Navigation-associated medial parietal neurons in monkeys
Open accessAbstract
To examine the neural basis of route knowledge by which one can reach one's destination, we recorded the activity of 580 neurons in the monkey medial parietal region (MPR) while monkeys actively navigated through a virtual environment. One hundred eighty of these neurons (31%) showed significant responses to the monkeys' movements in the virtual environment. Of these responsive neurons, 77% (139/180) showed responses associated with a specific movement at a specific location (navigation neurons), 8% (14/180) showed responses associated with a specific movement (movement-selective neurons), and the remaining 27 neurons (15%) were nonselective. We found navigation neurons whose responses to the same movement at the same location were modulated depending on the route that the monkey was currently taking, that is, in a route-selective manner (32 of 59 tested neurons among 139 navigation neurons, route-selective navigation neurons). The reversible inactivation of MPR neurons by muscimol resulted in a monkey becoming lost during the navigation task trial. These results suggest that MPR plays a critical role in route-based navigation by integrating location information and self-movement information.
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Cells in the retrosplenial/medial parietal region encode a variety of spatial quantities, not just heading direction.
“This is consistent with previous work indicating that cells in the retrosplenial/medial parietal region encode a variety of spatial quantities, not just heading direction33, 38.”
From Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe (2014) · cites this paper as [38]
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Self-citation
- Authors
- Sato, N., Sakata, H., Tanaka, Y. L., & Taira, M.
- Affiliations
- Nihon University (JP)
- Tokyo Seiei College (JP)
- Chiba University (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-11-07
- Volume
- 103
- Issue
- 45
- Pages
- 17001-17006
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1624861
- OpenAlex
- W2051529218
- Cited by
- 82
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nihon University
- Ministry of Education, Culture, Sports, Science and Technology (17022038)
- Japan Society for the Promotion of Science (17022038, 17300131)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- virtual navigation, muscimol inactivation, location data, spatial cognition
- MeSH terms
- Animals, Cognition, Locomotion, Macaca, Male, Models, Neurological, Neurons, Parietal Lobe, User-Computer Interface
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