works

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

Ma, X., Liu, Y., Liu, Y., Alexandrov, L. B., Edmonson, M. N., Gawad, C., Zhou, X., Li, Y., Rusch, M. C., Easton, J., et al. (2018) · Nature · doi:10.1038/nature25795 · Cited by 901 · see citing works

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

Chen, X., Bahrami, A., Pappo, A., Easton, J., Dalton, J., Hedlund, E., Ellison, D., Shurtleff, S., Wu, G., Wei, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.003 · Cited by 752 · see citing works

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

Meyers, P. A., Schwartz, C. L., Krailo, M. D., Healey, J. H., Bernstein, M. L., Betcher, D., Ferguson, W. S., Gebhardt, M. C., Goorin, A. M., Harris, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.14.0095 · Cited by 752 · see citing works

CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA

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Osteosarcoma: A Randomized, Prospective Trial of the Addition of Ifosfamide and/or Muramyl Tripeptide to Cisplatin, Doxorubicin, and High-Dose Methotrexate

Meyers, P. A., Schwartz, C. L., Krailo, M., Kleinerman, E. S., Betcher, D. L., Bernstein, M. L., Conrad, E. U., Ferguson, W. S., Gebhardt, M. C., Goorin, A. M., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.031 · Cited by 717 · see citing works

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Donehower, L. A., Soussi, T., Korkut, A., Liu, Y., Schultz, A., Cardenas, M., Li, X., Babur, Ö., Hsu, T., Lichtarge, O., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.001 · Cited by 707 · see citing works

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort

Smeland, S., Bielack, S. S., Whelan, J., Bernstein, M., Hogendoorn, P., Krailo, M. D., Gorlick, R., Janeway, K. A., Ingleby, F. C., Anninga, J., et al. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2018.11.027 · Cited by 704 · see citing works

Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery

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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Perry, J. A., Kiezun, A., Tonzi, P., Van Allen, E. M., Carter, S. L., Baca, S. C., Cowley, G. S., Bhatt, A. S., Rheinbay, E., Pedamallu, C. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419260111 · Cited by 481 · see citing works

Coley's toxins, tumor necrosis factor and cancer research: A historical perspective

Wiemann, B., & Starnes, C. O. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90023-x · Cited by 466 · see citing works

Genome-Informed Targeted Therapy for Osteosarcoma

Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452 · see citing works

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial

Bielack, S. S., Smeland, S., Whelan, J. S., Marina, N., Jovic, G., Hook, J. M., Krailo, M. D., Gebhardt, M., Pápai, Z., Meyer, J., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.60.0734 · Cited by 422 · see citing works

Presurgical Chemotherapy Compared With Immediate Surgery and Adjuvant Chemotherapy for Nonmetastatic Osteosarcoma: Pediatric Oncology Group Study POG-8651

Goorin, A. M., Schwartzentruber, D. J., Devidas, M., Gebhardt, M. C., Ayala, A. G., Harris, M. B., Helman, L. J., Grier, H. E., & Link, M. P. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.08.165 · Cited by 394 · see citing works

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Taylor, B., Nik‐Zainal, S., Wu, Y. L., Stebbings, L. A., Raine, K. M., Campbell, P. J., Rada, C. A., Stratton, M. R., & Neuberger, M. S. (2013) · eLife · doi:10.7554/elife.00534 · Cited by 376 · see citing works

Osteogenic Sarcoma under the Age of Twenty-one

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Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

Kovac, M., Blattmann, C., Ribi, S., Smida, J., Mueller, N. S., Engert, F., Castro-Giner, F., Weischenfeldt, J., Kovacova, M., Krieg, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms9940 · Cited by 353 · see citing works

Association Between Osteosarcoma and Deleterious Mutations in the RECQL4 Gene in Rothmund-Thomson Syndrome

Wang, L. L., Gannavarapu, A., Kozinetz, C. A., Levy, M. L., Lewis, R. A., Chintagumpala, M. M., Ruiz-Maldanado, R., Contreras-Ruiz, J., Cunniff, C., Erickson, R. P., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.9.669 · Cited by 338 · see citing works

A Phase I Dose–Escalation Study of Regorafenib (BAY 73–4506), an Inhibitor of Oncogenic, Angiogenic, and Stromal Kinases, in Patients with Advanced Solid Tumors

Mross, K. B., Frost, A., Steinbild, S., Hedbom, S., Büchert, M., Fasol, U., Unger, C., Krätzschmar, J., Heinig, R., Boix, O., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1900 · Cited by 335 · see citing works

Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study

Duffaud, F., Mir, O., Boudou-Rouquette, P., Piperno-Neumann, S., Penel, N., Bompas, E., Delcambre, C., Kalbacher, E., Italiano, A., Collard, O., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30742-3 · Cited by 331 · see citing works

Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial

Italiano, A., Mir, O., Mathoulin-Pelissier, S., Penel, N., Piperno-Neumann, S., Bompas, E., Chevreau, C., Duffaud, F., Entz-Werlé, N., Saada, E., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30825-3 · Cited by 326 · see citing works

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

Vlachos, A., Rosenberg, P. S., Atsidaftos, E., Alter, B. P., & Lipton, J. M. (2012) · Blood · doi:10.1182/blood-2011-08-375972 · Cited by 309 · see citing works

Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II–Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3

Lu, Y., Parker, L. L., Lu, T., Zheng, Z., Toomey, M. A., White, D. E., Yao, X., Li, Y. F., Robbins, P. F., Feldman, S. A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.74.5463 · Cited by 278 · see citing works

CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment

Fujiwara, T., Yakoub, M. A., Chandler, A., Christ, A. B., Yang, G., Ouerfelli, O., Rajasekhar, V. K., Yoshida, A., Kondo, H., Hata, T., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0591 · Cited by 270 · see citing works

Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma

Davis, L. E., Bolejack, V., Ryan, C. W., Ganjoo, K. N., Loggers, E. T., Chawla, S., Agulnik, M., Livingston, M. B., Reed, D., Keedy, V., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.02374 · Cited by 268 · see citing works

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Behjati, S., Tarpey, P. S., Haase, K., Ye, H., Young, M. D., Alexandrov, L. B., Farndon, S. J., Collord, G., Wedge, D. C., Martincorena, I., et al. (2017) · Nature Communications · doi:10.1038/ncomms15936 · Cited by 261 · see citing works

Neoadjuvant chemotherapy for high‐grade central osteosarcoma of the extremity: <i>Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor</i>

Bacci, G., Bertoni, F., Longhi, A., Ferrari, S., Forni, C., Biagini, R., Bacchini, P., Donati, D., Manfrini, M., Bernini, G., et al. (2003) · Cancer · doi:10.1002/cncr.11456 · Cited by 253 · see citing works

Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group

Ebb, D., Meyers, P., Grier, H., Bernstein, M., Gorlick, R., Lipshultz, S. E., Krailo, M., Devidas, M., Barkauskas, D. A., Siegal, G. P., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.4546 · Cited by 243 · see citing works

Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma

Mirabello, L., Zhu, B., Koster, R., Karlins, E., Dean, M., Yeager, M., Gianferante, M., Spector, L. G., Morton, L. M., Karyadi, D., et al. (2020) · JAMA Oncology · doi:10.1001/jamaoncol.2020.0197 · Cited by 243 · see citing works

Children's Oncology Group's 2013 blueprint for research: Bone tumors

Gorlick, R., Janeway, K., Lessnick, S., Randall, R. L., Marina, N., & on behalf of the COG Bone Tumor Committee (2013) · Pediatric Blood &amp; Cancer · doi:10.1002/pbc.24429 · Cited by 226 · see citing works

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates

Purcell, J. W., Tanlimco, S. G., Hickson, J. A., Fox, M., Sho, M., Durkin, L. M., Uziel, T., Powers, R., Foster, K., McGonigal, T. P., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0327 · Cited by 207 · see citing works

Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward

Lagmay, J. P., Krailo, M. D., Dang, H., Kim, A., Hawkins, D. S., Beaty, O., Widemann, B. C., Zwerdling, T., Bomgaars, L., Langevin, A.-M., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.65.5381 · Cited by 190 · see citing works

A phase I trial combining decitabine/dendritic cell vaccine targeting MAGE-A1, MAGE-A3 and NY-ESO-1 for children with relapsed or therapy-refractory neuroblastoma and sarcoma

Krishnadas, D. K., Shusterman, S., Bai, F., Diller, L., Sullivan, J. E., Cheerva, A. C., George, R. E., & Lucas, K. G. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1731-3 · Cited by 176 · see citing works

Programmed cell death 1 (PD-1) targeting in patients with advanced osteosarcomas: results from the PEMBROSARC study

Le Cesne, A., Marec-Berard, P., Blay, J.-Y., Gaspar, N., Bertucci, F., Penel, N., Bompas, E., Cousin, S., Toulmonde, M., Bessede, A., et al. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2019.07.018 · Cited by 174 · see citing works

Ganglioside GD2 as a therapeutic target for antibody‐mediated therapy in patients with osteosarcoma

Roth, M. E., Linkowski, M., Tarim, J., Piperdi, S., Sowers, R. S., Geller, D., Gill, J. B., & Gorlick, R. G. (2013) · Cancer · doi:10.1002/cncr.28461 · Cited by 166 · see citing works

The consequences of the chemotherapy of Hodgkin's disease: The 10th David A. Karnofsky memorial lecture

DeVita, V. T. (1981) · Cancer · doi:10.1002/1097-0142(19810101)47:1 · Cited by 164 · see citing works

Earliest hominin cancer: 1.7-million-year-old osteosarcoma from Swartkrans Cave, South Africa

Odes, E. J., Randolph-Quinney, P. S., Steyn, M., Throckmorton, Z., Smilg, J. S., Zipfel, B., Augustine, T. N., de Beer, F., Hoffman, J. W., Franklin, R. D., et al. (2016) · South African Journal of Science · doi:10.17159/sajs.2016/20150471 · Cited by 132 · see citing works

Improved assembly and variant detection of a haploid human genome using single‐molecule, high‐fidelity long reads

Vollger, M. R., Logsdon, G. A., Audano, P. A., Sulovari, A., Porubskỳ, D., Peluso, P. S., Wenger, A. M., Concepcion, G. T., Kronenberg, Z. N., Munson, K. M., et al. (2019) · Annals of Human Genetics · doi:10.1111/ahg.12364 · Cited by 122 · see citing works

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas

Joseph, C. G., Hwang, H., Jiao, Y., Wood, L. D., Kinde, I., Wu, J., Mandahl, N., Luo, J., Hruban, R. H., Diaz, L. A., et al. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22114 · Cited by 109 · see citing works

Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification

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Cancer‐germline gene expression in pediatric solid tumors using quantitative real‐time PCR

Jacobs, J. F. M., Brasseur, F., de Kaa, C. A. H., van de Rakt, M. W. M. M., Figdor, C. G., Adema, G. J., Hoogerbrugge, P. M., Coulie, P. G., & de Vries, I. J. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.22118 · Cited by 69 · see citing works

Response Evaluation Criteria in Solid Tumors (RECIST) following neoadjuvant chemotherapy in osteosarcoma

Guenther, L. M., Rowe, R. G., Acharya, P. T., Swenson, D. W., Meyer, S. C., Clinton, C. M., Guo, D., Sridharan, M., London, W. B., Grier, H. E., et al. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26896 · Cited by 66 · see citing works

Role of Tumor-Associated Macrophages in Sarcomas

Fujiwara, T., Healey, J. H., Ogura, K., Kondo, H., Kondo, H., Hata, T., Tazawa, H., Nakata, E., Kunisada, T., Fujiwara, T., et al. (2021) · Cancers · doi:10.3390/cancers13051086 · Cited by 60 · see citing works

The breakage–fusion–bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma

Selvarajah, S., Yoshimoto, M., Park, P. C., Maire, G., Paděrová, J., Bayani, J., Lim, G., Al-Romaih, K. I., Squire, J. A., & Zieleńska, M. (2006) · Chromosoma · doi:10.1007/s00412-006-0074-4 · Cited by 58 · see citing works

Assessment of resection margins in bone sarcoma treated by neoadjuvant chemotherapy: Literature review and guidelines of the bone group (GROUPOS) of the French sarcoma group and bone tumor study group (GSF-GETO/RESOS)

Gomez‐Brouchet, A., Mascard, É., Siegfried, A., Pinieux, G. D. B. D., Gaspar, N., Bouvier, C., Aubert, S., Marec‐Bérard, P., Piperno-Neumann, S., Marie, B., et al. (2019) · Orthopaedics & Traumatology Surgery & Research · doi:10.1016/j.otsr.2018.12.015 · Cited by 58 · see citing works

An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage–fusion–bridge cycle events in osteosarcoma

Lim, G., Karásková, J., Beheshti, B., Vukovic, B., Bayani, J., Selvarajah, S., Watson, S. K., Lam, W. L., Zieleńska, M., & Squire, J. A. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20157 · Cited by 57 · see citing works

First case of osteosarcoma in a dinosaur: a multimodal diagnosis

Ekhtiari, S., Chiba, K., Popović, S., Crowther, R., Wohl, G. R., Wong, A. K. O., Tanke, D. H., Dufault, D. M., Geen, O. D., Parasu, N., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30171-6 · Cited by 55 · see citing works

Integrated genetic and pharmacologic interrogation of rare cancers

Hong, A. L., Tseng, Y., Cowley, G. S., Jonas, O. H., Cheah, J. H., Kynnap, B. D., Doshi, M. B., Oh, C., Meyer, S. C., Church, A. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11987 · Cited by 54 · see citing works

LRRC15 Targeting in Soft-Tissue Sarcomas: Biological and Clinical Implications

Ben‐Ami, E., Perret, R. E., Huang, Y., Courgeon, F., Gokhale, P. C., Laroche‐Clary, A., Eschle, B. K., Velasco, V., Loarer, F. L., Algéo, M.-P., et al. (2020) · Cancers · doi:10.3390/cancers12030757 · Cited by 34 · see citing works

LRRC15 antibody‐drug conjugates show promise as osteosarcoma therapeutics in preclinical studies

Slemmons, K. K., Mukherjee, S., Meltzer, P. S., Purcell, J. W., & Helman, L. J. (2020) · Pediatric Blood & Cancer · doi:10.1002/pbc.28771 · Cited by 31 · see citing works

RECQ DNA Helicases and Osteosarcoma

Lu, L., Jin, W., & Wang, L. L. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-43085-6_3 · Cited by 28 · see citing works

The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA

Dişel, U., Madison, R. W., Abhishek, K., Chung, J., Trabucco, S. E., Matos, A. O., Frampton, G. M., Albacker, L. A., Reddy, V. P., Karadurmuş, N., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2018-0528 · Cited by 27 · see citing works

Targeted transcriptional profiling of the tumor microenvironment reveals lymphocyte exclusion and vascular dysfunction in metastatic osteosarcoma

Sorenson, L., Fu, Y., Hood, T., Warren, S. E., & McEachron, T. A. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1629779 · Cited by 19 · see citing works

Osteosarcoma of the extremities: Chemotherapy experience at Memorial Sloan-Kettering

Meyers, P. A., Heller, G., & Vlamis, V. (1993) · Cancer treatment and research · doi:10.1007/978-1-4615-3518-8_37 · Cited by 18 · see citing works

Osteosarcoma

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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

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Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

Shi, P., Cheng, Z., Zhao, K., Chen, Y., Zhang, A., Gan, W., & Zhang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01826-1 · Cited by 210 · see citing works

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks

Cillo, A. R., Mukherjee, E., Bailey, N. G., Onkar, S., Daley, J. D., Salgado, C. M., Li, X., Liu, D., Ranganathan, S., Burgess, M. A., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1471 · Cited by 91 · see citing works

A tumor microenvironment-based prognostic index for osteosarcoma

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Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

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Origin and Therapies of Osteosarcoma

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Current Status and Prospects of Clinical Treatment of Osteosarcoma

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Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

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Roles and mechanisms of copper homeostasis and cuproptosis in osteoarticular diseases

Han, J., Luo, J., Wang, C., Капилевич, Л. В., & Zhang, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116570 · Cited by 75 · see citing works

Current Status and Prospects of Targeted Therapy for Osteosarcoma

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Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors

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Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma

Li, T., Gao, M., Wu, Z., Yang, J., Mo, B., Yu, S., Gong, X., Liu, J., Wang, W., Luo, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202206779 · Cited by 72 · see citing works

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Chen, W., Li, Z., Yu, N., Zhang, L., Li, H., Chen, Y., Gong, F., Lin, W., He, X., Wang, S., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02129-1 · Cited by 71 · see citing works

Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence

Wang, Z., Zhai, B., Sun, J., Zhang, X., Zou, J., Shi, Y., & Guo, D. (2024) · Drug Delivery · doi:10.1080/10717544.2024.2400476 · Cited by 65 · see citing works

NIR Responsive Doxorubicin‐Loaded Hollow Copper Ferrite @ Polydopamine for Synergistic Chemodynamic/Photothermal/Chemo‐Therapy

Chu, X., Zhang, L., Li, Y., He, Y. H., Zhang, Y. X., & Du, C. (2022) · Small · doi:10.1002/smll.202205414 · Cited by 60 · see citing works

What is the role of microbial biotechnology and genetic engineering in medicine?

Santos‐Beneit, F. (2024) · MicrobiologyOpen · doi:10.1002/mbo3.1406 · Cited by 60 · see citing works

Deep learning models in classifying primary bone tumors and bone infections based on radiographs

Wang, H., He, Y., Wan, L., Li, C., Li, Z., Li, Z., Xu, H., & Tu, C. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00855-3 · Cited by 60 · see citing works

Acidity‐Triggered Transformable Polypeptide Self‐Assembly to Initiate Tumor‐Specific Biomineralization

Liu, Y., Jiang, Z., Tong, S., Sun, Y., Zhang, Y., Zhang, J., Zhao, D., Su, Y., Ding, J., & Chen, X. (2022) · Advanced Materials · doi:10.1002/adma.202203291 · Cited by 59 · see citing works

Surgical Treatment of Bone Sarcoma

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Multifunctional 3D-printed scaffolds eradiate orthotopic osteosarcoma and promote osteogenesis via microwave thermo-chemotherapy combined with immunotherapy

Ma, L., Zhou, J., Wu, Q., Luo, G., Zhao, M., Zhong, G., Zheng, Y., Meng, X., Cheng, S., & Zhang, Y. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122236 · Cited by 58 · see citing works

Synergetic Chemo‐Piezodynamic Therapy of Osteosarcoma Enabled by Defect‐Driven Lead‐Free Piezoelectrics

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Bioactive nanocomposite hydrogel enhances postoperative immunotherapy and bone reconstruction for osteosarcoma treatment

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Engineering a triple-functional magnetic gel driving mutually-synergistic mild hyperthermia-starvation therapy for osteosarcoma treatment and augmented bone regeneration

Yu, K., Zhou, H., Xu, Y., Cao, Y., Zheng, Y., & Liang, B. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01955-7 · Cited by 54 · see citing works

The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species

Gao, X., Zhang, J., Gong, Y., & Yan, L. W. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02844-3 · Cited by 54 · see citing works

One-Dimensional Ferroelectric Nanoarrays with Wireless Switchable Static and Dynamic Electrical Stimulation for Selective Regulating Osteogenesis and Antiosteosarcoma

Xiao, C., Fan, L., Zhou, S., Kang, X., Guan, P., Fu, R., Li, C., Ren, J. M., Wang, Z., Yu, P., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c07900 · Cited by 48 · see citing works

NGR‐Modified CAF‐Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma

Du, J., Meng, X., Yang, M., Chen, G., Li, J., Zhu, Z., Wu, X., Hu, W., Tian, M., Li, T., et al. (2025) · Advanced Science · doi:10.1002/advs.202410918 · Cited by 48 · see citing works

Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling

Yu, L., Zhu, H., Wang, Z., Huang, J., Zhu, Y., Fan, G., Wang, Y., Chen, X., & Zhou, G. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01624-7 · Cited by 47 · see citing works

Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans

Mannheimer, J., Tawa, G. J., Gerhold, D. L., Braisted, J. C., Sayers, C. M., McEachron, T. A., Meltzer, P. S., Mazcko, C. N., Beck, J. A., & LeBlanc, A. K. (2023) · Communications Biology · doi:10.1038/s42003-023-05208-z · Cited by 47 · see citing works

Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia

Wang, Y., Zhou, X., Li, Y., Hu, Q., Liu, H., Zhao, G., Wang, K., Zeng, J., Sun, M., & Lv, C. (2024) · Small · doi:10.1002/smll.202306916 · Cited by 46 · see citing works

Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach

Schott, C. R., Koehne, A. L., Sayles, L. C., Young, E. P., Luck, C., Yu, K., Lee, A. G., Breese, M. R., Leung, S. G., Xu, H., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0873 · Cited by 45 · see citing works

A multifunctional nano-hydroxyapatite/MXene scaffold for the photothermal/dynamic treatment of bone tumours and simultaneous tissue regeneration

Zhang, G., Lu, Y., Song, J., An, M., An, M., Chen, W., Han, P., Yao, X., & Zhang, X. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.08.176 · Cited by 43 · see citing works

Redox-active vitamin C suppresses human osteosarcoma growth by triggering intracellular ROS-iron–calcium signaling crosstalk and mitochondrial dysfunction

Vaishampayan, P., & Lee, Y. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103288 · Cited by 43 · see citing works

Metal-organic framework-mediated siRNA delivery and sonodynamic therapy for precisely triggering ferroptosis and augmenting ICD in osteosarcoma

Sun, N., Lei, Q., Wu, M., Gao, S., Yang, Z., Lv, X., Wei, R., Yan, F., & Cai, L. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101053 · Cited by 40 · see citing works

PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT

Zhang, W., Li, W., Yin, C., Feng, C., Liu, B., Xu, H., Jin, X., Tu, C., & Li, Z. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0163 · Cited by 39 · see citing works

Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

Yan, Z., Wu, X., Tan, W., Yan, J., Zhou, J., Chen, S., Miao, J., Cheng, J., Shuai, C., & Deng, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304595 · Cited by 38 · see citing works

Current status and future challenges of CAR-T cell therapy for osteosarcoma

Li, S., Zhang, H., & Shang, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1290762 · Cited by 36 · see citing works

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Wang, Y., Zhang, H., Qiang, H., Li, M., Cai, Y., Zhou, X., Xu, Y., Yan, Z., Dong, J., Gao, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304060 · Cited by 36 · see citing works

Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells

Zhang, F., Hao, Y., Yang, N., Liu, M., Luo, Y., Zhang, Y., Zhou, J., Liu, H., & Li, J. (2024) · BMC Cancer · doi:10.1186/s12885-024-11951-1 · Cited by 34 · see citing works

Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes

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Immunosuppressive Tumor Microenvironment of Osteosarcoma

Taylor, A. M., Sheng, J., Ng, P. K. S., Harder, J. M., Kumar, P., Ahn, J. Y., Cao, Y., Dzis, A. M., Jillette, N., Goodspeed, A. E., et al. (2025) · Cancers · doi:10.3390/cancers17132117 · Cited by 33 · see citing works

Deciphering the heterogeneity and immunosuppressive function of regulatory T cells in osteosarcoma using single-cell RNA transcriptome

Cheng, D., Zhang, Z., Mi, Z., Tao, W., Liu, D., Fu, J., & Fan, H. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107417 · Cited by 32 · see citing works

Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis

Zou, Y., Guo, S., Wen, L., Lv, D., Tu, J., Liao, Y., Chen, W., Chen, Z., Li, H., Chen, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101728 · Cited by 32 · see citing works

Nanomaterial-assisted theranosis of bone diseases

Zheng, K., Bai, J., Yang, H., Xu, Y., Pan, G., Wang, H., & Geng, D. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.12.014 · Cited by 32 · see citing works

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma

Kinnaman, M. D., Zaccaria, S., Makohon-Moore, A. P., Arnold, B., Levine, M. F., Gundem, G., Ossa, J. A., Głodzik, D., Rodriguez-Sanchez, I., Bouvier, N., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0385 · Cited by 31 · see citing works

Unraveling molecular aberrations and pioneering therapeutic strategies in osteosarcoma

Yan, P., Wang, J., Yue, B., & Wang, X. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189171 · Cited by 31 · see citing works

Biopolymer-based bone scaffold for controlled Pt (IV) prodrug release and synergistic photothermal-chemotherapy and immunotherapy in osteosarcoma

Yan, Z., Deng, Y., Huang, L., Zeng, J., Wang, D., Tong, Z., Fan, Q., Tan, W., Yan, J., Zang, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03253-w · Cited by 31 · see citing works

Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities

Du, X., Wei, H., Zhang, B., Wang, B., Li, Z., Pang, L. K., Zhao, R., & Yao, W. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1117867 · Cited by 31 · see citing works

Selenium-incorporated mesoporous silica nanoparticles for osteosarcoma therapy

He, L., Habibović, P., & van Rijt, S. (2023) · Biomaterials Science · doi:10.1039/d2bm02102a · Cited by 30 · see citing works

European standard clinical practice recommendations for children and adolescents with primary and recurrent osteosarcoma

van Ewijk, R., Herold, N., Baecklund, F., Baumhoer, D., Boye, K., Gaspar, N., Harrabi, S., Haveman, L., Hecker‐Nolting, S., Hiemcke‐Jiwa, L. S., et al. (2023) · EJC Paediatric Oncology · doi:10.1016/j.ejcped.2023.100029 · Cited by 30 · see citing works

Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma

An, F., Chang, W., Song, J., Zhang, J., Li, Z., Gao, P., Wang, Y., Xiao, Z., & Yan, C. (2024) · Journal of bone oncology · doi:10.1016/j.jbo.2024.100521 · Cited by 30 · see citing works

Multifunctional coatings of nickel-titanium implant toward promote osseointegration after operation of bone tumor and clinical application: a review

Du, T., Liu, J. S., Dong, J., Xie, H., Wang, X., Yang, X., & Yang, Y. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1325707 · Cited by 30 · see citing works

SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma

Huang, X., Xia, K., Wei, Z., Liu, W., Wei, Z., & Guo, W. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05803-6 · Cited by 30 · see citing works

T2-weighted MRI radiomics in high-grade intramedullary osteosarcoma: predictive accuracy in assessing histologic response to chemotherapy, overall survival, and disease-free survival

White, L. M., Atinga, A., Naraghi, A., Lajkosz, K., Wunder, J. S., Ferguson, P. C., Tsoi, K. M., Griffin, A. M., & Haider, M. A. (2022) · Skeletal Radiology · doi:10.1007/s00256-022-04098-2 · Cited by 30 · see citing works

A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

Li, C., Zhang, Y., Du, Y., Hou, Z., Zhang, Y., Cui, W., & Chen, W. (2023) · Small Science · doi:10.1002/smsc.202300027 · Cited by 30 · see citing works

Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

Liu, X., Liu, Y., Qiang, L., Ya, R., Lin, Y., Li, H., Chen, Q., Gao, S., Yang, X., Zhang, C., et al. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231170371 · Cited by 28 · see citing works

In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy

Yu, L., Fan, G., Wang, Q., Zhu, Y., Zhu, H., Chang, J., Wang, Z., Zhan, S., Hua, X., She, D., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06159-3 · Cited by 28 · see citing works

Hydroxyapatite coated titanium with curcumin and epigallocatechin gallate for orthopedic and dental applications

Kushram, P., Majumdar, U., & Bose, S. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213667 · Cited by 28 · see citing works

Probiotic Biofilm Modified 3D‐Printing Scaffolds for Improving Chemo‐Immunotherapy of Bone Tumor and Promoting Osteogenesis

Gu, H.-Y., Fan, J., Bao, P., Qu, W., Hu, Z., Qi, B., Zhang, X., & Yu, A. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311015 · Cited by 27 · see citing works

Construction of Osteosarcoma Diagnosis Model by Random Forest and Artificial Neural Network

Li, S., Que, Y., Yang, R., He, P., Xu, S., & Hu, Y. S. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030447 · Cited by 26 · see citing works

Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways

Zeng, X., Liu, S., Yang, H., Jia, M., Liu, W., & Zhu, W. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad070 · Cited by 26 · see citing works

Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions

Zhang, X., Zhao, Z., Wang, X., Zhang, S., Zhao, Z., Feng, W., Xu, L., Nie, J., Li, H., Liu, J., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06727-1 · Cited by 26 · see citing works

NIR‐II AIEgens nanosystem for fluorescence and chemiluminescence synergistic imaging‐guided precise resection in osteosarcoma surgery

Li, R., Liu, K., Hu, Q., Shen, J., Zuo, D., Wang, H., Zhu, X., & Sun, W. (2024) · Aggregate · doi:10.1002/agt2.658 · Cited by 26 · see citing works

Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)

Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., & Li, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5478 · Cited by 26 · see citing works

Sequential Therapy for Osteosarcoma and Bone Regeneration via Chemodynamic Effect and Cuproptosis Using a 3D‐Printed Scaffold with TME‐Responsive Hydrogel

Xie, D., Hu, C., Zhu, Y., Yao, J., Li, J., Xia, J., Ye, L., Jin, Y., Jiang, S., Hu, T., et al. (2024) · Small · doi:10.1002/smll.202406639 · Cited by 26 · see citing works

Fabrication of a composite 3D-printed titanium alloy combined with controlled in situ drug release to prevent osteosarcoma recurrence

Fan, D., Zhang, C., Wang, H., Wei, Q., Cai, H., Wei, F., Bian, Z., Liu, W., Wang, X., & Liu, Z. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100683 · Cited by 26 · see citing works

Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

Xu, Y., Yang, L., Li, M., Shu, H., Jia, N., Gao, Y., Shi, R., Yang, X., Zhang, Z., & Zhang, L. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.10.005 · Cited by 26 · see citing works

A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy

Liu, Y., Dong, S., Hu, W., Chen, Q., Zhang, S.-F., Song, K., Han, Z.-C., Li, M., Han, Z., Liu, W., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.007 · Cited by 25 · see citing works

PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Liu, B., Li, W., Zhang, W., Feng, C., Wan, L., He, S., Xu, R., Fu, Z., Liu, Z., Xu, H., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02250-7 · Cited by 25 · see citing works

PLOD2 high expression associates with immune infiltration and facilitates cancer progression in osteosarcoma

Wang, Z., Fan, G., Zhu, H., Yu, L., She, D., Wei, Y., Huang, J., Li, T., Zhan, S., Zhou, S., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.980390 · Cited by 25 · see citing works

The roles and mechanisms of circular RNAs related to mTOR in cancers

Cao, C., Wang, Y., Wu, X., Li, Z., Guo, J., & Sun, W. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24783 · Cited by 25 · see citing works

The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications

Zeng, J., Peng, Y., Wang, D., Ayesha, K., & Chen, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1123065 · Cited by 25 · see citing works

CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma

Cheng, L., Xiong, W., Li, S., Wang, G., Zhou, J., & Li, H. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3563 · Cited by 24 · see citing works

Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Wang, C., Zhang, Y., Kong, W., Rong, X., Zhong, Z., Jiang, L., Chen, S., Li, C., Zhang, F., & Jiang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s471900 · Cited by 24 · see citing works

Neoadjuvant Chemotherapy for Adults with Osteogenic Sarcoma

Robinson, M. J., & Davis, E. J. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01269-2 · Cited by 24 · see citing works

Towards precision medicine: design considerations for nanozymes in tumor treatment

Li, X., Hu, J., Zhao, Q., Yao, W., Jing, Z., & Jin, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05845-w · Cited by 24 · see citing works

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway

Cheng, J., Zhang, Y., Wan, R., Zhou, J., Wu, X., Fan, Q., He, J., Tan, W., & Deng, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.919108 · Cited by 24 · see citing works

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization

Sheng, G., Gao, Y., Ding, Q., Zhang, R., Wang, T., Jing, S., Zhao, H., Ma, T., Wu, H. K., & Yang, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03985-z · Cited by 24 · see citing works

Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine

Tan, L., Wang, Y., Hu, X., Du, G., Tang, X., & Min, L. (2023) · Biomolecules · doi:10.3390/biom13091362 · Cited by 24 · see citing works

Subtractive Nanopore Engineered MXene Photonic Nanomedicine with Enhanced Capability of Photothermia and Drug Delivery for Synergistic Treatment of Osteosarcoma

Hui, T., Fu, J., Zheng, B., Fu, C., Zhao, B., Zhang, T., Zhang, Y., Wang, C., Yu, L., Yang, Y., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c10572 · Cited by 24 · see citing works

Highly Biocompatible Polyester-Based Piezoelectric Elastomer with Antitumor and Antibacterial Activity for Ultrasound-Enhanced Piezoelectric Therapy

Deng, X., Zhao, R., Tang, Y., Yi, M., Ge, Z., Wang, D., Fang, Q., Xiong, Z., Duan, A., Liu, W., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c11749 · Cited by 24 · see citing works

Biomaterials‐Boosted Immunotherapy for Osteosarcoma

Sun, C., Li, S., & Ding, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400864 · Cited by 23 · see citing works

Tumor microenvironment in osteosarcoma: From cellular mechanism to clinical therapy

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