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PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Open accessAbstract
Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and current dogma holds that the SCN is required for the expression of circadian rhythms in peripheral tissues. Using a PERIOD2::LUCIFERASE fusion protein as a real-time reporter of circadian dynamics in mice, we report that, contrary to previous work, peripheral tissues are capable of self-sustained circadian oscillations for >20 cycles in isolation. In addition, peripheral organs expressed tissue-specific differences in circadian period and phase. Surprisingly, lesions of the SCN in mPer2(Luciferase) knockin mice did not abolish circadian rhythms in peripheral tissues, but instead caused phase desynchrony among the tissues of individual animals and from animal to animal. These results demonstrate that peripheral tissues express self-sustained, rather than damped, circadian oscillations and suggest the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level.
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“It has been shown that the circadian rhythm exists even at the organ level in the culture and the cellular level (48, 49).”
From Modeling the hypothalamus-pituitary-adrenal axis: A review and extension (2015) · cites this paper as [49]
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Metadata
- Authors
- Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., Menaker, M., & Takahashi, J. S.
- Affiliations
- Northwestern University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-02-12
- Volume
- 101
- Issue
- 15
- Pages
- 5339-5346
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC397382
- OpenAlex
- W2014313900
- Cited by
- 2,329
- References
- 41
- Citations by year
- 2026: 64 · 2025: 88 · 2024: 95 · 2023: 101 · 2022: 135 · 2021: 121 · 2020: 145 · 2019: 132 · 2018: 115 · 2017: 128 · 2016: 104 · 2015: 132 · 2014: 121 · 2013: 121 · 2012: 114
- FWCI
- 29.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- Korea Advanced Institute of Science and Technology
- National Institutes of Health
- National Institute of Mental Health (R01MH056647, MH 56647)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, peripheral circadian rhythms, suprachiasmatic nucleus, circadian period, circadian phase
- MeSH terms
- Animals, Circadian Rhythm, Cornea, Female, Kidney, Liver, Luciferases, Luminescent Measurements, Lung, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Nuclear Proteins, Phenotype, Pituitary Gland, Recombinant Fusion Proteins, Suprachiasmatic Nucleus, Culture Techniques, Mice
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