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Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques ( Macaca mulatta )
Open accessAbstract
People attend not only to their own experiences, but also to the experiences of those around them. Such social awareness profoundly influences human behavior by enabling observational learning, as well as by motivating cooperation, charity, empathy, and spite. Oxytocin (OT), a neurosecretory hormone synthesized by hypothalamic neurons in the mammalian brain, can enhance affiliation or boost exclusion in different species in distinct contexts, belying any simple mechanistic neural model. Here we show that inhaled OT penetrates the CNS and subsequently enhances the sensitivity of rhesus macaques to rewards occurring to others as well as themselves. Roughly 2 h after inhaling OT, monkeys increased the frequency of prosocial choices associated with reward to another monkey when the alternative was to reward no one. OT also increased attention to the recipient monkey as well as the time it took to render such a decision. In contrast, within the first 2 h following inhalation, OT increased selfish choices associated with delivery of reward to self over a reward to the other monkey, without affecting attention or decision latency. Despite the differences in species typical social behavior, exogenous, inhaled OT causally promotes social donation behavior in rhesus monkeys, as it does in more egalitarian and monogamous ones, like prairie voles and humans, when there is no perceived cost to self. These findings potentially implicate shared neural mechanisms.
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In the citing paper
“Of the above-mentioned studies, four (20,22,24,25) achieved oxytocin concentrations in excess of 20pg/ml from basal levels of <5pg/ml, while Dal Monte et al. reported a rise to 80pg/ml after nasal spray, but no significant rise with a nebulariser (23).Modi et al. reported a 100-fold increase in plasma in the macaque (to >300pg/ml), and a rise to ~60pg/ml (from 10pg/ml) after nebulariser”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [24]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Chang et al. gave 25IU oxytocin to two macaques, and reported a rise in CSF from ~20 to ~50pg/ml at 35min (24).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [24]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“neuropeptides have been shown to gain access to the brain following intranasal administration (Born et al., 2002;Chang et al., 2012).”
From Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict (2013) · cites this paper as Chang et al., 2012
In the citing paper
“This work provides anatomical support for other findings in macaques, which indicate that IN-OXT treatment increases gaze following67, increases socially oriented gaze68, and alters social attention in a wide variety of contexts69–74.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [68]
In the citing paper
“OT also enhances socially reinforced learning (Parr, 2014), and increases reward allocation to a partner monkey (Chang et al., 2012).”
From Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys (2016) · cites this paper as Chang et al., 2012
In the citing paper
“This way the expected period of rise in OT levels (20–45 min) coincided with the post-treatment viewing period (Chang et al., 2012; Dal Monte et al., 2014b).”
From Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys (2016) · cites this paper as Chang et al., 2012
In the citing paper
“Behavioral testing began 30 min after each treatment, given that animal studies in both rodents (53) and nonhuman primate (54, 55) have shown central elevations of OT concentration after 30 min from intranasal administration.”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [54]
In the citing paper
“This dose, administered intranasally, has been shown in nonhuman primates to increase OT levels in cerebrospinal fluid significantly (54) and to modulate social behavior (65), as well as to affect brain activity (66) and phasic activity of the parasympathetic nervous system (67) in humans.”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [54]
In the citing paper
“In rhesus macaques, three studies have found that treatment with IN-OT impacts social visual attention and looking behaviours in a variety of tasks (77-79).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [77]
In the citing paper
“The intranasal dose administered in the present study has been associated with changes in central function in humans 58, and similar or smaller doses of oxytocin or vasopressin (24–48 IU for oxytocin; 40–80 IU for vasopressin) have been associated with elevations in peptide levels in the cerebrospinnal fluid in humans or macaques of no more than approximately 55 pg/ml in actual levels 70, 71, 72,”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [73]
In the citing paper
“In rhesus macaques, for example, Chang et al. (2012) found that subjects that engaged in a food sharing task showed first greater selfish choices and after 2 h greater prosocial choices after inhaling oxytocin.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Finally, in some studies oxytocin only increases positive perceptions or social motivations toward others (Chang et al., 2012; Shamay-Tsoory et al., 2013) and in other studies it also amplifies pre-existing social motivations or perceptions, whether positive or negative (De Dreu, 2012).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Chang et al., 2012
In the citing paper
“More recently, Neumann et al. (2013) in mice and rats, and Chang et al. (2012) in rhesus monkeys showed that inhaled oxytocin arrives in the behaviorally-relevant parts of the brain and in the CSF, respectively, although the exact route remains elusive.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Chang et al., 2012
In the citing paper
“That oxytocin release may depend more on an individuals' social perception of an interaction than on the properties of the interaction itself mirrors other studies on human and non-human primates which suggest that inhaled oxytocin changes individuals' perception or motivation toward a social context (Chang et al., 2012; Parr et al., 2013, for reviews see: Bartz et al., 2011; Olff et al., 2013).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Studies using exogenous oxytocin have highlighted how a possible effect of oxytocin is to change individuals' social motivations or perceptions of a current social context, such that individuals that inhale oxytocin compared with those that do not, become more affiliative, attentive, prosocial or empathetic to the same social stimuli (e.g., Bartz et al., 2011; Chang et al., 2012; Parr et al., 2013”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Also, in monkeys, IN-OT or OT intake via a nebulizer (25 or 48 IU) increased OT CSF concentration compared to placebo (Chang et al. 2012; Dal Monte et al. 2014; Modi et al. 2014).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Chang et al. 2012
In the citing paper
“In nonhuman primates, exogenous inhaled oxytocin promotes social donation behavior 26 and focal infusion of oxytocin into the amygdala significantly increases prosocial decisions 7 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [26]
In the citing paper
“There is accumulated research on the role of IN-OT in promoting social exploration, enhancing social motivation and attenuating social vigilance in nonhuman primate models (Chang et al. 2012; Chang and Platt 2014; Ebitz and Platt 2013; Parr et al. 2013; Putnam et al. 2016).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Chang et al. 2012
In the citing paper
“It is estimated that only a small amount of intranasally administered oxytocin reaches the brain.33, 34, 46, 47”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [46]
In the citing paper
“Using a pediatric nebulizer, we recently showed that inhaled oronasal administration of OT increases its concentration in the cerebrospinal fluid (CSF), measured at 30 min post-delivery (Chang et al., 2012) (Fig. 1B).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Oronasal nebulization of OT amplifies these self-regarding and other-regarding preferences in rhesus macaques (Chang et al., 2012).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“When choosing between allocating juice rewards to a recipient monkey and no one at all, exogenous OT enhances the baseline prosocial bias (Fig. 2A).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Furthermore, inhaled OT significantly increases reaction times when the actor monkeys choose between donating juice rewards to the recipient monkey and no one (Chang et al., 2012) (Fig. 2C), inviting the possibility that OT promotes prosocial choices by increasing internal deliberative processing in rhesus macaques.”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“By contrast, when choosing between delivering juice rewards to themselves and to the recipients, inhaled OT amplifies the self-regarding preference (i.e., delivering juice to only themselves over only the recipients), essentially eliminating the small number of prosocial choices in this competitive context (Fig. 2A).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Amplified prosocial preference is accompanied by an increase in gaze shifts to the recipient monkeys’ face region following OT (Fig. 2B).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Critically, the OT-treated actors do not increase such gaze shifts to the recipient monkeys when the juice rewards are delivered to the recipients by the experimenter (i.e., cued condition) (Chang et al., 2012).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Based on these results, we conjecture that reduced vigilance might play a permissive role in social approach behavior, favoring increased attention to faces and eyes and subsequent enhancements in social cognition.”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“The efficacy of the nebulized inhalation method for delivering OT to the CNS in alert rhesus macaques prior to experimental tasks (Chang et al., 2012; Modi et al., in press) makes it easier to compare neurophysiological results from animal studies with behavioral or neuroimaging results obtained from both healthy people and those with neuropsychiatric disorders.”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Chang et al., 2012
In the citing paper
“Ultimately, prosocial responses occur through multiple processes both within and across species, some of which may be modified by OXT (Brosnan, Talbot, et al., 2015; Chang et al., 2012; Mustoe et al., 2015) while others may not (this study).”
From Inequity aversion strategies between marmosets are influenced by partner familiarity and sex but not by oxytocin (2016) · cites this paper as Chang et al., 2012
In the citing paper
“the exact transnasal-CNS route remains unknown, and the proportion of OXT that actually reaches the CNS is exceptionally small relative to the given dose (Born et al., 2002; Chang et al., 2012; Striepens et al., 2013; Dal Monte et al., 2014; Modi et al., 2014).”
From Marmosets treated with oxytocin are more socially attractive to their long-term mate (2015) · cites this paper as Chang et al., 2012
In the citing paper
“These results suggest that intranasal administration rapidly upregulates OT levels in the brain and plasma during the timeframe of behavioral testing, and that OT clears the system several hours after testing.”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Chang et al., 2012
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Citations
Cites
Does the autistic child have a “theory of mind” ?
Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985) · Cognition · doi:10.1016/0010-0277(85)90022-8 · Cited by 8,599
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Frith, C., & Frith, U. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.041 · Cited by 3,561
Fehr, E., & Fischbacher, U. (2003) · Nature · doi:10.1038/nature02043 · Cited by 3,475 · cited 3×
“Such vicarious reward could motivate social interactions as well as underlie observational learning and mutualistic behaviors such as alliance formation, social grooming, and group cohesion (Fehr and Fischbacher, 2003; Takahashi et al., 2009).”
BackgroundOxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581 · cited 3×
“OT can both promote cooperation and increase out-group bias depending on behavioral context (16, 17, 39).”
BackgroundSniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Research works printed but not linked: 1
- CA Pedersen Oxytocin Control of Maternal Behavior: Regulation of Sex Steroids and Offspring Stimuli. The Integrative Neurobiology of Affiliation, eds CS Carter, I Lederhendler, B Kirkpatrick (MIT Press, Cambridge, MA), pp. 301–320 (1999).
Cited by
Sorted by citations
Items 101–200 of 252
Bauman, M. D., Lesh, T. A., Rowland, D. J., Schumann, C. M., Smucny, J., Kukis, D. L., Cherry, S. R., McAllister, A. K., & Carter, C. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0449-y · Cited by 43
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva, M., & Chang, S. W. C. (2018) · American Journal of Primatology · doi:10.1002/ajp.22735 · Cited by 38
“This paradigm led to a selfregarding preference (choosing to reward themselves over the conspecific) as well as an other-regarding preference (choosing to reward the conspecific over neither) depending on context (Chang et al., 2012).”
BackgroundMethodResultInfluentialSelf-citationA precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40
“Also, in monkeys, IN-OT or OT intake via a nebulizer (25 or 48 IU) increased OT CSF concentration compared to placebo (Chang et al. 2012; Dal Monte et al. 2014; Modi et al. 2014).”
BackgroundMethodAlaerts, K., Bernaerts, S., Vanaudenaerde, B. M., Daniëls, N., & Wenderoth, N. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.01.008 · Cited by 42
Yeomans, D. C., Hanson, L. R., Carson, D. S., Tunstall, B. J., Lee, M. R., Tzabazis, A., Jacobs, D. L., & Frey, W. H. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01511-7 · Cited by 42
Oxytocin tempers calculated greed but not impulsive defense in predator–prey contests
Dreu, C. K. W. D., Scholte, H. S., van Winden, F. A. A. M., & Ridderinkhof, K. R. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu109 · Cited by 40
“…approach fits studies showing that oxytocin increases trust and generosity (Kosfeld et al., 2005; Baumgartner et al., 2008; De Dreu et al., 2010; Chang et al., 2012), and studies showing that oxytocin upregulates neural circuitries involved in empathic concern and reward processing (Skuse and…”
BackgroundMarmosets treated with oxytocin are more socially attractive to their long-term mate
Cavanaugh, J., Huffman, M. C., Harnisch, A. M., & French, J. A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00251 · Cited by 36
“The neuropeptides OXT and arginine-vasopressin (AVP) are transported to the CNS and accumulate in the cerebrospinal fluid (CSF) in humans (Born et al., 2002; Striepens et al., 2013) and macaques (Chang et al., 2012; Dal Monte et al., 2014).”
BackgroundFinger, E. C., Berry, S. M., Cummings, J. L., Coleman, K. K. L., Hsiung, G. R., Feldman, H., & Boxer, A. L. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0427-2 · Cited by 38
Cardoso, C., Orlando, M. A., Brown, C. A., & Ellenbogen, M. A. (2014) · Social Neuroscience · doi:10.1080/17470919.2013.873079 · Cited by 38
“…research has shown that 60 minutes of treadmill exercise is not sufficient to elicit changes in endogenous oxytocin release (Hew-Butler, Noakes, Soldin, & Verballs, 2008), and no increase in endogenous oxytocin was observed following vigorous cycling in another study (Chicharro et al., 2001).”
BackgroundSimpson, E. A., Paukner, A., Sclafani, V., Kaburu, S., Suomi, S. J., & Ferrari, P. F. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4480-x · Cited by 38
Direct reciprocity in animals: The roles of bonding and affective processes
Freidín, E., Carballo, F., & Bentosela, M. (2015) · International Journal of Psychology · doi:10.1002/ijop.12215 · Cited by 36
An evolutionary perspective on the behavioral consequences of exogenous oxytocin application
Ebitz, R. B., & Platt, M. L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00225 · Cited by 35
“, 2013) and live conspecifics (Chang et al., 2012), OT conversely obliterates the attentional salience of face images (Ebitz et al.”
InfluentialOxytocin and Behavior: Evidence for Effects in the Brain
Stevens, F. L., Wiesman, O., Feldman, R., Hurley, R. A., & Taber, K. H. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13030061 · Cited by 38
“CSF levels of OT after intranasal administration and altered prosocial behaviors.(54) At present, route(s) of uptake”
BackgroundInterplay between the oxytocin and opioid systems in regulating social behaviour
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 33
“In non-human primates, oxytocin increases time spent looking at faces [35,36], improves socially reinforced learning [37], increases the frequency of gaze following behaviours [38] and promotes the donation of rewards to social partners [39,40].”
Backgroundvan IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12355 · Cited by 33
Urinary oxytocin in capuchin monkeys: Validation and the influence of social behavior
Benítez, M. E., Sosnowski, M. J., Tomeo, O. B., & Brosnan, S. F. (2018) · American Journal of Primatology · doi:10.1002/ajp.22877 · Cited by 34
“To date, however, research on oxytocin has been largely confined to a handful of species (Pan troglodytes; Chang et al., 2012; Crockford et al., 2013;Macaca spp.; Ebitz, Watson, & Platt, 2013; Finkenwirth et al., 2015; Finkenwirth, Martins, Deschner, & Burkart, 2016;Callitrix spp.; e.g., example,; Freemanetal., 2014;M…”
BackgroundResultThe Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
Okamoto, Y., Ishitobi, M., Wada, Y., & Kosaka, H. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413120845 · Cited by 33
“Elevated levels following intranasally injected oxytocin were also confirmed in non-human primates [62-64].”
BackgroundXu, X., Yao, S., Xu, L., Geng, Y., Zhao, W., Ma, X., Kou, J., Luo, R., & Kendrick, K. M. (2017) · Scientific Reports · doi:10.1038/srep40589 · Cited by 33
“…effects of intranasal OXT are mediated via direct central or indirect peripheral routes 53 , although many reports in both humans 25 and monkeys 54–57 have consistently found increased concentrations in cerebrospinal fluid and the presence of radiolabelled peptides in the brain in rats after…”
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Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 34
Non-invasive primate head restraint using thermoplastic masks
Drucker, C. B., Carlson, M. L., Toda, K., DeWind, N. K., & Platt, M. L. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.06.013 · Cited by 34
“Other techniques facilitated by head fixation include microstimulation (Tehovnik et al., 2006) and drug delivery via intracranial injection (Kurata and Hoffman, 1994; Roy et al., 2014; Sommer and Wurtz, 2006) or a nebulizer (Chang et al., 2012).”
BackgroundMethodHelping behavior in prairie voles: a model of empathy and the importance of oxytocin
Kitano, K., Yamagishi, A., Horie, K., Nishimori, K., & Sato, N. (2022) · iScience · doi:10.1016/j.isci.2022.103991 · Cited by 31
Oxytocin reduces food sharing in capuchin monkeys by modulating social distance
Brosnan, S. F., Talbot, C. F., Essler, J. L., Leverett, K., Flemming, T., Dougall, P., Heyler, C., & Zak, P. J. (2015) · Behaviour · doi:10.1163/1568539x-00003268 · Cited by 30
“OT infusion had a similar effect at decreasing willingness to provide food for others at the expense of oneself in macaques (subjects serially chose whether to allocate rewards to themselves or another macaque; Chang et al., 2012).”
BackgroundResultInfluentialCoordinate transformation approach to social interactions
Chang, S. W. C. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00147 · Cited by 31
“For instance, oxytocin, known for its role in modulating social cognition (Donaldson and Young, 2008), amplifies both self and vicarious reinforcement (increases both red and green Gs in Figure 3) in rhesus monkeys during social decision-making in a context-dependent manner (Chang et al., 2012).”
BackgroundOxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain
Lefèvre, A., Mottolese, R., Redouté, J., Costes, N., Bars, D. L., Geoffray, M., Leboyer, M., & Sirigu, A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx272 · Cited by 31
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28
Oxytocin and the emergence of individual differences in the social regulation of stress
Chen, F. S., Heinrichs, M., & Johnson, S. C. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12332 · Cited by 31
Wiśniewski, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_11 · Cited by 30
Pharmacology of Economic and Social Decision Making
Crockett, M. J., & Fehr, E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416008-8.00014-0 · Cited by 29
Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study
Oliver, L. D., Stewart, C., Coleman, K., Kryklywy, J. H., Bartha, R., Mitchell, D. G. V., & Finger, E. C. (2020) · Neurology · doi:10.1212/wnl.0000000000010933 · Cited by 26
The marmoset as a model for investigating the neural basis of social cognition in health and disease
Samandra, R., Haque, Z. Z., Rosa, M. G. P., & Mansouri, F. A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104692 · Cited by 23
Velden, F. S. T., Baas, M., Shalvi, S., Kret, M. E., & Dreu, C. K. W. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.013 · Cited by 26
“Indeed, both humans and non-human mammals show increased benevolence under oxytocin, including tendencies to benefit con-specifics (Chang et al., 2012), to trust others (Baumgartner et al.”
InfluentialOpportunities and challenges for intranasal oxytocin treatment studies in nonhuman primates
Bauman, M. D., Murai, T., Hogrefe, C. E., & Platt, M. L. (2018) · American Journal of Primatology · doi:10.1002/ajp.22913 · Cited by 25
Río, R. T.-D., van den Burg, E. H., Stoop, R., & Hegoburu, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5030-5 · Cited by 26
Flanagan, J. C., Sippel, L. M., Maria, M. M. M., Hartwell, K. J., Brady, K. T., & Joseph, J. E. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1606626 · Cited by 29
Oxytocin and interpersonal relationships
Patin, A., Scheele, D., & Hurlemann, R. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_22 · Cited by 32
“…fluid oxytocin levels in both humans (Striepens et al. 2013) and macaques (Freeman et al. 2016; for studies including aerosolized OT, see Chang et al. 2012; Dal Monte et al. 2014; Modi et al. 2014), indicating that OT most likely enters the brain and has a direct effect on central OT…”
BackgroundBernaerts, S., Berra, E., Wenderoth, N., & Alaerts, K. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.002 · Cited by 24
“The efficacy of this time interval for intranasal oxytocin administration has been confirmed by animal research (Chang et al., 2012; Neumann et al., 2013) and human research (Daughters et al., 2015).”
Bridging the species gap in translational research for neurodevelopmental disorders
Ryan, A. M., Berman, R. F., & Bauman, M. D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.006 · Cited by 25
Intranasal oxytocin enhances socially-reinforced learning in rhesus monkeys
Parr, L. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00278 · Cited by 23
Comparison of anesthesia protocols for intravenous glucose tolerance testing in rhesus monkeys
Vaughan, K. L., Szarowicz, M. D., Herbert, R. L., & Mattison, J. A. (2014) · Journal of Medical Primatology · doi:10.1111/jmp.12104 · Cited by 23
Hall, K., Smith, M. F., Russell, J. L., Lambeth, S. P., Schapiro, S. J., & Brosnan, S. F. (2019) · Animal Behavior and Cognition · doi:10.26451/abc.06.01.04.2019 · Cited by 23
“Additionally, we followed other studies by including a 30-minute wait period between OT administration and the economic games to allow for OT uptake (Cavanaugh, Huffman, Harnisch, & French, 2015; Chang et al., 2012; Gossen et al., 2012; MacDonald et al., 2011; Porges & Carter, 2011; Scheele et al, 2013; Smith, Ågmo, B…”
BackgroundMethodInfluentialEffects of chronic oxytocin on attention to dynamic facial expressions in infant macaques
Parr, L. A., Brooks, J. M., Jonesteller, T., Moss, S., Jordano, J. O., & Heitz, T. R. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.028 · Cited by 23
“These procedures have been shown to successfully deliver IN-OT to the central and peripheral nervous systems in both monkeys and humans (Chang et al., 2012; Dal Monte et al., 2014b; Freeman et al., 2016; Modi et al. 2014; Striepens et al., 2013).”
BackgroundOxytocin improves the ability of dogs to follow informative pointing: a neuroemotional hypothesis
Macchitella, L., Stegagno, T., Giaconella, R., di Sorrentino, E. P., Schino, G., & Addessi, E. (2016) · RENDICONTI LINCEI · doi:10.1007/s12210-016-0579-6 · Cited by 22
“Several lines of evidence show that in non-human animals inhaled oxytocin reaches target brain areas and cerebrospinal fluid (e.g. mice and rats, Neumann et al. 2013; rhesus macaques, Chang et al. 2012; Liu et al. 2015).”
BackgroundInhaled vasopressin increases sociability and reduces body temperature and heart rate in rats
Ramos, L., Hicks, C., Caminer, A., & McGregor, I. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.013 · Cited by 21
“Nebulized, inhaled OT facilitated prosocial and altruistic behaviors in rhesus macaques and reduced vigilance toward social threats (Chang et al., 2012; Ebitz et al., 2013).”
BackgroundAn evolutionary behaviorist perspective on orgasm
Fleischman, D. S. (2016) · Socioaffective Neuroscience & Psychology · doi:10.3402/snp.v6.32130 · Cited by 21
Endorphins, oxytocin, sexuality and romantic relationships: An understudied area
Khajehei, M., & Behroozpour, E. (2018) · World Journal of Obstetrics and Gynecology · doi:10.5317/wjog.v7.i2.17 · Cited by 22
Zhao, W., Geng, Y., Luo, L., Zhao, Z., Ma, X., Xu, L., Yao, S., & Kendrick, K. M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00272 · Cited by 20
“It should be acknowledged that studies have reported variable time-courses for increased cerebrospinal fluid concentrations of OXT after intranasal application in either monkeys or humans (Chang et al., 2012; Guastella et al., 2013).”
BackgroundKasos, E., Kasos, K., Pusztai, F., Polyák, Á., Kovács, K. J., & Varga, K. (2018) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2018.1495009 · Cited by 20
Effects of Intranasal Oxytocin on Steroid Hormones in Men and Women
Wirth, M. M., Gaffey, A. E., & Martinez, B. S. (2015) · Neuropsychobiology · doi:10.1159/000381023 · Cited by 22
The effect of oxytocin on the anthropomorphism of touch
Peled‐Avron, L., Perry, A., & Shamay‐Tsoory, S. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.015 · Cited by 20
Clinical potential of oxytocin in autism spectrum disorder: current issues and future perspectives
Benner, S., & Yamasue, H. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000341 · Cited by 19
“In non-human primates, oxytocin administration results in enhanced sensitivity to rewards received by others (Chang et al., 2012).”
Oxytocin Increases Prosocial Behavior in Groups of African Lions
Burkhart, J. C., Gupta, S., Borrego, N., Heilbronner, S. R., & Packer, C. (2021) · iScience · doi:10.1016/j.isci.2022.104049 · Cited by 19
Oxytocin increases after affiliative interactions in male Barbary macaques
Rincon, A. V., Deschner, T., Schülke, O., & Ostner, J. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104661 · Cited by 21
Oxytocin and vasopressin increase male-directed threats and vocalizations in female macaques
Jiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-36332-0 · Cited by 20
Victory is its own reward: oxytocin increases costly competitive behavior in schizophrenia
Bradley, E., Brustkern, J., Coster, L. D., van den Bos, W., McClure, S. M., Seitz, A., & Woolley, J. D. (2019) · Psychological Medicine · doi:10.1017/s0033291719000552 · Cited by 21
“, 2017), and in macaques, it has been shown to increase sensitivity to rewards received by others (Chang et al., 2012).”
BackgroundBalint, Z. K., Raper, J., Michopoulos, V., Howell, L. H., Gunter, C., Bachevalier, J., & Sánchez, M. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0235946 · Cited by 18
“as mother-offspring bonds, social play, reciprocal prosocial interactions, strong family alliances that preserve the status in the social hierarchy, as well as social awareness (15-18).”
BackgroundDevelopment of social systems neuroscience using macaques
Isoda, M., Noritake, A., & Ninomiya, T. (2018) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.94.020 · Cited by 19
Festante, F., Ferrari, P. F., Thorpe, S., Buchanan, R. W., & Fox, N. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104467 · Cited by 19
“Following extensive research in animal models (Chang et al., 2012; Chang and Platt, 2014; Simpson et al., 2014), investigations involving human participants have demonstrated that, beyond the well known peripheral effects exerted by OT on reproduction-related behaviors, its central release in the brain, as a neuromodu…”
BackgroundBusnelli, M., Dagani, J., de Girolamo, G., Balestrieri, M., Pini, S., Saviotti, F. M., Scocco, P., Sisti, D., Rocchi, M., & Chini, B. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12359 · Cited by 19
Prinsen, J., Brams, S., & Alaerts, K. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.016 · Cited by 20
Social relevance drives viewing behavior independent of low-level salience in rhesus macaques
Solyst, J. A., & Buffalo, E. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00354 · Cited by 20
Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories
Parmaksiz, D., & Kim, Y. (2024) · The Neuroscientist · doi:10.1177/10738584241268754 · Cited by 21
Goh, K. K., & Lu, M. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.09.013 · Cited by 18
Fletcher, R., Amemori, K., Goodwin, M. S., & Graybiel, A. M. (2012) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2012.6346855 · Cited by 16
“The hormone oxytocin, for example, has been shown to enhance certain social skills in monkeys and humans and has been used in the treatment of autism [3].”
BackgroundSmith, M. F., Leverett, K. L., Wilson, B. J., & Brosnan, S. F. (2019) · American Journal of Primatology · doi:10.1002/ajp.22973 · Cited by 16
“…in animals in some scenarios (Chang, Barter, Ebitz, Watson, & Platt, 2012; A. S. Smith, Ågmo, Birnie, & French, 2010; mesotocin (avian homologue); Duque, Leichner, Ahmann, & Stevens, 2018) but it decreases prosocial behavior and food sharing in others (Brosnan et al., 2015; Chang et al., 2012).”
BackgroundZarei, S. A., Sheibani, V., Tomaz, C. A. B., & Mansouri, F. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.050 · Cited by 17
“Oxytocin was delivered within the test cage and 60min after the end of oxytocin administration (maximum oxytocin absorption of cerebrospinal fluid [38,39]), monkeys (within the test cage) were transferred to the testing cubicle and allowed to perform the cognitive task (Fig.”
InfluentialTaubert, J., Flessert, M., Liu, N., & Ungerleider, L. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-51422-3 · Cited by 17
The effect of intranasal oxytocin on social reward processing in humans: a systematic review
Kraus, J., Výborová, E., & Silani, G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1244027 · Cited by 16
“(74) used six rhesus macaques to measure CSF levels of oxytocin and found significant increase after 35 min, however, the prosocial behavioral effects were manifested no earlier than 2 h post-administration.”
BackgroundMethodTaylor, J. H., Intorre, A. A., & French, J. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00181 · Cited by 16
“However, when choosing to reward the self or another, OT increased selfish choices (56).”
BackgroundSocial processing by the primate medial frontal cortex
Putnam, P. T., & Chang, S. W. C. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.12.003 · Cited by 19
Pedersen, C. A., Chang, S. W. C., & Williams, C. L. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.033 · Cited by 17
“…prairie vole (Young and Wang, 2004) and marmosets (Smith et al., 2010), studies indicating OT regulation of social interactions in rhesus macaques (Chang et al., 2012; Parr et al., 2013; Ebitz et al., 2013; Winslow et al., 2003) and the rapidly accumulating number of reports of OT influences…”
BackgroundInfluentialIntranasal Oxytocin Failed to Affect Chimpanzee (Pan troglodytes) Social Behavior
Proctor, D. P., Calcutt, S. E., Burke, K., & de Waal, F. Β. Μ. (2016) · Animal Behavior and Cognition · doi:10.12966/abc.04.08.2016 · Cited by 14
“Human doses range from 18–60 IU (Heinrichs et al., 2003; MacDonald et al., 2011) and rhesus macaques, who weigh much less than humans, are dosed with 24 or 48 IU (Chang et al., 2012; Parr, Modi, Siebert, & Young, 2013).”
Intranasal Oxytocin Does Not Modulate Responses to Alcohol in Social Drinkers
Vena, A. A., King, A. C., Lee, R., & de Wit, H. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13814 · Cited by 14
“While some show increased CSF concentrations of oxytocin within 30 to 60 minutes of intranasal administration (Chang et al., 2012; Dal Monte et al., 2014; Freeman et al., 2016; Modi et al., 2014), another shows no significant changes (Modi et al.”
Differences in how macaques monitor others: Does serotonin play a central role?
Weinberg‐Wolf, H., & Chang, S. W. C. (2019) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1494 · Cited by 13
Is ‘bench-to-bedside’ realistic for autism? An integrative neuroscience approach
Bauman, M. D., & Schumann, C. M. (2013) · Neuropsychiatry · doi:10.2217/npy.13.18 · Cited by 13
“Recent studies using nonhuman primates indicate that inhaled OT in rhesus monkeys penetrates the CNS and increases prosocial behaviors in a reward allocation test [77].”
BackgroundThe role of oxytocin on peaceful associations and sociality in mammals
Romero, T., Onishi, K., & Hasegawa, T. (2016) · Behaviour · doi:10.1163/1568539x-00003358 · Cited by 13
Intranasal oxytocin in rhesus monkeys alters brain networks that detect social salience and reward
Parr, L. A., Mitchell, T., & Hecht, E. E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22915 · Cited by 13
Eye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces
Marsh, N., Scheele, D., Postin, D., Onken, M., & Hurlemann, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.629760 · Cited by 12
“Furthermore, the peptide enhances socially reinforced learning (15), and increases reward allocation to a partner monkey (16).”
BackgroundCan oxytocin inhibit stress-induced hyperalgesia?
Li, Y.-X., An, H. Y., Wen, Z., Tao, Z.-Y., & Cao, D. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101996 · Cited by 13
Putnam, P. T., Chu, C.-C. J., Fagan, N. A., Monte, O. D., & Chang, S. W. C. (2023) · Neuron · doi:10.1016/j.neuron.2023.05.020 · Cited by 12
Oxytocin modulates mate-guarding behavior in marmoset monkeys
Cavanaugh, J., Mustoe, A. C., Womack, S. L., & French, J. A. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.10.009 · Cited by 13
“OT generally promotes the expression of social gaze and attention in rhesus macaques and humans (Bartz et al., 2011; Chang et al., 2012; Guastella et al., 2008; Putnam et al., 2016), and attenuates vigilant responses to aversive facial expressions and dominant individuals in macaques (Ebitz et al.”
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0047 · Cited by 13
Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review
Papadea, D., Dalla, C., & Tata, D. Α. (2023) · Brain Sciences · doi:10.3390/brainsci13030461 · Cited by 12
“Similarly, rhesus macaques were more likely to choose to reward another monkey, when the alternative was to reward no monkey at all, after OXT treatment [90].”
BackgroundBehavioral screening tools for identifying autism in macaques: existing and promising tests
Qin, D., Wu, S., Chen, Y., & Hu, X. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.018 · Cited by 12
Oxytocin and pair compatibility in adult male rhesus macaques (Macaca mulatta)
Berg, M. R., Heagerty, A., & Coleman, K. (2019) · American Journal of Primatology · doi:10.1002/ajp.23031 · Cited by 11
Vardanjani, M. M., Ghasemian, S., Sheibani, V., & Mansouri, F. A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113409 · Cited by 10
Oxytocin modulates responses to inequity in dogs
Romero, T., Konno, A., Nagasawa, M., & Hasegawa, T. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.12.023 · Cited by 9
-Phasic Model of xytocin (): A systematic conceptual review of oxytocin-related ERP research
Pehlivanoglu, D., Myers, E., & Ebner, N. C. (2020) · Biological Psychology · doi:10.1016/j.biopsycho.2020.107917 · Cited by 11
Jiang, Y., Feng, S., Belkaya, N., & Platt, M. L. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0133 · Cited by 9
“(c) Intranasal oxytocin delivery The procedure for intranasal OT delivery in macaque monkeys has been described in detail previously [68,78,79].”
BackgroundTaylor, J. H., Carp, S. B., & French, J. A. (2019) · Developmental Psychobiology · doi:10.1002/dev.21892 · Cited by 10
Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques
Leon, D. D., Nishitani, S., Walum, H., McCormack, K. M., Wilson, M. E., Smith, A. K., Young, L. J., & Sánchez, M. M. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104856 · Cited by 7
Oxytocin and vasopressin: the social networking buttons of the body
Mitra, A. K. (2021) · AIMS molecular science · doi:10.3934/molsci.2021003 · Cited by 6
“A research work on this aspect has indicated that administering oxytocin using either intranasal spray or a nebulizer to 15 primates (Macaca mulatta) has increased the oxytocin concentration in the cerebrospinal fluid as well as in blood [89].”
BackgroundThe vicarious construal effect: Seeing and experiencing the world through different eyes.
Jung, M. H., Gonzalez, F. J., & Critcher, C. R. (2019) · Journal of Personality and Social Psychology · doi:10.1037/pspa0000179 · Cited by 6
Oxytocin and social gaze during a dominance categorization task in tufted capuchin monkeys
Sosnowski, M. J., Kano, F., & Brosnan, S. F. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.977771 · Cited by 6
“Why would naturally-occurring oxytocin impact gaze behavior differently than exogenously administered oxytocin? One oft-considered possibility is that intranasally administered exogenous oxytocin might not cross the blood-brain barrier due to its large molecular size (Leng and Ludwig, 2016), although recent literature…”
BackgroundThe Effects of Affective Social Bonds on the Interactions and Survival of Simulated Agents
Khan, I., Lewis, M., & Cañamero, L. D. (2019) · International Conference on Affective Computing and Intelligent Interaction Workshops and Demos (ACIIW) · doi:10.1109/aciiw.2019.8925031 · Cited by 6
“[8] and empathy [6], [9], as well as anti-social behaviours”
BackgroundAutonomic arousal tracks outcome salience not valence in monkeys making social decisions.
Basile, B. M., Joiner, J. A., Monte, O. D., Fagan, N. A., Karaskiewicz, C. L., Lucas, D. R., Chang, S. W. C., & Murray, E. A. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000424 · Cited by 6
Oxytocin effects on socially transmitted food preferences are moderated by familiarity between rats
Noguer‐Calabús, I., Schäble, S., Dören, J., & Kalenscher, T. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06682-x · Cited by 6
“In non-human primates, OXT boosts own-and other-regarding preferences (Chang et al. 2012), and in humans, OXT has been shown to promote social cognition and prosocial behavior, too (Jurek and Neumann 2018; Marsh et al. 2021).”
Brain games: Toward a neuroecology of social behavior
Gariépy, J., Chang, S. W. C., & Platt, M. L. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12001938 · Cited by 5
Renicker, M. D., Cysewski, N., Palmer, S., Nakonechnyy, D., Keef, A., Thomas, M., Mágori, K., & Daberkow, D. P. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00105 · Cited by 5
Combinatorial approaches for treating neuropsychiatric social impairment
Don, W., Tsheringla, S., McPartland, J. C., & Allsop, S. A. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0051 · Cited by 6
Bauman, M. D., Crawley, J. N., & Berman, R. F. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0022368 · Cited by 5
Metadata
- Authors
- Chang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L.
- Affiliations
- Duke University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-01-03
- Volume
- 109
- Issue
- 3
- Pages
- 959-964
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3271866
- OpenAlex
- W2134524153
- Cited by
- 252
- References
- 49
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 15 · 2020: 8 · 2019: 24 · 2018: 27 · 2017: 24 · 2016: 25 · 2015: 20 · 2014: 28 · 2013: 27 · 2012: 12
- FWCI
- 41.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH086712, R01MH086712, R01MH095894)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vicarious reinforcement, self-reinforcement, social donations, prosocial behavior, selfishness, rhesus monkeys, social attention, reward sensitivity, social cognition, primate social behavior
- MeSH terms
- Administration, Intranasal, Animals, Decision Making, Humans, Macaca mulatta, Oxytocin, Reinforcement, Psychology, Reward, Time Factors, Inhalation Exposure
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