CoChat
Sign Up
Cited by 143Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Running rewires the neuronal network of adult-born dentate granule cells

Open access
Vivar, Carmen, Peterson, Benjamin D., van Praag, Henriette·2016·NeuroImage
DOI 10.1016/j.neuroimage.2015.11.031PMC PMC6003242
Open this paper in CoChat — free account

Abstract

Exercise improves cognition in humans and animals. Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain area important for learning and memory. It is unclear how running modifies the circuitry of new dentate gyrus neurons to support their role in memory function. Here we combine retroviral labeling with rabies virus mediated trans-synaptic retrograde tracing to define and quantify new neuron afferent inputs in young adult male C57Bl/6 mice, housed with or without a running wheel for one month. Exercise resulted in a shift in new neuron networks that may promote sparse encoding and pattern separation. Neurogenesis increased in the dorsal, but not the ventral, dentate gyrus by three-fold, whereas afferent traced cell labeling doubled in number. Regional analysis indicated that running differentially affected specific inputs. Within the hippocampus the ratio of innervation from inhibitory interneurons and glutamatergic mossy cells to new neurons was reduced. Distal traced cells were located in sub-cortical and cortical regions, including perirhinal, entorhinal and sensory cortices. Innervation from entorhinal cortex (EC) was augmented, in proportion to the running-induced enhancement of adult neurogenesis. Within EC afferent input and short-term synaptic plasticity from lateral entorhinal cortex, considered to convey contextual information to the hippocampus was increased. Furthermore, running upregulated innervation from regions important for spatial memory and theta rhythm generation, including caudo-medial entorhinal cortex and subcortical medial septum, supra- and medial mammillary nuclei. Altogether, running may facilitate contextual, spatial and temporal information encoding by increasing adult hippocampal neurogenesis and by reorganization of new neuron circuitry.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2015.11.031

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Running, unlike fluoxetine, increases neurogenesis in the dorsal, but not in the ventral region of the dentate gyrus.

    “Notably, running, unlike fluoxetine increases neurogenesis in the dorsal, but not in the ventral region of the dentate gyrus (Vivar et al., 2016), a finding that satisfactorily correlates the different types of cognitive response induced by the two stimuli with the different area of the dentate gyrus activated by them.”

    From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Vivar et al., 2016

    The Results section (“Running increases new granule cell (GC) number and total afferent input”; page unavailable) reports increased neurogenesis in the dorsal, but not the ventral, dentate gyrus of running mice. The paper does not report a fluoxetine comparison, so it does not support the claim’s “unlike fluoxetine” qualification. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Running, similarly to fluoxetine, enhances the plasticity of new neurons by increasing dendritic complexity and spine density as well as short-term synaptic plasticity from lateral entorhinal cortex.

    “Remarkably, running, similarly to fluoxetine, enhances also the plasticity of new neurons, by increasing dendritic complexity and spine density (Eadie et al., 2005;Stranahan et al., 2007) as well as the shortterm synaptic plasticity from lateral entorhinal cortex, thus favoring the integration of contextual and spatial information (Vivar et al., 2016(Vivar et al., , 2013)).”

    From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Vivar et al., 2016

  • Running increases the ratio of inhibitory interneuron versus excitatory mossy cell innervation onto new granule neurons and enhances the number of new axon fibers projecting to the CA3 and CA2 subregions.

    “Using viral-based methods, running has been found to increase the ratio of inhibitory interneuron versus excitatory mossy cell innervation onto new granule neurons (Sah et al., 2017; Vivar et al., 2016) as well as to enhance the number of new axon fibers projecting to the CA3 and CA2 subregions (Llorens-Martín et al., 2015).”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Vivar et al., 2016

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Vivar, C., Peterson, B. D., & van Praag, H.
Affiliations
National Institutes of Health (US)
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2016-05
Volume
131
Pages
29-41
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2015.11.031
PMC
PMC6003242
OpenAlex
W2213316970
Semantic Scholar
cfdb576062edc1575c97b54dd1fdbeefd35f460a
Cited by
143
References
95
Citations by year
2026: 7 · 2025: 8 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 15 · 2020: 17 · 2019: 19 · 2018: 17 · 2017: 16 · 2016: 13
FWCI
6.22
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
running, adult hippocampal neurogenesis, dentate gyrus, dentate gyrus granule cells, entorhinal cortex, mossy cells, inhibitory interneurons, synaptic plasticity, pattern separation, sparse coding, spatial memory, contextual memory, theta oscillations, medial septum, mammillary nuclei, exercise and cognition
MeSH terms
Aging, Animals, Cerebellar Nuclei, Male, Mice, Inbred C57BL, Nerve Net, Neuronal Plasticity, Neurons, Running, Mice, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review