The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Open accessAbstract
The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics. To investigate the neural basis of these effects, we combined intranasal oxytocin administration with high-resolution functional magnetic resonance imaging in a unique emotion classification task. Emotional faces were briefly presented while controlling for the initial fixation, and measuring subsequent eye movements. Oxytocin had differential effects on the activity of specific amygdala subregions. On the one hand, it attenuated activation in lateral and dorsal regions of the anterior amygdala for fearful faces but enhanced activity for happy expressions, thus indicating a shift of the processing focus toward positive social stimuli. On the other hand, oxytocin increased the likelihood of reflexive gaze shifts toward the eye region irrespective of the depicted emotional expression. This gazing pattern was related to an increase of activity in the posterior amygdala and an enhanced functional coupling of this region to the superior colliculi. Thus, different behavioral effects of oxytocin seem to be closely related its specific modulatory influence on subregions within the human amygdala.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Functioning as both a neurotransmitter and a hormone, oxytocin's targets are widespread and include the hippocampus and the amygdala (10–12).”
From Oxytocin promotes human ethnocentrism (2011) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“and the activity of amygdala subregions is also modulated by OXT (Gamer et al., 2010).”
From Oxytocin Modulates Social Distance between Males and Females (2012) · cites this paper as Gamer et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“These studies have repeatedly demonstrated decreased amygdala activation, which has been interpreted as a neural mechanism underlying oxytocin’s anxiolytic effects18,20,21.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [21]
In the citing paper
“This dose, administered intranasally, has been shown in nonhuman primates to increase OT levels in cerebrospinal fluid significantly (54) and to modulate social behavior (65), as well as to affect brain activity (66) and phasic activity of the parasympathetic nervous system (67) in humans.”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [66]
In the citing paper
“separate OXT-application studies in humans have indicated that there may be differential amygdala reactivity to fearful faces and fearful/threatening scenes in men (14, 15) and women (16, 17).”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [14]
In the citing paper
“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [14]
In the citing paper
“In humans, alterations in amygdala responses to positive and negative emotions have been reported in neuropsychiatric conditions, such as autism and schizophrenia [72,73], in association with OXTR genetic variants [41,102] or following intranasal OXT [33,36,38,103].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [103]
In the citing paper
“In this context, the insula17 as well as the amygdala seem to be key target regions in the brain, with oxytocin modulating amygdala responsiveness to emotional faces18–22 or social stimuli in general23.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [21]
In the citing paper
“attenuating activation of amygdala to social stimuli (Baumgartner et al, 2008;Domes et al, 2007a;Gamer et al, 2010;Kirsch et al, 2005)”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Gamer et al, 2010
In the citing paper
“Gamer and colleagues found that oxytocin’s effects on amygdala activity elicited by emotional faces was dependent on the valence of stimuli but the effects of oxytocin on enhancement of gaze shifts towards the eyes was valence independent (Gamer et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“In addition, oxytocin suppresses amygdala activation for fearful faces but enhances activity for happy faces (Gamer et al., 2010).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Oxytocin decreases amygdala activation during the perception of fear-inducing or aversive social stimuli; it has been suggested that this explains the stress-reducing effects of oxytocin (Gamer et al., 2010;Riem et al., 2011).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Gamer et al., 2010
In the citing paper
“Because projections between the amygdala and brainstem are involved in fear behavior and arousal (LeDoux, 2000) it has been suggested that decreased amygdala activation might be the underlying neural mechanism of the anxiolytic effects of oxytocin (Gamer et al., 2010;Riem et al., 2011).”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Gamer et al., 2010
In the citing paper
“Research in humans has almost exclusively focused on the role of oxytocin in the regulation of prosocial behavior, including trust, attachment, and sexual behavior (2–5), largely ignoring potential effects of the neuropeptide on ingestive behavior and metabolism.”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [4]
In the citing paper
“intranasal oxytocin administration has been shown to reliably modulate neuropsychological functions in a series of studies (2–5) in the absence of relevant side effects (16).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [4]
In the citing paper
“Following intranasal OT (Syntocinon spray, Novartis), humans spend more time visually inspecting the eye region of faces compared to placebo (i.e., all inactive ingredients except for the peptide) (Gamer et al., 2010; Guastella et al., 2008).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Furthermore, OT inhalation reduces amygdala activation when viewing fearful faces but increases amygdala activation when viewing happy faces (Gamer et al., 2010).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Gamer et al., 2010
In the citing paper
“Importantly, the activity of amygdala sub-regions has been shown to be modulated by the neuropeptide oxytocin (OT; Gamer et al., 2010;Hurlemann et al., 2010), indicating that OT is a candidate hormone for modulating interpersonal distance.”
From OT promotes closer interpersonal distance among highly empathic individuals (2015) · cites this paper as Gamer et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,403
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
A mechanism for impaired fear recognition after amygdala damage
Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005) · Nature · doi:10.1038/nature03086 · Cited by 1,331 · cited 4×
“This observation precisely accounts for the clinical findings of reduced spontaneous fixations on the eye region and a failure to identify fearful expressions in a patient with complete bilateral amygdala damage (20, 21).”
BackgroundInfluential
Cited by
Sorted by citations
Items 201–300 of 487
Dissociable medial temporal pathways for encoding emotional item and context information
Ritchey, M., Wang, S.-F., Yonelinas, A. P., & Ranganath, C. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2018.12.015 · Cited by 49
Vargas, T., Conley, R. E., & Mittal, V. A. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.11.004 · Cited by 56
Chen, F. S., Minson, J. A., Schöne, M., & Heinrichs, M. (2013) · Psychological Science · doi:10.1177/0956797613491968 · Cited by 50
“Throughout human history, eye contact has been considered a powerful tool of interpersonal influence.”
BackgroundDevelopmental effects of oxytocin neurons on social affiliation and processing of social information
Nunes, A. R., Gliksberg, M., Varela, S. A. M., Teles, M., Wircer, E., Blechman, J., Petri, G., Levkowitz, G., & Oliveira, R. F. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2939-20.2021 · Cited by 47
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 53
Boll, S., Gamer, M., Kalisch, R., & Büchel, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.021 · Cited by 51
“Although a few human fMRI studies (Davis et al., 2010; Gamer et al., 2010) reported promising results with respect to a functional dissociation of amygdala subregions, little is known about the functional contribution of the amygdaloid nuclei to the processing of complex social stimuli such as…”
BackgroundEnter, D., Terburg, D., Harrewijn, A., Spinhoven, P., & Karin Roelofs, A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.008 · Cited by 47
“Gaze avoidance of eye contact was reliably indexed as relative reduction of initial gaze fixations on the eye-region (Becker and Detweiler-Bedell, 2009; Gamer et al., 2010; Gamer and Büchel, 2012; Garner et al., 2006 .”
Association between the oxytocin receptor ( OXTR ) gene and children's social cognition at 18 months
Wade, M., Hoffmann, T. J., Wigg, K., & Jenkins, J. M. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12148 · Cited by 55
“…al. 2009), empathic accuracy (Bartz et al. 2010), trusting behavior (Kosfeld et al. 2005), generosity (Barraza & Zak 2009), altruistic behavior (Zak et al. 2007), cooperation (Declerck et al. 2010), eye gaze (Gamer et al. 2010) and the ability to infer others’ emotional states (Domes et al. 2007).”
Attentional mechanisms of social perception are biased in social phobia
Boll, S., Bartholomaeus, M., Peter, U., Lupke, U., & Gamer, M. (2016) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.04.004 · Cited by 57
Distinct Processing of Aversive Experience in Amygdala Subregions
Michely, J., Rigoli, F., Rutledge, R. B., Hauser, T. U., & Dolan, R. J. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.07.008 · Cited by 46
“Recent neuroimag ng studies suggest that CMA and BLA might have distinct functional roles in humans, primarily in the context of associative learning (14, 15), threat prioritisation (16), and social functioning (17, 18).”
BackgroundStevens, S., Rist, F., & Gerlach, A. L. (2010) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2010.11.001 · Cited by 46
Imaging-Genetics in Autism Spectrum Disorder: Advances, Translational Impact, and Future Directions
Ameis, S. H., & Szatmári, P. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00046 · Cited by 49
“Neuroimaging studies have indicated that oxytocin administration promotes prosocial effects in healthy controls that seem to be mediated through altered limbic circuit activation in response to social stimuli (Gamer et al., 2010; Meyer-Lindenberg et al., 2011).”
BackgroundVideo-Based Eye Tracking in Sex Research: A Systematic Literature Review
Wenzlaff, F., Briken, P., & Dekker, A. (2015) · The Journal of Sex Research · doi:10.1080/00224499.2015.1107524 · Cited by 46
Shou, X., Xu, X., Zeng, X., Liu, Y., Yuan, H., Xing, Y., Jia, M., Wei, Q.-Y., Han, S., Zhang, R., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0109-2 · Cited by 45
Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth
Marusak, H. A., Furman, D. J., Kuruvadi, N., Shattuck, D. W., Joshi, S. H., Joshi, A. A., Etkin, A., & Thomason, M. E. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.015 · Cited by 47
“Importantly, administration of intranasal oxytocin appears to alter activity in the basolateral amygdala (Gamer et al., 2010), which may partially explain oxytocin's implicated role in attenuating fear responses.”
BackgroundKiss, I., Levy‐Gigi, E., & Kéri, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.005 · Cited by 45
Female psychopharmacology matters! Towards a sex-specific psychopharmacology
Bolea-Alamanac, B. M., Bailey, S., Lovick, T. A., Scheele, D., & Valentino, R. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747578 · Cited by 46
“15 faces but enhances activity in a more ventral cluster for happy expressions (Gamer et al., 2010).”
BackgroundSeeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 43
“Perhaps given the multiple mechanisms through which oxytocin is proposed to act on the brain, oxytocin shows stimulus- and contextdependent effects in both humans and rodents – for example, divergent modulation of amygdala subregions in response to fearful versus happy facial expressions (Gamer et al., 2010), or diffe…”
Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
Faraji, J., Karimi, M., Soltanpour, N., Moharrerie, A., Rouhzadeh, Z., Lotfi, H., Hosseini, S. A., Jafari, S. Y., Roudaki, S., Moeeini, R., et al. (2018) · eLife · doi:10.7554/elife.40262 · Cited by 46
“, 2016) and it was assumed that OT is involved in social behaviours and social memory (Gamer et al., 2010; Bernaerts et al., 2017; Kirsch et al., 2005; Baumgartner et al., 2008; Kosfeld et al., 2005; Auyeung et al., 2015).”
BackgroundLischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx107 · Cited by 47
“This mechanism has so far only been demonstrated in healthy individuals (Gamer et al., 2010), but it may also work in individuals suffering from ASD, GSAD and BPD because oxytocin appears to affect both abnormal gaze behavior and abnormal (para-)limbic activity in these disorders (e.g. Andari et…”
BackgroundResultInfluentialKról, M. E., & Król, M. K. (2019) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2019.04.022 · Cited by 44
Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.10.019 · Cited by 41
“Given the evidence that OXT may be especially involved in the initial allocation of attentional resources (Gamer, Zurowski & Buchel, 2010), future studies could consider whether monitoring early fixations would result in a stronger relation between eye-gaze and empathy.”
BackgroundEffect of distracting faces on visual selective attention in the monkey
Landman, R., Sharma, J., Sur, M., & Desimone, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420167111 · Cited by 43
“In humans (57) and in monkeys (58), OT has been shown to reduce responses to negative facial expressions not only in the amygdala, but also in inferior temporal cortex and prefrontal cortex (58).”
BackgroundEffects of Oxytocin on Women's Aggression Depend on State Anxiety
Campbell, A. C., & Hausmann, M. (2013) · Aggressive Behavior · doi:10.1002/ab.21478 · Cited by 42
Huffmeijer, R., Alink, L. R. A., Tops, M., Grewen, K., Light, K. C., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.008 · Cited by 43
“…activation among male participants in response to different facial expressions after oxytocin compared to placebo administration (Domes et al., 2007a; Kirsch et al., 2005; Meyer-Lindenberg, 2008; Petrovic et al., 2008), although some have obtained more complex findings (e.g., Gamer et al., 2010).”
Oxytocin Reduces Face Processing Time but Leaves Recognition Accuracy and Eye-Gaze Unaffected
Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617716000886 · Cited by 42
“However, evidence to support an effect of OXT on eye-gaze is mixed (e.g., Andari et al., 2010; Domes et al., 2010, 2013; Gamer et al., 2010; Guastella et al., 2008; Lischke et al., 2012a).”
Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder
Timmermann, M., Jeung, H., Schmitt, R., Boll, S., Freitag, C. M., Bertsch, K., & Herpertz, S. C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.07.483 · Cited by 47
Intrinsic, dynamic and effective connectivity among large-scale brain networks modulated by oxytocin
Jiang, X., Ma, X., Geng, Y., Zhao, Z., Zhou, F., Zhao, W., Yao, S., Yang, S., Zhao, Z., Becker, B., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117668 · Cited by 39
Neurobiological Mechanisms Underlying the Blocking Effect in Aversive Learning
Eippert, F., Gamer, M., & Büchel, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1210-12.2012 · Cited by 45
“While the former analysis was used for the examination of cortical regions, the latter analysis was performed to investigate subcortical effects with greater precision (Eippert et al., 2009; Gamer et al., 2010).”
MethodOxytocin Enhances the Neural Efficiency of Social Perception
Tillman, R. M., Gordon, I., Naples, A. J., Rolison, M. J., Leckman, J. F., Feldman, R., Pelphrey, K. A., & McPartland, J. C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00071 · Cited by 43
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva, M., & Chang, S. W. C. (2018) · American Journal of Primatology · doi:10.1002/ajp.22735 · Cited by 38
“As wasalreadymentioned, someof themostverified findingson theeffects of OT in the human brain involve a reduction in amygdala activation (Baumgartner et al., 2008; Domes, Heinrichs, Glascher, et al., 2007; Gamer et al., 2010; Kirsch et al., 2005).”
BackgroundInfluentialGazeAlyze: a MATLAB toolbox for the analysis of eye movement data
Berger, C., Winkels, M., Lischke, A., & Höppner, J. (2011) · Behavior Research Methods · doi:10.3758/s13428-011-0149-x · Cited by 40
Intranasal oxytocin modulates neural functional connectivity during human social interaction
Rilling, J. K., Chen, X., Chen, X., & Haroon, E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22740 · Cited by 40
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00572 · Cited by 42
Noto, T., Zhou, G., Yang, Q., Lane, G., & Zelano, C. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.752320 · Cited by 44
Tops, S., Habel, U., & Radke, S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.03.002 · Cited by 42
“Given the attenuation of amygdala responses to angry faces after oxytocin administration (Gamer et al., 2010), Puglia et al.”
BackgroundBreastfeeding experience differentially impacts recognition of happiness and anger in mothers
Krol, K. M., Kamboj, S. K., Curran, H. V., & Grossmann, T. (2014) · Scientific Reports · doi:10.1038/srep07006 · Cited by 36
Kumar, J., Vӧllm, B., & Palaniyappan, L. K. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu051 · Cited by 40
“Even a single-dose administration of OXT has a notable influence on the stimulus-induced responses and connectivity of the amygdala (Kirsch et al., 2005; Domes et al., 2007; Domes et al., 2010; Gamer et al., 2010).”
BackgroundOxytocin and emotion processing
Simplicio, M. C. D., & Harmer, C. J. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116641872 · Cited by 40
“…findings on facial-expression recognition and attentional biases: increased attention to facial features that convey a social meaning (eyes, mouth) following oxytocin administration (Gamer et al., 2010; Guastella et al., 2008) could in turn facilitate emotion recognition regardless of emotion type.”
BackgroundResultInfluentialIde, J. S., Nedic, S., Wong, K. F. K., Strey, S. L., Lawson, E. A., Dickerson, B. C., Wald, L. L., Camera, G. L., & Mujica-Parodi, L. R. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.02.035 · Cited by 39
Neural Control of Vascular Reactions: Impact of Emotion and Attention
Okon‐Singer, H., Mehnert, J., Hoyer, J., Hellrung, L., Schaare, H. L., Dukart, J., & Villringer, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0747-13.2014 · Cited by 37
“Analogously, different amygdala subregions were shown to mediate valence-related and attention/predictiveness effects during emotional processing (Gamer et al., 2010; Boll et al., 2013).”
BackgroundVariation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment
Bernhard, R. M., Chaponis, J., Siburian, R., Gallagher, P., Ransohoff, K. J., Wikler, D. I., Perlis, R. H., & Greene, J. D. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw103 · Cited by 41
“Likewise, intranasal administration of oxytocin has been shown to attenuate the amygdala’s response to faces (Domes et al., 2007; Gamer et al., 2010; Koch et al., 2015), fear inducing stimuli (Kirsch et al.”
BackgroundInfluentialTully, J., Gabay, A. S., Brown, D., Murphy, D., & Blackwood, N. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.11.017 · Cited by 39
“Three (Bertsch et al., 2013; Gamer et al., 2010; Petrovic et al., 2008) showed modulation of the amygdala, while two (Petrovic et al.”
BackgroundInfluentialAttachment and Developmental Psychopathology
Fearon, P. R. M., Groh, A. M., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., & Roisman, G. I. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy108 · Cited by 41
The human medial amygdala: structure, diversity, and complexity of dendritic spines
Dall’Oglio, A., Dutra, A. C. L., Moreira, J. E., & Rasia‐Filho, A. A. (2015) · Journal of Anatomy · doi:10.1111/joa.12358 · Cited by 37
Autism Pathogenesis: The Superior Colliculus
Jure, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01029 · Cited by 38
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36
The effects of oxytocin on social reward learning in humans
Clark-Elford, R., Nathan, P. J., Bonnie Auyeung, B., Voon, V., Sule, A., Müller-Sedgwick, U., Dudas, R. B., Sahakian, B. J., Phan, K. L., & Baron‐Cohen, S. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001120 · Cited by 35
“, 2009), increase the response of the amygdala to happy faces (Gamer et al., 2010) and potentiate the effects of social reinforcement learning (Hurlemann et al.”
BackgroundInfluentialModulating amygdala responses to emotion: Evidence from pharmacological fMRI
Patin, A., & Hurlemann, R. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.10.004 · Cited by 36
“(2009) and Gamer et al. (2010) show that while in women T increases response to fearful faces, it decreases this response n men.”
Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans
Brodmann, K., Gruber, O., & Goya‐Maldonado, R. (2017) · Brain Connectivity · doi:10.1089/brain.2017.0528 · Cited by 35
“…show that OT selectively modulated the activation of different amygdala sub-regions depending on the valence of the presented emotional facial expressions, but also that OT-induced gaze shifts toward the eye region of a face irrespective of the presented emotional expression (Gamer et al., 2010).”
Pharmacotherapy for Neuropsychiatric Symptoms in Frontotemporal Dementia
Le, C., & Finger, E. (2021) · CNS Drugs · doi:10.1007/s40263-021-00854-5 · Cited by 26
An evolutionary perspective on the behavioral consequences of exogenous oxytocin application
Ebitz, R. B., & Platt, M. L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00225 · Cited by 35
“While OT has been reported to blunt activity in one amygdala subregion in an fMRI study (Gamer et al., 2010), it is important to note that the amygdala is not a unitary structure, but rather a collection of interconnected nuclei that make very different contributions to behavior (Ursin and Kaada,…”
InfluentialZunhammer, M., Geis, S., Busch, V., Eichhammer, P., & Greenlee, M. W. (2016) · Scientific Reports · doi:10.1038/srep31606 · Cited by 35
Brain circuits signaling the absence of emotion in body language
Sokolov, A. A., Zeidman, P., Erb, M., Pollick, F. E., Fallgatter, A. J., Ryvlin, P., Friston, K. J., & Pavlova, M. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007141117 · Cited by 36
Bernaerts, S., Boets, B., Steyaert, J. G., Wenderoth, N., & Alaerts, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01069-w · Cited by 36
Decreased Plasma Oxytocin Levels in Patients With PTSD
Carmassi, C., Marazziti, D., Mucci, F., Vecchia, A. D., Barberi, F. M., Baroni, S., Giannaccini, G., Palego, L., Massimetti, G., & Dell’Osso, L. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.612338 · Cited by 39
Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder
Alcorn, J. L., Rathnayaka, N. S., Swann, A. C., Moeller, F. G., & Lane, S. D. (2015) · The Psychological Record · doi:10.1007/s40732-015-0139-y · Cited by 38
Interplay between the oxytocin and opioid systems in regulating social behaviour
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 34
From Oxytocin to Compassion: The Saliency of Distress
Kucerova, B., Levit‐Binnun, N., Gordon, I., & Golland, Y. (2023) · Biology · doi:10.3390/biology12020183 · Cited by 36
“Furthermore, oxytocin can improve the detection and recognition of emotional signals by modulating low-level attentional processes, specifically by increasing the time of gaze and number of saccades towards the eye region of facial stimuli [61–64], even in young children [65] and, in particular, for faces expressing f…”
Oxytocin release deficit and social cognition in craniopharyngioma patients
Brandi, M., Gebert, D., Kopczak, A., Auer, M. K., & Schilbach, L. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12842 · Cited by 33
Regional subcortical shape analysis in premanifest Huntington's disease
Tang, X., Ross, C. A., Johnson, H. J., Paulsen, J. S., Laurent Younes, B., Albin, R. L., Ratnanather, J. T., & Miller, M. I. (2018) · Human Brain Mapping · doi:10.1002/hbm.24456 · Cited by 34
Large household reduces dementia mortality: A cross-sectional data analysis of 183 populations
You, W., & Henneberg, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263309 · Cited by 33
Chen, X., Gautam, P., Haroon, E., & Rilling, J. K. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.006 · Cited by 34
“…oxytocin has been shown to modulate various aspects of social behavior, such as empathy (ShamayTsoory et al., 2013), trust (Baumgartner et al., 2008), in-group preference (De Dreu et al., 2010), and memory of socially relevant cues (Domes et al., 2007a; Gamer et al., 2010; Groppe et al., 2013).”
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 34
Alaerts, K., Bernaerts, S., Prinsen, J., Dillen, C., Steyaert, J. G., & Wenderoth, N. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0653-8 · Cited by 36
Brown, E. C., Taş, C., Kuzu, D., Esen-Danacı, A., Karin Roelofs, A., & Brüne, M. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.06.038 · Cited by 33
“There have been some suggestions that oxytocin can enhance the salience of social cues, increasing the affective valence, and thus also the attention towards social stimuli (Averbeck, 2010; Tabak, 2013), which is also indicated by an increase in amygdala activity (Gamer et al., 2010).”
BackgroundKim, Y., Oh, S.-M., Corfield, F., Jeong, D.-W., Jang, E.-Y., & Treasure, J. L. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.2.160 · Cited by 33
Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based?
Lee, S. Y., Lee, A. R., Hwangbo, R., Han, J., Hong, M., & Bahn, G. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.312 · Cited by 33
“frequently gazed at the eye region despite instructions to gaze at the mouth region [56].”
BackgroundCommon and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear
Kreuder, A., Scheele, D., Schultz, J., Hennig, J., Marsh, N., Dellert, T., Ettinger, U., Philipsen, A., Babasiz, M., Herscheid, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920147117 · Cited by 27
Matsuda, Y.-T., Fujimura, T., Katahira, K., Okada, M., Ueno, K., Cheng, K., & Okanoya, K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00551 · Cited by 37
“…involved in processing valence rather than arousal are consistent with the results of these recent studies, which have demonstrated greater activity in the lateral subregion of the amygdala in response to unpleasant faces than in response to pleasant faces (Davis et al., 2010; Gamer et al., 2010).”
BackgroundResultOxytocin reduces food sharing in capuchin monkeys by modulating social distance
Brosnan, S. F., Talbot, C. F., Essler, J. L., Leverett, K., Flemming, T., Dougall, P., Heyler, C., & Zak, P. J. (2015) · Behaviour · doi:10.1163/1568539x-00003268 · Cited by 30
“OT’s anxiolytic effects occur through the down-regulation of amygdala activity (Kirsch et al., 2005; Gamer et al., 2010) and the inhibition of stress hormones, including epinephrine, noriephinephrine and ACTH (Bissett et al.”
BackgroundEffects of gaze direction, head orientation and valence of facial expression on amygdala activity
Sauer, A., Mothes‐Lasch, M., Miltner, W. H. R., & Straube, T. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst100 · Cited by 33
“, 2011) and processing of emotional facial expressions (Hoffman et al., 2007; Gamer et al., 2010).”
InfluentialCrespi, B. J., & Procyshyn, T. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.004 · Cited by 32
Nguyen, M. N., Nishijo, M., Nguyen, A. T. N., Bor, A., Nakamura, T., Hori, E., Nakagawa, H., Ono, T., & Nishijo, H. (2013) · Toxicology · doi:10.1016/j.tox.2013.09.005 · Cited by 30
5-HTTLPR modulates the recognition accuracy and exploration of emotional facial expressions
Boll, S., & Gamer, M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00255 · Cited by 31
“Here, we replicated earlier findings showing that participants orient their gaze toward diagnostically relevant facial features irrespective of task demands (Gamer and Büchel, 2009; Gamer et al., 2010; Kliemann et al., 2012; Scheller et al., 2012).”
BackgroundResultInfluentialLischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx134 · Cited by 29
Le, J., Kou, J., Zhao, W., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00803 · Cited by 33
Horta, M., Ziaei, M., Lin, T., Porges, E. C., Fischer, H., Feifel, D., Spreng, R. N., & Ebner, N. C. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.016 · Cited by 26
“For example, in young men, intranasal OT reduced amygdala activity in response to unpleasant social (Gamer et al., 2010) and emotional stimuli (Domes et al.”
BackgroundLe, J., Kou, J., Zhao, W., Fu, M., Zhang, Y., Becker, B., & Kendrick, K. M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0830-x · Cited by 29
Oxytocin increases bias, but not accuracy, in face recognition line-ups
Bate, S., Bennetts, R. J., Parris, B. A., Bindemann, M., Udale, R. C., & Bussunt, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu150 · Cited by 33
“…et al. , 2013) or approach-withdrawal (Ditzen et al. , 2009; Kemp and Guastella, 2011) mechanism, is supported by several lines of neuroimaging and behavioural evidence (Petrovic et al. , 2008; Shamay-Tsoory et al. , 2009; Gamer et al. , 2010; De Dreu et al. , 2010, 2011; Bartz et al. , 2011).”
Genetic and psychological underpinnings of motivation and satisfaction of industrial salespeople
Bagozzi, R. P., & Verbeke, W. J. M. I. (2019) · Industrial Marketing Management · doi:10.1016/j.indmarman.2019.08.011 · Cited by 29
Acute and Repeated Intranasal Oxytocin Differentially Modulate Brain-wide Functional Connectivity
Pagani, M., Felice, A. D., Montani, C., Galbusera, A., Papaleo, F., & Gozzi, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.036 · Cited by 27
Divergent effects of oxytocin on eye contact in bonobos and chimpanzees
Brooks, J., Kano, F., Sato, Y., Yeow, H., Morimura, N., Nagasawa, M., Kikusui, T., & Yamamoto, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105119 · Cited by 28
The effect of constraining eye-contact during dynamic emotional face perception—an fMRI study
Hadjikhani, N. K., Zürcher, N. R., Lassalle, A., Hippolyte, L., Ward, N., & Johnels, J. Å. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx046 · Cited by 33
“In typical participants, it has been suggested that the amygdala triggers reflexive orientation towards fearful eyes (Gamer and Buchel, 2009; Gamer et al., 2010).”
BackgroundHirosawa, T., Kikuchi, M., Higashida, H., Okumura, E., Ueno, S., Shitamichi, K., Yoshimura, Y., Munesue, T., Tsubokawa, T., Haruta, Y., et al. (2012) · Scientific Reports · doi:10.1038/srep00384 · Cited by 25
Jeung-Maarse, H., Schmitgen, M. M., Schmitt, R., Bertsch, K., & Herpertz, S. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01549-9 · Cited by 29
Kovács, B., & Kéri, S. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.02.010 · Cited by 26
“Similarly, higher resolution scanning would allow a more detailed investigation of the amygdala-complex at the level of subnuclei [27].”
BackgroundOxytocin and Prader-Willi Syndrome
Kabasakalian, A., Ferretti, C. J., & Hollander, E. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_28 · Cited by 26
Oxytocin promotes attention to social cues regardless of group membership
Pfundmair, M., Zwarg, C., Paulus, M., & Rimpel, A. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.03.006 · Cited by 23
Potential for oxytocin use in children and adolescents with mental illness
Netherton, E., & Schatte, D. J. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1212 · Cited by 24
“Gamer et al. (2010) found that administered oxytocin decreased amygdala activity in response to threatening stimuli, represented using pictures of frowning faces, and increased amygdala activity in response to positive stimuli, represented using smiling faces.”
BackgroundLateral OFC Activity Predicts Decision Bias due to First Impressions during Ultimatum Games
Kim, H., Choi, M.-J., & Jang, I.-J. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00136 · Cited by 25
Oxytocin modulates hemodynamic responses to monetary incentives in humans
Mickey, B. J., Heffernan, J., Heisel, C. J., Peciña, M., Hsu, D. T., Zubieta, J.-K., & Love, T. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4423-6 · Cited by 24
“There is evidence to suggest that oxytocinergic effects may be salience (e.g., Wittfoth-Schardt et al. 2012) or valence-dependent (e.g., Domes et al. 2013b; Gamer and Büchel 2012; Gamer et al. 2010; Kis et al. 2013).”
InfluentialRío, R. T.-D., van den Burg, E. H., Stoop, R., & Hegoburu, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5030-5 · Cited by 26
Cellular components of the human medial amygdaloid nucleus
Dall'Oglio, A., Xavier, L. L., Hilbig, A., Ferme, D., Moreira, J. E., Achaval, M., & Rasia‐Filho, A. A. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23192 · Cited by 24
“It is also important for recognizing fearful faces and the positive valence of happy faces (Gamer et al., 2010), which suggests that the Me is vital for modulating emotions and social behaviors.”
BackgroundLinking social behaviour and anxiety to attention to emotional faces in Williams syndrome
Kirk, H., Hocking, D. R., Riby, D. M., & Cornish, K. M. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.09.042 · Cited by 26
Moerkerke, M., Daniëls, N., der Donck, S. V., Tibermont, L., Tang, T., Debbaut, E., Bamps, A., Prinsen, J., Steyaert, J. G., Alaerts, K., et al. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13850 · Cited by 26
Electro-acupuncture improves the social interaction behavior of rats
Zhang, H., Li, H.-X., Dai, Y., Xu, X., Han, S., Zhang, R., & Han, J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.014 · Cited by 24
What does Williams syndrome reveal about the determinants of social behavior?
Järvinen, A., & Bellugi, U. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00321 · Cited by 24
“Neuroimaging data pinpoint contingencies between the effects of OT and the nature of the stimulus: OT decreases amygdala responses for fearful faces, while increasing responses for happy faces (Gamer et al., 2010).”
BackgroundEffects of oxytocin on human social approach measured using intimacy equilibriums
Liu, J. C., Guastella, A. J., & Dadds, M. R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.09.002 · Cited by 24
“For example, studies have found that oxytocin increases gaze to the eye region of faces presented through photographs (Andari et al., 2010; Gamer et al., 2010; Guastella et al., 2008).”
BackgroundBernaerts, S., Berra, E., Wenderoth, N., & Alaerts, K. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.002 · Cited by 24
“Exogenously administered OT has also been shown to stimulate gaze towards the eye region (Gamer et al., 2010; Guastella et al., 2008) and increase eye contact (Auyeung et al., 2015).”
Metadata
- Authors
- Gamer, M., Zurowski, B., & Büchel, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-04-26
- Volume
- 107
- Issue
- 20
- Pages
- 9400-9405
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2889107
- OpenAlex
- W2077718235
- Cited by
- 487
- References
- 53
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 25 · 2020: 38 · 2019: 16 · 2018: 31 · 2017: 40 · 2016: 30 · 2015: 38 · 2014: 43 · 2013: 59 · 2012: 46
- FWCI
- 68.76
- Type
- journal article
- Language
- en
- Update notices
- correction (2011-01-18)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, amygdala subregions, emotional face processing, valence, attentional bias, gaze shifts, eye movements, superior colliculus, social cognition
- MeSH terms
- Adult, Amygdala, Attention, Double-Blind Method, Emotions, Eye Movements, Face, Germany, Humans, Magnetic Resonance Imaging, Male, Oxytocin, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
