The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Open accessAbstract
The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics. To investigate the neural basis of these effects, we combined intranasal oxytocin administration with high-resolution functional magnetic resonance imaging in a unique emotion classification task. Emotional faces were briefly presented while controlling for the initial fixation, and measuring subsequent eye movements. Oxytocin had differential effects on the activity of specific amygdala subregions. On the one hand, it attenuated activation in lateral and dorsal regions of the anterior amygdala for fearful faces but enhanced activity for happy expressions, thus indicating a shift of the processing focus toward positive social stimuli. On the other hand, oxytocin increased the likelihood of reflexive gaze shifts toward the eye region irrespective of the depicted emotional expression. This gazing pattern was related to an increase of activity in the posterior amygdala and an enhanced functional coupling of this region to the superior colliculi. Thus, different behavioral effects of oxytocin seem to be closely related its specific modulatory influence on subregions within the human amygdala.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Functioning as both a neurotransmitter and a hormone, oxytocin's targets are widespread and include the hippocampus and the amygdala (10–12).”
From Oxytocin promotes human ethnocentrism (2011) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“and the activity of amygdala subregions is also modulated by OXT (Gamer et al., 2010).”
From Oxytocin Modulates Social Distance between Males and Females (2012) · cites this paper as Gamer et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“These studies have repeatedly demonstrated decreased amygdala activation, which has been interpreted as a neural mechanism underlying oxytocin’s anxiolytic effects18,20,21.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [21]
In the citing paper
“This dose, administered intranasally, has been shown in nonhuman primates to increase OT levels in cerebrospinal fluid significantly (54) and to modulate social behavior (65), as well as to affect brain activity (66) and phasic activity of the parasympathetic nervous system (67) in humans.”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [66]
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [14]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [14]
In the citing paper
“In humans, alterations in amygdala responses to positive and negative emotions have been reported in neuropsychiatric conditions, such as autism and schizophrenia [72,73], in association with OXTR genetic variants [41,102] or following intranasal OXT [33,36,38,103].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [103]
In the citing paper
“In this context, the insula17 as well as the amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces18–22 or social stimuli in general23.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [21]
In the citing paper
“attenuating activation of amygdala to social stimuli (Baumgartner et al, 2008;Domes et al, 2007a;Gamer et al, 2010;Kirsch et al, 2005)”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Gamer et al, 2010
In the citing paper
“Gamer and colleagues found that oxytocin’s effects on amygdala activity elicited by emotional faces was dependent on the valence of stimuli but the effects of oxytocin on enhancement of gaze shifts towards the eyes was valence independent (Gamer et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“In addition, oxytocin suppresses amygdala activation for fearful faces but enhances activity for happy faces (Gamer et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Oxytocin decreases amygdala activation during the perception of fear-inducing or aversive social stimuli; it has been suggested that this explains the stress-reducing effects of oxytocin (Gamer et al., 2010;Riem et al., 2011).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Gamer et al., 2010
In the citing paper
“Because projections between the amygdala and brainstem are involved in fear behavior and arousal (LeDoux, 2000) it has been suggested that decreased amygdala activation might be the underlying neural mechanism of the anxiolytic effects of oxytocin (Gamer et al., 2010;Riem et al., 2011).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Gamer et al., 2010
In the citing paper
“Research in humans has almost exclusively focused on the role of oxytocin in the regulation of prosocial behavior, including trust, attachment, and sexual behavior (2–5), largely ignoring potential effects of the neuropeptide on ingestive behavior and metabolism.”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [4]
In the citing paper
“intranasal oxytocin administration has been shown to reliably modulate neuropsychological functions in a series of studies (2–5) in the absence of relevant side effects (16).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [4]
In the citing paper
“Following intranasal OT (Syntocinon spray, Novartis), humans spend more time visually inspecting the eye region of faces compared to placebo (i.e., all inactive ingredients except for the peptide) (Gamer et al., 2010; Guastella et al., 2008).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Furthermore, OT inhalation reduces amygdala activation when viewing fearful faces but increases amygdala activation when viewing happy faces (Gamer et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Importantly, the activity of amygdala sub-regions has been shown to be modulated by the neuropeptide oxytocin (OT; Gamer et al., 2010;Hurlemann et al., 2010), indicating that OT is a candidate hormone for modulating interpersonal distance.”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Gamer et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,403
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
A mechanism for impaired fear recognition after amygdala damage
Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005) · Nature · doi:10.1038/nature03086 · Cited by 1,331 · cited 4×
“This observation precisely accounts for the clinical findings of reduced spontaneous fixations on the eye region and a failure to identify fearful expressions in a patient with complete bilateral amygdala damage (20, 21).”
BackgroundInfluential
Cited by
Sorted by citations
Items 301–400 of 487
Intranasal oxytocin enhances socially-reinforced learning in rhesus monkeys
Parr, L. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00278 · Cited by 23
Mayer, A. V., Wermter, A.-K., Stroth, S., Alter, P., Haberhausen, M., Stehr, T., Paulus, F. M., Krach, S., & Kamp-Becker, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-94407-x · Cited by 23
Zhuang, Q., Zhu, S., Yang, X., Zhou, X., Xu, X., Chen, Z., Lan, C., Zhao, W., Becker, B., Yao, S., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120972347 · Cited by 23
“…may be primarily due to a greater influence on positive reinforcement and is in agreement with several previous studies reporting enhanced behavioral or neural responses to positive valence stimuli (Domes et al., 2013; Gamer et al., 2010; Guastella et al., 2008; Xu et al., 2015; Yao et al., 2018).”
BackgroundResultInfluentialZimmermann, J., Deris, N., Montag, C., Reuter, M., Felten, A., Becker, B., Weber, B., & Markett, S. A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.06.014 · Cited by 23
“Previous intranasal oxytocin administration studies revealed subregion specific effects on task-induced amygdala activity (Gamer et al., 2011) as well as on the intrinsic connectivity of the amygdala (Eckstein et al., 2017), with differential effects of oxytocin on the functional connectivity of…”
Amygdala activity for the modulation of goal-directed behavior in emotional contexts
Maeda, K., Kunimatsu, J., & Hikosaka, O. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005339 · Cited by 19
Lancaster, K., Goldbeck, L., Puglia, M. H., Morris, J. P., & Connelly, J. J. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy086 · Cited by 25
“Given that prior literature has found differential effects of oxytocin in subregions of the amygdala (Gamer et al., 2010), we conducted a final ROI analysis using a probabilistic mask of the basolateral amygdala to examine whether effects of OXTR methylation on amygdala gray matter were specific to the central nucleus.”
MethodOxytocin increases eye gaze in schizophrenia
Bradley, E. R., Seitz, A., Niles, A. N., Rankin, K. P., Mathalon, D. H., O'Donovan, A., & Woolley, J. D. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.07.039 · Cited by 22
“Importantly, oxytocin-induced changes in amygdala activation have been linked to changes in visual attention to faces (Gamer et al., 2010).”
BackgroundResultThe Social-Cognitive Basis of Personality Disorders: Commentary on the Special Issue
Herpertz, S. C. (2013) · Journal of Personality Disorders · doi:10.1521/pedi.2013.27.1.113 · Cited by 22
Ellenbogen, M. A., Linnen, A., Cardoso, C., & Joober, R. (2014) · Psychophysiology · doi:10.1111/psyp.12263 · Cited by 24
Chen, Y., Li, Q., Zhang, Q., Kou, J., Zhang, Y., Cui, H., Wernicke, J., Montag, C., Becker, B., Kendrick, K. M., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.589878 · Cited by 26
Endorphins, oxytocin, sexuality and romantic relationships: An understudied area
Khajehei, M., & Behroozpour, E. (2018) · World Journal of Obstetrics and Gynecology · doi:10.5317/wjog.v7.i2.17 · Cited by 22
Soriano, J. R., Daniëls, N., Prinsen, J., & Alaerts, K. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa093 · Cited by 21
“Several lines of evidence provide support for oxytocin’s impact on increasing social salience (see Shamay-Tsoory and Abu-Akel, 2016 for a review) by, for example, showing increased dwelling time towards the eye region of faces after intranasal administration of oxytocin (Guastella et al., 2008; Gamer et al., 2010; Auy…”
BackgroundMalykhin, N. V., Pietrasik, W., Aghamohammadi‐Sereshki, A., Hoang, K. N., Fujiwara, E., & Olsen, F. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25152 · Cited by 20
Atkinson, A. P., & Smithson, H. E. (2020) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/xhp0000712 · Cited by 20
“Gamer et al. (2010) did, though, find that participants were faster to classify happiness with fixation on the center of the mouth and to classify fear with fixation on the midpoint between the eyes.”
BackgroundMaking Sense of Computational Psychiatry
Mujica-Parodi, L. R., & Strey, H. H. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa013 · Cited by 20
“…of oxytocin when patients played several variations of a neuroeconomic game, as well as subsequent neuroimaging experiments of fear (Kirsch et al., 2005), conditioned fear (Petrovic et al., 2008), and fearful faces (Domes et al., 2007; Gamer et al., 2010), seemed initially to support this model.”
ResultNostalgia enhances detection of death threat: neural and behavioral evidence
Yang, Z., Sedikides, C., Izuma, K., Wildschut, T., Kashima, E. S., Luo, Y. L. L., Chen, J., & Cai, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-91322-z · Cited by 21
The effect of intranasal oxytocin on visual processing and salience of human faces
Hovey, D., Martens, L., Laeng, B., Leknes, S., & Westberg, L. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00991-3 · Cited by 20
The amygdala encodes level of perceived fear but not emotional ambiguity in visual scenes
Kryklywy, J. H., Nantes, S. G., & Mitchell, D. G. V. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.06.010 · Cited by 19
Dong, N., Du, P., Hao, X., He, Z., Hou, W., Wang, L., Yuan, W., Yang, J., Jia, R., & Tai, F. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.07.006 · Cited by 20
Awareness modulates responses of the amygdala and the visual cortex to highly arousing visual threat
Hoffmann, M., Lipka, J., Mothes‐Lasch, M., Miltner, W. H. R., & Straube, T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.05.064 · Cited by 18
“studies with increased number of trials, event-related designs, the use of pattern analysis or increased spatial resolution by higher field strength and/or suited acquisition parameters (Gamer and Buchel, 2009; Gamer et al., 2010).”
Oxytocin and the Biopsychology of Performance in Team Sports
Pepping, G., & Timmermans, E. J. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/567363 · Cited by 24
“[85] investigated the neural basis of the modulatory effects of oxytocin on processing positive social stimuli and gaze-orientating behavior.”
BackgroundFestante, F., Ferrari, P. F., Thorpe, S., Buchanan, R. W., & Fox, N. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104467 · Cited by 19
“Following the administration of acute OT, several functional neuroimaging (fMRI) investigations have reported attenuated amygdala activation for fearful and stressful stimuli and, in contrast, enhanced activation of this region in response to the presentation of stimuli with positive valence (Gamer et al., 2010; Labus…”
BackgroundGenetic variation in the oxytocin system and its link to social motivation in human infants
Krol, K. M., Namaky, N., Monakhov, M. V., Lai, P. S., Ebstein, R. P., & Großmann, T. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105290 · Cited by 18
“that heightened oxytocin exposure is associated with increased brain or behavioral responding to positive stimuli and a simultaneous attenuated response to negative stimuli in adults (Gamer et al., 2010; Kirsch et al., 2005; Krol et al., 2014b; Marsh et al., 2010), non-human primates (Parr et al.”
BackgroundCoenjaerts, M., Adrovic, B., Trimborn, I., Philipsen, A., Hurlemann, R., & Scheele, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-29754-y · Cited by 17
Mouth versus eyes: Gaze fixation during perception of sung interval size.
Russo, F., Sandstrom, G. M., & Maksimowski, M. (2011) · Psychomusicology Music Mind and Brain · doi:10.1037/h0094007 · Cited by 14
Oxytocin's impact on social face processing is stronger in homosexual than heterosexual men
Thienel, M., Heinrichs, M., Fischer, S., Ott, V., Jan Born, A., & Hallschmid, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.013 · Cited by 18
“In imaging studies in male participants, intranasal oxytocin dampened the amygdala response to threatening social stimuli like negative facial expressions (Kirsch et al., 2005; Domes et al., 2007; Gamer et al., 2010) and attenuated the deterioration of ratings of likeability for male faces induced by aversive conditio…”
Romero‐Martínez, Á., Sarrate‐Costa, C., & Moya‐Albiol, L. (2021) · Biology · doi:10.3390/biology10121334 · Cited by 19
“Furthermore, empirical research included in this review pointed out that administration of oxytocin, cortisol, and/or testosterone also interfered with activation of some of the structures involved in processing emotional stimuli [34,40,117,127].”
BackgroundO’Connell, G., Whalley, H. C., Mukherjee, P., Stanfield, A. C., Montag, C., Hall, J., & Reuter, M. (2012) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2012.21007 · Cited by 17
“Gamer and colleagues [34] used combined fMRI and eye-tracking to investigate the link between social atten-”
BackgroundEffects of Intensity of Facial Expressions on Amygdalar Activation Independently of Valence
Lin, H., Müller-Bardorff, M., Mothes‐Lasch, M., Buff, C., Brinkmann, L., Miltner, W. H. R., & Straube, T. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00646 · Cited by 19
“…of the amygdala is supposed to form the main visual input region of the amygdala and to be involved in the encoding of facial expression (e.g., Gamer et al., 2010; Boll et al., 2011; Sauer et al., 2014); whereas the corticomedial amygdala, which comprises of the medial, cortical and central…”
BackgroundLan, C., Liu, C., Li, K., Zhao, Z., Yang, J., Ma, Y., Scheele, D., Yao, S., Kendrick, K. M., & Becker, B. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac037 · Cited by 18
“In line with the functional role of this pathway previous OXT studies in humans reported that OXT induced a modulation effect on the functional connectivity between amygdala and the superior colliculus toward both threatening and non-threatening social stimuli (Kirsch, 2005; Gamer et al., 2010).”
BackgroundAmygdala activation to threat under attentional load in individuals with anxiety disorder
Straube, T., Lipka, J., Sauer, A., Mothes‐Lasch, M., & Miltner, W. H. R. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-12 · Cited by 16
“The amygdala’s influence on attentional functions is not specific for anxious subjects or anxiety disorders, but can be found in healthy subjects as well (for example, [43,44,50]).”
BackgroundMelchers, M., Montag, C., Markett, S. A., Niazy, N., Groß-Bölting, J., Zimmermann, J., & Reuter, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.036 · Cited by 17
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16
Koven, N. S., & Max, L. K. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.018 · Cited by 16
“, 2011), boosting the capacity to attend to the eye region of the face (Gamer et al., 2010), and increasing mentalization through a decoding of eye expression (MacDonald et al.”
BackgroundTaubert, J., Flessert, M., Liu, N., & Ungerleider, L. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-51422-3 · Cited by 17
Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence
Liu, Y., Wu, B., Wang, X., Li, W., Zhang, T., Wu, X., & Han, S. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx116 · Cited by 15
“OT vs placebo administration increased neural responses in the reward system in response to happy faces (Gamer et al., 2010) and during anticipation of social reward (Groppe et al.”
BackgroundSkyberg, A. M., Newman, B. T., Graves, A. J., Goldstein, A. M., Brindley, S. R., Kim, M., Druzgal, T. J., Connelly, J. J., & Morris, J. P. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02380-y · Cited by 17
Wang, T., Tang, Q., Wu, X., & Chen, X. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173015 · Cited by 16
Beach, S. R. H., Lei, M., Brody, G. H., & Philibert, R. A. (2016) · Prevention Science · doi:10.1007/s11121-016-0709-5 · Cited by 17
“At the same time, the oxytocin system has been shown to regulate cognitive and emotional responses, reduce activation of the amygdala, and augment connectivity between the amygdala and brain structures supporting affective control (Gamer et al. 2010; Puglia et al. 2015), all potential longer-term outcomes of interest…”
Chronic central oxytocin infusion impairs sociability in mandarin voles
Du, P., He, Z., Cai, Z., Hao, X., Dong, N., Yuan, W., Hou, W., Yang, J., Jia, R., & Tai, F. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.09.006 · Cited by 14
“For example, the amygdala, a region of the brain that is strongly involved in social perception and emotional processing, has been implicated as one of the key regions involved in mediating neuronal actions of OT on social behavior in humans (Baumgartner et al., 2008; Gamer et al., 2010; Hurlemann et al., 2010) as wel…”
Morphological Features of Human Dendritic Spines
Renner, J., & Rasia‐Filho, A. A. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_9 · Cited by 18
Effects of Intranasal Oxytocin on Emotion Recognition in Korean Male: A Dose-Response Study
Shin, N. Y., Park, H. Y., Jung, W. H., & Kwon, J. S. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.02.19 · Cited by 14
Distinctive amygdala subregions involved in emotion-modulated Stroop interference
Han, H. J., Lee, K.-H., Kim, H. T., & Kim, H. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst021 · Cited by 16
“Third, a few recent studies have applied high-resolution imaging protocols with isotropic voxel sizes that range from 1.5 to 2 mm 3 in order to examine separate amygdala subregions (Gamer et al., 2010; Bach et al., 2011; Prévost et al., 2011, 2012).”
InfluentialSauer, C., Montag, C., Reuter, M., & Kirsch, P. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.06.005 · Cited by 13
Functional Magnetic Resonance Imaging of the Amygdala and Subregions at 3 Tesla: A Scoping Review
Foster, S., Breukelaar, I. A., Ekanayake, K., Lewis, S. J., & Korgaonkar, M. S. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28836 · Cited by 13
“Only four studies used high-resolution data exclusively 17,45,46,62 while two other studies used a combination of high and standard resolution data.”
van Dillen, L. F., Enter, D., Peters, L. P. M., DIJK, W. W. V., & Rotteveel, M. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.01.016 · Cited by 14
The role of oxytocin on peaceful associations and sociality in mammals
Romero, T., Onishi, K., & Hasegawa, T. (2016) · Behaviour · doi:10.1163/1568539x-00003358 · Cited by 13
Yue, T., Yue, C., Liu, G., & Huang, X. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00205 · Cited by 13
“While previous studies indicated that OXT can increase recruitment of attentional resources to facial cues (Gamer et al., 2010; Tollenaar et al., 2013), we could infer that, because of the effects of OXT, participants could pay more attention to the facial EMO information and ignore the…”
BackgroundIntranasal oxytocin in rhesus monkeys alters brain networks that detect social salience and reward
Parr, L. A., Mitchell, T., & Hecht, E. E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22915 · Cited by 13
Eye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces
Marsh, N., Scheele, D., Postin, D., Onken, M., & Hurlemann, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.629760 · Cited by 13
“While prior studies investigated the effects of OXT on the ability to recognize differences between self and others (43), emotion expression (44), and gaze toward the eye-region of neutral faces (26), it remains unclear whether the facilitating effects of OXT vary as a function of facial familiarity.”
BackgroundProcyshyn, T. L., Lombardo, M. V., Lai, M., Jassim, N., Bonnie Auyeung, B., Crockford, S. K., Deakin, J., Soubramanian, S., Sule, A., Terburg, D., et al. (2022) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsac016 · Cited by 14
“Such studies have reported that a single dose of intranasal oxytocin influences amygdala activation in neurotypical participants (Kirsch et al., 2005; Gamer et al., 2010; Pincus et al., 2010; Radke et al., 2017; Geng et al., 2018; Xin et al., 2020), in people with affective or anxiety-related disorders (Labuschagne et…”
Oxytocin promotes species-relevant outgroup attention in bonobos and chimpanzees
Brooks, J., Kano, F., Kawaguchi, Y., & Yamamoto, S. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105182 · Cited by 13
Oxytocin Decreases Accuracy in the Perception of Social Deception
Israel, S., Hart, E., & Winter, E. (2013) · Psychological Science · doi:10.1177/0956797613500794 · Cited by 14
Oxytocin facilitates socially directed attention
Le, J., Zhao, W., Kou, J., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2021) · Psychophysiology · doi:10.1111/psyp.13852 · Cited by 13
Mayer, A. V., Preckel, K., Ihle, K., Piecha, F. A., Junghanns, K., Reiche, S., Rademacher, L., Müller‐Pinzler, L., Stolz, D. S., Kamp‐Becker, I., et al. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.10.004 · Cited by 12
West, T. V., & Mendes, W. B. (2023) · Advances in experimental social psychology · doi:10.1016/bs.aesp.2022.11.002 · Cited by 12
Spilka, M. J., Keller, W. R., Buchanan, R. W., Gold, J. M., Koenig, J. I., & Strauss, G. P. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13421 · Cited by 13
Boyle, A., Johnson, A. P., & Ellenbogen, M. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105796 · Cited by 12
Festante, F., Rayson, H., Paukner, A., Kaburu, S., Toschi, G., Fox, N. A., & Ferrari, P. F. (2021) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2021.100950 · Cited by 12
Thorson, K. R., McKernan, S. M., West, T. V., Woolley, J. D., Mendes, W. B., & Stauffer, C. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-99957-8 · Cited by 12
The Multifaceted Role of Oxytocinergic System and OXTR Gene
Hasan, R. (2024) · Global Medical Genetics · doi:10.1055/s-0044-1779039 · Cited by 12
“34 The effect of oxytocin on the human brain depends on the expression of the OXTR gene.”
BackgroundTemporal dynamics of intranasal oxytocin in human brain electrophysiology
Zelenina, M., Kosilo, M., da Cruz, J. N., Antunes, M. C. D. S., Figueiredo, P., Mehta, M. A., & Prata, D. P. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab404 · Cited by 10
“As expected from previous studies (Gamer et al. 2010), they observed the expected left amygdala inhibition response to fear to be most effective at the 45–70 min interval postadministration.”
BackgroundResultInfluentialThe medial amygdala’s neural circuitry: Insights into social processing and sex differences
Ignacio, B., Baeza, J., Ruiz, B., Romero, J. P., Yáñez, P., Ramírez, C., Caprile, T., Farkas, C., & Recabal, A. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101190 · Cited by 11
“The amygdala likely plays a role in coordinating complex emotions like music perception (Blood and Zatorre, 2001), interpretation of faces depicting different emotions (Gamer et al., 2010), and empathy, the lack of which may also result in psychiatric disorders.”
Empathy: The genetics-environment-endocrine-brain mechanism
Yang, Y., Yi, T. A. N. G., Peng, W., Lu, X., Hu, L., & Chen, J. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972017-00832 · Cited by 10
Peripheral Oxytocin Predicts Higher-Level Social Cognition in Men Regardless of Empathy Quotient
Deuse, L., Wudarczyk, O. A., Rademacher, L., Kaleta, P., Karges, W., Kacheva, S., Gründer, G., & Lammertz, S. E. (2018) · Pharmacopsychiatry · doi:10.1055/a-0590-4850 · Cited by 11
“Shamay-Tsoory and AbuAkel [15] proposed a theoretical framework that credits OT with regulating the salience of socially relevant information and is empirically supported by eye-tracking [16] and brain-imaging data [17].”
BackgroundSocialStress and Social Approach
Heinrichs, M., Chen, F. S., Domes, G., & Kumsta, R. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9780511843716.028 · Cited by 10
Oxytocin modulates responses to inequity in dogs
Romero, T., Konno, A., Nagasawa, M., & Hasegawa, T. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.12.023 · Cited by 9
“Consistent with this idea, oxytocin receptors are densely 449 localized in brain areas implicated in emotional and social information processing, such as the 450 amygdala, hypothalamus, or nucleus accumbens [56, 57].”
BackgroundFoveal processing of emotion-informative facial features
Duran, N., & Atkinson, A. P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260814 · Cited by 10
Witte, A., Riem, M., van der Knaap, N., de Moor, M. D., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105731 · Cited by 8
“studies examining the effects of oxytocin administration on amygdala activation (Gamer et al., 2010; Skvortsova et al., 2020), and can provide valuable information about which parts of the brain are differentially activated after hormone administration.”
BackgroundDoes the Amygdala Mediate Oxytocin Effects on Socially Reinforced Learning?
Gamer, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2847-10.2010 · Cited by 9
Intranasal oxytocin attenuates insula activity in response to dynamic angry faces
Ma, Y., Ran, G., Hu, N., Hu, Y., Long, W., & Chen, X. (2020) · Biological Psychology · doi:10.1016/j.biopsycho.2020.107976 · Cited by 9
Effects of intranasal oxytocin on tactile perception
Silva, J. U., Galhardoni, R., de Andrade, D. C., & Brito, I. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.032 · Cited by 10
Oxytocin and social learning in socially anxious men and women
Flechsenhar, A., Levine, S. M., Müller, L. E., Herpertz, S. C., & Bertsch, K. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109930 · Cited by 8
Intranasal oxytocin enhances the perception of ambiguous averted gaze in women but not in men
Zheng, Y., Shi, Y., Jia, H., Gao, S., & Hu, Z. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05828-5 · Cited by 8
Zimmermann, K. M., Schmidt, K. D., Gronow, F., Sommer, J. B., Leweke, F., & Jansen, A. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118223 · Cited by 9
Antecedents of Moral Pride: the Harder the Action, the Greater the Pride?
Etxebarría, I., Ortiz, M. J., Apodaca, P., Pascual, A., & Conejero, S. (2014) · The Spanish Journal of Psychology · doi:10.1017/sjp.2014.56 · Cited by 8
Empathy as a Concept from Bench to Bedside: A Translational Challenge
Uysal, N., Çamsarı, U. M., Ateş, M., Kandiş, S., Karakılıç, A., & Camsari, G. B. (2019) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.23457 · Cited by 8
“recognition accuracy (32, 33), although controversy exists (34, 35).”
BackgroundPauwels, L., Declerck, C. H., & Boone, C. (2017) · Games · doi:10.3390/g8020020 · Cited by 7
“The finding that eyes of negative valence are more successful in enforcing a prosocial norm is readily reconciled with other studies: functional Magnetic Resonance research has corroborated that eyes expressing anger are anxiogenic, heightening arousal [40].”
ResultIntranasal Oxytocin Increases Perceptual Salience of Faces in the Absence of Awareness
Xue, S., Wu, H.-B., Zhang, L., & Zhang, D.-X. (2020) · Psychiatry Investigation · doi:10.30773/pi.2019.0130 · Cited by 8
Mädchen mit Störungen des Sozialverhaltens
Stadler, C., Euler, F., & Schwenck, C. (2013) · Kindheit und Entwicklung · doi:10.1026/0942-5403/a000110 · Cited by 8
der Donck, S. V., Moerkerke, M., Dlhosova, T., Vettori, S., Dzhelyova, M. P., Alaerts, K., & Boets, B. (2022) · Psychophysiology · doi:10.1111/psyp.14026 · Cited by 8
Smith, J. F., Hur, J., Kaplan, C. M., & Shackman, A. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/272302 · Cited by 7
Oxytocin differentially modulates the early neural responses to faces and non-social stimuli
Moses, E., Nelson, N. L., Taubert, J., & Pegna, A. J. (2024) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsae010 · Cited by 6
“…(Liu et al. , 2015; Wang et al. , 2017; Grace et al. , 2018; Tully et al. , 2018), with marked reductions in the activity elicited by fearful faces (Kirsch et al. , 2005; Dodhia et al. , 2014; Grace et al. , 2018) and marked increases in the activity elicited by happy faces (Gamer et al. , 2010).”
BackgroundOral Oxytocin Blurs Sex Differences in Amygdala Responses to Emotional Scenes
Lan, C., Kou, J., Liu, Q., Qing, P., Zhang, X., Song, X., Xu, D., Zhang, Y., Chen, Y., Zhou, X., et al. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.05.010 · Cited by 7
Liu, Y. T., Wang, D., & Li, H. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab277 · Cited by 7
Amygdala subfield and prefrontal cortex abnormalities in patients with functional seizures
Nasrullah, N., Kerr, W. T., Stern, J. M., Wang, Y., Tatekawa, H., Lee, J. K., Karimi, A. H., Sreenivasan, S. S., Engel, J., Eliashiv, D. E., et al. (2023) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2023.109278 · Cited by 6
Lee, M., Lori, A., Langford, N. A., & Rilling, J. K. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105869 · Cited by 6
Hellwig, A. F., Wroblewski, K. L., Krol, K. M., Connelly, J. J., & Allen, J. P. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107123 · Cited by 5
Gao, X., Wu, Y., Zheng, R., Kou, Y., Xing, H., Li, K., & Zhang, M. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1823431 · Cited by 8
“It assigns emotional and motivational significance to stimuli (81–83), influencing attention (84, 85) and food choices (86, 87).”
Two functions of the primate amygdala in social gaze
Gilardeau, S., Cirillo, R., Jazayeri, M., Dupuis, C., Wirth, S., & Duhamel, J. (2021) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2021.107881 · Cited by 9
László, K., Vörös, D., Kiss, O., László, B. R., Ollmann, T., Péczely, L., Mintál, K., Tóth, A., Kovács, A., Zagorácz, O., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092309 · Cited by 6
“also shows that OT increases AMY activity in response to pleasant stimuli but decreases AMY activity in response to unpleasant social stimuli [38].”
BackgroundOn the preparation and characterization of thin NiTi shape memory alloy wires for MEMS
Casati, R., Vedani, M., Tofail, S. A. M., Dikinson, C., & Tuissi, A. (2012) · Frattura ed Integrità Strutturale · doi:10.3221/igf-esis.23.01 · Cited by 5
From histology to macroscale function in the human amygdalaPreprint
Auer, H., Cabalo, D. G., Rodríguez‐Cruces, R., Benkarim, O. M., Paquola, C., DeKraker, J., Wang, Y., Valk, S. L., Bernhardt, B. C., & Royer, J. (2024) · eLife · doi:10.7554/elife.101950 · Cited by 5
Morphological heterogeneity of neurons in the human central amygdaloid nucleus
Vásquez, C. E., Guerra, K. T. K., Renner, J., & Rasia‐Filho, A. A. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25319 · Cited by 7
Meisner, O. C., Monte, O. D., Fagan, N., Nandy, A. S., & Chang, S. W. C. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.2416-24.2025 · Cited by 4
Association between salivary oxytocin levels and the amygdala and hippocampal volumes
Shou, Q., Yamada, J., Nishina, K., Matsunaga, M., Matsuda, T., & Takagishi, H. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02543-5 · Cited by 4
Brain Oxytocin is a Main Regulator of Prosocial Behaviour - Link to Psychopathology
Lukas, M., & Inga, N. (2011) · InTech eBooks · doi:10.5772/18841 · Cited by 7
“More specifically, it could be shown that OT promotes the activity in amygdala regions involved in the processing of positive social stimuli (Gamer et al., 2010), an effect that was shown to generalize to facial expressions, irrespective of their valence (Domes et al., 2007a) .”
Aliyari, H., Golabi, S., Sahraei, H., Sahraei, M., Bidgoli, B. M., Daliri, M. R., Hazrati, R., Tadayyoni, H., & Kazemi, M. (2022) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2022.3811.1 · Cited by 4
“OT facilitates the social approach by reducing anxiety and neuroendocrine stress responses and has shown significant effects on anatomically distinct amygdala regions associated with valence processing (Gamer et al., 2010) which is in line with our results in the current study.”
ResultQiao, Z., der Donck, S. V., Moerkerke, M., Dlhosova, T., Vettori, S., Dzhelyova, M. P., van Winkel, R., Alaerts, K., & Boets, B. (2022) · Brain Sciences · doi:10.3390/brainsci12091224 · Cited by 5
“Indeed, at a behavioral level, OT has been found to increase attention orientation toward faces, in particular, expressive faces [26,27], and to increase looking times toward the eye region [10,28].”
BackgroundOxytocin attenuates racial categorization in 14-month-old infants
Ferera, M., Feldman, R., Zagoory‐Sharon, O., & Diesendruck, G. (2023) · Infant Behavior and Development · doi:10.1016/j.infbeh.2023.101824 · Cited by 4
Metadata
- Authors
- Gamer, M., Zurowski, B., & Büchel, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-04-26
- Volume
- 107
- Issue
- 20
- Pages
- 9400-9405
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2889107
- OpenAlex
- W2077718235
- Cited by
- 487
- References
- 53
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 25 · 2020: 38 · 2019: 16 · 2018: 31 · 2017: 40 · 2016: 30 · 2015: 38 · 2014: 43 · 2013: 59 · 2012: 46
- FWCI
- 68.76
- Type
- journal article
- Language
- en
- Update notices
- correction (2011-01-18)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, amygdala subregions, emotional face processing, valence, attentional bias, gaze shifts, eye movements, superior colliculus, social cognition
- MeSH terms
- Adult, Amygdala, Attention, Double-Blind Method, Emotions, Eye Movements, Face, Germany, Humans, Magnetic Resonance Imaging, Male, Oxytocin, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
