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The colorectal microRNAome

Cummins, Jordan M., He, Yiping, Leary, Rebecca J., Pagliarini, Ray, Diaz, Luis A., Sjoblom, Tobias, Barad, Omer, Bentwich, Zvi, Szafranska, Anna E., Labourier, Emmanuel, Raymond, Christopher K., Roberts, Brian S., Juhl, Hartmut, Kinzler, Kenneth W., Vogelstein, Bert, Velculescu, Victor E.·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0511155103
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Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have important regulatory roles in multicellular organisms. The public miRNA database contains 321 human miRNA sequences, 234 of which have been experimentally verified. To explore the possibility that additional miRNAs are present in the human genome, we have developed an experimental approach called miRNA serial analysis of gene expression (miRAGE) and used it to perform the largest experimental analysis of human miRNAs to date. Sequence analysis of 273,966 small RNA tags from human colorectal cells allowed us to identify 200 known mature miRNAs, 133 novel miRNA candidates, and 112 previously uncharacterized miRNA* forms. To aid in the evaluation of candidate miRNAs, we disrupted the Dicer locus in three human colorectal cancer cell lines and examined known and novel miRNAs in these cells. These studies suggest that the human genome contains many more miRNAs than currently identified and provide an approach for the large-scale experimental cloning of novel human miRNAs in human tissues.

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Crossref · 10.1073/pnas.0511155103

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Citations

Cites

Research works printed but not linked: 31

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Metadata

Authors
Cummins, J. M., He, Y., Leary, R. J., Pagliarini, R., Diaz, L. A., Sjoblom, T., Barad, O., Bentwich, Z., Szafranska, A. E., Labourier, E., Raymond, C. K., Roberts, B. S., Juhl, H., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E.
Affiliations
  • The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231;
  • Rosetta Genomics, 10 Plaut Street, Science Park, Rehovot 76706, Israel;
  • Ambion Diagnostics, 2130 Woodward Street, Austin, TX 78744;
  • Rosetta Inpharmatics, 401 Terry Avenue North, Seattle, WA 98109; and
  • Indivumed GmbH, Center for Cancer Research at the Israelitic Hospital, Orchideenstieg 14, 22297 Hamburg, Germany
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2006-02-27
Volume
103
Issue
10
Pages
3687-3692
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.0511155103
Cited by
744
References
2
Language
en

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