An evolutionary perspective on the behavioral consequences of exogenous oxytocin application
Open accessAbstract
Oxytocin (OT) is released in response to social signals, particularly positive ones like eye contact, social touch, sexual behavior, and affiliative vocalizations. Conversely, exogenous delivery of OT has diverse behavioral effects, sometimes promoting affiliative and prosocial behaviors, but sometimes suppressing them. Here, we argue that one unifying interpretation of these diverse effects is to view OT as an evolutionarily conserved physiological signal indicating affiliative interactions and predicting their behavioral consequences. In this model, OT regulates the way information about the social environment accesses the neural circuitry responsible for social behavior, thereby shaping it in sometimes counter intuitive but adaptive ways. Notably, prosociality is not always the most adaptive response to an affiliative signal from another individual. In many circumstances, an asocial or even antisocial response may confer greater fitness benefits. We argue that the behavioral effects of exogenous OT delivery not only parallel the behavioral effects of affiliative interactions, but are themselves adaptive responses to affiliative interactions. In support of this idea, we review recent evidence that OT does not unilaterally enhance social attention, as previously thought, but rather can reduce the typical prioritization of social information at the expense of other information or goals. Such diminished social vigilance may be an adaptive response to affiliative social interactions because it frees attentional resources for the pursuit of other goals. Finally, we predict that OT may mediate other behavioral consequences of social interactions, such as reduced predator vigilance, and argue that this is a rich avenue for future behavioral and neurobiological study.
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IN-OT promotes social exploration, enhances social motivation, and attenuates social vigilance in nonhuman primate models.
“There is accumulated research on the role of IN-OT in promoting social exploration, enhancing social motivation and attenuating social vigilance in nonhuman primate models (Chang et al. 2012; Chang and Platt 2014; Ebitz and Platt 2013; Parr et al. 2013; Putnam et al. 2016).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Ebitz and Platt 2013
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Links between the neurobiology of oxytocin and human musicality
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- Authors
- Ebitz, R. B., & Platt, M. L.
- Affiliations
- Duke University (US)
- Corresponding author
- Ebitz, R. Becket
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 7
- Pages
- 225-225
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC3894461
- OpenAlex
- W2166013573
- Cited by
- 35
- References
- 108
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 2
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Defense (W81XWH1110584, W81XWH-11-1-, W81XWH)
- National Institutes of Health (W81XWH)
- National Institute of Mental Health (R01MH086712, R01MH089484, R01MH096875)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- oxytocin, affiliative behavior, prosocial behavior, antisocial behavior, social attention, social vigilance, evolutionary perspective, social information processing, predator vigilance, social signals, adaptive behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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