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Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Open accessAbstract
The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics. To investigate the neural basis of these effects, we combined intranasal oxytocin administration with high-resolution functional magnetic resonance imaging in a unique emotion classification task. Emotional faces were briefly presented while controlling for the initial fixation, and measuring subsequent eye movements. Oxytocin had differential effects on the activity of specific amygdala subregions. On the one hand, it attenuated activation in lateral and dorsal regions of the anterior amygdala for fearful faces but enhanced activity for happy expressions, thus indicating a shift of the processing focus toward positive social stimuli. On the other hand, oxytocin increased the likelihood of reflexive gaze shifts toward the eye region irrespective of the depicted emotional expression. This gazing pattern was related to an increase of activity in the posterior amygdala and an enhanced functional coupling of this region to the superior colliculi. Thus, different behavioral effects of oxytocin seem to be closely related its specific modulatory influence on subregions within the human amygdala.
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In the citing paper
“Functioning as both a neurotransmitter and a hormone, oxytocin's targets are widespread and include the hippocampus and the amygdala (10–12).”
From Oxytocin promotes human ethnocentrism (2011) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“and the activity of amygdala subregions is also modulated by OXT (Gamer et al., 2010).”
From Oxytocin Modulates Social Distance between Males and Females (2012) · cites this paper as Gamer et al., 2010
In the citing paper
“This dose, administered intranasally, has been shown in nonhuman primates to increase OT levels in cerebrospinal fluid significantly (54) and to modulate social behavior (65), as well as to affect brain activity (66) and phasic activity of the parasympathetic nervous system (67) in humans.”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [66]
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [14]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [14]
In the citing paper
“In humans, alterations in amygdala responses to positive and negative emotions have been reported in neuropsychiatric conditions, such as autism and schizophrenia [72,73], in association with OXTR genetic variants [41,102] or following intranasal OXT [33,36,38,103].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [103]
In the citing paper
“In this context, the insula17 as well as the amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces18–22 or social stimuli in general23.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [21]
In the citing paper
“These studies have repeatedly demonstrated decreased amygdala activation, which has been interpreted as a neural mechanism underlying oxytocin’s anxiolytic effects18,20,21.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [21]
In the citing paper
“attenuating activation of amygdala to social stimuli (Baumgartner et al, 2008;Domes et al, 2007a;Gamer et al, 2010;Kirsch et al, 2005)”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Gamer et al, 2010
In the citing paper
“Gamer and colleagues found that oxytocin’s effects on amygdala activity elicited by emotional faces was dependent on the valence of stimuli but the effects of oxytocin on enhancement of gaze shifts towards the eyes was valence independent (Gamer et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“In addition, oxytocin suppresses amygdala activation for fearful faces but enhances activity for happy faces (Gamer et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Oxytocin decreases amygdala activation during the perception of fear-inducing or aversive social stimuli; it has been suggested that this explains the stress-reducing effects of oxytocin (Gamer et al., 2010;Riem et al., 2011).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Gamer et al., 2010
In the citing paper
“Because projections between the amygdala and brainstem are involved in fear behavior and arousal (LeDoux, 2000) it has been suggested that decreased amygdala activation might be the underlying neural mechanism of the anxiolytic effects of oxytocin (Gamer et al., 2010;Riem et al., 2011).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Gamer et al., 2010
In the citing paper
“Research in humans has almost exclusively focused on the role of oxytocin in the regulation of prosocial behavior, including trust, attachment, and sexual behavior (2–5), largely ignoring potential effects of the neuropeptide on ingestive behavior and metabolism.”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [4]
In the citing paper
“intranasal oxytocin administration has been shown to reliably modulate neuropsychological functions in a series of studies (2–5) in the absence of relevant side effects (16).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [4]
In the citing paper
“Following intranasal OT (Syntocinon spray, Novartis), humans spend more time visually inspecting the eye region of faces compared to placebo (i.e., all inactive ingredients except for the peptide) (Gamer et al., 2010; Guastella et al., 2008).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Furthermore, OT inhalation reduces amygdala activation when viewing fearful faces but increases amygdala activation when viewing happy faces (Gamer et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Importantly, the activity of amygdala sub-regions has been shown to be modulated by the neuropeptide oxytocin (OT; Gamer et al., 2010;Hurlemann et al., 2010), indicating that OT is a candidate hormone for modulating interpersonal distance.”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Gamer et al., 2010
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Citations
Cites
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Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives
Vitale, E. M., & Smith, A. S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.846315 · Cited by 127
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“This and related work has led to the hypothesis that oxytocin may mediate prosocial behaviors by increasing positive social stimulus processing, reducing anxiety related to threat cues, and improving the capacity to attend to social cues.(25) Studies examining the neural response to oxytocin administration in FTD are…”
BackgroundThe human amygdala is necessary for developing and expressing normal interpersonal trust
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Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress
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“, 2008), attention-shift to socially relevant cues (Gamer et al., 2010), improved mind-reading from facial expressions (Domes et al.”
BackgroundRole of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 102
Intranasal oxytocin effects on social cognition: A critique
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“…there is also Please cite this article as: Evans, S.L., et al., Intranasal oxytocin http://dx.doi.org/10.1016/j.brainres.2013.11.008 evidence that OT can enhance amygdala activity for happy expressions, possibly reflecting a shift of processing toward positive social stimuli (Gamer et al., 2010).”
InfluentialOxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99
Acute intranasal oxytocin improves positive self-perceptions of personality
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“This may occur, in part, via three distinct changes in information processing: increased salience of social stimuli (Bartz et al. 2011; Gamer et al. 2010; Perry et al. 2010), facilitated processing of positive interpersonal stimuli in the environment (Marsh et al. 2010; Unkelbach et al. 2008), and…”
BackgroundInfluentialKoch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98
Oxytocin decreases aversion to angry faces in an associative learning task
Evans, S., Shergill, S. S., & Averbeck, B. B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.110 · Cited by 97
“Functional imaging results suggest that oxytocin increases eye movements towards the eye region in healthy subjects by making them more salient or appetitive (Gamer et al ., 2010).”
Declerck, C. H., Boone, C., & Kiyonari, T. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst040 · Cited by 96
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95
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“It is not written to evaluate clinical practice, but rather to review interventions that have attempted to improve joint attention, relate them to the SMH and oxytocin, and discuss implications of oxytocin findings for interventions.”
BackgroundThe Role of the Oxytocin System in Anxiety Disorders
Yoon, S., & Kim, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_7 · Cited by 96
Wang, D., Yan, X., Li, M., & Ma, Y. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx085 · Cited by 86
“amygdala activity was mainly contributed by the contrasts examining IN-OT effects on positive social and affective processes (Gamer et al., 2010; Rilling et al., 2012,2014; Rupp et al., 2013), whereas the OT-decreased amygdala activity was mainly contributed by contrasts on negative-valenced processes”
BackgroundOxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal
Riem, M. M. E., van IJzendoorn, M. H., Tops, M., Boksem, M. A. S., Rombouts, S. A. R. B., & Bakermans-Kranenburg, M. J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.011 · Cited by 91
“Oxytocin decreases amygdala activation during the perception of fear-inducing or aversive social stimuli; it has been suggested that this explains the stress-reducing effects of oxytocin (Gamer et al., 2010; Riem et al., 2011).”
InfluentialHu, J., Qi, S., Becker, B., Luo, L., Gao, S., Gong, Q., Hurlemann, R., & Kendrick, K. M. (2015) · Human Brain Mapping · doi:10.1002/hbm.22760 · Cited by 98
“…OXT has been shown to influence amygdala, insula and fusiform and superior temporal gyri responses to emotional faces [Domes et al., 2007, 2010; Gamer et al., 2010; Kirsch et al., 2005] there was no evidence for this, at least in the context of the neutral expression face switching to a happy…”
BackgroundAmygdala lesions in rhesus macaques decrease attention to threat
Monte, O. D., Costa, V. D., Noble, P. L., Murray, E. A., & Averbeck, B. B. (2015) · Nature Communications · doi:10.1038/ncomms10161 · Cited by 97
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“…& Pare, 2010) and in terms of comparability to the few existing fMRI studies that previously reported functional dissociations of amygdala subregions in humans on the basis of high-resolution fMRI (Davis et al., 2010; Gamer et al., 2010; Bach et al., 2011; Boll et al., 2011; Prevost et al., 2011).”
BackgroundResultOxytocin specifically enhances valence-dependent parasympathetic responses
Gamer, M., & Büchel, C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.007 · Cited by 86
“Blood oxygenation level dependent functional images and eye movements were additionally acquired during the task but these data are reported elsewhere (Gamer et al., 2010).”
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OT promotes closer interpersonal distance among highly empathic individuals
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“Importantly, the activity of amygdala sub-regions has been shown to be modulated by the neuropeptide oxytocin (OT; Gamer et al., 2010; Hurlemann et al., 2010), indicating that OT is a candidate hormone for modulating interpersonal distance.”
The many faces of oxytocin: Implications for psychiatry
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“The neural mechanism for this OT effect on attachment avoidance may relate to OT action in portions of the amygdala and hippocampus (Andari et al., 2012; Kirsch et al., 2005; Gamer et al., 2010).”
BackgroundIn the face of fear: Anxiety sensitizes defensive responses to fearful faces
Grillon, C., & Charney, D. R. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01268.x · Cited by 86
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Oxytocin enhances attention to the eye region in rhesus monkeys
Dal Monte, O., Noble, P. L., Costa, V. D., & Averbeck, B. B. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00041 · Cited by 80
“Consistent with effects seen in humans (Challinor et al., 1994; Gamer et al., 2010; Kliemann et al., 2010, 2012; Arizpe et al., 2012), our findings indicated that varying the presentation location of the stimuli affects patterns of eye movements.”
BackgroundMethodInfluentialAmygdala subnuclei response and connectivity during emotional processing
Hrybouski, S., Aghamohammadi‐Sereshki, A., Madan, C. R., Shafer, A. T., Baron, C. A., Seres, P., Beaulieu, C., Olsen, F., & Malykhin, N. V. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.056 · Cited by 85
“, 2013), processing of emotional facial expressions (Boll et al., 2011; Gamer et al., 2010), appetitive conditioning (Prévost et al.”
MethodInfluentialSex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces.
Luo, L., Becker, B., Geng, Y., Zhao, Z., Gao, S., Zhao, W., Yao, S., Zheng, X., Ma, X., Gao, Z., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.08.079 · Cited by 79
“Although there has been some inconsistency in relation to reported effects of valence, most studies in men have found decreased limbic, particularly amygdala, responses to negatively valenced faces (Domes et al., 2007; Gamer et al., 2010; Kirsch et al., 2005).”
ResultShackman, A. J., Stockbridge, M. D., Tillman, R. M., Kaplan, C. M., Tromp, D., Fox, A. S., & Gamer, M. (2016) · Journal of Experimental Psychopathology · doi:10.5127/jep.054015 · Cited by 84
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“The current findings are in agreement with oxytocin administration studies that report a valence-specific impact on the processing of emotions (Gamer et al., 2010; Marsh et al., 2010; Gamer and Buchel, 2012; Kirsch et al., 2005) and critically extend them by identifying similar effects early in development now using a…”
Oxytocin and socioemotional aging: current knowledge and future trends
Ebner, N. C., Maura, G. M., MacDonald, K., Westberg, L., & Fischer, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00487 · Cited by 78
“Furthermore, intranasal administration of OT increases overall gaze time toward faces (Guastella et al., 2008; Andari et al., 2010; Averbeck, 2010; Gamer et al., 2010) and increases emotion recognition, specifically of happy and fearful faces (and under certain conditions angry faces; see…”
BackgroundMethodInfluentialGeng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Hurlemann, R., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00512 · Cited by 78
Oxytocin attenuates neural reactivity to masked threat cues from the eyes
Kanat, M., Heinrichs, M., Schwarzwald, R., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.183 · Cited by 77
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73
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The rehabilitation of face recognition impairments: a critical review and future directions
Bate, S., & Bennetts, R. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00491 · Cited by 76
Amygdala subregions differentially respond and rapidly adapt to threatening voices
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Maternal oxytocin response during mother–infant interaction: Associations with adult temperament
Strathearn, L., Iyengar, U., Fonagy, P., & Kim, S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.014 · Cited by 76
“…cooperation in response to social cues (Declerck et al., 2010), facial emotion recognition (Marsh et al., 2010; Rimmele et al., 2009), eye gaze (Gamer et al., 2010; Guastella et al., 2008a), trust (Baumgartner et al., 2008) and attachment (Buchheim et al., 2009), but appears to reduce some…”
Fan, Y., Pestke, K., Feeser, M., Aust, S., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.123 · Cited by 75
The other side of the coin: oxytocin decreases the adherence to fairness norms
Radke, S., & de Bruijn, E. R. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00193 · Cited by 73
“, 2007), and social perception (Guastella et al., 2008a,b; Keri and Benedek, 2009; Gamer et al., 2010), suggesting a strong association between OXT and empathy (Zak et al.”
BackgroundInfluentialDirect Evidence for Domain-Sensitive Functional Subregions in Human Entorhinal Cortex
Schultz, H., Sommer, T., & Peters, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5126-11.2012 · Cited by 73
“During each of the six sessions, 307 volumes were acquired, using a T2*-weighted EPI sequence (37 slices, 2 2 2 mm, no gap, TR 2.37 s, TE 30 ms) that was previously established to identify differential functional responses of amygdala subregions (Gamer et al., 2010).”
BackgroundMethodInfluentialOxytocin and vasopressin: Social neuropeptides with complex neuromodulatory functions
Benarroch, E. E. (2013) · Neurology · doi:10.1212/wnl.0b013e31828cfb15 · Cited by 74
“OXT increased activation of the right posterior amygdala regardless of the depicted emotional facial expression; this was associated with increased functional coupling of the right posterior amygdala to the superior colliculus and probability of reflexive gaze shifts toward the eye region of the face.(65) During emoti…”
BackgroundChang, S. W. C., & Platt, M. L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.006 · Cited by 71
“Following intranasal OT (Syntocinon spray, Novartis), humans spend more time visually inspecting the eye region of faces compared to placebo (i.e., all inactive ingredients except for the peptide) (Gamer et al., 2010; Guastella et al., 2008).”
BackgroundOxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71
“, 2010), and attention to socially relevant information of human faces (Guastella et al., 2008a; Gamer et al., 2010).”
BackgroundOxytocin response in a trust game and habituation of arousal
Kéri, S., & Kiss, I. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.011 · Cited by 72
Social neuroscience: The social brain, oxytocin, and health
Norman, G. J., Hawkley, L. C., Cole, S. W., Berntson, G. G., & Cacioppo, J. T. (2011) · Social Neuroscience · doi:10.1080/17470919.2011.568702 · Cited by 77
Restoring effects of oxytocin on the attentional preference for faces in autism
Kanat, M., Spenthof, I., Riedel, A., van Elst, L. T., Heinrichs, M., & Domes, G. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.67 · Cited by 70
Oxytocin administration alters HPA reactivity in the context of parent–infant interaction
Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.06.006 · Cited by 70
“An fMRI study showed that gaze to the eye region was linked with enhanced functional connectivity between the amygdala and the superior colliculi (Gamer et al., 2010), brain circuits involving social information processing.”
Striepens, N., Matusch, A., Kendrick, K. M., Mihov, Y., Elmenhorst, D., Becker, B., Lang, M., Coenen, H. H., Maier, W., Hurlemann, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.026 · Cited by 71
“A number of previous studies have reported reduced amygdala activity in response to OXT treatment (Bethlehem et al., 2013; Gamer et al., 2010; Striepens et al., 2011).”
BackgroundIntranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw123 · Cited by 72
“Key words: PTSD; oxytocin; social; reward; insula; medication-enhanced psychotherapy (MEP)”
BackgroundHuffmeijer, R., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2012) · Gerontology · doi:10.1159/000341333 · Cited by 71
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
Tollenaar, M. S., Chatzimanoli, M., van der Wee, N. J. A., & Putman, P. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.018 · Cited by 68
“That is, Guastella et al. (2008a,b) found increased gaze behavior to neutral faces and Gamer et al. (2010) to neutral, happy and fearful expressions.”
Schneider-Hassloff, H., Straube, B., Jansen, A., Nuscheler, B., Wemken, G., Witt, S. H., Rietschel, M., & Kircher, T. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.009 · Cited by 71
“For the left amygdala enhanced responses to fearful faces in comparison to happy faces have been reported, and OXT administration reversed the response pattern [Gamer et al., 2010].”
BackgroundResultEckstein, M., Markett, S. A., Kendrick, K. M., Ditzen, B., Liu, F., Hurlemann, R., & Becker, B. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.078 · Cited by 70
“Initial evidence for subregion-specific effects of IN-OT on amygdala functioning in humans was provided by a task-based fMRI study reporting that the effects of IN-OT in the domains of valence and attention relate to subregion-specific activity changes in the anterior and posterior amygdala (Gamer et al., 2010).”
InfluentialEffects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.41 · Cited by 69
“Previous neuroimaging studies have shown that intranasal oxytocin reduced amygdala reactivity for emotional faces in healthy males (Gamer et al, 2010; Kirsch et al, 2005; Petrovic et al, 2008) and patients with social anxiety disorder (Labuschagne et al, 2010), although the results were mixed…”
BackgroundResultInfluentialThe effect of oxytocin on attention to angry and happy faces in chronic depression
Domes, G., Normann, C., & Heinrichs, M. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0794-9 · Cited by 73
Tang, Y., Chen, Z., Tao, H., Li, C., Zhang, X., Tang, A., & Liu, Y. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.004 · Cited by 68
Interpersonal Threat Sensitivity in Borderline Personality Disorder: An Eye-Tracking Study
Bertsch, K., Krauch, M., Stopfer, K., Haeussler, K., Herpertz, S. C., & Gamer, M. (2017) · Journal of Personality Disorders · doi:10.1521/pedi_2017_31_273 · Cited by 68
Oxytocin modulates fMRI responses to facial expression in macaques
Liu, N., Hadj-Bouziane, F., Jones, K. B., Turchi, J. N., Averbeck, B. B., & Ungerleider, L. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508097112 · Cited by 65
“001], but not between expression and treatment [F (3, 522) = 1.”
BackgroundInfluentialOxytocin reduces amygdala responses during threat approach
Radke, S., Volman, I., Kokal, I., Roelofs, K., de Bruijn, E. R. A., & Toni, I. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.028 · Cited by 67
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
Mapping the developmental pathways of child conduct problems through the neurobiology of empathy
Moul, C., Hawes, D. J., & Dadds, M. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.016 · Cited by 72
Jiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25607-1 · Cited by 69
Mishra, A., Rogers, B. P., Chen, L. M., & Gore, J. C. (2013) · Human Brain Mapping · doi:10.1002/hbm.22249 · Cited by 66
“Therefore, as different subregions of the amygdala are known to be involved in distinct brain functions [Gamer et al., 2010; Vizueta et al., 2012], it is plausible that distinct functional networks should be associated with these subregions.”
BackgroundOxytocin's Fingerprint in Personality Traits and Regional Brain Volume
Andari, E., Schneider, F. C., Mottolese, R., Vindras, P., & Sirigu, A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs328 · Cited by 63
“cin also increases the activity of another subregion of the amygdala during the classification of happy faces or when subjects shift their gaze toward the eye region regardless of the emotional valence of the face (Gamer et al. 2010).”
BackgroundOxytocin and the salience of social cues
Averbeck, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004892107 · Cited by 64
“(1) report on a study in which they show that subjects given OT, relative to subjects given placebo, are more likely to make eye movements toward the eye region when viewing images of human faces, which replicates and extends previous work (2, 3).”
BackgroundOxytocin modulates amygdala reactivity to masked fearful eyes
Kanat, M., Heinrichs, M., Mader, I., van Elst, L. T., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.111 · Cited by 65
“Notably, oxytocin’s effects on both facial emotion processing and eye gazing behavior seem to be mediated via the amygdala (Gamer et al, 2010; for a recent review, see Kanat et al, 2014) and to occur very early during stimulus perception (Kanat et al, 2015; Schulze et al, 2011).”
BackgroundAdaptive coding of the value of social cues with oxytocin, an fMRI study in autism spectrum disorder
Andari, E., Richard, N., Leboyer, M., & Sirigu, A. (2016) · Cortex · doi:10.1016/j.cortex.2015.12.010 · Cited by 62
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62
“…attenuated right amygdala responses to fearful, neutral and happy facial expressions (Domes et al., 2007), and left amygdala reactivity to fearful (Gamer et al., 2010) and angry (Kirsch et al., 2005) faces, although no effects of OT have also been reported (Montag et al., 2013; Sauer et al.,…”
InfluentialReprint of: Emotion and cognition and the amygdala: From “what is it?” to “what's to be done?”
Pessoa, L. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.02.030 · Cited by 65
Antitumor activity of benzaldehyde.
Kochi, M., Takeuchi, S., Mizutani, T., Mochizuki, K., Matsumoto, Y., & Saito, Y. (1980) · PubMed · Cited by 62
Oxytocin selectively modulates brain response to stimuli probing social synchrony
Lévy, J., Goldstein, A., Zagoory‐Sharon, O., Weisman, O., Schneiderman, I., Eidelman-Rothman, M., & Feldman, R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.066 · Cited by 63
“For instance, OT increased amygdalar response depending on the valence of social stimuli (Gamer et al., 2010) or on the participants' gender (Domes et al., 2010).”
BackgroundQuintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 66
“OT administration may also facilitate face-processing networks in the amygdala (Gamer et al., 2010) in addition to attenuating fear responses.”
BackgroundMate-choice copying, social information processing, and the roles of oxytocin
Kavaliers, M., Matta, R., & Choleris, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.003 · Cited by 63
“…et al., 2016; Guastella et al., 2008, 2010; Norman et al., 2011; Theodoridou et al., 2009; Theodoridou et al., 2011; Unkelbach et al., 2008) and, as in mice, these OT effects have been correlated with activation of the medial amygdala (Gamer et al., 2010; Huber et al. 2005; Hurlemann et al. 2010).”
Genetic modulation of oxytocin sensitivity: A pharmacogenetic approach
Chen, F. S., Kumsta, R., Dvorak, F., Domes, G., Yim, O. S., Ebstein, R. P., & Heinrichs, M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.163 · Cited by 59
The human amygdala drives reflexive orienting towards facial features
Gamer, M., Schmitz, A. K., Tittgemeyer, M., & Schilbach, L. (2013) · Current Biology · doi:10.1016/j.cub.2013.09.008 · Cited by 59
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61
Li, H., Jiang, T., An, S., Xu, M., Gou, L., Ren, B., Shi, X., Wang, X., Yan, J., Yuan, J., et al. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.022 · Cited by 66
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 61
The impact of oxytocin on stress: the role of sex
Love, T. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.06.018 · Cited by 56
Sociality, pathogen avoidance, and the neuropeptides oxytocin and arginine vasopressin
Kavaliers, M., & Choleris, E. (2011) · Psychological Science · doi:10.1177/0956797611420576 · Cited by 57
“Likewise, the amygdala complex has also been associated with various behavioral actions following intranasal administration of OT in humans (Gamer et al., 2010).”
BackgroundOxytocin sharpens self-other perceptual boundary
Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.010 · Cited by 58
“Oxytocin also dampens amygdala reactivity to threatening faces (Kirsch et al., 2005; Domes et al., 2007; Petrovic et al., 2008; Gamer et al., 2010) and modulates social memory (Heinrichs et al.”
BackgroundMarmosets as model species in neuroscience and evolutionary anthropology
Burkart, J. M., & Finkenwirth, C. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.09.003 · Cited by 63
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte, O., Piva, M., Anderson, K. M., Tringides, M., Holmes, A. J., & Chang, S. W. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702725114 · Cited by 55
Influence of Early Life Stress on Intra- and Extra-Amygdaloid Causal Connectivity
Grant, M. M., Wood, K. H., Sreenivasan, K. R., Wheelock, M. D., White, D. M., Thomas, J., Knight, D. C., & Deshpande, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.28 · Cited by 56
Sniff and mimic–Intranasal oxytocin increases facial mimicry in a sample of men
Korb, S., Malsert, J., Strathearn, L., Vuilleumier, P., & Niedenthal, P. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.003 · Cited by 54
“Indeed, several studies have shown that oxytocin can change neural activity in the amygdala, and amygdala-dependent social learning (Domes et al., 2007a; Gamer et al., 2010; Hurlemann et al., 2010).”
BackgroundOxytocin effects on neural correlates of self-referential processing
Liu, Y., Sheng, F., Woodcock, K. A., & Han, S. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.08.003 · Cited by 55
Moons, W. G., Way, B. M., & Taylor, S. E. (2014) · Emotion · doi:10.1037/a0035503 · Cited by 59
Martial arts increase oxytocin production
Rassovsky, Y., Harwood‐Gross, A., Zagoory‐Sharon, O., & Feldman, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-49620-0 · Cited by 55
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53
“The apparent inconsistency is likely due to region-specific effects of oxytocin within the amygdala (Gamer et al., 2010).”
BackgroundInfluentialEffects of Oxytocin and Vasopressin on Preferential Brain Responses to Negative Social Feedback
Gozzi, M., Dashow, E. M., Thurm, A. E., Swedo, S. E., & Zink, C. F. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.248 · Cited by 54
Mothers' amygdala response to positive or negative infant affect is modulated by personal relevance
Strathearn, L., & Kim, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00176 · Cited by 59
“One fMRI study of intranasal oxytocin using unknown face cues, revealed greater amygdala activation to negative faces in placebo condition, but greater activation to positive, smiling faces after intranasal oxytocin (Gamer et al., 2010).”
BackgroundCircuits for social learning: a unified model and application to autism spectrum disorder
DeMayo, M. M., Young, L. J., Hickie, I. B., Song, Y. J. C., & Guastella, A. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.034 · Cited by 52
“While in humans, oxytocin induced alterations in functional activity of the amygdala have been linked to performance on a broad range of socialcognitive tasks (Bethlehem et al., 2013; Gamer et al., 2010).”
BackgroundAssociation between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards
Damiano, C. R., Aloi, J. M., Dunlap, K., Burrus, C. J., Mosner, M. G., Kozink, R. V., McLaurin, R. E., Mullette-Gillman, O. A., Carter, R., Huettel, S. A., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-7 · Cited by 56
“[44,45,86-91] and plasma OXT levels are associated with striatal responses to a social reward (that is, reciprocated cooperation) [45,46].”
BackgroundSomppi, S., Törnqvist, H., Topál, J., Koskela, A., Hänninen, L. T., Krause, C. M., & Vainio, O. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01854 · Cited by 55
“In primates, oxytocin alters the interconnection patterns of those brain regions involved in attention, perception and emotion regulation (Kirsch et al., 2005; Gamer et al., 2010).”
Simons, R. L., Lei, M., Beach, S. R. H., Cutrona, C. E., & Philibert, R. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000420 · Cited by 57
Metadata
- Authors
- Gamer, M., Zurowski, B., & Büchel, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-04-26
- Volume
- 107
- Issue
- 20
- Pages
- 9400-9405
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2889107
- OpenAlex
- W2077718235
- Cited by
- 487
- References
- 53
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 25 · 2020: 38 · 2019: 16 · 2018: 31 · 2017: 40 · 2016: 30 · 2015: 38 · 2014: 43 · 2013: 59 · 2012: 46
- FWCI
- 68.76
- Type
- journal article
- Language
- en
- Update notices
- correction (2011-01-18)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, amygdala subregions, emotional face processing, valence, attentional bias, gaze shifts, eye movements, superior colliculus, social cognition
- MeSH terms
- Adult, Amygdala, Attention, Double-Blind Method, Emotions, Eye Movements, Face, Germany, Humans, Magnetic Resonance Imaging, Male, Oxytocin, Photic Stimulation
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