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A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth
Open accessAbstract
Significance: Children from families of low socioeconomic status (SES) are vulnerable to a variety of health problems. These risks begin in early childhood and persist across the lifecourse. Studies hint that nurturant parenting may offset these health risks, but it remains unclear whether these findings reflect a causal process and have clinical utility. Here we describe a randomized controlled trial, which sought to improve parenting and build youth competencies in low-SES African American families. The endpoint was low-grade inflammation, a process that underlies many health problems to which low-SES youth are vulnerable. Eight years after the intervention, youth who participated had significantly less inflammation than controls. If substantiated, these findings may provide a strategy for narrowing some of America’s social and racial disparities in health.
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“Multiple works have found that stress induced white blood cell programs and associated chronic diseases can be alleviated via social buffering (e.g., maternal warmth, social support, and family intervention) (Jiang et al., 2021; Miller et al., 2014; Tuchscherer et al., 2016).”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Miller et al., 2014
In the citing paper
“Considerable evidence suggests that caregiving-focused interventions, for instance, may mitigate the physiological effects of ELA.”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [98]
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“Some parameters improved by caregiving-focused interventions in longitudinal research include ELA-associated chronic inflammation [98], telomere shortening (accelerated genetic aging) [99], and gray matter volumetric changes [100].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [98]
In the citing paper
“An intervention study also showed that relative to a waitlist control, a 7-week family-oriented psychosocial intervention implemented among low-SES, 11-year-old youth resulted in lower markers of inflammation when youth were 19-years-old (Miller et al., 2014).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Miller et al., 2014
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Metadata
- Authors
- Miller, G. E., Brody, G. H., Yu, T., & Chen, E.
- Affiliations
- Northwestern University (US)
- University of Georgia (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-07-21
- Volume
- 111
- Issue
- 31
- Pages
- 11287-11292
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4128159
- OpenAlex
- W2123137959
- Cited by
- 180
- References
- 61
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 13 · 2023: 15 · 2022: 13 · 2021: 22 · 2020: 27 · 2019: 17 · 2018: 13 · 2017: 25 · 2016: 16 · 2015: 8 · 2014: 2
- FWCI
- 21.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL108723)
- National Institute on Drug Abuse (P30DA027827)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD058502)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Food Security and Health in Diverse Populations
- Keywords
- inflammation, low socioeconomic status, African American youth, cytokines, family relationships, youth competencies, racial disparities in health, rural Georgia
- MeSH terms
- Adolescent, Black or African American, Child, Family Relations, Female, Humans, Inflammation, Male, Mothers, Social Class, Social Support, Cytokines, Parenting, Young Adult
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